Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis

Neurobiology of Disease

Volumn 15, Issue 3, 2004, Pages 544-552

  Jang, Taichang ^a   Litofsky, N Scott ^a   Smith, Thomas W ^a   Ross, Alonzo H ^a   Recht, Lawrence D ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ethylnitrosourea (ENU); GFAP; Glial neoplasms; Nestin; Neurocarcinogenesis; Rat; Subventricular zone

Indexed keywords

BROXURIDINE; ETHYLNITROSOUREA; NESTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN TISSUE; BRAIN TUMOR; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MALE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STAB WOUND; TUMOR CELL;

ANIMALS; BRAIN INJURIES; BRAIN NEOPLASMS; CARCINOGENS; CELL LINEAGE; ETHYLNITROSOUREA; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; MICROSCOPY, CONFOCAL; NERVE TISSUE PROTEINS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR MARKERS, BIOLOGICAL;

EID: 1842524041     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2003.11.016     Document Type: Article

References (51)

1. Almqvist P.M., Mah R., Lendahl U., Jacobsson B., Hendson G. Immunohistochemical detection of nestin in pediatric brain tumors. J. Histochem. Cytochem. 50:2002;147-158.
2. Bachoo R.M., Maher E.A., Ligon K.L., Sharpless N.E., Chan S.S., You M.J., Tang Y., DeFrances J., Stover E., Weissleder R.et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cells. 1:2002;269-277.
3. Berenblum I., Shubik P. A new, quantitative approach to the study of the stages of chemical carcinogenesis in the mouse's skin. Br. J. Cancer. 1:1947;379-391.
4. Berenblum I., Shubik P. An experimental study of the initiating stage of carcinogenesis, and a re-examination of the somatic cell mutation of cancer. Br. J. Cancer. 3:1949;109-118.
5. Bernier P.J., Vinet J., Cossette M., Parent A. Characterization of the subventricular zone of the adult human brain: evidence for the involvement of Bcl-2. Neurosci. Res. 37:2000;67-78.
6. Brook G.A., Pérez-Bouza A., Noth J., Nacimento W. Astrocytes re-express nestin in differentiated target territories of the adult rat hippocampus. NeuroReport. 10:1999;1007-1011.
7. Clarke S.R., Shetty A.K., Bradley J.L., Turner D.A. Reactive astrocytes express the embryonic intermediate neurofilament nestin. NeuroReport. 5:1994;1885-1888.
8. Dahlstrand J., Collins V.P., Lendahl U. Expression of the Class VI intermediate filament nestin in human central nervous system tumors. Cancer Res. 52:1992;5334-5341.
9. Dahlstrand J., Lardelli M., Lendahl U. Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Dev. Brain Res. 84:1995;109-129.
10. Druckrey H., Ivankovic S., Preussmann R. Teratogenic and carcinogenic effects in the offspring after a single injection of ethylnitrosourea to pregnant rats. Nature. 210:1966;1378-1379.
11. Duggal N., Schmidt-Kastner R., Hakim A.M. Nestin expression in reactive astrocytes following focal cerebral ischemia in rats. Brain Res. 768:1997;1-9.
12. Farber E. Putative precursor lesions: summary and some analytical considerations. Cancer Res. 36:1976;2703-2705.
13. Foulds L. Multiple etiologic factors in neoplastic development. Cancer Res. 25:1965;1339-1347.
14. Frisén J., Johansson C.B., Török C., Risling M., Lendahl U. Rapid, widespread, and long-lasting induction of nestin contributes to the generation of glial scar tissue after CNS injury. J. Cell Biol. 131:1995;453-464.
15. Galloway P.G., Likavec M.J., Perry G. Immunohistochemical recognition of ethylnitrosourea induced rat brain microtumors by anti-Leu 7 monoclonal antibody. Cancer Lett. 49:1990;243-248.
16. Giordana M.T., Migheli A., Mocellini C., Villare F., Schiffer D. Immunohistochemical observations on rat radial glia: relationship with the origin of ethylnitrosourea-induced tumors. Acta Neuropathol. 84:1992;387-393.
17. Goth R., Rajewsky M.F. Persistence of O6-ethylguanine in rat brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc. Natl. Acad. Sci. U. S. A. 71:1974;639-643.
18. Hockfield S., McKay R.D.G. Identification of major cell classes in the developing mammalian nervous system. J. Neurosci. 5:1985;3310-3328.
19. Holmin S., Almqvist P., Lendahl U., Mathiesen T. Adult nestin-expressing subependymal cells differentiate to astrocytes in response to brain injury. Eur. J. Neurosci. 9:1997;65-75.
20. Ikeda T., Mashimoto H., Iwasaki K., Shimokawa I., Matsuo T. A sequential ultrastructural and histoautoradiographic study of early neoplastic lesions in ethylnitrosourea-induced rat glioma. Acta Pathol. Jpn. 39:1989;487-495.
21. Inskip P.D., Linet M.S., Heineman E.F. Etiology of brain tumors in adults. Epidemiol. Rev. 17:1995;382-414.
22. Kakita A., Goldman J.E. Patterns and dynamics of SVZ cell migration in the postnatal forebrain: monitoring living progenitors in slice preparations. Neuron. 23:1999;461-472.
