Preparation and optimization of a series of 3-carboxamido-5- phenacylaminopyrazole bradykinin B1 receptor antagonists

Journal of Medicinal Chemistry

Volumn 50, Issue 21, 2007, Pages 5161-5167

  Dressen, Darren ^a   Garofalo, Albert W ^a   Hawkinson, Jon ^a   Hom, Dennis ^a   Jagodzinski, Jacek ^a   Marugg, Jennifer L ^a   Neitzel, Martin L ^a   Pleiss, Michael A ^a   Szoke, Balazs ^a   Tung, Jay S ^a   Wone, David W G ^a   Wu, Jing ^a   Zhang, Heather ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CARBOXAMIDO 5 PHENACYLAMINOPYRAZOLE; BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG INDICATION; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PAIN; PRIMATE;

BENZAMIDES; CRYSTALLOGRAPHY, X-RAY; FIBROBLASTS; HUMANS; LUNG; MOLECULAR STRUCTURE; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTOR, BRADYKININ B1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35348906205     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051292n     Document Type: Article

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