메뉴 건너뛰기




Volumn 5, Issue 6, 2005, Pages 721-727

Cladribine for multiple sclerosis: Review and current status

Author keywords

2 chloro 2 deoxyadenosine; Cladribine; Immunosuppressive therapy; Lymphotoxicity; Multiple sclerosis

Indexed keywords

CARBAMAZEPINE; CHEMOKINE; CHLORAMBUCIL; CLADRIBINE; COMPLEMENT; CORTICOSTEROID; CYTARABINE; FLUDARABINE; PHENYTOIN; PLACEBO; PURINE DERIVATIVE;

EID: 27944443692     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.5.6.721     Document Type: Review
Times cited : (82)

References (54)
  • 1
    • 0001514703 scopus 로고
    • Antileukemic and immunosuppressive activity of 2-chloro-2′- deoxyadenosine
    • Carson DA, Wasson DB, Beutler E. Antileukemic and immunosuppressive activity of 2-chloro-2′-deoxyadenosine. Proc. Natl Acad. Sci. 81, 2232-2236 (1984).
    • (1984) Proc. Natl. Acad. Sci. , vol.81 , pp. 2232-2236
    • Carson, D.A.1    Wasson, D.B.2    Beutler, E.3
  • 2
    • 0026799508 scopus 로고
    • Cladribine (2-chlorodeoxyadenosine)
    • Beutler E. Cladribine (2-chlorodeoxyadenosine). Lancet 340, 952-956 (1992).
    • (1992) Lancet , vol.340 , pp. 952-956
    • Beutler, E.1
  • 3
    • 0027740067 scopus 로고
    • 2-Chlorodeoxyadenosine: Hairy cell leukemia takes a surprising turn
    • Beutler E, Carson DA. 2-Chlorodeoxyadenosine: hairy cell leukemia takes a surprising turn. Blood Cells 19, 559-568 (1993).
    • (1993) Blood Cells , vol.19 , pp. 559-568
    • Beutler, E.1    Carson, D.A.2
  • 4
    • 0028029143 scopus 로고
    • New chemotherapeutic agent: 2-Chlorodeoxyadenosine
    • Beutler E. New chemotherapeutic agent: 2-chlorodeoxyadenosine. Semin. Hematol. 31, 40-45 (1994).
    • (1994) Semin. Hematol. , vol.31 , pp. 40-45
    • Beutler, E.1
  • 5
    • 0028945716 scopus 로고
    • 2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia
    • Saven A, Lemon RH, Kosty M, Beutler E, Piro LD. 2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia. J. Clin. Oncol. 13, 570-574 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 570-574
    • Saven, A.1    Lemon, R.H.2    Kosty, M.3    Beutler, E.4    Piro, L.D.5
  • 6
    • 0028221174 scopus 로고
    • Complete hematologic remissions in chronic-phase, Philadelphia- chromosome-positive, chronic myelogenous leukemia after 2-chlorodeoxyadenosine
    • Saven A, Piro LD, Lemon RH. Complete hematologic remissions in chronic-phase, Philadelphia-chromosome-positive, chronic myelogenous leukemia after 2-chlorodeoxyadenosine. Cancer 73, 2953-2963 (1994).
    • (1994) Cancer , vol.73 , pp. 2953-2963
    • Saven, A.1    Piro, L.D.2    Lemon, R.H.3
  • 7
    • 0023758320 scopus 로고
    • 2-Chlorodeoxyadenosine: An effective new agent for the treatment of chronic lymphocytic leukemia
    • Piro LD, Carrera CJ, Beutler E, Carson DA. 2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia. Blood 72, 1069-1073 (1988).
    • (1988) Blood , vol.72 , pp. 1069-1073
    • Piro, L.D.1    Carrera, C.J.2    Beutler, E.3    Carson, D.A.4
  • 8
    • 0025274664 scopus 로고
    • Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine
    • Piro LD, Carrera CJ, Carson DA, Beutler E. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N. Engl. J. Med. 322, 1117-1121 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1117-1121
    • Piro, L.D.1    Carrera, C.J.2    Carson, D.A.3    Beutler, E.4
  • 9
    • 0027465143 scopus 로고
    • High complete remission rate from 2-chloro-2′-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: Response predicted by rapid decrease of blood lymphocyte count
    • Juliusson G, Liliemark J. High complete remission rate from 2-chloro-2′-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count. J. Clin. Oncol. 11, 679-689 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , pp. 679-689
    • Juliusson, G.1    Liliemark, J.2
  • 10
    • 0028925970 scopus 로고
    • Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia
    • Juliusson G, Heldal D, Hippe E. Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia. J. Clin. Oncol. 13, 989-995 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 989-995
    • Juliusson, G.1    Heldal, D.2    Hippe, E.3
  • 11
    • 0031820075 scopus 로고    scopus 로고
    • Cladribine for untreated or early low-grade non-Hodgkin's lymphoma
    • Liliemark J, Martinsson U, Cavallin-Stahl E. Cladribine for untreated or early low-grade non-Hodgkin's lymphoma. Leuk. Lymphoma 30, 573-581 (1998).
