Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6340-6344

  Sugawara, Akihiro ^a   Sunazuka, Toshiaki ^a   Hirose, Tomoyasu ^a   Nagai, Kenichiro ^a   Yamaguchi, Yukie ^a   Hanaki, Hideaki ^a   Sharpless, K Barry ^b   Omura, Satoshi ^a  

^a KITASATO INSTITUTE   (Japan)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Anti MRSA and VRE agent; Click chemistry; Erythromycin A; Macrolides

Indexed keywords

11,12 DI O ISOBUTYRYL 8,9 ANHYDROERYTHROMYCIN A 6,9 HEMIKETAL; ACETAL DERIVATIVE; ACETYLENE; AZIDE; COPPER; ERYTHROMYCIN DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CYCLOADDITION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; QUANTUM YIELD; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; CATALYSIS; COPPER; DRUG DESIGN; ENTEROCOCCUS; ERYTHROMYCIN; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANCE;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 35248866227     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.068     Document Type: Article

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