Induction of Arthritis in SCID Mice by T Cells Specific for the "Shared Epitope" Sequence in the G3 Domain of Human Cartilage Proteoglycan

Arthritis and Rheumatism

Volumn 48, Issue 10, 2003, Pages 2959-2973

  Hanyecz, Anita ^a   Bárdos, Tamás ^a   Berlo, Suzanne E ^b   Buzás, Edit ^c   Nesterovitch, Andrew B ^d   Mikecz, Katalin ^d   Glant, Tibor T ^d  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UTRECHT UNIVERSITY   (Netherlands)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA DR4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PROTEOGLYCAN; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; BINDING SITE; DISEASE PREDISPOSITION; IMMUNIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE;

ADOPTIVE TRANSFER; AGGRECANS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARTHRITIS; CARTILAGE; CROSS REACTIONS; EPITOPES; EPITOPES, T-LYMPHOCYTE; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HYBRIDOMAS; IMMUNIZATION; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C; MICE, SCID; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; T-LYMPHOCYTES;

EID: 0141733607     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11275     Document Type: Article

References (56)

1. Struyk L, Hawes GE, Chatila MK, Breedveld FC, Kurnick JT, van den Elsen PJ. T cell receptors in rheumatoid arthritis. Arthritis Rheum 1995;38:577-89.
2. Fox DA. The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum 1997;40:598-609.
3. Theofilopoulos AN. The basis of autoimmunity. Part II. Genetic predisposition. Immunol Today 1995;16:150-9.
4. Gregersen PK. Genetics of rheumatoid arthritis: confronting complexity. Arthritis Res 1999;1:37-44.
5. Theofilopoulos AN, Dummer W, Kono DH. T cell homeostasis and systemic autoimmunity. J Clin Invest 2001;108:335-40.
6. Glant T, Csongor J, Szücs T. Immunopathologic role of proteoglycan antigens in rheumatoid joint diseases. Scand J Immunol 1980;11:247-52.
7. Stuart JM, Townes AS, Kang AH. The role of collagen autoimmunity in animal models and human diseases. Invest Dermatol 1982;79:121s-7s.
8. Glant TT, Finnegan A, Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms and genetics. Crit Rev Immunol. In press.
9. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med 1977;146:857-68.
10. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunization against heterologous type II collagen induces arthritis in mice. Nature 1980;282:666-8.
11. Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice: clinical features and histopathology. Arthritis Rheum 1987;30:201-12.
12. Trentham DE, Townes AS, Kang AH, David JR. Humoral and cellular immunity to collagen in type II collagen-induced arthritis in rats. J Clin Invest 1978;61:89-96.
13. Stuart JM, Townes AS, Kang AH. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. J Clin Invest 1982;69:673-83.
14. Mikecz K, Glant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum 1987;30:306-18.
15. Glant TT, Buzàs EI, Finnegan A, Negroiu G, Cs-Szabó G, Mikecz K. Critical role of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J Immunol 1998;160:3812-9.
16. Glant TT, Cs-Szabó G, Nagase H, Jacobs JJ, Mikecz K. Progressive polyarthritis induced in BALB/c mice by aggrecan from human osteoarthritic cartilage. Arthritis Rheum 1998;41:1007-18.
17. Glant TT, Bárdos T, Vermes C, Chandrasekaran R, Valdéz JC, Otto JM, et al. Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease. Arthritis Rheum 2001;44:682-92.
18. Otto JM, Cs-Szabó G, Gallagher J, Velins S, Mikecz K, Buzás EI, et al. Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Arthritis Rheum 1999;42:2524-31.
19. Otto JM, Chandrasekaran R, Vermes C, Mikecz K, Finnegan A, Rickert SE, et al. A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis. J Immunol 2000;165:5278-86.
20. Adarichev VA, Bárdos T, Christodoulou S, Phillips MT, Mikecz K, Glant TT. Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis. Immunogenetics 2002;54:184-92.
21. Adarichev VA, Nesterovitch AB, Bárdos T, Biesczat D, Chandrasekaran R, Vermes C, et al. Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum 2003;48:1708-20.
22. Mikecz K, Glant TT, Buzás E, Poole AR. Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (non-immunized) BALB/c mice. Arthritis Rheum 1990;33:866-76.
23. Buzás EI, Mikecz K, Finnegan A, Hudecz F, Glant TT. T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan (aggrecan) in arthritis [abstract]. Arthritis Rheum 1999;42 Suppl 9:S259.
24. Bárdos T, Buzás EI, Glant TT. Proteoglycan-induced arthritis is significantly altered by self and non-self peptide sequences in pre- and co-immunization experiments [abstract]. Arthritis Rheum 2000;43 Suppl 9:S231.
25. Bárdos T, Buzás EI, Finnegan A, Mikecz K, Glant TT. Altered peptide ligands dictate cytokine profiles and modify the clinical appearance of arthritis [abstract]. Arthritis Rheum 2000;43 Suppl 9:S396.
