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Volumn 61, Issue 11, 2007, Pages 1922-1930

Emerging oral therapies for multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

BETA1A INTERFERON; BG 000012; BG 00012; CLADRIBINE; FINGOLIMOD; GLATIRAMER; IBUPROFEN; INTERFERON BETA SERINE; INTERLEUKIN 10; INTERLEUKIN 4; LAQUINIMOD; MITOXANTRONE; NATALIZUMAB; PARACETAMOL; PLACEBO; ROQUINIMEX; TERIFLUNOMIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 35348845728     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2007.01561..x     Document Type: Review
Times cited : (46)

References (102)
  • 1
    • 33744488268 scopus 로고    scopus 로고
    • Emerging therapeutic targets in multiple sclerosis
    • Fontoura P, Steinman L, Miller A. Emerging therapeutic targets in multiple sclerosis. Curr Opin Neurol 2006 19 : 260 6.
    • (2006) Curr Opin Neurol , vol.19 , pp. 260-266
    • Fontoura, P.1    Steinman, L.2    Miller, A.3
  • 2
    • 0030056764 scopus 로고    scopus 로고
    • Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis
    • Lucchinetti CF, Bruck W, Rodriguez M, Lassmann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain Pathol 1996 6 : 259 74.
    • (1996) Brain Pathol , vol.6 , pp. 259-274
    • Lucchinetti, C.F.1    Bruck, W.2    Rodriguez, M.3    Lassmann, H.4
  • 3
    • 3843127502 scopus 로고    scopus 로고
    • Evidence for pathogenic heterogeneity in multiple sclerosis
    • Lucchinetti CF, Bruck W, Lassmann H. Evidence for pathogenic heterogeneity in multiple sclerosis. Ann Neurol 2004 56 : 308.
    • (2004) Ann Neurol , vol.56 , pp. 308
    • Lucchinetti, C.F.1    Bruck, W.2    Lassmann, H.3
  • 4
    • 34249818493 scopus 로고    scopus 로고
    • Oral disease-modifying treatments for multiple sclerosis: The story so far
    • Kieseier BC, Wiendl H. Oral disease-modifying treatments for multiple sclerosis: the story so far. CNS Drugs 2007 21 : 483 502.
    • (2007) CNS Drugs , vol.21 , pp. 483-502
    • Kieseier, B.C.1    Wiendl, H.2
  • 5
    • 0003443998 scopus 로고    scopus 로고
    • Avonex®. UK. (accessed 8 March 2007).
    • Avonex®. Summary of Product Characteristics. UK. http://emc. medicines.org.uk (accessed 8 March 2007).
    • Summary of Product Characteristics.
  • 6
    • 0003443998 scopus 로고    scopus 로고
    • Betaferon® UK. (accessed 10 May 2007).
    • Betaferon® Summary of Product Characteristics, UK. http://emc.medicines.org.uk (accessed 10 May 2007).
    • Summary of Product Characteristics
  • 7
    • 0003443998 scopus 로고    scopus 로고
    • Rebif® UK. (accessed 3 May 2006).
    • Rebif® Summary of Product Characteristics, UK. http://emc.medicines. org.uk (accessed 3 May 2006).
    • Summary of Product Characteristics
  • 8
    • 0003443998 scopus 로고    scopus 로고
    • Copaxone® UK. (accessed 23 March 2006).
    • Copaxone® Summary of Product Characteristics, UK. http://emc.medicines.org.uk (accessed 23 March 2006).
    • Summary of Product Characteristics
  • 9
    • 0003443998 scopus 로고    scopus 로고
    • Tysabri® UK. (accessed 19 June 2007).
    • Tysabri® Summary of Product Characteristics, UK. http://emc. medicines.org.uk (accessed 19 June 2007).
    • Summary of Product Characteristics
  • 10
    • 33746445987 scopus 로고    scopus 로고
    • Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis
    • Cox D, Stone J. Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis. J Neurosci Nurs 2006 38 : 167 71.
    • (2006) J Neurosci Nurs , vol.38 , pp. 167-171
    • Cox, D.1    Stone, J.2
  • 11
    • 15544367711 scopus 로고    scopus 로고
    • Self-injection anxiety training: A treatment for patients unable to self-inject injectable medications
    • Mohr DC, Cox D, Merluzzi N. Self-injection anxiety training: a treatment for patients unable to self-inject injectable medications. Mult Scler 2005 11 : 182 5.
    • (2005) Mult Scler , vol.11 , pp. 182-185
    • Mohr, D.C.1    Cox, D.2    Merluzzi, N.3
  • 12
    • 0035018884 scopus 로고    scopus 로고
    • Injectable medication for the treatment of multiple sclerosis: The influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject
    • Mohr DC, Boudewyn AC, Likosky W, Levine E, Goodkin DE. Injectable medication for the treatment of multiple sclerosis: the influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann Behav Med 2001 23 : 125 32.