    • (1998) Leuk. Lymphoma , vol.30 , pp. 573-581
    • Liliemark, J.1    Martinsson, U.2    Cavallin-Stahl, E.3
  • 12
    • 0026723519 scopus 로고
    • 2-Chlorodeoxyadenosine: An active agent in the treatment of cutaneous T-cell lymphoma
    • Saven A, Carrera CJ, Carson DA, Beutler E, Piro LD. 2- chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma. Blood 80, 587-592 (1992).
    • (1992) Blood , vol.80 , pp. 587-592
    • Saven, A.1    Carrera, C.J.2    Carson, D.A.3    Beutler, E.4    Piro, L.D.5
  • 13
    • 0029824568 scopus 로고    scopus 로고
    • 2-Chlorodeoxyadenosine: A potent antimetabolite with major activity in the treatment of indolent lymphoproliferative disorders
    • Saven A, Piro LD. 2-chlorodeoxyadenosine: a potent antimetabolite with major activity in the treatment of indolent lymphoproliferative disorders. Hematol. Cell Ther. 38(Suppl. 2), S93-S101 (1996).
    • (1996) Hematol. Cell Ther. , vol.38 , Issue.SUPPL. 2
    • Saven, A.1    Piro, L.D.2
  • 14
    • 0030013103 scopus 로고    scopus 로고
    • Cladribine and mitoxantrone dose escalation in indolent non-Hodgkin's lymphoma
    • Saven A, Lee T, Kosty M, Piro L. Cladribine and mitoxantrone dose escalation in indolent non-Hodgkin's lymphoma. J. Clin. Oncol. 14, 2139-2144 (1996).
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2139-2144
    • Saven, A.1    Lee, T.2    Kosty, M.3    Piro, L.4
  • 15
    • 0027235634 scopus 로고
    • 2-Chlorodeoxyadenosine in the treatment of chronic refractory immune thrombocytopenic purpura
    • Figueroa M, McMillan R. 2-chlorodeoxyadenosine in the treatment of chronic refractory immune thrombocytopenic purpura. Blood 81, 3484-3485 (1993).
    • (1993) Blood , vol.81 , pp. 3484-3485
    • Figueroa, M.1    McMillan, R.2
  • 16
    • 0028876402 scopus 로고
    • Oral 2-chlorodeoxyadenosine in psoriatic arthritis. A preliminary report
    • Eibschutz B, Baird SM, Weisman MH. Oral 2-chlorodeoxyadenosine in psoriatic arthritis. A preliminary report. Arthritis Rheum. 38, 1604-1609 (1995).
    • (1995) Arthritis Rheum. , vol.38 , pp. 1604-1609
    • Eibschutz, B.1    Baird, S.M.2    Weisman, M.H.3
  • 17
    • 0036673867 scopus 로고    scopus 로고
    • 2-Chloro-2′-deoxyadenosine in the treatment of Sjogren's syndrome-associated B cell lymphoproliferation
    • Voulgarelis M, Petroutsos G, Moutsopoulos HM, Skopouli FN. 2-chloro-2′-deoxyadenosine in the treatment of Sjogren's syndrome-associated B cell lymphoproliferation. Arthritis Rheum. 46, 2248-2249 (2002).
    • (2002) Arthritis Rheum. , vol.46 , pp. 2248-2249
    • Voulgarelis, M.1    Petroutsos, G.2    Moutsopoulos, H.M.3    Skopouli, F.N.4
  • 19
    • 3543092965 scopus 로고    scopus 로고
    • 2-Chlorodeoxyadenosine in nonmalignant disorders
    • Marcel Dekker, Inc., NY, USA
    • Beutler E, Carson D, Sipe JC et al. 2-chlorodeoxyadenosine in nonmalignant disorders. In: Nucleoside Analogues in Cancer Therapy. Marcel Dekker, Inc., NY, USA, 359-382 (1997).
