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Volumn 9, Issue 5, 2007, Pages 289-299

Topical calcineurin inhibitors in pediatric atopic dermatitis: A critical analysis of current issues

Author keywords

Atopic dermatitis, treatment; Calcineurin inhibitors, therapeutic use; Children; Pimecrolimus, therapeutic use; Tacrolimus, therapeutic use

Indexed keywords

ANTIINFLAMMATORY AGENT; BETAMETHASONE; CALCINEURIN INHIBITOR; CLOCORTOLONE PIVALATE; CORTICOSTEROID; CYCLOSPORIN A; DRUG VEHICLE; EMOLLIENT AGENT; FLUTICASONE PROPIONATE; MOMETASONE FUROATE; PIMECROLIMUS; PNEUMOCOCCUS VACCINE; TACROLIMUS;

EID: 35048898681     PISSN: 11745878     EISSN: None     Source Type: Journal    
DOI: 10.2165/00148581-200709050-00002     Document Type: Review
Times cited : (15)

References (98)
  • 1
    • 17244365003 scopus 로고    scopus 로고
    • Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis
    • Breuer K, Werfel T, Kapp A. Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis. Am J Clin Dermatol 2005; 6: 65-77
    • (2005) Am J Clin Dermatol , vol.6 , pp. 65-77
    • Breuer, K.1    Werfel, T.2    Kapp, A.3
  • 2
    • 0033772646 scopus 로고    scopus 로고
    • The prevalence of atopic dermatitis in Oregon schoolchildren
    • Laughter D, Istvan JA, Tofte SJ, et al. The prevalence of atopic dermatitis in Oregon schoolchildren. J Am Acad Dermatol 2000; 43: 649-55
    • (2000) J Am Acad Dermatol , vol.43 , pp. 649-655
    • Laughter, D.1    Istvan, J.A.2    Tofte, S.J.3
  • 3
    • 0036167566 scopus 로고    scopus 로고
    • Clinical features of atopic dermatitis
    • Beltrani VS. Clinical features of atopic dermatitis. Immunol Allergy Clin North Am 2002; 22: 25-42
    • (2002) Immunol Allergy Clin North Am , vol.22 , pp. 25-42
    • Beltrani, V.S.1
  • 5
    • 33645880750 scopus 로고    scopus 로고
    • Cost effectiveness of management of mild-to-moderate atopic dermatitis with 1% pimecrolimus cream in children and adolescents 2-17 years of age
    • Ellis CN, Kahler KH, Grueger J, et al. Cost effectiveness of management of mild-to-moderate atopic dermatitis with 1% pimecrolimus cream in children and adolescents 2-17 years of age. Am J Clin Dermatol 2006; 7: 133-9
    • (2006) Am J Clin Dermatol , vol.7 , pp. 133-139
    • Ellis, C.N.1    Kahler, K.H.2    Grueger, J.3
  • 6
    • 11144299024 scopus 로고    scopus 로고
    • The role of topical calcineurin inhibitors in atopic dermatitis
    • Alomar A, Berth-Jones J, Bos JD, et al. The role of topical calcineurin inhibitors in atopic dermatitis. Br J Dermatol 2004; 151 Suppl. 70: 3-27
    • (2004) Br J Dermatol , vol.151 , Issue.SUPPL. 70 , pp. 3-27
    • Alomar, A.1    Berth-Jones, J.2    Bos, J.D.3
  • 8
    • 35048886629 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation. Elidel [prescribing information]. East Hanover (NJ): Novartis Pharmaceuticals Corporation, 2006
    • Novartis Pharmaceuticals Corporation. Elidel [prescribing information]. East Hanover (NJ): Novartis Pharmaceuticals Corporation, 2006
  • 9
    • 35048897568 scopus 로고    scopus 로고
    • Astellas Pharma US, Inc. Protopic [prescribing information]. Deerfield (IL): Astellas Pharma US, Inc., 2006
    • Astellas Pharma US, Inc. Protopic [prescribing information]. Deerfield (IL): Astellas Pharma US, Inc., 2006
  • 10
    • 23844529653 scopus 로고    scopus 로고
    • Consensus statement on the safety profile of topical calcineurin inhibitors
