Sensing hypoxia in the carotid body: From stimulus to response

Essays in Biochemistry

Volumn 43, Issue , 2007, Pages 43-60

  Kumar, Prem ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; OXYGEN; POTASSIUM CHANNEL;

ANIMAL; ANOXIA; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; CAROTID BODY; HISTOLOGY; HUMAN; METABOLISM; NERVE CELL; OXYGEN CONSUMPTION; PATHOLOGY; PHYSIOLOGY; PRESSURE; REVIEW; THEORETICAL MODEL;

ANIMALS; ANOXIA; CALCIUM; CAROTID BODY; HUMANS; MODELS, ANATOMIC; MODELS, BIOLOGICAL; MODELS, THEORETICAL; NEURONS; OXYGEN; OXYGEN CONSUMPTION; POTASSIUM CHANNELS; PRESSURE;

EID: 35248848916     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSE0430043     Document Type: Article

References (51)

1. McDonald, D.M. (1981) Peripheral chemoreceptors. Structure-function relationships of the carotid body, in: Regulation of Breathing, Volume 17, Lung Biology in Health and Disease (Hornbein, T.F., ed.), pp. 105-319, Dekker, New York
2. Rumsey, W.L., Iturriaga, R., Spergel, D., Lahiri S. & Wilson, D.F. (1991) Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body. Am. J. Physiol. 261, C614-C622
3. Kumar, P., Nye, P.C. & Torrance, R.W. (1988) Do oxygen tension variations contribute to the respiratory oscillations of chemoreceptor discharge in the cat? J. Physiol. 395, 531-552
4. Whalen, W.J., Savoca, J. & Nair, P. (1973) Oxygen tension measurements in carotid body of the cat Am. J. Physiol. 225, 986-991
5. 2. Pflugers Arch. 393, 313-317
6. Garland, R.J., Kinkead, R. & Milsom, W.K. (1994) The ventilatory response to changes in arterial oxygen content. Respir. Physiol. 96, 199-211
7. Vidruk, E.H., Olson, Jr, E.B., Ling, L. & Mitchell, G.S. (2001) Responses of single-unit carotid body chemoreceptors in adult rats. J. Physiol. 531, 165-170
8. 2 sensors and multiple transmitters? Exp. Physiol. 91, 17-23
9. Kara, T., Narkiewicz, K. & Somers, V.K. (2003) Chemoreflexes- physiology and clinical implications. Acta Physiol. Scand. 177, 377-384
10. Buckler, K.J. & Vaughan-Jones, R.D. (1994) Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J. Physiol. 476, 423-428
11. Shirahata, M. & Fitzgerald, R.S. (1991) Dependency of hypoxic chemotransduction in cat carotid body on voltage-gated calcium channels. J. Appl. Physiol. 71, 1062-1069
12. 2+ channels in stimulus-evoked catecholamine release from chemoreceptor cells of the carotid body. Neuroscience 47, 463-472
13. Buckler, K.J. & Vaughan-Jones, R.D. (1998) Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells. J. Physiol. 513, 819-833
14. Rocher, A., Geijo-Barrientos, E., Caceres, A.I., Rigual, R., Gonzalez, C. & Almaraz, L (2005) Role of voltage-dependent calcium channels in stimulus-secretion coupling in rabbit carotid body chemoreceptor cells. J. Physiol. 562, 407-420
15. Buniel, M.C., Schilling, W.P. & Kunze, D.L (2003) Distribution of transient receptor potential channels in the rat carotid chemosensory pathway. J. Comp. Neurol. 464, 404-413
16. Lahiri, S., Roy, A., Baby, S.M., Hoshi, T., Semenza, G.L & Prabhakar, N.R. (2006) Oxygen sensing in the body. Prog. Biophys. Mot. Biol. 91, 249-286
17. Vandier, C., Conway, A.F., Landauer, R.C. & Kumar, P. (1999) Presynaptic action of adenosine on a 4-aminopyridine-sensitive current in the rat carotid body. J. Physiol. 515, 419-429
18. Prasad, M., Fearon, I.M., Zhang, M., Laing, M., Vollmer, C. & Nurse, C.A. (2001) Expression of P2×2 and P2×3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J. Pbysiol. 537, 667-677
19. Zhang, M., Zhong, H., Vollmer, C. & Nurse, C.A. (2000) Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J. Physiol. 525, 143-158
20. Rong, W., Gourine, A.V., Cockayne, D.A., Xiang, Z., Ford, A.P., Spyer, K.M. & Burnstock, G. (2003) Pivotal role of nucleotide P2×2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J. Neurosd. 23, 11315-11321
21. Kumar, P. & Bin-Jaliah, I. (2007) Adequate stimuli of the carotid body: more than an oxygen sensor? Respir. Physiol Neurobiol. 157, 12-21
22. 2 in type I chemoreceptor cells. Science 241, 580-582
