Changes in VEGF expression and in the vasculature during the growth of early-stage ethylnitrosourea-induced malignant astrocytomas in rats

Virchows Archiv

Volumn 433, Issue 5, 1998, Pages 457-463

  Yoshimura, Fumihide ^a   Kaidoh, Toshiyuki ^a,b   Inokuchi, Tetsuo ^a   Shigemori, Minoru ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Ethylnitrosourea (ENU); Malignant astrocytoma; Vascular endothelial growth factor (VEGF)

Indexed keywords

ETHYLNITROSOUREA; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; BLOOD VESSEL DIAMETER; FEMALE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME;

ANIMALS; ASTROCYTOMA; BLOOD VESSELS; BRAIN NEOPLASMS; ENDOTHELIAL GROWTH FACTORS; ETHYLNITROSOUREA; FEMALE; IMMUNOENZYME TECHNIQUES; LYMPHOKINES; NEOVASCULARIZATION, PATHOLOGIC; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VON WILLEBRAND FACTOR;

EID: 0031783867     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050274     Document Type: Article

References (28)

1. Adams JC (1981) Heavy metal intensification of DAB-based HRP reaction product. J Histochem Cytochem 29:775
2. Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxena A, Craig Clark W, Robertson JT, Ali IU, Oldfield EH (1993) Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 91:153-159
3. Bilzer T, Reifenberger G, Wechsler W (1989) Chemical induction of brain tumours in rats by nitrosoureas: molecular biology and neuropathology. Neurotoxicol Teratol 11:551-556
4. Brown FB, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Dvorak HF, Senger DR (1993) Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am J Pathol 143:1255-1262
5. Cox DJ, Pilkington GJ, Lantos PL (1976) The fine structure of blood vessels in ethylnitrosourea-induced tumours of the rat nervous system. With special reference to the breakdown of the blood-brain barrier. Br J Exp Pathol 57:419-430
6. Dvorak HF, Brown LF, Detmar M, Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146:1029-1039
7. Ferrara N, Henzel W (1989) Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161:851-858
8. Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235:442-447
9. Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumour dormancy in vivo by prevention of neovascularization. J Exp Med 136:261-276
10. Goldman CK, Kim J, Wong WL, King V, Brock T, Gillespie GY (1993) Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4:121-133
11. Hori K, Suzuki M, Tunda S, Saito S (1990) In vivo analysis of tumour vascularization in the rat. Jpn J Cancer Res 81:279-288
12. Ijichi A, Sakuma S, Tofilon PJ (1995) Hypoxia-induced vascular endothelial growth factor expression in normal rat astrocyte cultures. Glia 14:87-93
13. Inoue T, Tashima T, Nishio S, Takeshita I, Iwaki T, Fukui M (1988) Vascular permeability and cell kinetics of ethylnitrosourea (ENU)-induced rat brain tumours. Acta Neurochir (Wien) 91:67-72
14. Kikuoka M (1989) Microvascular architecture of ethylnitrosourea-induced brain tumours in rats: scanning electron microscopic study of vascular corrosion casts. Kawasaki Med J 15:62-71
15. Klagsbrun M, D'Amore PA (1991) Regulators of angiogenesis. Annu Rev Physiol 53:217-239
16. Leung SY, Chan AS, Wong MP, Yuen ST, Cheung N, Chung LP (1997) Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. Am J Surg Pathol 21:941-950
17. Miyagami M, Smith BH, McKeever PE, Chronwall BM, Greenwood MA, Kornhlith PL (1987) Immunocytochemical localization of factor VIII-related antigen in tumours of the human central nervous system. J Neurooncol 4:269-285
18. Nishio S, Ohta M, Abe M, Kitamura K (1983) Microvascular abnormalities in ethylnitrosourea (ENU)-induced rat brain tumours: Structural basis for altered blood-brain barrier function. Acta Neuropathol 59:1-10
19. Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, Wiestler OD (1997) Expression and distribution of vascular endothelial growth factor protein in human brain tumours. Acta Neuropathol 93:109-117
20. Plate KH, Breier G, Weich HA, Risau W (1992) Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359:845-848
21. Plate KH, Breier G, Weich HA, Mennel HD, Risau W (1994) Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulation mechanisms. Int J Cancer 59:520-529
22. Qu-Hong, Nagy JA, Senger DR, Dvorak HF, Dvorak AM (1995) Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumour microvascular endothelium. J Histochem Cytochem 43:381-389
23. Samoto K, Ikezaki K, Ono M, Shono T, Kohno K, Kuwano M, Fukui M (1995) Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumours. Cancer Res 55:1189-1193
24. Sawada T, Nakamura M, Sakurai I (1988) An immunohistochemical study of neovasculature in human brain tumours. Acta Pathol Jpn 38:713-721
25. Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845
26. Stein I, Neemam M, Shweiki D, Itin A, Keshet E (1995) Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15:5363-5368
27. Takano S, Yoshii Y, Kondo S, Suzuki H, Maruno T, Shirai S, Nose T (1996) Concentration of vascular endothelial growth factor in the serum and tumour tissue of brain tumour patients. Cancer Res 56:2185-2190
28. Toi M, Hoshina S, Takayanagi T, Tominaga T (1994) Association of vascular endothelial growth factor expression with tumour angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85:1045-1049