    • Bieber T, Cork M, Ellis C, et al. Consensus statement on the safety profile of topical calcineurin inhibitors. Dermatology 2005; 211: 77-8
    • (2005) Dermatology , vol.211 , pp. 77-78
    • Bieber, T.1    Cork, M.2    Ellis, C.3
  • 11
    • 33646089913 scopus 로고    scopus 로고
    • The use of topical calcineurin inhibitors in dermatology: Safety concerns. Report of the American Academy of Dermatology Association Task Force
    • Berger TG, Duvic M, Van Voorhees AS, et al. The use of topical calcineurin inhibitors in dermatology: safety concerns. Report of the American Academy of Dermatology Association Task Force. J Am Acad Dermatol 2006; 54: 818-23
    • (2006) J Am Acad Dermatol , vol.54 , pp. 818-823
    • Berger, T.G.1    Duvic, M.2    Van Voorhees, A.S.3
  • 12
    • 20444506718 scopus 로고    scopus 로고
    • Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology
    • Fonacier L, Spergel J, Charlesworth EN, et al. Report of the Topical Calcineurin Inhibitor Task Force of the American College of Allergy, Asthma and Immunology and the American Academy of Allergy, Asthma and Immunology. Allergy Clin Immunol 2005; 115: 1249-53
    • (2005) Allergy Clin Immunol , vol.115 , pp. 1249-1253
    • Fonacier, L.1    Spergel, J.2    Charlesworth, E.N.3
  • 15
    • 33745956277 scopus 로고    scopus 로고
    • Safety of topical calcineurin inhibitors in atopic dermatitis: Evaluation of the evidence
    • Spergel JM, Leung DYM. Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidence. Curr Allergy Asthma Rep 2006; 6: 270-4
    • (2006) Curr Allergy Asthma Rep , vol.6 , pp. 270-274
    • Spergel, J.M.1    Leung, D.Y.M.2
  • 16
    • 0031792219 scopus 로고    scopus 로고
    • A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children
    • Boguniewicz M, Fiedler VC, Raimer S, et al. A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. J Allergy Clin Immunol 1998; 102: 637-44
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 637-644
    • Boguniewicz, M.1    Fiedler, V.C.2    Raimer, S.3
  • 17
    • 18144409596 scopus 로고    scopus 로고
    • Tacrolimus ointment 0.03% shows efficacy and safety in pediatric and adult patients with mild to moderate atopic dermatitis
    • Chapman MS, Schachner LA, Breneman D, et al. Tacrolimus ointment 0.03% shows efficacy and safety in pediatric and adult patients with mild to moderate atopic dermatitis. J Am Acad Dermatol 2005; 53: S177-85
    • (2005) J Am Acad Dermatol , vol.53
    • Chapman, M.S.1    Schachner, L.A.2    Breneman, D.3
  • 18
    • 0035157388 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children
    • Kang S, Lucky AW, Pariser D, et al. Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. J Am Acad Dermatol 2001; 44: S58-64
    • (2001) J Am Acad Dermatol , vol.44
    • Kang, S.1    Lucky, A.W.2    Pariser, D.3
  • 19
    • 0035164433 scopus 로고    scopus 로고
    • A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients
    • Paller A, Eichenfield LF, Leung DYM, et al. A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients. J Am Acad Dermatol 2001; 44: S47-57
    • (2001) J Am Acad Dermatol , vol.44
    • Paller, A.1    Eichenfield, L.F.2    Leung, D.Y.M.3
  • 20
    • 0033898753 scopus 로고    scopus 로고
    • Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis
    • Reitamo S, Wollenberg A, Schöpf E, et al. Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. Arch Dermatol 2000; 136: 999-1006
    • (2000) Arch Dermatol , vol.136 , pp. 999-1006