23. Perez-Garcia, M.T., Colinas, O., Miguel-Velado, E., Moreno-Dominguez, A. & Lopez-Lopez, J.R. (2004) Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing. J. Physiol. 557, 457-471
24. + current. Neurosci. Lett. 119, 253-256
25. Overholt, J.L., Ficker, E., Yang, T., Shams, H., Bright, G.R. & Prabhakar, N.R. (2000) HERG-like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body. J. Neurophysiol. 83, 1150-1157
26. Buckler, K.J., Williams, B.A. & Honore, E. (2000) An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J. Physiol. 525, 135-142
27. + channels essential for carotid body chemo-transduction? Respir. Physiol. 110, 211-218
28. + channels in isolated type I cells of the neonatal rat carotid body. J. Physiol. 483, 559-565
29. Pardal, R., Ludewig, U., Garcia-Hirschfeld, J. & Lopez-Barneo, J. (2000) Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium. Proc Natl. Acad. Sci. U.S.A. 97, 2361-2366
30. Pepper, D.R., Landauer, R.C. & Kumar, P. (1995) Effect of charybdotoxin on hypoxic chemosensi-tivity in the adult rat carotid body in vitro. J. Physiol. 487P, 177P
31. B receptors and TASK-l. J. Physiol. 553, 83-94
32. Wyatt, C.N. & Buckler, K.J. (2004) The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells. J. Physiol. 556, 175-191
33. + channel TASK-l. Am. J. Physiol. Cell. Physiol. 286, C391-C397
34. Biscoe, T.J. & Duchen, M.R. (1990) Responses of type I cells dissociated from the rabbit carotid body to hypoxia. J. Physiol. 428, 39-59
35. Wilson, D.F., Mokashi, A., Chugh, D., Vinogradov, S., Osanai, S. & Lahiri, S. (1994) The primary oxygen sensor of the cat carotid body is cytochrome a3 of the mitochondrial respiratory chain. FEBS Lett. 351, 370-374
36. Ortega-Saenz, P., Pardal, R., Garcia-Fernandez, M. & Lopez-Barneo, J. (2003) Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells. J. Physiol. 548, 789-800
37. Gonzalez, C., Sanz-Alfayate, G., Agapito, M.T., Gomez-Nino, A., Rocher, A. & Obeso, A. (2002) Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir. Physiol. Neurobiol. 132, 17-41
38. Acker, H. (1994) Mechanisms and meaning of cellular oxygen sensing in the organism. Respir. Physiol. 95, 1-10
39. 2+], and respiratory responses to hypoxia. Brain Res. 872, 188-193
40. He, L., Chen, J., Dinger, B., Sanders, K., Sundar, K., Hoidal, J. & Fidone, S. (2002) Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice. Am. J. Physiol. Cell Pkysiol. 282, C27-C33
41. He, L., Dinger, B., Sanders, K., Hoidal, J., Obeso, A., Stensaas, L., Fidone, S. & Gonzalez, C. (2005) Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells. Am. J. Physiol. Lung Cell Mol. Physiol. 289, L916-L924
42. 2. J. Appl. Physiol. 50, 884-891
43. Barbe, C., Al-Hashem, F., Conway, A.F., Dubuis, E., Vandier, C. & Kumar, P. (2002) A possible dual site of action for carbon monoxide-mediated chemoexcitation in the rat carotid body. J. Physiol. 543, 933-945
44. Piruat, J.I., Pintado, CO., Ortega-Saenz, P., Roche, M. & Lopez-Barneo, J. (2004) The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia. Mol. Cell. Biol. 24, 10933-10940
45. Williams, B.A. & Buckler, K.J. (2004) Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type I cells. Am. J. Physiol. Lung Cell Mol. Physiol. 286, L221-L230
46. Hardie, D.G., Hawley, S.A. & Scott, J.W. (2006) AMP-activated protein kinase-development of the energy sensor concept. J. Physiol. 574, 7-15
47. 2-sensing cells? J. Biol. Chem. 280, 41504-41511
48. Wyatt, C.N., Kumar, P., Aley, P., Peers, C., Hardie, D.G. & Evans, A.M. (2006) Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? Adv. Exp. Med. Biol. 580, 191-196; discussion 351-359
49. Williams, S.E., Wootton, P., Mason, H.S., Bould, J., lles, D.E., Riccardi, D., Peers, C. & Kemp, P.J. (2004) Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306, 2093-2097
50. Prabhakar, N.R. (1998) Endogenous carbon monoxide in control of respiration. Respir. Physiol. 114, 57-64
51. + channels of rat chemoreceptor cells by a membranerestricted and CO-sensitive mechanism. Circ. Res. 89, 430-436