    • (2001) Ann Behav Med , vol.23 , pp. 125-132
    • Mohr, D.C.1    Boudewyn, A.C.2    Likosky, W.3    Levine, E.4    Goodkin, D.E.5
  • 14
    • 0037180479 scopus 로고    scopus 로고
    • Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE trial
    • Panitch H, Goodin DS, Francis G et al. Randomized, comparative study of interferon beta-1a treatment regimens in MS: the EVIDENCE trial. Neurology 2002 59 : 1496 506.
    • (2002) Neurology , vol.59 , pp. 1496-1506
    • Panitch, H.1    Goodin, D.S.2    Francis, G.3
  • 15
    • 20144382021 scopus 로고    scopus 로고
    • Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis
    • Rio J, Porcel J, Tellez N et al. Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis. Mult Scler 2005 11 : 306 9.
    • (2005) Mult Scler , vol.11 , pp. 306-309
    • Rio, J.1    Porcel, J.2    Tellez, N.3
  • 16
    • 33748884971 scopus 로고    scopus 로고
    • Recurrent injection site reactions from interferon beta 1-b
    • Samuel L, Lowenstein EJ. Recurrent injection site reactions from interferon beta 1-b. J Drugs Dermatol 2006 5 : 366 7.
    • (2006) J Drugs Dermatol , vol.5 , pp. 366-367
    • Samuel, L.1    Lowenstein, E.J.2
  • 18
    • 0042932742 scopus 로고    scopus 로고
    • Interrupted therapy: Stopping and switching of the beta-interferons prescribed for MS
    • Tremlett HL, Oger J. Interrupted therapy: stopping and switching of the beta-interferons prescribed for MS. Neurology 2003 61 : 551 4.
    • (2003) Neurology , vol.61 , pp. 551-554
    • Tremlett, H.L.1    Oger, J.2
  • 19
    • 33847138511 scopus 로고    scopus 로고
    • Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): A comparison of interferon beta therapies for relapsing-remitting multiple sclerosis
    • Limmroth V, Malessa R, Zettl UK et al. Quality Assessment in Multiple Sclerosis Therapy (QUASIMS): a comparison of interferon beta therapies for relapsing-remitting multiple sclerosis. J Neurol 2007 254 : 67 77.
    • (2007) J Neurol , vol.254 , pp. 67-77
    • Limmroth, V.1    Malessa, R.2    Zettl, U.K.3
  • 20
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet 1998 352 : 1498 504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 21
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial. the IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology 1995 45 : 1277 85.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 22
    • 25844457405 scopus 로고    scopus 로고
    • A randomized, multicentre, open-label, parallel-group trial of the tolerability of interferon beta-1a (Rebif) administered by autoinjection or manual injection in relapsing-remitting multiple sclerosis
    • Mikol D, Lopez-Bresnahan M, Taraskiewicz S, Chang P, Rangnow J. A randomized, multicentre, open-label, parallel-group trial of the tolerability of interferon beta-1a (Rebif) administered by autoinjection or manual injection in relapsing-remitting multiple sclerosis. Mult Scler 2005 11 : 585 91.
    • (2005) Mult Scler , vol.11 , pp. 585-591
    • Mikol, D.1    Lopez-Bresnahan, M.2    Taraskiewicz, S.3    Chang, P.4    Rangnow, J.5
  • 23
    • 34547121717 scopus 로고    scopus 로고
    • Immunogenicity and tolerability of an investigational formulation of interferon beta-1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically-controlled, Phase IIIb study in adults with multiple sclerosis
    • Giovannoni G, Barbarash O, Casset-Semanez F et al. Immunogenicity and tolerability of an investigational formulation of interferon beta-1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically-controlled, Phase IIIb study in adults with multiple sclerosis. Clin Ther 2007 29 : 1128 450.
    • (2007) Clin Ther , vol.29 , pp. 1128-1450
    • Giovannoni, G.1    Barbarash, O.2    Casset-Semanez, F.3
  • 24
    • 0031730234 scopus 로고    scopus 로고
    • Consequences of intermittent treatment for hypertension: The case for medication compliance and persistence
    • Cramer JA. Consequences of intermittent treatment for hypertension: the case for medication compliance and persistence. Am J Manag Care 1998 4 : 1563 8.
    • (1998) Am J Manag Care , vol.4 , pp. 1563-1568
    • Cramer, J.A.1
  • 28
    • 1642397582 scopus 로고    scopus 로고
    • Variations in patients' adherence to medical recommendations: A quantitative review of 50 years of research
    • DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004 42 : 200 9.
    • (2004) Med Care , vol.42 , pp. 200-209
    • Dimatteo, M.R.1
  • 30
    • 0002435182 scopus 로고
    • The magnitude of compliance and non-compliance
    • In: Haynes, R.B., Taylor, D.W., Sackett, D.L., eds. Baltimore, MD: The Johns Hopkins University Press
    • Sackett DL, Snow JC. The magnitude of compliance and non-compliance. In : Haynes RB, Taylor DW, Sackett DL, eds. Compliance in Health Care. Baltimore, MD : The Johns Hopkins University Press, 1979 : 11 22.