    • Reitamo, S.1    Wollenberg, A.2    Schöpf, E.3
  • 21
    • 0242322394 scopus 로고    scopus 로고
    • A short-term trial of tacrolimus ointment for atopic dermatitis
    • Ruzicka T, Bieber T, Schöpf E, et al. A short-term trial of tacrolimus ointment for atopic dermatitis. N Engl J Med 1997; 337: 816-21
    • (1997) N Engl J Med , vol.337 , pp. 816-821
    • Ruzicka, T.1    Bieber, T.2    Schöpf, E.3
  • 22
    • 31544483145 scopus 로고    scopus 로고
    • Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: Results from a randomized, double-blind, vehicle-controlled study
    • Schachner LA, Lamerson C, Sheehan MP, et al. Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled study. Pediatrics 2005; 116: e334-42
    • (2005) Pediatrics , vol.116
    • Schachner, L.A.1    Lamerson, C.2    Sheehan, M.P.3
  • 23
    • 6044233377 scopus 로고    scopus 로고
    • Tacrolimus ointment: Utilization patterns in children under age 2 years
    • Housman TS, Norton AB, Feldman SR, et al. Tacrolimus ointment: utilization patterns in children under age 2 years. Dermatol Online J 2004; 10: 2
    • (2004) Dermatol Online J , vol.10 , pp. 2
    • Housman, T.S.1    Norton, A.B.2    Feldman, S.R.3
  • 24
    • 0141819272 scopus 로고    scopus 로고
    • The safety and efficacy of tacrolimus therapy in patients younger than 2 years with atopic dermatitis
    • Patel RR, Vander Straten MR, Korman NJ. The safety and efficacy of tacrolimus therapy in patients younger than 2 years with atopic dermatitis. Arch Dermatol 2003; 139: 1184-6
    • (2003) Arch Dermatol , vol.139 , pp. 1184-1186
    • Patel, R.R.1    Vander Straten, M.R.2    Korman, N.J.3
  • 25
    • 0036553479 scopus 로고    scopus 로고
    • Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents
    • Eichenfield LF, Lucky AW, Boguniewicz M, et al. Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents. J Am Acad Dermatol 2002; 46: 495-504
    • (2002) J Am Acad Dermatol , vol.46 , pp. 495-504
    • Eichenfield, L.F.1    Lucky, A.W.2    Boguniewicz, M.3
  • 26
    • 0036634394 scopus 로고    scopus 로고
    • Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children
    • Wahn U, Bos JD, Goodfield M, et al. Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children. Pediatrics 2002; 110: e2
    • (2002) Pediatrics , vol.110
    • Wahn, U.1    Bos, J.D.2    Goodfield, M.3
  • 27
    • 13444311052 scopus 로고    scopus 로고
    • Use of pimecrolimus cream 1% (Elidel® ) in the treatment of atopic dermatitis in infants and children: The effects of ethnic origin and baseline disease severity on treatment outcome
    • Eichenfield LF, Lucky AW, Langley RGB, et al. Use of pimecrolimus cream 1% (Elidel® ) in the treatment of atopic dermatitis in infants and children: the effects of ethnic origin and baseline disease severity on treatment outcome. Int J Dermatol 2005; 44: 70-5
    • (2005) Int J Dermatol , vol.44 , pp. 70-75
    • Eichenfield, L.F.1    Lucky, A.W.2    Langley, R.G.B.3
  • 28
    • 0037324145 scopus 로고    scopus 로고
    • Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants
    • Ho VC, Gupta A, Kaufmann R, et al. Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants. J Pediatr 2003; 142: 155-62
    • (2003) J Pediatr , vol.142 , pp. 155-162
    • Ho, V.C.1    Gupta, A.2    Kaufmann, R.3
  • 29
    • 0036677154 scopus 로고    scopus 로고
    • Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug
    • Kapp A, Papp K, Bingham A, et al. Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug. J Allergy Clin Immunol 2002; 110: 277-84
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 277-284
    • Kapp, A.1    Papp, K.2    Bingham, A.3
  • 30
    • 20444490896 scopus 로고    scopus 로고
    • Long-term treatment of atopic dermatitis with pimecrolimus cream 1% in infants does not interfere with the development of protective antibodies after vaccination
    • Papp KA, Breuer K, Meurer M, et al. Long-term treatment of atopic dermatitis with pimecrolimus cream 1% in infants does not interfere with the development of protective antibodies after vaccination. J Am Acad Dermatol 2005; 52: 247-53
    • (2005) J Am Acad Dermatol , vol.52 , pp. 247-253
    • Papp, K.A.1    Breuer, K.2    Meurer, M.3
  • 31
    • 20444488914 scopus 로고    scopus 로고
    • Long-term control of atopic dermatitis with pimecrolimus cream 1% in infants and young children: A two-year study
    • Papp KA, Werfel T, Fölster-Holst R, et al. Long-term control of atopic dermatitis with pimecrolimus cream 1% in infants and young children: a two-year study. J Am Acad Dermatol 2005; 52: 240-6
    • (2005) J Am Acad Dermatol , vol.52 , pp. 240-246
    • Papp, K.A.1    Werfel, T.2    Fölster-Holst, R.3
  • 32
    • 33644836845 scopus 로고    scopus 로고
    • Safety and tolerability of 1% pimecrolimus cream among infants: Experience with 1133 patients treated for up to 2 years
    • Paul C, Cork M, Rossi AB, et al. Safety and tolerability of 1% pimecrolimus cream among infants: experience with 1133 patients treated for up to 2 years. Pediatrics 2006; 117: e118-28
    • (2006) Pediatrics , vol.117
    • Paul, C.1    Cork, M.2    Rossi, A.B.3
  • 33
    • 20444457467 scopus 로고    scopus 로고
    • Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis
    • Hoetzenecker W, Ecker R, Kopp T, et al. Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis. J Allergy Clin Immunol 2005; 115: 1276-83
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1276-1283
    • Hoetzenecker, W.1    Ecker, R.2    Kopp, T.3
  • 34
    • 1842639441 scopus 로고    scopus 로고
    • Corticosteroids but not pimecrolimus affect viability, maturation and immune function of murine epidermal Langerhans cells
    • Hoetzenecker W, Meingassner JG, Ecker R, et al. Corticosteroids but not pimecrolimus affect viability, maturation and immune function of murine epidermal Langerhans cells. J Invest Dermatol 2004; 122: 673-84
    • (2004) J Invest Dermatol , vol.122 , pp. 673-684
    • Hoetzenecker, W.1    Meingassner, J.G.2    Ecker, R.3
  • 35
    • 0041825562 scopus 로고    scopus 로고
    • Pimecrolimus does not affect the differentiation, maturation and function of human monocyte-derived dendritic cells, in contrast to corticosteroids
    • Kalthoff FS, Chung J, Musser P, et al. Pimecrolimus does not affect the differentiation, maturation and function of human monocyte-derived dendritic cells, in contrast to corticosteroids. Clin Exp Immunol 2003; 133: 350-9
    • (2003) Clin Exp Immunol , vol.133 , pp. 350-359
    • Kalthoff, F.S.1    Chung, J.2    Musser, P.3
  • 36
    • 0242550810 scopus 로고    scopus 로고
    • Pimecrolimus does not affect Langerhans cells in murine epidermis
    • Meingassner JG, Kowalsky E, Schwendinger H, et al. Pimecrolimus does not affect Langerhans cells in murine epidermis. Br J Dermatol 2003; 149: 853-7
    • (2003) Br J Dermatol , vol.149 , pp. 853-857
    • Meingassner, J.G.1    Kowalsky, E.2    Schwendinger, H.3
