Erythropoietin protects the intestine against ischemia/reperfusion injury in rats

Molecular Medicine

Volumn 13, Issue 9-10, 2007, Pages 509-517

  Guneli, Ensari ^a   Cavdar, Zahide ^b   Islekel, Huray ^b   Sarioglu, Sulen ^b   Erbayraktar, Serhat ^b   Kiray, Muge ^b   Sokmen, Selman ^b   Yilmaz, Osman ^a   Gokmen, Necati ^a  

^a IZMIR UNIVERSITY   (Turkey)

^b DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ERYTHROPOIETIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MYELOPEROXIDASE; RECOMBINANT ERYTHROPOIETIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE ISCHEMIA; JEJUNUM; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE;

ANIMALS; APOPTOSIS; CATALASE; ERYTHROPOIETIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INJECTIONS, INTRAPERITONEAL; INTESTINES; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 35348846589     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2007-00032.Guneli     Document Type: Article

References (54)

1. Granger DN, Korthuis RJ. (1995) Physiologic mechanisms of postischemic tissue injury. Annu. Rev. Physiol. 57:311-32.
2. Brandt, JL. (2003) Mesenteric vascular disease. Current Diagnosis and Treatment in Gastroenterology. New York: Section 1.9.
3. Mallick IH, Yang W, Winslet WC, Seifalian AM. (2004) Ischemia-Reperfusion Injury of the Intestine and Protective Strategies Against Injury. Dig. Dis. Sci. 49:1359-77.
4. Erbayraktar S et al. (2006) Carbamylated erythropoietin reduces radiosurgically-induced brain injury. Mol. Med. 12:74-80.
5. Siren AL, Ehrenreich H. (2001) Erythropoietin - a novel concept for neuroprotection. Eur. Arch. Psychiatry Clin. Neurosci. 25:179-84.
6. Celik M et al. (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc. Natl. Acad. Sci. 99:2258-63.
7. Erbayraktar S et al. (2003) Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc. Natl. Acad. Sci. 100:6741-6746.
8. Erbayraktar S, Yilmaz O, Gokmen N, Brines M. (2003) Erythropoietin is a multifunctional tissue-protective cytokine. Curr. Hematol. Rep. 2:465-470.
9. Contaldo C et al. ( 2007) Human recombinant erythropoietin protects the striated muscle microcirculation of the dorsal skinfold from postischemic injury in mice. Am. J. Physiol. Heart. Circ. Physiol. 293:274-283.
10. Brines M et al. (2004) Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc. Natl. Acad. Sci. 101:14907-12.
11. Juul SE et al. (1999) Why is erythropoietin present in human milk? Studies of erythropoietin receptors on enterocytes of human and rat neonates. Pediatr. Res. 46: 263-8.
12. Cuzzocrea S et al. (2004) Erythropoietin reduces the development of experimental inflammatory bowel disease. J. Pharmacol. Exp. Ther. 311:1272-80.
13. Ledbetter DJ, Juul SE. (2000) Erythropoietin and the incidence of necrotizing enterocolitis in infants with very low birth weight. J. Pediatr. Surg. 35:178-82.
14. Fatouros M et al. (1999) Alterations in body weight, breaking strength, and wound healing in wistar rats treated pre- and postoperatively with erythropoietin or granulocyte macrophage-colony stimulating factor: Evidence of a previously unknown anabolic effect of erythropoietin? J. Lab. Clin. Med. 133:253-9.
15. Lipsic E et al. (2004) Timing of erythropoietin treatment for cardioprotection in ischemia-reperfusion. J. Cardiovasc. Pharmacol. 44:473-9.
16. Sharples EL et al. (2004) Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J. Am. Soc. Nephrol. 15:2115-24.
17. Solaroglu A, Dede FS, Okutan E, Bayrak A, Haberal A, Kilinc K. (2004) A single dose of erythropoietin attenuates lipid peroxidation in experimental liver ischemia-reperfusion injury in the rat fetus. J. Matern. Fetal. Neonatal. Med. 16:231-4.
18. Wu H et al. (2006) Pretreatment with recombined human erythropoietin attenuates ischemia - reperfusion-induced lung injury in rats. Eur. J. Cardiothorac. Surg. 29:902-7.
19. Villa P et al. (2003) Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J. Exp. Med. 198:971-5.
20. Junk AK et al. (2002) Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc. Natl. Acad. Sci. 99:10659-64.
21. Tatum VL, Changchit C, Chow CK. (1990) Measurement of malonaldehyde by HPLC with fluorescence detection. Lipids 25:226-9.
22. Wiechelman KJ, Braun RD, Fitzpatrick JD. (1988) Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for color formation. Anal. Biochem. 175:231-7.
23. Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN. (1970) Intestinal mucosal lesion in low-flow states. I. A morphologic, hemodynamic and metabolic reappraisal. Arch. Surg. 101:478.