    • (1997) Nucleoside Analogues in Cancer Therapy , pp. 359-382
    • Beutler, E.1    Carson, D.2    Sipe, J.C.3
  • 20
    • 0015515283 scopus 로고
    • Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity
    • Giblett ER, Anderson JE, Cohen F, Pollara B, Meuwissen HJ. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 2, 1067-1069 (1972).
    • (1972) Lancet , vol.2 , pp. 1067-1069
    • Giblett, E.R.1    Anderson, J.E.2    Cohen, F.3    Pollara, B.4    Meuwissen, H.J.5
  • 21
    • 0017639365 scopus 로고
    • Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)
    • Carson DA, Kaye J, Seegmiller JE. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). Proc. Natl Acad. Sci. 74, 5677-5681 (1977).
    • (1977) Proc. Natl. Acad. Sci. , vol.74 , pp. 5677-5681
    • Carson, D.A.1    Kaye, J.2    Seegmiller, J.E.3
  • 22
    • 3042870116 scopus 로고
    • Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo
    • Carson DA, Wasson DB, Kaye J. Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc. Natl Acad. Sci. 77, 6865-6869 (1980).
    • (1980) Proc. Natl. Acad. Sci. , vol.77 , pp. 6865-6869
    • Carson, D.A.1    Wasson, D.B.2    Kaye, J.3
  • 23
    • 0020612685 scopus 로고
    • Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes
    • Carson DA, Wasson DB, Taetle R, Yu A. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 62, 737-743 (1983).
    • (1983) Blood , vol.62 , pp. 737-743
    • Carson, D.A.1    Wasson, D.B.2    Taetle, R.3    Yu, A.4
  • 24
    • 0031043125 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of cladribine
    • Liliemark J. The clinical pharmacokinetics of cladribine. Clin. Pharmacokinet. 32, 120-131 (1997).
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 120-131
    • Liliemark, J.1
  • 26
    • 0022492499 scopus 로고
    • DNA strand breaks, NAD metabolism, and programmed cell death
    • Carson DA, Seto S, Wasson DB, Carrera CJ. DNA strand breaks, NAD metabolism, and programmed cell death. Exp. Cell Res. 164, 273-281 (1986).
    • (1986) Exp. Cell Res. , vol.164 , pp. 273-281
    • Carson, D.A.1    Seto, S.2    Wasson, D.B.3    Carrera, C.J.4
  • 27
    • 0022622873 scopus 로고
    • Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes
    • Seto S, Carrera CJ, Wasson DB, Carson DA. Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes. J. Immunol. 136, 2839-2843 (1986).
    • (1986) J. Immunol. , vol.136 , pp. 2839-2843
    • Seto, S.1    Carrera, C.J.2    Wasson, D.B.3    Carson, D.A.4
  • 28
    • 0022509945 scopus 로고
    • Biochemical basis for deoxyadenosine and 2-chlorodeoxyadenosine toxicity to resting human lymphocytes
    • Seto S, Carrera CJ, Wasson DB, Carson DA. Biochemical basis for deoxyadenosine and 2-chlorodeoxyadenosine toxicity to resting human lymphocytes. Adv. Exp. Med. Biol. 195(PtB), 577-582 (1986).
    • (1986) Adv. Exp. Med. Biol. , vol.195 , Issue.PART B , pp. 577-582
    • Seto, S.1    Carrera, C.J.2    Wasson, D.B.3    Carson, D.A.4
  • 31
    • 0031739385 scopus 로고    scopus 로고
    • Safety and tolerability of subcutaneous cladribine therapy in progressive multiple sclerosis
    • Selby R, Brandwein J, O'Connor P. Safety and tolerability of subcutaneous cladribine therapy in progressive multiple sclerosis. Can. J. Neurol. Sci. 25, 295-299 (1998).
    • (1998) Can. J. Neurol. Sci. , vol.25 , pp. 295-299
    • Selby, R.1    Brandwein, J.2    O'Connor, P.3
  • 32
    • 23444434940 scopus 로고    scopus 로고
    • Autoreactive CD8+ T cells in multiple sclerosis: A new target for therapy?
    • Friese MA, Fugger L. Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain 128, 1747-1763 (2005).
    • (2005) Brain , vol.128 , pp. 1747-1763
    • Friese, M.A.1    Fugger, L.2
  • 33
    • 0026336727 scopus 로고
    • 2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes
    • Carrera CJ, Piro LD, Saven A, Beutler E, Terai C, Carson DA. 2-chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes. Adv. Exp. Med. Biol. 309A, 15-18 (1991).
