VEGF immunopositivity related to malignancy degree, proliferative activity and angiogenesis in ENU-induced gliomas

Journal of Molecular Neuroscience

Volumn 33, Issue 2, 2007, Pages 163-172

  Bulnes, S ^a   Lafuente, J V ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Angiogenesis; Ethylnitrosourea; Glioma; Proliferation index; Vascular endothelial growth factor (VEGF)

Indexed keywords

ETHYLNITROSOUREA; GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; OLIGODENDROCYTE AB 2; PROTEIN DERIVATIVE; PROTEIN S 100; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 165;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; CANCER SCREENING; CANCER STAGING; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIOMA; HISTOLOGY; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MORPHOLOGY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROGLIOMA; PRENATAL EXPOSURE; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RAT; SOLID TUMOR; TUMOR LOCALIZATION;

ALKYLATING AGENTS; ANIMALS; CELL PROLIFERATION; ETHYLNITROSOUREA; FEMALE; FETUS; GLIOMA; HUMANS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 35348817937     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-007-0061-0     Document Type: Article

References (40)

1. Bergers, G., & Benjamin, L. E. (2003). Tumorigenesis and the angiogenic switch. Nature Reviews Cancer, 3, 401-410.
2. Bielas, J. H., & Heddle, J. A. (2000). Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proceedings of the National Academy of Science USA, 97, 11391-11396.
3. Bigner, D. D., McLendon, R. E., & Bruner, J. M. (1998). Russell and Rubinstenin's Pathology of tumors of the nervous system (6th ed.). London: Arnold.
4. Bulnes-Sesma, S., Ullibarri-Ortiz, N., & Lafuente-Sanchez, J. V. (2006). Tumour induction by ethylnitrosourea in the central nervous system. Revista de neurología, 43, 733-738.
5. Carmeliet, P., & Jain, R. K. (2000). Angiogenesis in cancer and other diseases. Nature, 407, 249-257.
6. Chan, A. S., Leung, S. Y., Wong, M. P., Yuen, S. T., Cheung, N., Fan, Y. W., et al. (1998). Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. American Journal of Surgical Pathology, 22, 816-826.
7. Dvorak, H. F. (2006). Discovery of vascular permeability factor (VPF). Experimental Cell Research, 312, 522-526.
8. Engelbergs, J., Thomale, J., & Rajewsky, M. F. (2000). Role of DNA repair in carcinogen-induced ras mutation. Mutation Research, 450, 139-153.
9. Engelhard, H. H., Stelea, A., & Mundt, A. (2003). Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis. Surgical Neurology, 60, 443-456.
10. Ferrara, N. (2001). Role of vascular endothelial growth factor in regulation of physiological angiogenesis. American Journal of Physiology Cell Physiology, 280, 1358-1366.
11. Ferrara, N., Gerber, H. P., & LeCouter, J. (2003). The biology of VEGF and its receptors. Natural Medicines, 9, 669-676.
12. Folkman, J. (2000). Tumor angiogenesis, in cancer medicine. In J. F. Holland et al. (Ed.) (p. 132:152). Hamilton, Ontario, Canada: B. C. Decker Inc.
13. Gil-Perotin, S., Marin-Husstege, M., Li, J., Soriano-Navarro, M., Zindy, F., Roussel, M. F., et al. (2006). Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. Journal of Neuroscience, 26, 1107-1116.
14. Jang, T., Litofsky, N. S., Smith, T. W., Ross, A. H., & Recht, L. D. (2004). Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiology of Disease, 15, 544-552.
15. Katayama, K., Ueno, M., Yamauchi, H., Nagata, T., Nakayama, H., & Doi, K. (2005a). Ethylnitrosourea induces neural progenitor cell apoptosis after S-phase accumulation in a p53-dependent manner. Neurobiology of Disease, 18, 218-225.
16. Katayama, K., Ueno, M., Yamauchi, H., Nakayama, H., & Doi, K. (2005b). Microarray analysis of genes in fetal central nervous system after ethylnitrosourea administration. Birth Defects Research, Part B, Developmental and Reproductive Toxicology, 74, 255-260.
17. Ke, L. D., Shi, Y. X., Im, S. A., Chen, X., & Yung, W. K. (2000). The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines. Clinical Cancer Research, 6, 2562-2572.
18. Kish, P. E., Blaivas, M., Strawderman, M., Muraszko, K.M., Ross, D.A., Ross, B. D., et al. (2001). Magnetic resonance imaging of ethyl-nitrosourea- induced rat gliomas: A model for experimental therapeutics of low-grade gliomas. J. Neurooncol., 53, 243-257.