26. Kim JH, Glant TT, Lesley J, Hyman R, Mikecz K. Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand. Exp Cell Res 2000;256:445-53.
27. Glant TT. Antigen-specific T-lymphocyte clone as a tool in proteoglycan research. In: Maroudas A, Kuettner KE, editors. Methods in cartilage research. London: Academic Press; 1990. p. 177-81.
28. Buzás EI, Brennan FR, Mikecz K, Garzó M, Negroiu G, Holló K, et al. A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice. J Immunol 1995;155:2679-87.
29. Broeren CPM, Verjans GMGM, van Eden W, Kusters JG, Lenstra JA, Logtenberg T. Conserved nucleotide sequences at the 5′ end of T cell receptor variable genes facilitate polymerase chain reaction amplification. Eur J Immunol 1991;21:569-73.
30. Bárdos T, Mikecz K, Finnegan A, Zhang J, Glant TT. T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system. J Immunol 2002;168:6013-21.
31. Bárdos T, Czipri M, Vermes C, Zhang J, Mikecz K, Glant TT. Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice. Clin Exp Immunol 2002;129:224-31.
32. Bogen B, Lambris JD. Minimum length of an idiotypic peptide and a model for its binding to a major histocompatibility complex class II molecule. EMBO J 1989;8:1947-52.
33. d molecules. J Immunol 1989;143:3289-94.
34. Buzás E, Mikecz K, Brennan FR, Glant TT. Mediators of auto-pathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice. Cell Immunol 1994;158:292-304.
35. + T cells. Cell Immunol 1992;144:347-57.
36. Mikecz K, Glant TT. Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis. Arthritis Rheum 1994;37:1395-403.
37. Finnegan A, Grusby MJ, Kaplan CD, O'Neill SK, Eibel H, Koreny T, et al. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 2002;169:3345-52.
38. Gregersen P, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
39. Gough A, Faint J, Salmon M, Hassell A, Wordsworth P, Pilling D, et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 1994;37:1166-70.
40. Albani S, Carson DA. A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol Today 1996;17:466-70.
41. Albani S, Keystone EC, Nelson JL, Ollier WE, La Cava A, Montemayor AC, et al. Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat Med 1995;1:448-52.
42. Albani S, Carson DA, Roudier J. Genetic and environmental factors in the immune pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am 1992;18:729-40.
43. Albani S, Tuckwell JE, Esparza L, Carson DA, Roudier J. The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB1*0401 molecule. J Clin Invest 1992;89:327-31.
44. La Cava A, Nelson JL, Ollier WE, MacGregor A, Keystone EC, Thorne JC, et al. Genetic bias in immune responses to a cassette shared by different microorganisms in patients with rheumatoid arthritis. J Clin Invest 1997;100:658-63.
45. Albani S, Ravelli A, Massa M, de Benedetti F, Andree G, Roudier J, et al. Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity. J Pediatr 1994;124:561-5.
46. Lohmander LS, Neame PJ, Sandy JD. The structure of aggrecan fragments in human synovial fluid: evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum 1993;36:1214-22.
47. Dudhia J, Davidson CM, Wells TM, Vynios DH, Hardingham TE, Bayliss MT. Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage. Biochem J 1996; 313:933-40.
48. Lee V, Chen L, Paiwand F, Cao L, Wu Y, Inman R, et al. Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation. J Biol Chem 2002;277:22279-88.
49. Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992;358:155-7.
50. Sun JB, Olsson T, Wang WZ, Xiao BG, Kostulas V, Fredrikson S, et al. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 1991;21:1461-8.
51. Sugimoto C, Hasegawa M, Kato A, Zheng HY, Ebihara H, Taguchi F, et al. Evolution of human polyomavirus JC: implications for the population history of humans. J Mol Evol 2002;54:285-97.
52. Leroux J-Y, Guerassimov A, Cartman A, Delaunay N, Webber C, Rosenberg LC, et al. Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/ c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo. J Clin Invest 1996;97:621-32.
53. Buzás EI, Brennan FR, Mikecz K, Negroiu G, Holló K, Glant TT. A T cell hybridoma recognizes cartilage proteoglycan and induces arthritis in mice [abstract]. Trans Orthop Res Soc 1995;20:320.
54. Zhang Y, Guerassimov A, Leroux J-Y, Cartman A, Webber C, Lalic R, et al. Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice: evidence for T cell involvement and the immunosuppressive influence of keratan sulfate on recognition of T and B cell epitopes. J Clin Invest 1998;101:1678-86.
55. Guerassimov A, Zhang YP, Banerjee S, Cartman A, Leroux JY, Rosenberg LC, et al. Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate. Arthritis Rheum 1998;41:1019-25.
56. Karopoulos C, Rowley MJ, Ilic MZ, Handley CJ. Presence of antibodies to native G1 domain of aggrecan core protein in synovial fluids from patients with various joint diseases. Arthritis Rheum 1996;39:1990-7.