  • 37
    • 0035081866 scopus 로고    scopus 로고
    • The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: A randomized, double-blind controlled study
    • Queille-Roussel C, Paul C, Duteil L, et al. The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. Br J Dermatol 2001; 144: 507-13
    • (2001) Br J Dermatol , vol.144 , pp. 507-513
    • Queille-Roussel, C.1    Paul, C.2    Duteil, L.3
  • 38
    • 15944379581 scopus 로고    scopus 로고
    • Post-transplant lymphoproliferative disorder in children: Incidence, prognosis, and treatment options
    • Faye A, Vilmer E. Post-transplant lymphoproliferative disorder in children: incidence, prognosis, and treatment options. Pediatr Drugs 2005; 7: 55-65
    • (2005) Pediatr Drugs , vol.7 , pp. 55-65
    • Faye, A.1    Vilmer, E.2
  • 39
    • 1342304173 scopus 로고    scopus 로고
    • Lymphomas after solid organ transplantation: A collaborative transplant study report
    • Opelz G, Döhler B. Lymphomas after solid organ transplantation: a collaborative transplant study report. Am J Transplant 2004; 4: 222-30
    • (2004) Am J Transplant , vol.4 , pp. 222-230
    • Opelz, G.1    Döhler, B.2
  • 40
    • 26244448556 scopus 로고    scopus 로고
    • Topical tacrolimus and pimecrolimus and the risk of cancer: How much cause for concern?
    • Ormerod AD. Topical tacrolimus and pimecrolimus and the risk of cancer: how much cause for concern? Br J Dermatol 2005; 153: 701-5
    • (2005) Br J Dermatol , vol.153 , pp. 701-705
    • Ormerod, A.D.1
  • 41
  • 43
    • 35048859391 scopus 로고    scopus 로고
    • Astellas Pharma US, Inc. Prograf [prescribing information]. Deerfield (IL): Astellas Pharma US, Inc., 2006
    • Astellas Pharma US, Inc. Prograf [prescribing information]. Deerfield (IL): Astellas Pharma US, Inc., 2006
  • 44
    • 20144388441 scopus 로고    scopus 로고
    • A multicenter study of the pharmacokinetics of tacrolimus ointment after first and repeated application to children with atopic dermatitis
    • Harper J, Smith C, Rubins A, et al. A multicenter study of the pharmacokinetics of tacrolimus ointment after first and repeated application to children with atopic dermatitis. J Invest Dermatol 2005; 124: 695-9
    • (2005) J Invest Dermatol , vol.124 , pp. 695-699
    • Harper, J.1    Smith, C.2    Rubins, A.3
  • 45
    • 33644819775 scopus 로고    scopus 로고
    • Low systemic absorption and good tolerability of pimecrolimus, administered as 1% cream (Elidel® ) in infants with atopic dermatitis: A multicenter, 3-week, open-label study
    • Staab D, Pariser D, Gottlieb AB, et al. Low systemic absorption and good tolerability of pimecrolimus, administered as 1% cream (Elidel® ) in infants with atopic dermatitis: a multicenter, 3-week, open-label study. Pediatr Dermatol 2005; 22: 465-71
    • (2005) Pediatr Dermatol , vol.22 , pp. 465-471
    • Staab, D.1    Pariser, D.2    Gottlieb, A.B.3
  • 46
    • 10744229850 scopus 로고    scopus 로고
    • Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patients
    • Allen BR, Lakhanpaul M, Morris A, et al. Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patients. Arch Dis Child 2003; 88: 969-73
    • (2003) Arch Dis Child , vol.88 , pp. 969-973
    • Allen, B.R.1    Lakhanpaul, M.2    Morris, A.3
  • 47
    • 33645119731 scopus 로고    scopus 로고
    • Low systemic exposure in infants with atopic dermatitis in a 1-year pharmacokinetic study with pimecrolimus cream 1%. Exp
    • Lakhanpaul M, