An expeditious synthesis of tamoxifen, a representative SERM (selective estrogen receptor modulator), via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7599-7617

  Shiina, Isamu ^a   Sano, Yoshiyuki ^a   Nakata, Kenya ^a   Suzuki, Masahiko ^a   Yokoyama, Toshikazu ^a   Sasaki, Akane ^a   Orikasa, Tomoko ^a   Miyamoto, Tomomi ^a   Ikekita, Masahiko ^a   Nagahara, Yukitoshi ^a   Hasome, Yoshimune ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Aromatic aldehyde; Cinnamyltrimethylsilane; Droloxifene; Hafnium tetrachloride; Tamoxifen; Three component coupling

Indexed keywords

1,1,2 TRIARYL 3 ACETOXYBUTANE; 3,4,4 TRIARYLBUTENE; ACETALDEHYDE; ALDEHYDE; ALKENE; ANISOLE; BENZOPHENONE; BENZYL DERIVATIVE; BETA CHLOROPHENETOLE; CINNAMYLTRIMETHYLSILANE; DROLOXIFENE; LEWIS ACID; PHENETOLE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SILANE DERIVATIVE; TAMOXIFEN; TAMOXIFEN DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CATALYST; CHEMICAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION;

ALDEHYDES; AMINO ACIDS, AROMATIC; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CINNAMATES; HUMANS; MOLECULAR STRUCTURE; PHENYL ETHERS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; TIME FACTORS; TRIMETHYLSILYL COMPOUNDS;

TETRA;

EID: 35348816924     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.008     Document Type: Article

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