Endothelins

New England Journal of Medicine

Volumn 333, Issue 6, 1995, Pages 356-363

  Epstein, Franklin H ^a   Levin, Ellis Robert ^b  

^a Long Beach Veterans Hospital ^*

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [[ (HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

BRAIN ISCHEMIA; CONGESTIVE HEART FAILURE; DUCTUS ARTERIOSUS; GENE EXPRESSION REGULATION; HUMAN; HYPERTENSION; MOLECULAR BIOLOGY; NEPHROTOXICITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; ENDOTHELINS; HUMAN; KIDNEY DISEASES; LUNG DISEASES; RECEPTORS, ENDOTHELIN; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029116310     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199508103330607     Document Type: Review

References (89)

1. Hickey KA, Rubanyi GM, Paul RJ, Highsmith RF Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol 1985; 248: C550-C556
2. Yanagisawa M, Kurihara H, Kimura S, A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415
3. Nakamura S, Naruse M, Naruse K, Demura H, Uemura H Immunocytochemical localization of endothelin in cultured bovine endothelial cells. Histochemistry 1990; 94: 475-477
4. Inoue A, Yanagisawa M, Takuwa Y, Mitsui Y, Kobayashi M, Masaki T The human preproendothelin-1 gene. J Biol Chem 1989; 264: 14954-14959
5. de Nucci G, Thomas R, D'Orleans-Juste P, Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A 1988; 85: 9797-9800
6. Yoshimoto S, Ishizaki Y, Sasaki T, Murota S-I Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells. Stroke 1991; 22: 378-383
7. Wei C-M, Lerman A, Rodeheffer RJ, Endothelin in human congestive heart failure. Circulation 1994; 89: 1580-1586
8. Simonson MS Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375-411
9. Rubanyi GM, Polokoff MA Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 1994; 46: 325-415
10. Shinmi O, Kimura S, Sawamura T, Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain. Biochem Biophys Res Commun 1989; 164: 587-593
11. Lee M-E, Bloch KD, Clifford JA, Quertermous T Functional analysis of the endothelin-1 gene promoter: evidence for an endothelial cell-specific cis-acting sequence. J Biol Chem 1990; 265: 10446-10450
12. Wilson DB, Dorfman DM, Orkin SH A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol 1990; 10: 4854-4862
13. Hu R-M, Chuang MY, Prins B, High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells. J Clin Invest 1994; 93: 1056-1062
14. Hu R-M, Levin ER, Pedram A, Frank HJL Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells: mediation through the C receptor. J Biol Chem 1992; 267: 17384-17389
15. Xu D, Emoto N, Giaid A ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994; 78: 473-485
16. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990; 348: 730-732
17. Simonson MS, Dunn MJ Cellular signaling by peptides of the endothelin gene family. FASEB J 1990; 4: 2989-3000
18. Clarke JG, Benjamin N, Larkin SW, Webb DJ, Davies GJ, Maseri A Endothelin is a potent long-lasting vasoconstrictor in men. Am J Physiol 1989; 257: H2033-H2035
19. Goligorsky MS, Tsukahara H, Magazine H, Andersen TT, Malik AB, Bahou WF Termination of endothelin signaling: role of nitric oxide. J Cell Physiol 1994; 158: 485-494
20. Simonson MS, Herman WH Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1: cross-talk between G protein-coupled receptors and pp60c-src. J Biol Chem 1993; 268: 9347-9357
21. Ono K, Tsujimoto G, Sakamoto A, Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents. Nature 1994; 370: 301-304
22. Sakurai T, Yanagisawa M, Takuwa Y, Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 1990; 348: 732-735
23. Aramori I, Nakanishi S Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells. J Biol Chem 1992; 267: 12468-12474
24. Koh E, Morimoto S, Kim S, Nabata T, Miyashita Y, Ogihara T Endothelin stimulates Na+/H+ exchange in vascular smooth muscle cells. Biochem Int 1990; 20: 375-380
25. Hirata Y, Emori T, Eguchi S, Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J Clin Invest 1993; 91: 1367-1373
26. Filep JG, Herman F, Battistini B, Chabrier PE, Braquet P, Sirois P Antiaggregatory and hypotensive effects of endothelin-1 in beagle dogs: role for prostacyclin. J Cardiovasc Pharmacol 1991; 17: Suppl 7: S216-S218
27. Baynash AG, Hosoda K, Giaid A, Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 1994; 79: 1277-1285
28. Hosoda K, Hammer RE, Richardson JA, Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 1994; 79: 1267-1276
29. Puffenberger EG, Hosoda K, Washington SS, A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 1994; 79: 1257-1266