23. Kaya S.S., Mahmood A., Li Y., Yavuz E., Chopp M. Expression of nestin after traumatic brain injury in rat brain. Brain Res. 840:1999;153-157.
24. Koestner A. Characterization of N-nitrosourea-induced tumors of the nervous system; Their prospective value for studies of neurocarcinogenesis and brain tumor therapy. Toxicol. Pathol. 18:1990;186-192.
25. Kokkinakis D.M., Watson M.L., Honig L.S., Rushing E.J., Mickey B.E., Schold S.C. Characterization of initiated cells in N-methylnitrosourea-induced carcinogenesis of the CNS in the adult rat. Neuro-Oncology. 3:2001;99-112.
26. Krum J.M., Rosenstein J.M. Transient coexpression of nestin, GFAP, and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds. Exp. Neurol. 160:1999;348-360.
27. Lantos P.L., Cox D.J. The origin of experimental brain tumours: a sequential study. Experientia. 32:1976;1467-1468.
28. Lantos P.L., Pilkington G.J. The development of experimental brain tumors. A sequential light and electron microscope study of the subependymal plate: I. Early lesions (Abnormal cell clusters). Acta Neuropathol. 45:1979;167-175.
29. Lendahl U., Zimmerman L.B., McKay R.D.G. CNS stem cells express a new class of intermediate filament protein. Cell. 60:1990;585-595.
30. Levison S.W., Goldman J.E. Multipotential and lineage restricted precursors coexist in the mammalian perinatal subventricular zone. J. Neurosci. Res. 48:1997;83-94.
31. Levison S.W., Chuang C., Abramson B.J., Goldman J.E. The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated. Development. 119:1993;611-622.
32. Li Y., Chopp M. Temporal profile of nestin expression after focal cerebral ischemia in adult rat. Brain Res. 838:1999;1-10.
33. Maekawa A., Onodera H., Tanigawa H., Furuta K., Takahashi M., Kurokawa Y.et al. Spontaneous tumors of the nervous system and associated organs and/or tissues in rats. Gann. 75:1984;784-791.
34. Maher E.A., Furnari F.B., Bachoo R.M., Rowitch D.H., Louis D.N., Cavenee W.K., DePinho R.A. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15:2001;1311-1333.
35. Mennel H.D., Simon H. Morphology of early stages of ENU-induced brain tumors in rats. Exp. Pathol. 28:1985;207-214.
36. Morshead C.M., Craig C.G., van der Kooy D. In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain. Development. 125:1998;2251-2261.
37. Peterson D.L., Sheridan P.J., Brown W.E. Animal models for brain tumors: historical perspectives and future directions. J. Neurosurg. 80:1994;865-876.
38. Pilkington G.J., Lantos P.L. The development of experimental brain tumors. A sequential light and electron microscope study of the subependymal plate. II. Microtumors. Acta Neuropathol. (Berl). 45:1979;177-185.
39. Schiffer D., Giordana M.T., Pezzotta S., Lechner C., Paoletti P. Cerebral tumors induced by transplacental ENU: study of the different tumoral stages, particularly of early proliferations. Acta Neuropathol. 41:1978;27-31.
40. Schiffer D., Giordana M.T., Mauro A., Racagni G., Bruno F., Pezzotta S., Paoletti P. Experimental brain tumors by transplacental ENU. Multifactorial study of the latency period. Acta Neuropathol. 49:1980;117-122.
41. Selikoff I.J., Hammond E.C. Brain tumors in the chemical industry. Ann. N. Y. Acad. Sci. 381:1982;1-364.
42. Shabad L.M. Precancerous morphologic lesions. J. Natl. Cancer Inst. 50:1973;1421-1428.
43. Solt D., Farber E. New principle for the analysis of chemical carcinogenesis. Nature. 263:1976;701-703.
44. Sugawara K., Kurihara H., Negishi M., Saito N., Nakazato Y., Sasaki T., Takeuchi T. Nestin as a marker for proliferative endothelium in gliomas. Lab. Invest. 82:2002;345-351.
45. Swann P.F., Magee P.N. Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate. Biochem. J. 125:1971;841-847.
46. Tohyama T., Lee V.M.-Y., Rorke L.B., Marvin M., McKay R.D.G., Trojanowski J.Q. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab. Invest. 66:1992;303-313.
47. Trosko J.E. Commentary: is the concept of "tumor promotion" a useful paradigm? Mol. Carcinog. 30:2001;131-137.
48. Trosko J.E., Chang C.-C. Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. Mutat. Res. 480-481:2001;219-229.
49. Wood G.A., Korkola J.E., Archer M.C. Tissue-specific resistance to cancer development in the rat: phenotypes of tumor-modifier genes. Carcinogenesis. 23:2002;1-9.
50. Yoshino T., Motoi M., Ogawa K. Immunohistochemical studies on cellular character of microtumors induced by ethylnitrosourea in the rat brain utilizing anti-Leu 7 and anti-glial fibrillary acidic protein antibodies. Acta Neuropathol. 66:1985;167-169.
51. Yoshino T., Motoi M., Ogawa K. Morphological maturation of tumor cells induced by ethylnitrosourea (ENU) n rat brains: I. On the tumors by administration of ENU in the late gestational stage. Acta Pathol. Jpn. 35:1985;1385-1396.