    • (1991) Adv. Exp. Med. Biol. , vol.309 A , pp. 15-18
    • Carrera, C.J.1    Piro, L.D.2    Saven, A.3    Beutler, E.4    Terai, C.5    Carson, D.A.6
  • 34
    • 0027468268 scopus 로고
    • 2-chlorodeoxyadenosine dose escalation in nonhematologic malignancies
    • Saven A, Kawasaki H, Carrera CJ. 2-chlorodeoxyadenosine dose escalation in nonhematologic malignancies. J. Clin. Oncol. 11, 671-678 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , pp. 671-678
    • Saven, A.1    Kawasaki, H.2    Carrera, C.J.3
  • 35
    • 0025935563 scopus 로고
    • On the pharmacokinetics of 2-chloro-2′-deoxyadenosine in humans
    • Liliemark J, Juliusson G. On the pharmacokinetics of 2-chloro-2′- deoxyadenosine in humans. Cancer Res. 51, 5570-5572 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 5570-5572
    • Liliemark, J.1    Juliusson, G.2
  • 36
    • 0027056958 scopus 로고
    • On the bioavailability of oral and subcutaneous 2-chloro-2′- deoxyadenosine in humans: Alternative routes of administration
    • Liliemark J, Albertioni F, Hassan M, Juliusson G. On the bioavailability of oral and subcutaneous 2-chloro-2′-deoxyadenosine in humans: alternative routes of administration. J. Clin. Oncol. 10, 1514-1518 (1992).
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1514-1518
    • Liliemark, J.1    Albertioni, F.2    Hassan, M.3    Juliusson, G.4
  • 37
    • 0029608809 scopus 로고
    • Effect of repeated treatments with cladribine (2-chlorodeoxyadenosine) on blood counts in multiple sclerosis patients
    • Grieb P, Stelmasiak Z, Solski J, Nowicki J, Jakubowska B, Ryba M. Effect of repeated treatments with cladribine (2-chlorodeoxyadenosine) on blood counts in multiple sclerosis patients. Arch. Immunol. Ther. Exp. 43, 323-327 (1995).
    • (1995) Arch. Immunol. Ther. Exp. , vol.43 , pp. 323-327
    • Grieb, P.1    Stelmasiak, Z.2    Solski, J.3    Nowicki, J.4    Jakubowska, B.5    Ryba, M.6
  • 38
    • 0032908474 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis
    • Romine JS, Sipe JC, Koziol JA, Zyroff J, Beutler E. A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis. Proc. Assoc. Am. Physicians 111, 35-44 (1999).
    • (1999) Proc. Assoc. Am. Physicians , vol.111 , pp. 35-44
    • Romine, J.S.1    Sipe, J.C.2    Koziol, J.A.3    Zyroff, J.4    Beutler, E.5
  • 42
    • 0029099349 scopus 로고
    • Infectious and immunosuppressive complications of purine analog therapy
    • Cheson BD. Infectious and immunosuppressive complications of purine analog therapy. J. Clin. Oncol. 13, 2431-2448 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2431-2448
    • Cheson, B.D.1
  • 44
    • 0034646216 scopus 로고    scopus 로고
    • Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI study group
    • Rice GP, Filippi M, Comi G. Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group. Neurology 54, 1145-1155 (2000).
    • (2000) Neurology , vol.54 , pp. 1145-1155
    • Rice, G.P.1    Filippi, M.2    Comi, G.3
  • 45
    • 0034642247 scopus 로고    scopus 로고
    • Whole brain volume changes in patients with progressive MS treated with cladribine
    • Filippi M, Rovaris M, Iannucci G, Mennea S, Sormani MP, Comi G. Whole brain volume changes in patients with progressive MS treated with cladribine. Neurology 55, 1714-1718 (2000).
    • (2000) Neurology , vol.55 , pp. 1714-1718
    • Filippi, M.1    Rovaris, M.2    Iannucci, G.3    Mennea, S.4    Sormani, M.P.5    Comi, G.6
  • 46
    • 0034194016 scopus 로고    scopus 로고
    • The effect of cladribine on T(1) 'black hole' changes in progressive MS
    • Filippi M, Rovaris M, Rice GP. The effect of cladribine on T(1) 'black hole' changes in progressive MS. J. Neurol. Sci. 176, 42-44 (2000).