30. Kon V, Sugiura M, Inagami T, Harvie BR, Ichikawa I, Hoover RL Role of endothelin in cyclosporine-induced glomerular dysfunction. Kidney Int 1990; 37: 1487-1491
31. Ferrario RG, Foulkes R, Salvati P, Patrono C Hemodynamic and tubular effects of endothelin and thromboxane in the isolate perfused rat kidney. Eur J Pharmacol 1989; 171: 127-134
32. Goetz KL, Wang BC, Madwed JB, Zhu JL, Leadley RJ Jr Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs. Am J Physiol 1988; 255: R1064-R1068
33. Sadoshima J-I, Xu Y, Slayter HS, Izumo S Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993; 75: 977-984
34. Ito H, Hirata Y, Adachi S, Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 1993; 92: 398-403
35. Cozza EN, Chiou S, Gomez-Sanchez CE Endothelin-1 potentiation of angiotensin II stimulation of aldosterone production. Am J Physiol 1992; 262: R85-R89
36. Pfeffer MA, Braunwald E, Moye LA, Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial. N Engl J Med 1992; 327: 669-677
37. Boulanger C, Luscher TF Release of endothelin from the porcine aorta: inhibition by endothelium-derived nitric oxide. J Clin Invest 1990; 85: 587-590
38. Prins BA, Hu R-M, Nazario B, Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells. J Biol Chem 1994; 269: 11938-11944
39. Kohno M, Yasunari K, Yokokawa K, Murakawa K, Horio T, Takeda T Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest 1991; 87: 1999-2004
40. Thiemermann C, Lidbury PS, Thomas GR, Vane JR Endothelin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit. J Cardiovasc Pharmacol 1989; 13: Suppl 5: S138-S141
41. Miura K, Yukimura T, Yamashita Y, et al. Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins. J Pharmacol Exp Ther 1991;256:11-7
42. Macquin-Mavier I, Levame M, Istin N, Harf A Mechanisms of endothelin-mediated bronchoconstriction in the guinea pig. J Pharmacol Exp Ther 1989; 250: 740-745
43. Haynes WG, Webb DJ Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 1994; 344: 852-854
44. Seo B, Oemar BS, Siebenmann R, von Segesser L, Luscher TF Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Circulation 1994; 89: 1203-1208
45. Tabuchi Y, Nakamaru M, Rakugi H, Nagano M, Mikami H, Ogihara T Endothelin inhibits presynaptic adrenergic neurotransmission in rat mesenteric artery. Biochem Biophys Res Commun 1989; 161: 803-808
46. Lopez JA, Armstrong ML, Piegors DJ, Heistad DD Vascular responses to endothelin-1 in atherosclerotic primates. Arteriosclerosis 1990; 10: 1113-1118
47. Schiebinger RJ, Gomez-Sanchez CE Endothelin: a potent stimulus of atrial natriuretic peptide secretion by superfused rat atria and its dependency on calcium. Endocrinology 1990; 127: 119-125
48. Battistini B, D'Orleans-Juste P, Sirois P Endothelins: circulating plasma levels and presence in other biologic fluids. Lab Invest 1993; 68: 600-628
49. Kurihara H, Yamaoki K, Nahai R, Endothelin: a potent vasoconstrictor associated with coronary vasospasm. Life Sci 1989; 44: 1937-1943
50. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A Endothelin in myocardial infarction. Nature 1990; 344: 114-114
51. Grover GJ, Dzwonczyk S, Parham CS The endothelin-1 receptor antagonist BQ-123 reduced infarct size in a canine model of coronary occlusion and reperfusion. Cardiovasc Res 1993; 27: 1613-1618
52. Brunner F, du Toit EF, Opie LH Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts. J Mol Cell Cardiol 1992; 24: 1291-1305
53. Pacher R, Bergler-Klein J, Globits S, Plasma big endothelin-1 concentrations in congestive heart failure patients with or without systemic hypertension. Am J Cardiol 1993; 71: 1293-1299
54. Omland T, Lie RT, Aakvaag A, Aarsland T, Dickstein K Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction. Circulation 1994; 89: 1573-1579
55. Lerman A, Hildebrand FL Jr, Aarhus LL, Burnett JC Jr Endothelin has biological actions at pathophysiological concentrations. Circulation 1991; 83: 1808-1814
56. Shubeita HE, McDonough PM, Harris AN, Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem 1990; 265: 20555-20562
57. Rosolowsky LJ, Campbell WB Endothelin enhances adrenocorticotropin-stimulated aldosterone release from cultured bovine adrenal cells. Endocrinology 1990; 126: 1860-1866
58. Clavell AL, Wright RS, Thomas MR, Brandt RR, Opgenorth TJ, Burnett JC Jr Elevated endogenous endothelin mediates systemic vasoconstriction in experimental chronic congestive failure. J Am Coll Cardiol 1994; 172A-172A abstract.
59. Douglas SA, Louden C, Vickery-Clark LM, A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty: protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. Circ Res 1994; 75: 190-197