19. Kleihues, P., & Cavenee, W. K. (2000). Pathology and genetics of tumours of the nervous system. Lyon: IARC Press.
20. Kokkinakis, D. M., Rushing, E. J., Shareef, M. M., Ahmed, M. M., Yang, S., Singha, U. K., et al. (2004). Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague Dawley rats. Journal of Neuropathology and Experimental Neurology, 63, 1182-1199.
21. Koutcher, J. A., Hu, X., Xu, S., Gade, T. P., Leeds, N., Zhou, X. J., et al. (2002). MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials. Neoplasia, 4, 480-485.
22. Kroh, H. (1987). Periphery of ethylnitrosourea-induced spinal gliomas in rats with special reference to the vascular structure. Acta Neuropathologica (Berl), 73, 92-98.
23. Lafuente, J. V., Adan, B., Alkiza, K., Garibi, J. M., Rossi, M., & Cruz-Sanchez, F. F. (1999). Expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor-beta (PDGFR-beta) in human gliomas. Journal of Molecular Neuroscience, 13, 177-185.
24. Lafuente, J. V., Bulnes, S., Mitre, B., & Riese, H. H. (2002). Role of VEGF in an experimental model of cortical micronecrosis. Amino Acids, 23, 241-245.
25. Lantos, P. L. (1986). Development of nitrosourea-induced brain tumours with a special note on changes occurring during latency. Food and Chemical Toxicology, 24, 121-127.
26. Machein, M. R., Knedla, A., Knoth, R., Wagner, S., Neuschl, E., & Plate, K. H. (2004). Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. American Journal of Pathology, 165, 1557-1570.
27. Mukherjee, J., Ghosh, A., Ghosh, A., & Chaudhuri, S. (2006). ENU administration causes genomic instability along with single nucleotide polymorphisms in p53 during gliomagenesis: T11TS administration demonstrated in vivo apoptosis of these genetically altered tumor cells. Cancer Biology and Therapy, 5, 156-164.
28. Nagashima, G., Suzuki, R., Asai, J., & Fujimoto, T. (2002). Immunohistochemical analysis of reactive astrocytes around glioblastoma: an immunohistochemical study of postmortem glioblastoma cases. Clinical Neurology and Neurosurgery, 104, 125-131.
29. Naumov, G. N., Bender, E., Zurakowski, D., Kang, S. Y., Sampson, D., Flynn, E., et al. (2006). A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. Journal of the National Cancer of Institute, 98, 316-325.
30. O'Neill, J. P. (2000). DNA damage, DNA repair, cell proliferation, and DNA replication: How do gene mutations result? Proceedings of the National Academy of Science U.S.A., 97, 11137-11139.
31. Plate, K. H. (1999). Mechanisms of angiogenesis in the brain. Journal of Neuropathology and Experimental Neurology, 58, 313-320.
32. Reifenberger, G., Kros, J. M., Louis, D. N., & Collins, V. P. (2000). Oligodendroglial tumours and mixed glioma, in pathology and genetics of tumours of the nervous system. In P. Kleihues & W. K. Cavenee (Ed.) (pp. 55-70). Lyon: IARC Press.
33. Reifenberger, G., & Louis, D. N. (2003). Oligodendroglioma: Toward molecular definitions in diagnostic neuro-oncology. Journal of Neuropathology and Experimental Neurology, 62, 111-126.
34. Schiffer, D., Giordana, M. T., Pezzotta, S., Lechner, C., & Paoletti, P. (1978). Cerebral tumors induced by transplacental ENU: study of the different tumoral stages, particularly of early proliferations. Acta Neuropathologica (Berl), 41, 27-31.
35. Schlageter, K. E., Molnar, P., Lapin, G. D., & Groothuis, D. R. (1999). Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties. Microvasclar Research, 58, 312-328.
36. Tonini, T., Rossi, F., & Claudio, P. P. (2003). Molecular basis of angiogenesis and cancer. Oncogene, 22, 6549-6556.
37. Vaquero, J., Oya, S., Coca, S., & Zurita, M. (1994). Experimental induction of primitive neuro-ectodermal tumours in rats: A re-appraisement of the ENU-model of neurocarcinogenesis. Acta. Neurochirurgica, 131, 294-301.
38. Vaquero, J., Zurita, M., Coca, S., Oya, S., & Morales, C. (2000). Prognostic significance of clinical and angiogenesis-related factors in low-grade oligodendrogliomas. Surgical Neurology, 54, 229-234.
39. Yoshimura, F., Kaidoh, T., Inokuchi, T., & Shigemori, M. (1998). Changes in VEGF expression and in the vasculature during the growth of early-stage ethylnitrosourea-induced malignant astrocytomas in rats. Virchows Archive, 433, 457-463.
40. Zook, B. C., Simmens, S. J., & Jones, R. V. (2000). Evaluation of ENU-induced gliomas in rats: Nomenclature, immunochemistry, and malignancy. Toxicologic Pathology, 28, 193-201.