Dietary quercetin inhibits 1,2-dimethylhydrazine-induced liver DNA damage without altering colon DNA damage or precancerous lesion formation in rats

Nutrition Research

Volumn 27, Issue 10, 2007, Pages 659-664

  No, Ha Na ^a   Kwon, Hoonjeong ^b   Park, You Gyoung ^b   Cheon, Choong Ill ^a   Park, Jong Sug ^c   Park, Taesun ^d   Aruoma, Okezie I ^e   Sung, Mi Kyung ^a  

^a Sookmyung Women's University   (South Korea)

^b Seoul National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

^d Yonsei University   (South Korea)

^e TOURO COLLEGE   (United States)

Author keywords

1,2 Dimethylhydrazine; Antioxidants; Colon cancer; Colon aberrant crypts; Oxidative DNA damage; Quercetin; Rats

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 8 HYDROXYGUANINE; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CANCER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; DRUG EFFECT; DRUG INHIBITION; FOOD INTAKE; LIVER; MALE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; RAT; TISSUE INJURY;

RATTUS;

EID: 35348823612     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2007.08.001     Document Type: Article

References (35)

1. Wogan G.N., Hecht S.S., Felton J.S., Conney A.H., and Loeb L.A. Environmental and chemical carcinogenesis. Semin Cancer Biol 14 (2004) 473-486
2. Halliwell B., and Aruoma O.I. DNA damage by oxygen-derived species: its mechanism and measurement in mammalian systems. FEBS Lett 281 (1991) 9-19
3. Leonard S.S., Harris G.K., and Shi X. Metal-induced oxidative stress and signal transduction. Free Radic Biol Med 37 (2004) 1921-1942
4. Steinmetz K.A., and Potter J.D. Vegetables, fruits and cancer prevention: a review. J Am Diet Assoc 96 (1996) 1027-1039
5. Birt D.F., Hendrich S., and Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90 (2001) 157-177
6. Bors W., and Saran M. Radical scavenging by flavonoid antioxidants. Free Radic Res Commun 2 (1987) 289-294
7. Kuo S.M. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110 (1996) 41-48
8. Agullo G., Gamet L., Besson C., Demigne C., and Remesy C. Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT-29 and Caco-2 cells. Cancer Lett 87 (1994) 55-63
9. Deschner E.E., Ruperto J., Wong G., and Newmark H.L. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 12 (1991) 1193-1196
10. Akagi K., Hirose M., Hoshiya T., Mizoguchi Y., Ito N., and Shirai T. Modulating effects of ellagic acid, vanillin and quercetin in a rat medium-term, multi-organ carcinogenesis model. Cancer Lett 94 (1995) 113-121
11. Exon J.H., Magnuson B.A., South E.H., and Hendrix K. Dietary quercetin, immune functions and colonic carcinogenesis in rats. Immunopharmacol Immunotoxicol 20 (1998) 173-190
12. Pereira M.A., Grubbs C.J., Barnes L.H., Li H., Olson G.R., Eto I., et al. Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. Carcinogenesis 17 (1996) 1305-1311
13. Mahmoud N.N., Carothers A.M., Grunberger D., Bilinski R.T., Churchill M.R., Martucci C., et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis 21 (2000) 921-927
14. Sahu S.C., and Washington M.C. Quercetin-induced lipid peroxidation and DNA damage in isolated rat liver nuclei. Cancer Lett 58 (1991) 75-79
15. Boots A.W., Li H., Schins P.F., Duffin R., Heemskerk J.W.M., Bast A., et al. The quercetin paradox. Toxicol Appl Pharmacol 222 (2007) 89-96
16. Matsuo M., Sasaki N., Saga K., and Kaneko T. Cytotoxicity of flavonoids toward culture normal human cells. Biol Pharm Bull 28 (2005) 253-259
17. Sasak M., Nakamura H., Tsuchiya S., Horie S., Kashiwayanagi M., Saito T., et al. Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation. Biol Pharm Bull 30 (2007) 682-686
18. Yamashita N., and Kawanishi S. Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin. Free Radic Res 33 (2000) 623-633
19. Ong C.S., Tran E., Nguyen T.T., Ong C.K., Lee S.K., Lee J.J., et al. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Oncol Rep 11 (2004) 727-733
20. Ozawa T., Tanaka M., Sugiyama S., Hattori K., Ito T., Ohno K., et al. Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy. Biochem Biophys Res Commun 170 (1990) 830-836
21. Lambert J.D., Hong J., Yang G., Liao J., and Yang C.S. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr 81 suppl (2005) 284S-291S
22. Oravec C.T., Jones C.A., and Huberman E. Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay. Cancer Res 46 (1986) 5068-5071
23. Bull A.W., Burd A.D., and Nigri N.D. Effect of inhibitors of tumorigenesis on the formation of O6-methylguanine in the colon of 1,2-dimethylhydrazine-treated rats. Cancer Res 41 (1981) 4938-4941
24. Swenberg J.A., Cooper H.K., Bucchler J., and Kleihues P. 1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pre-treatment with disulfiram. Cancer Res 39 (1979) 465-467
25. Dolara P., Luceri C., De Filippo C., Femia A.P., Giovannelli L., Caderni G., et al. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat Res 591 (2005) 237-246
26. Sengottuvelan M., Senthilkumar R., and Nalini N. Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim Biophys Acta 1760 (2006) 1175-1183
27. Bolognesi C., Mariani M.R., and Boffa L.C. Target tissue damage in inbred mouse strains with different degrees of susceptibility to the colon carcinogen 1,2-dimethylhydrazine. Carcinogenesis 9 (1988) 1347-1350
28. Sakihama Y., Cohen M.F., Grace S.C., and Yamasaki H. Plant phenolic antioxidant and pro-oxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicol 177 (2002) 67-80
29. Yoshono M., Haneda M., Naruse M., and Murakami K. Pro-oxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2′-deoxyguanosine in DNA. Mol Gen Metab 68 (2002) 468-472
30. Duthie S.J., Johnson W., and Dobson V.L. The effect of dietary flavonoids on DNA damage (strand breaks and oxidized pyrimidine) and growth in human cells. Mutat Res 390 (1997) 141-151
31. Choi E.J., Chee K.M., and Lee B.H. Anti- and pro-oxidant effects of chronic quercetin administration in rats. Eur J Pharmacol 482 (2003) 281-285
32. Matsukawa Y., Nishino H., Okuyama Y., Matsui T., Matsumoto Y., Matsumura D., et al. Effects of quercetin and/or restraint stress on formation of aberrant cyprt foci induced by azoxymethane in rat colons. Oncology 54 (2003) 118-121
33. Gee J.M., Hara H., and Johnson I.T. Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. Nutr Cancer (2002) 193-201
34. Williams R.J., Spencer J.P.F., and Rice-Evans C. Flavonoids: antioxidants or signaling molecules?. Free Radic Biol Med 36 (2004) 838-849
35. Chen X., Yin O.Q.P., and Chow M.S.S. Pharmacokinetics and modeling of quercetin and metabolites. Pharm Res 22 (2005) 892-901