Insulin sensitivity, vascular function, and iron stores in voluntary blood donors

Diabetes Care

Volumn 30, Issue 10, 2007, Pages 2685-2689

  Zheng, Haoyi ^a   Patel, Milan ^a   Cable, Ritchard ^b   Young, Lawrence ^a   Katz, Stuart D ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AMERICAN RED CROSS BLOOD SERVICES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN;

ADULT; AGED; ARTICLE; BLOOD DONOR; BRACHIAL ARTERY; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HUMAN; HYPERGLYCEMIA; INSULIN SENSITIVITY; IRON STORAGE; MALE; VASCULAR ENDOTHELIUM;

AGED; BIOLOGICAL MARKERS; BLOOD DONORS; CROSS-SECTIONAL STUDIES; HUMANS; INSULIN; IRON; MIDDLE AGED; VASCULAR PATENCY; VASODILATION;

EID: 35148881593     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc07-0748     Document Type: Article

References (31)

1. Sullivan JL: Iron and the sex difference in heart disease risk. Lancet 1:1293-1294, 1981
2. Sullivan JL: Is stored iron safe? J Lab Clin Med 144:280-284, 2004
3. Zheng H, Cable R, Spencer B, Votto N, Katz SD: Iron stores and vascular function in voluntary blood donors. Arterioscler Thromb Vasc Biol 25:1577-1583, 2005
4. Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, Dalman RL, Malenka DJ, Ozaki CK, Lavori PW: Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA 297:603-610, 2007
5. Swaminathan S, Fonseca VA, Alam MG, Shah SV: The role of iron in diabetes and its complications. Diabetes Care 30:1926-1933, 2007
6. Fernandez-Real JM, Lopez-Bermejo A, Ricart W: Cross-talk between iron metabolism and diabetes. Diabetes 51:2348-2354, 2002
7. Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, Engel S, Ratner RE, Iskandrian AE, the Detection of Ischemia in Asymptomatic Diabetics Investigators: Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care 27:1954-1961, 2004
8. Beckman JA, Creager MA, Libby P: Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287: 2570-2581, 2002
9. Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S: Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab 89:1096-1101, 2004
10. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470, 1999
11. Diagnosis and classification of diabetes mellitus (Position Statement). Diabetes Care 29 (Suppl. 1):S43-S48, 2006
12. Zheng H, Huang X, Zhang Q, Katz SD: Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects. Kidney Int 69:679-684, 2006
13. Rajpathak S, Ma J, Manson J, Willett WC, Hu FB: Iron intake and the risk of type 2 diabetes in women: a prospective cohort study. Diabetes Care 29:1370-1376, 2006
14. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB: Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 291:711-717, 2004
15. Jehn ML, Guallar E, Clark JM, Couper D, Duncan BB, Ballantyne CM, Hoogeveen RC, Harris ZL, Pankow JS: A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 165:1047-1054, 2007
16. Ford ES, Cogswell ME: Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care 22:1978-1983, 1999
17. Finch CA, Cook JD, Labbe RF, Culala M: Effect of blood donation on iron stores as evaluated by serum ferritin. Blood 50:441-447, 1977
18. Jiang R, Ma J, Ascherio A, Stampfer MJ, Willett WC, Hu FB: Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. Am J Clin Nutr 79:70-75, 2004
19. Fernandez-Real JM, Lopez-Bermejo A, Ricart W: Iron stores, blood donation, and insulin sensitivity and secretion. Clin Chem 51:1201-1205, 2005
20. Facchini FS, Saylor KL: Effect of iron depletion on cardiovascular risk factors: studies in carbohydrate-intolerant patients. Ann N Y Acad Sci 967:342-351, 2002
21. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Lopez-Bermejo A, Ricart W: Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity. Diabetes Care 25:2249-2255, 2002
22. Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A, Yasskiy A: Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation 111:310-314, 2005
23. Rask-Madsen C, King GL: Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab 3:46-56, 2007
24. Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Sakamoto T, Kugiyama K, Ogawa H, Yasue H: Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 34:146-154, 1999
25. Title LM, Cummings PM, Giddens K, Nassar BA: Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J Am Coll Cardiol 36:2185-2191, 2000
26. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC, Creager MA: Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 97:1695-1701, 1998
27. Tesfamariam B, Cohen RA: Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 263:H321-H326, 1992
28. Beckman JA, Goldfine AB, Gordon MB, Creager MA: Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation 103:1618-1623, 2001
29. Ihlemann N, Rask-Madsen C, Perner A, Dominguez H, Hermann T, Kober L, Torp-Pedersen C: Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects. Am J Physiol Heart Circ Physiol 285:H875-H882, 2003
30. Hirai N, Kawano H, Hirashima O, Motoyama T, Moriyama Y, Sakamoto T, Kugiyama K, Ogawa H, Nakao K, Yasue H: Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. Am J Physiol Heart Circ Physiol 279:H1172-H1178, 2000
31. Zheng H, Dimayuga C, Hudaihed A, Katz SD: Effect of dexrazoxane on homocysteine-induced endothelial dysfunction in normal subjects. Arterioscler Thromb Vasc Biol 22:E15-E18, 2002