    • (1979) Compliance in Health Care. , pp. 11-22
    • Sackett, D.L.1    Snow, J.C.2
  • 32
    • 0002768747 scopus 로고
    • The measurement of medical compliance in the treatment of disease
    • In: Karoly, P., ed. New York: John Wiley & Sons
    • Cluss PA, Epstein LH. The measurement of medical compliance in the treatment of disease. In : Karoly P, ed. Measurement Strategies in Health Psychology. New York : John Wiley & Sons, 1985 : 403 32.
    • (1985) Measurement Strategies in Health Psychology. , pp. 403-432
    • Cluss, P.A.1    Epstein, L.H.2
  • 33
    • 0035885062 scopus 로고    scopus 로고
    • Strategies for optimizing adherence to highly active antiretroviral therapy: Lessons from research and clinical practice
    • Stone VE. Strategies for optimizing adherence to highly active antiretroviral therapy: lessons from research and clinical practice. Clin Infect Dis 2001 33 : 865 72.
    • (2001) Clin Infect Dis , vol.33 , pp. 865-872
    • Stone, V.E.1
  • 35
    • 0032562985 scopus 로고    scopus 로고
    • Public health implications of antiretroviral therapy and HIV drug resistance
    • Wainberg MA, Friedland G. Public health implications of antiretroviral therapy and HIV drug resistance. JAMA 1998 279 : 1977 83.
    • (1998) JAMA , vol.279 , pp. 1977-1983
    • Wainberg, M.A.1    Friedland, G.2
  • 36
    • 0141841678 scopus 로고    scopus 로고
    • Medication compliance feedback and monitoring in a clinical trial: Predictors and outcomes
    • Cramer J, Rosenheck R, Kirk G, Krol W, Krystal J. Medication compliance feedback and monitoring in a clinical trial: predictors and outcomes. Value Health 2003 6 : 566 73.
    • (2003) Value Health , vol.6 , pp. 566-573
    • Cramer, J.1    Rosenheck, R.2    Kirk, G.3    Krol, W.4    Krystal, J.5
  • 37
    • 0037065322 scopus 로고    scopus 로고
    • Helping patients follow prescribed treatment: Clinical applications
    • Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA 2002 288 : 2880 3.
    • (2002) JAMA , vol.288 , pp. 2880-2883
    • Haynes, R.B.1    McDonald, H.P.2    Garg, A.X.3
  • 38
    • 0030912908 scopus 로고    scopus 로고
    • Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis
    • Mohr DC, Goodkin DE, Likosky W, Gatto N, Baumann KA, Rudick RA. Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Arch Neurol 1997 54 : 531 3.
    • (1997) Arch Neurol , vol.54 , pp. 531-533
    • Mohr, D.C.1    Goodkin, D.E.2    Likosky, W.3    Gatto, N.4    Baumann, K.A.5    Rudick, R.A.6
  • 39
    • 0030332317 scopus 로고    scopus 로고
    • Et al Therapeutic expectations of patients with multiple sclerosis upon initiating interferon beta-1b: Relationship to adherence to treatment
    • Mohr DC, Goodkin DE, Likosky W, Gatto N, Neilley LK, Griffin C, et al Therapeutic expectations of patients with multiple sclerosis upon initiating interferon beta-1b: relationship to adherence to treatment. Mult Scler 1996 2 : 222 6.
    • (1996) Mult Scler , vol.2 , pp. 222-226
    • Mohr, D.C.1    Goodkin, D.E.2    Likosky, W.3    Gatto, N.4    Neilley, L.K.5    Griffin, C.6
  • 40
    • 35348897458 scopus 로고    scopus 로고
    • Adherence to disease-modifying therapy for multiple sclerosis
    • Cohen BA. Adherence to disease-modifying therapy for multiple sclerosis. Int J MS Care 2006 Suppl. 1 : 32 7.
    • (2006) Int J MS Care , Issue.1 , pp. 32-37
    • Cohen, B.A.1
  • 41
  • 42
    • 0035133856 scopus 로고    scopus 로고
    • Treatment-related empowerment: Preliminary evaluation of a new measure in patients with advanced HIV disease
    • Webb DG, Horne R, Pinching AJ. Treatment-related empowerment: preliminary evaluation of a new measure in patients with advanced HIV disease. Int J STD AIDS 2001 12 : 103 7.
    • (2001) Int J STD AIDS , vol.12 , pp. 103-107
    • Webb, D.G.1    Horne, R.2    Pinching, A.J.3
  • 43
    • 0034710203 scopus 로고    scopus 로고
    • Depression is a risk factor for noncompliance with medical treatment: Meta-analysis of the effects of anxiety and depression on patient adherence
    • DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 2000 160 : 2101 7.
    • (2000) Arch Intern Med , vol.160 , pp. 2101-2107
    • Dimatteo, M.R.1    Lepper, H.S.2    Croghan, T.W.3
  • 44
    • 0031017851 scopus 로고    scopus 로고
    • Patient preferences for oral versus intravenous palliative chemotherapy
    • Liu G, Franssen E, Fitch MI, Warner E. Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol 1997 15 : 110 5.
    • (1997) J Clin Oncol , vol.15 , pp. 110-115
    • Liu, G.1    Franssen, E.2    Fitch, M.I.3    Warner, E.4
  • 45
    • 31544437749 scopus 로고    scopus 로고
    • A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer
    • Twelves C, Gollins S, Grieve R, Samuel L. A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer. Ann Oncol 2006 17 : 239 45.
    • (2006) Ann Oncol , vol.17 , pp. 239-245
    • Twelves, C.1    Gollins, S.2    Grieve, R.3    Samuel, L.4
  • 46
    • 31544469565 scopus 로고    scopus 로고
    • Patients' preference for administration of endocrine treatments by injection or tablets: Results from a study of women with breast cancer
    • Fallowfield L, Atkins L, Catt S et al. Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer. Ann Oncol 2006 17 : 205 10.
    • (2006) Ann Oncol , vol.17 , pp. 205-210
    • Fallowfield, L.1    Atkins, L.2    Catt, S.3
  • 48
    • 19944431309 scopus 로고    scopus 로고
    • Availability of inhaled insulin promotes greater perceived acceptance of insulin therapy in patients with type 2 diabetes
    • Freemantle N, Blonde L, Duhot D et al. Availability of inhaled insulin promotes greater perceived acceptance of insulin therapy in patients with type 2 diabetes. Diabetes Care 2005 28 : 427 8.
    • (2005) Diabetes Care , vol.28 , pp. 427-428
    • Freemantle, N.1    Blonde, L.2    Duhot, D.3
  • 49
    • 7444270287 scopus 로고    scopus 로고
    • Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes: Results of a 6-month, randomized, comparative trial
    • Quattrin T, Belanger A, Bohannon NJ, Schwartz SL. Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes: results of a 6-month, randomized, comparative trial. Diabetes Care 2004 27 : 2622 7.
    • (2004) Diabetes Care , vol.27 , pp. 2622-2627
    • Quattrin, T.1    Belanger, A.2    Bohannon, N.J.3    Schwartz, S.L.4
  • 50
    • 4644372272 scopus 로고    scopus 로고
    • Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: Results of a 6-month, randomized, comparative trial
    • Hollander PA, Blonde L, Rowe R et al. Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial. Diabetes Care 2004 27 : 2356 62.
    • (2004) Diabetes Care , vol.27 , pp. 2356-2362
    • Hollander, P.A.1    Blonde, L.2    Rowe, R.3
  • 51
    • 2542456983 scopus 로고    scopus 로고
    • Patient satisfaction and glycemic control after 1 year with inhaled insulin (Exubera) in patients with type 1 or type 2 diabetes
    • Rosenstock J, Cappelleri JC, Bolinder B, Gerber RA. Patient satisfaction and glycemic control after 1 year with inhaled insulin (Exubera) in patients with type 1 or type 2 diabetes. Diabetes Care 2004 27 : 1318 23.
    • (2004) Diabetes Care , vol.27 , pp. 1318-1323
    • Rosenstock, J.1    Cappelleri, J.C.2    Bolinder, B.3    Gerber, R.A.4
  • 52
    • 0034878676 scopus 로고    scopus 로고
    • Patient compliance and persistence with antihyperglycemic drug regimens: Evaluation of a medicaid patient population with type 2 diabetes mellitus
    • Dailey G, Kim MS, Lian JF. Patient compliance and persistence with antihyperglycemic drug regimens: evaluation of a medicaid patient population with type 2 diabetes mellitus. Clin Ther 2001 23 : 1311 20.
    • (2001) Clin Ther , vol.23 , pp. 1311-1320
    • Dailey, G.1    Kim, M.S.2    Lian, J.F.3
  • 53
    • 32544449771 scopus 로고    scopus 로고
    • Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: A multicentre, double-blind, randomised, placebo-controlled study
    • Filippi M, Wolinsky JS, Comi G. Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study. Lancet Neurol 2006 5 : 213 20.
    • (2006) Lancet Neurol , vol.5 , pp. 213-220
    • Filippi, M.1    Wolinsky, J.S.2    Comi, G.3
  • 54
    • 0034122123 scopus 로고    scopus 로고
    • Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
    • Herrmann ML, Schleyerbach R, Kirschbaum BJ. Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology 2000 47 : 273 89.
    • (2000) Immunopharmacology , vol.47 , pp. 273-289
    • Herrmann, M.L.1    Schleyerbach, R.2    Kirschbaum, B.J.3
  • 55
    • 0028985102 scopus 로고
    • The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism
    • Cherwinski HM, McCarley D, Schatzman R, Devens B, Ransom JT. The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism. J Pharmacol Exp Ther 1995 272 : 460 8.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 460-468
    • Cherwinski, H.M.1    McCarley, D.2    Schatzman, R.3    Devens, B.4    Ransom, J.T.5
  • 56
    • 25444448197 scopus 로고    scopus 로고
    • Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: Involvement of impaired integrin activation and immunologic synapse formation
    • Zeyda M, Poglitsch M, Geyeregger R et al. Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. Arthritis Rheum 2005 52 : 2730 9.
