Enhanced microtubule binding and tubulin assembly properties of conformationally constrained paclitaxel derivatives

Biochemistry

Volumn 46, Issue 41, 2007, Pages 11514-11527

  Shanker, Natasha ^a   Kingston, David G I ^b   Ganesh, Thota ^b,c   Yang, Chao ^b   Alcaraz, Ana A ^c   Geballe, Matthew T ^c   Banerjee, Abhijit ^a   McGee, Dennis ^a   Snyder, James P ^c   Bane, Susan ^a  

^a BINGHAMTON UNIVERSITY   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BIOASSAY; CELLS; CONFORMATIONS; DERIVATIVES; POLYMERIZATION;

META POSITIONS; MICROTUBULE POLYMERIZATION; PACLITAXEL DERIVATIVES; TUBULIN ASSEMBLY;

PROTEINS;

DOCETAXEL; GUANOSINE DIPHOSPHATE; MAGNESIUM ION; PACLITAXEL; PACLITAXEL DERIVATIVE; TAXANE DERIVATIVE;

ARTICLE; BINDING COMPETITION; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROTUBULE; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING, COMPETITIVE; BRAIN; CATTLE; KINETICS; MICROTUBULES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PACLITAXEL; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 35348833682     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700753y     Document Type: Article

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