24. Park PO, Haglund U, Bulkley GB, Falt K. (1990) The sequence of development of intestinal tissue injury following strangulation ischemia and reperfusion. Surgery. 107:574.
25. Zimmerman BJ, Granger DN. (1994) Mechanisms of reperfusion injury. Am. J. Med. Sci. 307:284-92.
26. Kettle AJ, Winterbourn CC. (1997) Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox. Rep. 3:3-15.
27. Liu X et al. (2006) Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion. Life Sci. 78:2255-64.
28. Chattonadhyay T, Das C, Bandyopadhyay D, Datta AG. (2000) Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical. Biochem. Pharmacol. 59:419-25.
29. Chakraborty M, Ghosal J, Biswas T, Data AG. (1988) Effect of erythropoietin on membrane lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase of rat RBC. Biochem. Med. Metab. Biol. 40:8-18.
30. Akisu M, Kullahcioglu GF, Baka M, Husseyinov A, Kultursay N. (2001a) The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. Eur. J. Pediatr. Surg. 11:167-72.
31. Akisu M, Tuzun S, Arslanoglu S, Yalaz M, Kultursay N. (2001b) Effect of recombinant human erythropoietin administration on lipid peroxidation and antioxidant enzyme(s) activities in preterm infants. Acta. Med. Okayama. 55:357-62.
32. Cross CE, Halliwell B, Allen A. (1984) Antioxidant protection: A function of tracheobronchial and gastrointestinal mucus. Lancet. 1:1328-30.
33. Digicaylioglu M, Lipton SA. (2001) Erythropoietin-mediated neuroprotection involves crosstalk between Jak2 and NF-κB signaling cascades. Nature. 412:641-7.
34. Genc S, Akhisaroglu M, Kuralay F, Genc K. (2002) Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine- induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro. Neurosci. Lett. 321:73-76.
35. Kumral A et al. (2005) Protective effects of erythropoietin against ethanol-induced apoptotic neurodegeneration and oxidative stress in the developing C57BL/6 mouse brain. Brain Res. Dev. Brain Res. 160:146-56.
36. Sakanaka M et al. (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc. Natl. Acad. Sci. 95:4635-40.
37. Turi S, Nemeth I, Varga I, Bodrogi T, Matkovics B. (1992) The effect of erythropoietin on the cellular defense mechanism of red blood cells in children with chronic renal failure. Pediatr. Nephrol. 6:536-41.
38. Kerr JF, Wyllie AH, Currie AR. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:239-57.
39. Ikeda H et al. (1998) Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut. 42:530-7.
40. Noda T, Iwakiri R, Fujimoto K, Matsuo S, Aw TY. (1998) Programmed cell death induced by ischemia-reperfusion in rat intestinal mucosa. Am. J. Physiol. 274:270-6.
41. Parsa CJ et al. (2004) Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts. J. Biol. Chem. 279:20655-62.
42. Brines M and Cerami A. (2006) Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise. Kidney Int. 70:246-50.
43. Bai J, Cederbaum AI. (2001) Mitochondrial catalase and oxidative injury. Biol. Signals Recept. 10:189-99.
44. Buttke TM, Sandstrom PA. (1994) Oxidative stress as a mediator of apoptosis. Immunol. Today. 15:7-10.
45. Curtin JF, Donovan M, Cotter TG. (2002) Regulation and measurement of oxidative stress in apoptosis. J. Immunol. Methods. 265:49-72.
46. Kojima M et al. (2003) Effects of antioxidative agents on apoptosis induced by ischaemia-reperfusion in rat intestinal mucosa. Aliment Pharmacol. Ther. 1:139-45.
47. Roviezzo F et al. (2007) Protective role of PI3-kinase-Akt-eNOS signaling pathway in intestinal injury associated with splanchnic artery occlusion shock. Br. J. Pharmacol. 151:377-83.
48. Munzel T, Daiber A, Ullrich V, Mulsch A. (2005) Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase. Arterioscl. Thromb. Vasc. Biol. 25:1551-7.
49. Rui T et al. (2005) Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc. Res. 65:719-27.
50. Lopez Ongil SL, Saura M, Lamas S, Rodriguez Puyol M, Rodriguez Puyol D. (1996) Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric oxide synthase in vascular endothelial cells. Exp. Nephrol. 4:37-42.
51. Banerjee D, Rodriguez M, Nag M, Adamson JW. (2000) Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity. Kidney Int. 57:1895-904
52. Wang XQ, Vaziri ND. (1999) Erythropoietin depresses nitric oxide synthase expression by human endothelial cells. Hypertension. 33:894-9
53. Calapai MC et al. (2000) Erythropoietin protects against brain ischemia injury by inhibition of nitric oxide formation, Eur. J. Pharmacol. 401:349-356.
54. Li H, Wallerath T, Münzel T, Förestermann U. (2002) Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs, Nitric Oxide. 7:149-64.