    • (2000) J. Neurol. Sci. , vol.176 , pp. 42-44
    • Filippi, M.1    Rovaris, M.2    Rice, G.P.3
  • 47
    • 0032979685 scopus 로고    scopus 로고
    • Hypointense and hyperintense lesions on magnetic resonance imaging in secondary-progressive MS patients
    • Adams HP, Wagner S, Sobel DF. Hypointense and hyperintense lesions on magnetic resonance imaging in secondary-progressive MS patients. Eur. Neurol. 42, 52-63 (1999).
    • (1999) Eur. Neurol. , vol.42 , pp. 52-63
    • Adams, H.P.1    Wagner, S.2    Sobel, D.F.3
  • 48
    • 0030028827 scopus 로고    scopus 로고
    • A comparison of two neurologic scoring instruments for multiple sclerosis
    • Koziol JA, Frutos A, Sipe JC, Romine JS, Beutler E. A comparison of two neurologic scoring instruments for multiple sclerosis. J. Neurol. 243, 209-213 (1996).
    • (1996) J. Neurol. , vol.243 , pp. 209-213
    • Koziol, J.A.1    Frutos, A.2    Sipe, J.C.3    Romine, J.S.4    Beutler, E.5
  • 49
    • 0032974875 scopus 로고    scopus 로고
    • Perils and pitfalls in the interpretation of clinical trials: A reflection on the recent experience in multiple sclerosis
    • Goodin DS. Perils and pitfalls in the interpretation of clinical trials: a reflection on the recent experience in multiple sclerosis. Neuroepidemiology 18, 53-63 (1999).
    • (1999) Neuroepidemiology , vol.18 , pp. 53-63
    • Goodin, D.S.1
  • 50
    • 0034001516 scopus 로고    scopus 로고
    • The cladribine trial in secondary progressive multiple sclerosis: A reanalysis
    • Beutler E, Koziol JA. The cladribine trial in secondary progressive multiple sclerosis: a reanalysis. Neuroepidemiology 19, 109-112 (2000).
    • (2000) Neuroepidemiology , vol.19 , pp. 109-112
    • Beutler, E.1    Koziol, J.A.2
  • 51
    • 0033986810 scopus 로고    scopus 로고
    • The cladribine trial in secondary progressive MS: Response
    • Goodin DS. The cladribine trial in secondary progressive MS: response. Neuroepidemiology 19, 53-54 (2000).
    • (2000) Neuroepidemiology , vol.19 , pp. 53-54
    • Goodin, D.S.1
  • 52
    • 0034575321 scopus 로고    scopus 로고
    • The levels of C3 and C4 components of the complement in the sera of relapsing-remitting multiple sclerosis patients (RR-MS) treated by 2-CDA (cladribine)
    • Bartosik-Psujek H, Stelmasiak Z, Mitosek-Szewczyk K, Belniak-Legiec E, Dobosz B. The levels of C3 and C4 components of the complement in the sera of relapsing-remitting multiple sclerosis patients (RR-MS) treated by 2-CDA (cladribine). Ann. Univ. Mariae Curie Sklodowska (Med) 55, 231-234 (2000).
    • (2000) Ann. Univ. Mariae Curie Sklodowska (Med.) , vol.55 , pp. 231-234
    • Bartosik-Psujek, H.1    Stelmasiak, Z.2    Mitosek-Szewczyk, K.3    Belniak-Legiec, E.4    Dobosz, B.5
  • 53
    • 2542553435 scopus 로고    scopus 로고
    • Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine
    • Bartosik-Psujek H, Belniak E, Mitosek-Szewczyk K, Dobosz B, Stelmasiak Z. Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine. Acta Neurol Scand. 109, 390-392 (2004).
    • (2004) Acta Neurol Scand. , vol.109 , pp. 390-392
    • Bartosik-Psujek, H.1    Belniak, E.2    Mitosek-Szewczyk, K.3    Dobosz, B.4    Stelmasiak, Z.5
  • 54
    • 0034851504 scopus 로고    scopus 로고
    • Effect of cladribine treatment on β-2 microglobulin and soluble intercellular adhesion molecule 1 (ICAM-1) in patients with multiple sclerosis
    • Niezgoda A, Losy J, Mehta PD. Effect of cladribine treatment on β-2 microglobulin and soluble intercellular adhesion molecule 1 (ICAM-1) in patients with multiple sclerosis. Folia Morphol. 60, 225-228 (2001).
    • (2001) Folia Morphol. , vol.60 , pp. 225-228
    • Niezgoda, A.1    Losy, J.2    Mehta, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.