60. Oliver FJ, de la Rubia G, Feener EP, Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J Biol Chem 1991; 266: 23251-23256
61. Frank HJL, Levin ER, Hu R-M, Pedram A Insulin stimulates endothelin binding and action on cultured vascular smooth muscle cells. Endocrinology 1993; 133: 1092-1097
62. Yokokawa K, Tahara H, Kohno M, Hypertension associated with endothelin-secreting malignant hemangioendothelioma. Ann Intern Med 1991; 114: 213-215
63. Kurihara Y, Kurihara H, Suzuki H, Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994; 368: 703-710
64. Deng AY, Dene H, Pravenec M, Rapp JP Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 1994; 93: 2701-2709
65. Branch DW, Dudley DJ, Mitchell MD Preliminary evidence for homeostatic mechanism regulating endothelin production in pre-eclampsia. Lancet 1991; 337: 943-945
66. Schumacher WA, Steinbacher TE, Allen GT, Ogletree ML Role of thromboxane receptor activation in the bronchospastic response to endothelin. Prostaglandins 1990; 40: 71-79
67. Mattoli S, Mezzetti M, Riva G, Allegra L, Fasoli A Specific binding of endothelin on human bronchial smooth muscle cells in culture and secretion of endothelin-like material from bronchial epithelial cells. Am J Respir Cell Mol Biol 1990; 3: 145-151
68. Mattoli S, Soloperto M, Marini M, Fasoli A Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J Allergy Clin Immunol 1991; 88: 376-384
69. Giaid A, Michel RP, Stewart DJ, Sheppard M, Corrin B, Hamid Q Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Lancet 1993; 341: 1550-1554
70. Giaid A, Yanagisawa M, Langleben D, Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993; 328: 1732-1739
71. Bunchman TE, Brookshire CA Cyclosporine-induced synthesis of endothelin by cultured human endothelial cells. J Clin Invest 1991; 88: 310-314
72. Lanese DM, Conger JD Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles. J Clin Invest 1993; 91: 2144-2149
73. Fogo A, Hellings SE, Inagami T, Kon V Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity. Kidney Int 1992; 42: 770-774
74. Chan L, Chittinandana A, Shapiro JI, Shanley PF, Schrier RW Effect of an endothelin-receptor antagonist on ischemic acute renal failure. Am J Physiol 1994; 266: F135-F138
75. Clozel M, Breu V, Burri K, Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature 1993; 365: 759-761
76. Coceani F, Kelsey ZL Endothelin-1 release from lamb ductus arteriosus: relevance to postnatal closure of the vessel. Can J Physiol Pharmacol 1991; 69: 218-221
77. Levin ER Atrial natriuretic peptide and endothelin: interactions in the central nervous system and periphery. Mol Cell Neurosci 1991; 2: 189-201
78. Levin ER, Frank HJL, Pedram A Endothelin receptors on cultured fetal rat diencephalic glia. J Neurochem 1992; 58: 659-666
79. Vigne P, Lopez Farre A, Frelin C Na(+)-K(+)-Cl- cotransporter of brain capillary endothelial cells: properties and regulation by endothelins, hyperosmolar solutions, calyculin A, and interleukin-1. J Biol Chem 1994; 269: 19925-19930
80. Yamamoto T, Kimura T, Ota K, Central effects of endothelin-1 on vasopressin release, blood pressure, and renal solute excretion. Am J Physiol 1992; 262: E856-E862
81. Ouchi Y, Kim S, Souza AC, Central effect of endothelin on blood pressure in conscious rats. Am J Physiol 1989; 256: H1747-H1751
82. Samson WK, Murphy TC Antidipsogenic actions of endothelins are exerted via the endothelin-A receptor in the brain. Am J Physiol 1993; 265: R1212-R1215
83. Shichiri M, Hirata Y, Kanno K, Ohta K, Emori T, Marumo F Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus. Biochem Biophys Res Commun 1989; 163: 1332-1337
84. Kanyicksa B, Burris TP, Freeman ME Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture. Biochem Biophys Res Commun 1991; 174: 338-343
85. Ziv I, Fleminger G, Djaldetti R, Achiron A, Melamed E, Sokolovsky M Increased plasma endothelin-1 in acute ischemic stroke. Stroke 1992; 23: 1014-1016
86. Encabo A, Ferrer M, Marin J, Villamor J, Balfagon G Vasoconstrictive responses elicited by endothelin in bovine cerebral arteries. Gen Pharmacol 1992; 23: 263-267
87. Suzuki R, Masaoka H, Hirata Y, Marumo F, Isotani E, Hirakawa K The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 1992; 77: 96-100
88. Huneidi AHS, Thiemermann C, Lidbury PS, Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol 1991; 17: Suppl 7: S492-S495
89. Willette RN, Zhang H, Mitchell MP, Sauermelch CF, Ohlstein EH, Sulpizio AC Nonpeptide endothelin antagonist: cerebrovascular characterization and effects on delayed cerebral vasospasm. Stroke 1994; 25: 2450-2456