Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca2+-activated K+ channel blockers

Journal of Medicinal Chemistry

Volumn 50, Issue 21, 2007, Pages 5070-5075

  Graulich, Amaury ^a   Dilly, Sébastien ^b   Farce, Amaury ^b   Scuvée Moreau, Jacqueline ^a   Waroux, Olivier ^a   Lamy, Cédric ^a   Chavatte, Philippe ^b   Seutin, Vincent ^a   Liégeois, Jean François ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE DERIVATIVE; APAMIN; CALCIUM CHANNEL; DEQUALINIUM; ISOQUINOLINE DERIVATIVE; LAUDANOSINE; N METHYLLAUDANOSINE; N METHYLNOSCAPINE; NOSCAPINE; POTASSIUM CHANNEL; RADIOLIGAND; UNCLASSIFIED DRUG; XYLENE;

AFTERHYPERPOLARIZATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM CONDUCTANCE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; ISOMER; MALE; MOLECULAR MODEL; NONHUMAN; POTASSIUM CONDUCTANCE; RADIOASSAY; RAT; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; BRAIN; DOPAMINE; ISOQUINOLINES; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEURONS; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35348839071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070412j     Document Type: Article

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