Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern

Journal of Rheumatology

Volumn 34, Issue 10, 2007, Pages 1959-1970

  Sun, Yubo ^a   Firestein, Gary ^b   Boyle, David ^b   Gruber, Helen ^a   Cheung, Herman ^c,d  

^a CAROLINAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of Miami College of Engineering   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

AGC1; Autoantigen; CCL2; CHI3L1; HAPLN1; PRG4; Rheumatoid arthritis; Synoviocytes; Telomerase

Indexed keywords

AUTOANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN 1; TELOMERASE;

ARTICLE; CELL CULTURE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; UNINDEXED SEQUENCE;

ADULT; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CELLS, CULTURED; DNA, SINGLE-STRANDED; FEMALE; FIBROBLASTS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MATRIX METALLOPROTEINASE 1; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SYNOVIAL FLUID; TELOMERASE; TRANSDUCTION, GENETIC;

EID: 35148821164     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.
2. Goronzy JJ, Weyand CM. T-cell regulation in rheumatoid arthritis. Curr Opin Rheumatol 2004;16:212-7.
3. Muller-Ladner U. T cell-independent cellular pathways of rheumatoid joint destruction. Curr Opin Rheumatol 1995;7:222-8.
4. Fassbender HG. Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Collagen Rel Res 1983;3:141-55.
5. Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB, Wilder RL. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Investigat 1989;83:1267-76.
6. Muller-Ladner U, Kriegsmann J, Franklin BN, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996;149:1607-15.
7. Wang AZ, Wang JC, Fisher GW, Diamond HS. Interleukin-1-beta-stimulated invasion of articular cartilage by rheumatoid synovial fibroblasts is inhibited by antibodies to specific integrin receptors and by collagenase inhibitors. Arthritis Rheum 1997;40:1298-307.
8. Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001;19:163-96.
9. Cagnard N, Letourneur F, Essabbani A, et al. Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes. Eur Cytokine Netw 2005;16:289-92.
10. van der Pouw Kraan TC, van Gaalen FA, Huizinga TW, Pieterman E, Breedveld FC, Verweij CL. Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair. Genes Immun 2003;4:187-96.
11. Devauchelle V, Marion S, Cagnard N, et al. DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets. Genes Immun 2004;5:597-608.
12. Kasperkovitz PV, Timmer TC, Smeets TJ, et al. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum 2005;52:430-41.
13. Takemura S, Braun A, Crowson C, et al. Lymphoid neogenesis in rheumatoid synovitis. J Immunol 2001;167:1072-80.
14. Shi K, Hayashida K, Kaneko M, et al. Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J Immunol 2001;166:650-5.
15. Meyerson M, Counter CM, Eaton EN, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90:785-95.
16. McCarthy GM, Mitchell PG, Cheung HS. The mitogenic response to stimulation with basic calcium phosphate crystals is accompanied by induction and secretion of collagenase in human fibroblasts. Arthritis Rheum 1991;34:1021-30.
17. Sun Y, Firestein GS, Wenger L, Huang CY, Cheung HS. Telomerase-transduced osteoarthritic fibroblast-like synoviocyte cell line. Biochem Biophys Res Commun 2004;323:1287-92.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acids Res 2001;29:e45.
19. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Fassbender HG, Gay S. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int 1992;12:53-9.
20. Aicher WK, Heer AH, Trabandt A, et al. Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients. J Immunol 1994;152:5940-8.
21. Grimbacher B, Aicher WK, Peter HH, Eibel H. Measurement of transcription factor c-fos and EGR-1 mRNA transcription levels in synovial tissue by quantitative RT-PCR. Rheumatol Int 1997;17:109-12.
22. Jeong JG, Kim JM, Cho H, Hahn W, Yu SS, Kim S. Effects of IL-1-beta on gene expression in human rheumatoid synovial fibroblasts. Biochem Biophys Res Commun 2004;324:3-7.
23. Koch AE, Kunkel SL, Harlow LA, et al. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J Clin Invest 1992;90:772-9.
24. Luchetti MM, Piccinini G, Mantovani A, et al. Expression and production of the long pentraxin PTX3 in rheumatoid arthritis. Clin Exp Immunol 2000;119:196-202.
25. Johansen JS, Stoltenberg M, Hansen M, et al. Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. Rheumatology Oxford 1999;38:618-26.
26. Matsumoto T, Tsurumoto T. Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters. Clin Exp Rheumatol 2001;19:655-60.
27. Vos K, Miltenburg AM, van Meijgaarden KE, et al. Cellular immune response to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions. Rheumatology Oxford 2000;39:1326-31.
28. Guerassimov A, Zhang Y, Banerjee S, et al. Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis. J Rheumatol 1998;25:1480-4.
29. Doran MC, Goodstone NJ, Hobbs RN, Ashton BA. Cellular immunity to cartilage link protein in patients with inflammatory arthritis and non-arthritic controls. Ann Rheum Dis 1995;54:466-70.
30. Li NL, Zhang DQ, Zhou KY, et al. Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients. Cell Res 2000;10:39-49.
31. Glant TT, Mikecz K. Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis. Methods Mol Med 2004;102:313-38.
32. Berlo SE, Guichelaar T, Ten Brink CB, et al. Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice. Arthritis Rheum 2006;54:2423-33.
33. Berthelot JM. Could rheumatoid arthritis result from an abnormal T cell response towards lubricin/superficial zone protein? Med Hypotheses 2004;62:894-7.
34. Harigai M, Hara M, Yoshimura T, Leonard EJ, Inoue K, Kashiwazaki S. Monocyte chemoattractant protein-1 (MCP-1) in inflammatory joint diseases and its involvement in the cytokine network of rheumatoid synovium. Clin Immunol Immunopathol 1993;69:83-91.
35. Ellingsen T, Buus A, Stengaard-Pedersen K. Plasma monocyte chemoattractant protein 1 is a marker for joint inflammation in rheumatoid arthritis. J Rheumatol 2001;28:41-6.
36. Taylor PC, Peters AM, Paleolog E, et al. Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum 2000;43:38-47.
37. Brigstock DR. Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 2002;5:153-65.
38. Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF. Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J Biol Chem 2005;280:8229-37.
39. Nishida T, Kubota S, Kojima S, et al. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J Bone Miner Res 2004;19:1308-19.
40. Yu C, Le AT, Yeger H, Perbal B, Alman BA. NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol 2003;201:609-15.
41. Baeten D, Boots AM, Steenbakkers PG, et al. Human cartilage gp-39+, CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis. Arthritis Rheum 2000;43:1233-43.
42. Steenbakkers PG, Baeten D, Rovers E, et al. Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies. J Immunol 2003;170:5719-27.
43. Hanyecz A, Bardos T, Berlo SE, et al. Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan. Arthritis Rheum 2003;48:2959-73.
44. Zou J, Zhang Y, Thiel A, et al. Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis. Rheumatology Oxford 2003;42:846-55.
45. Cook AD, Rowley MJ, Mackay IR, Gough A, Emery P. Antibodies to type II collagen in early rheumatoid arthritis. Correlation with disease progression. Arthritis Rheum 1996;39:1720-7.
46. Brinckerhoff CE, Harris ED Jr. Survival of rheumatoid synovium implanted into nude mice. Am J Pathol 1981;103:411-9.