    • (2005) Arthritis Rheum , vol.52 , pp. 2730-2739
    • Zeyda, M.1    Poglitsch, M.2    Geyeregger, R.3
  • 57
    • 33645799680 scopus 로고    scopus 로고
    • A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
    • O'Connor PW, Li D, Freedman MS et al. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 2006 66 : 894 900.
    • (2006) Neurology , vol.66 , pp. 894-900
    • O'Connor, P.W.1    Li, D.2    Freedman, M.S.3
  • 58
    • 4744340401 scopus 로고    scopus 로고
    • Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats
    • Yang JS, Xu LY, Xiao BG, Hedlund G, Link H. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats. J Neuroimmunol 2004 156 : 3 9.
    • (2004) J Neuroimmunol , vol.156 , pp. 3-9
    • Yang, J.S.1    Xu, L.Y.2    Xiao, B.G.3    Hedlund, G.4    Link, H.5
  • 60
    • 0034003613 scopus 로고    scopus 로고
    • Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials
    • Tan IL, Lycklama a Nijeholt GJ, Polman CH, Ader HJ, Barkhof F. Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials. Mult Scler 2000 6 : 99 104.
    • (2000) Mult Scler , vol.6 , pp. 99-104
    • Tan, I.L.1    Lycklama Nijeholt, A.G.J.2    Polman, C.H.3    Ader, H.J.4    Barkhof, F.5
  • 61
    • 34547431060 scopus 로고    scopus 로고
    • Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors
    • doi:10.1111/j.1471-4159.2007.04629.x.
    • Mullershausen F, Craveiro LM, Shin Y et al. Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors. J Neurochem 2007 doi:10.1111/j.1471-4159.2007.04629.x.
    • (2007) J Neurochem
    • Mullershausen, F.1    Craveiro, L.M.2    Shin, Y.3
  • 62
    • 33846864904 scopus 로고    scopus 로고
    • The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
    • Payne SG, Oskeritzian CA, Griffiths R et al. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1- phosphate receptors. Blood 2007 109 : 1077 85.
    • (2007) Blood , vol.109 , pp. 1077-1085
    • Payne, S.G.1    Oskeritzian, C.A.2    Griffiths, R.3
  • 63
    • 3142588813 scopus 로고    scopus 로고
    • New immunosuppressants with potential implication in multiple sclerosis
    • Gonsette RE. New immunosuppressants with potential implication in multiple sclerosis. J Neurol Sci 2004 223 : 87 93.
    • (2004) J Neurol Sci , vol.223 , pp. 87-93
    • Gonsette, R.E.1
  • 64
    • 33947278231 scopus 로고    scopus 로고
    • New immunosuppressive drugs for prevention and treatment of rejection in renal transplant
    • Segoloni GP, Quaglia M. New immunosuppressive drugs for prevention and treatment of rejection in renal transplant. J Nephrol 2006 19 : 578 86.
    • (2006) J Nephrol , vol.19 , pp. 578-586
    • Segoloni, G.P.1    Quaglia, M.2
  • 65
    • 77955799815 scopus 로고    scopus 로고
    • Oral fingolimod (FTY720) for relapsing multiple sclerosis
    • Kappos L, Antel J, Comi G et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006 355 : 1124 40.
    • (2006) N Engl J Med , vol.355 , pp. 1124-1140
    • Kappos, L.1    Antel, J.2    Comi, G.3
  • 67
    • 2642687679 scopus 로고    scopus 로고
    • Fumaric acid esters suppress peripheral CD4- and CD8-positive lymphocytes in psoriasis
    • Hoxtermann S, Nuchel C, Altmeyer P. Fumaric acid esters suppress peripheral CD4- and CD8-positive lymphocytes in psoriasis. Dermatology 1998 196 : 223 30.
    • (1998) Dermatology , vol.196 , pp. 223-230
    • Hoxtermann, S.1    Nuchel, C.2    Altmeyer, P.3
  • 68
    • 0032858530 scopus 로고    scopus 로고
    • Treatment of severe psoriasis with fumaric acid esters: Scientific background and guidelines for therapeutic use. the German Fumaric Acid Ester Consensus Conference
    • Mrowietz U, Christophers E, Altmeyer P. Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference. Br J Dermatol 1999 141 : 424 9.
    • (1999) Br J Dermatol , vol.141 , pp. 424-429
    • Mrowietz, U.1    Christophers, E.2    Altmeyer, P.3
  • 69
    • 5144233487 scopus 로고    scopus 로고
    • Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications
    • Arnon R, Aharoni R. Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc Natl Acad Sci U S A 2004 101 (Suppl. 2 14593 8.
    • (2004) Proc Natl Acad Sci U S a , vol.101 , Issue.2 , pp. 14593-14598
    • Arnon, R.1    Aharoni, R.2
  • 71
    • 0001514703 scopus 로고
    • Antileukemic and immunosuppressive activity of 2-chloro-2′- deoxyadenosine
    • Carson DA, Wasson DB, Beutler E. Antileukemic and immunosuppressive activity of 2-chloro-2′-deoxyadenosine. Proc Natl Acad Sci U S A 1984 81 : 2232 6.
    • (1984) Proc Natl Acad Sci U S a , vol.81 , pp. 2232-2236
    • Carson, D.A.1    Wasson, D.B.2    Beutler, E.3
  • 72
    • 0026723519 scopus 로고
    • 2-Chlorodeoxyadenosine: An active agent in the treatment of cutaneous T-cell lymphoma
    • Saven A, Carrera CJ, Carson DA, Beutler E, Piro LD. 2- Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma. Blood 1992 80 : 587 92.
    • (1992) Blood , vol.80 , pp. 587-592
    • Saven, A.1    Carrera, C.J.2    Carson, D.A.3    Beutler, E.4    Piro, L.D.5
  • 73
    • 0028925970 scopus 로고
    • Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia
    • Juliusson G, Heldal D, Hippe E et al. Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia. J Clin Oncol 1995 13 : 989 95.
    • (1995) J Clin Oncol , vol.13 , pp. 989-995
    • Juliusson, G.1    Heldal, D.2    Hippe, E.3
  • 74
    • 0032530684 scopus 로고    scopus 로고
    • Long-term follow-up of patients with hairy cell leukemia after cladribine treatment
    • Saven A, Burian C, Koziol JA, Piro LD. Long-term follow-up of patients with hairy cell leukemia after cladribine treatment. Blood 1998 92 : 1918 26.
    • (1998) Blood , vol.92 , pp. 1918-1926
    • Saven, A.1    Burian, C.2    Koziol, J.A.3    Piro, L.D.4
  • 75
    • 6944230907 scopus 로고    scopus 로고
    • Durable response but prolonged cytopenia after cladribine treatment in relapsed patients with indolent non-Hodgkin's lymphomas: Results of a Japanese phase II study
    • Ogura M, Morishima Y, Kobayashi Y et al. Durable response but prolonged cytopenia after cladribine treatment in relapsed patients with indolent non-Hodgkin's lymphomas: results of a Japanese phase II study. Int J Hematol 2004 80 : 267 77.
    • (2004) Int J Hematol , vol.80 , pp. 267-277
    • Ogura, M.1    Morishima, Y.2    Kobayashi, Y.3
  • 76
    • 0035366389 scopus 로고    scopus 로고
    • Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic diseases
    • Krance RA, Hurwitz CA, Head DR et al. Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic diseases. J Clin Oncol 2001 19 : 2804 11.
    • (2001) J Clin Oncol , vol.19 , pp. 2804-2811
    • Krance, R.A.1    Hurwitz, C.A.2    Head, D.R.3
  • 77
    • 0028173001 scopus 로고
    • Primary therapy of Waldenstrom's macroglobulinemia with 2-chlorodeoxyadenosine
    • Dimopoulos MA, Kantarjian H, Weber D et al. Primary therapy of Waldenstrom's macroglobulinemia with 2-chlorodeoxyadenosine. J Clin Oncol 1994 12 : 2694 8.
    • (1994) J Clin Oncol , vol.12 , pp. 2694-2698
    • Dimopoulos, M.A.1    Kantarjian, H.2    Weber, D.3
  • 78
    • 0031043125 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of cladribine
    • Liliemark J. The clinical pharmacokinetics of cladribine. Clin Pharmacokinet 1997 32 : 120 31.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 120-131
    • Liliemark, J.1
  • 79
    • 0036941246 scopus 로고    scopus 로고
    • Complete remission of chronic plaque psoriasis and gastric marginal zone B-cell lymphoma of MALT type after treatment with 2-chlorodeoxyadenosine
    • Valencak J, Trautinger F, Fiebiger WC, Raderer M. Complete remission of chronic plaque psoriasis and gastric marginal zone B-cell lymphoma of MALT type after treatment with 2-chlorodeoxyadenosine. Ann Hematol 2002 81 : 662 5.
    • (2002) Ann Hematol , vol.81 , pp. 662-665
    • Valencak, J.1    Trautinger, F.2    Fiebiger, W.C.3    Raderer, M.4
  • 80
    • 0030780827 scopus 로고    scopus 로고
    • The safety profile of low-dose cladribine in refractory rheumatoid arthritis. a pilot trial
    • Schirmer M, Mur E, Pfeiffer KP, Thaler J, Konwalinka G. The safety profile of low-dose cladribine in refractory rheumatoid arthritis. A pilot trial. Scand J Rheumatol 1997 26 : 376 9.
    • (1997) Scand J Rheumatol , vol.26 , pp. 376-379
    • Schirmer, M.1    Mur, E.2    Pfeiffer, K.P.3    Thaler, J.4    Konwalinka, G.5
  • 81
    • 0031935284 scopus 로고    scopus 로고
    • A pilot study of 2-chloro-2′-deoxyadenosine in the treatment of systemic lupus erythematosus-associated glomerulonephritis
    • Davis JC Jr., Austin H 3rd., Boumpas D et al. A pilot study of 2-chloro-2′-deoxyadenosine in the treatment of systemic lupus erythematosus-associated glomerulonephritis. Arthritis Rheum 1998 41 : 335 43.
    • (1998) Arthritis Rheum , vol.41 , pp. 335-343
    • Davis Jr., J.C.1    Austin III, H.2    Boumpas, D.3
  • 82
    • 0033645381 scopus 로고    scopus 로고
    • An open-label pilot trial of cladibrine (2-cholordeoxyadenosine) in patients with primary sclerosing cholangitis
    • Duchini A, Younossi ZM, Saven A, Bordin GM, Knowles HJ, Pockros PJ. An open-label pilot trial of cladibrine (2-cholordeoxyadenosine) in patients with primary sclerosing cholangitis. J Clin Gastroenterol 2000 31 : 292 6.
    • (2000) J Clin Gastroenterol , vol.31 , pp. 292-296
    • Duchini, A.1    Younossi, Z.M.2    Saven, A.3    Bordin, G.M.4    Knowles, H.J.5    Pockros, P.J.6
  • 83
    • 0028227814 scopus 로고
    • 2-Chlorodeoxyadenosine as treatment of severe acute graft-versus-host disease
    • Pless M, Gratwohl A, Tichelli A, Speck B, Betticher DC. 2-Chlorodeoxyadenosine as treatment of severe acute graft-versus-host disease. Blood 1994 84 : 987 9.
    • (1994) Blood , vol.84 , pp. 987-989
    • Pless, M.1    Gratwohl, A.2    Tichelli, A.3    Speck, B.4    Betticher, D.C.5
  • 84
    • 0029850884 scopus 로고    scopus 로고
    • Pharmacology of purine nucleoside analogues
    • Plunkett W, Gandhi V. Pharmacology of purine nucleoside analogues. Hematol Cell Ther 1996 38 (Suppl. 2 S67 74.
    • (1996) Hematol Cell Ther , vol.38 , Issue.2
    • Plunkett, W.1    Gandhi, V.2
  • 85
    • 0026799508 scopus 로고
    • Cladribine (2-chlorodeoxyadenosine)
    • Beutler E. Cladribine (2-chlorodeoxyadenosine). Lancet 1992 340 : 952 6.
    • (1992) Lancet , vol.340 , pp. 952-956
    • Beutler, E.1
  • 86
    • 0034646216 scopus 로고    scopus 로고
    • Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group
    • Rice GP, Filippi M, Comi G. Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group. Neurology 2000 54 : 1145 55.
    • (2000) Neurology , vol.54 , pp. 1145-1155
    • Rice, G.P.1    Filippi, M.2    Comi, G.3
  • 87
    • 0032908474 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis
    • Romine JS, Sipe JC, Koziol JA, Zyroff J, Beutler E. A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis. Proc Assoc Am Physicians 1999 111 : 35 44.
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 35-44
    • Romine, J.S.1    Sipe, J.C.2    Koziol, J.A.3    Zyroff, J.4    Beutler, E.5
  • 89
  • 90
    • 0035140670 scopus 로고    scopus 로고
    • Effect of immunosuppressive cladribine treatment on serum leucocytes system in two-year clinical trial in patients with chronic progressive multiple sclerosis
    • Janiec K, Wajgt A, Kondera-Anasz Z. Effect of immunosuppressive cladribine treatment on serum leucocytes system in two-year clinical trial in patients with chronic progressive multiple sclerosis. Med Sci Monit 2001 7 : 93 8.
    • (2001) Med Sci Monit , vol.7 , pp. 93-98
    • Janiec, K.1    Wajgt, A.2    Kondera-Anasz, Z.3
  • 91
    • 27944443692 scopus 로고    scopus 로고
    • Cladribine for multiple sclerosis: Review and current status
    • Sipe JC. Cladribine for multiple sclerosis: review and current status. Expert Rev Neurother 2005 5 : 721 7.
    • (2005) Expert Rev Neurother , vol.5 , pp. 721-727
    • Sipe, J.C.1
  • 92
    • 9744238804 scopus 로고    scopus 로고
    • A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis
    • Leuschen MP, Filipi M, Healey K. A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. Mult Scler 2004 10 : 636 42.
    • (2004) Mult Scler , vol.10 , pp. 636-642
    • Leuschen, M.P.1    Filipi, M.2    Healey, K.3
  • 93
    • 3543093883 scopus 로고    scopus 로고
    • Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: A randomized trial
    • Rio J, Nos C, Bonaventura I et al. Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial. Neurology 2004 63 : 525 8.
    • (2004) Neurology , vol.63 , pp. 525-528
    • Rio, J.1    Nos, C.2    Bonaventura, I.3
  • 94
    • 33745904768 scopus 로고    scopus 로고
    • Reduction of injection site reactions in multiple sclerosis (MS) patients newly started on interferon beta 1b therapy with two different devices
    • Brochet B, Lemaire G, Beddiaf A. Reduction of injection site reactions in multiple sclerosis (MS) patients newly started on interferon beta 1b therapy with two different devices. Rev Neurol (Paris) 2006 162 : 735 40.
    • (2006) Rev Neurol (Paris) , vol.162 , pp. 735-740
    • Brochet, B.1    Lemaire, G.2    Beddiaf, A.3
  • 95
    • 33645281423 scopus 로고    scopus 로고
    • Safety and tolerability of a 'refrigeration-free' formulation of interferon beta-1b-results of a double-blind, multicentre, comparative study in patients with relapsing-remitting or secondary progressive multiple sclerosis
    • Baum K. Safety and tolerability of a 'refrigeration-free' formulation of interferon beta-1b-results of a double-blind, multicentre, comparative study in patients with relapsing-remitting or secondary progressive multiple sclerosis. J Int Med Res 2006 34 : 1 12.
    • (2006) J Int Med Res , vol.34 , pp. 1-12
    • Baum, K.1
  • 96
    • 2342637729 scopus 로고    scopus 로고
    • A multicenter, open-label, phase II study of the immunogenicity and safety of a new prefilled syringe (liquid) formulation of Avonex in patients with multiple sclerosis
    • Phillips JT, Rice G, Frohman E et al. A multicenter, open-label, phase II study of the immunogenicity and safety of a new prefilled syringe (liquid) formulation of Avonex in patients with multiple sclerosis. Clin Ther 2004 26 : 511 21.
    • (2004) Clin Ther , vol.26 , pp. 511-521
    • Phillips, J.T.1    Rice, G.2    Frohman, E.3
  • 97
    • 0031305776 scopus 로고    scopus 로고
    • A Multiple Sclerosis (MS) Center Injection Training Program
    • Pfohl DC. A Multiple Sclerosis (MS) Center Injection Training Program. Axone 1997 19 : 29 33.
    • (1997) Axone , vol.19 , pp. 29-33
    • Pfohl, D.C.1
  • 98
    • 0030340127 scopus 로고    scopus 로고
    • Education and self-management of interferon beta-1b therapy for multiple sclerosis
    • 357-8.
    • Keating MM, Ostby PL. Education and self-management of interferon beta-1b therapy for multiple sclerosis. J Neurosci Nurs 1996 28 : 350 2, 357 8.
    • (1996) J Neurosci Nurs , vol.28 , pp. 350-352
    • Keating, M.M.1    Ostby, P.L.2
  • 99
    • 35348919028 scopus 로고    scopus 로고
    • [A wide support of patients with multiple sclerosis promotes success of long-term therapy]
    • Sidorenko TV, Khachanova NV, Boiko AN. [A wide support of patients with multiple sclerosis promotes success of long-term therapy]. Zh Nevrol Psikhiatr Im S S Korsakova 2006 3 : 96 100.
    • (2006) Zh Nevrol Psikhiatr Im S S Korsakova , vol.3 , pp. 96-100
    • Sidorenko, T.V.1    Khachanova, N.V.2    Boiko, A.N.3
  • 100
    • 1842432687 scopus 로고    scopus 로고
    • Long-term treatment optimization in individuals with multiple sclerosis using disease-modifying therapies: A nursing approach
    • Denis L, Namey M, Costello K et al. Long-term treatment optimization in individuals with multiple sclerosis using disease-modifying therapies: a nursing approach. J Neurosci Nurs 2004 36 : 10 22.
    • (2004) J Neurosci Nurs , vol.36 , pp. 10-22
    • Denis, L.1    Namey, M.2    Costello, K.3
  • 101
    • 35348878121 scopus 로고    scopus 로고
    • Thessaloniki, Greece: European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Sept 28-1 Oct. (Abstract 60).
    • Rieckmann P. DMDs: Balancing Expectations and Adherence to Treatment. Thessaloniki, Greece : European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Sept 28-1 Oct 2005 (Abstract 60).
    • DMDs: Balancing Expectations and Adherence to Treatment. , pp. 2005
    • Rieckmann, P.1
  • 102
    • 33748695513 scopus 로고    scopus 로고
    • Fingolimod and sphingosine-1-phosphate-modifiers of lymphocyte migration
    • Massberg S, von Andrian UH. Fingolimod and sphingosine-1-phosphate- modifiers of lymphocyte migration. N Engl J Med 2006 355 : 1088 91.
    • (2006) N Engl J Med , vol.355 , pp. 1088-1091
    • Massberg, S.1    Von Andrian, U.H.2


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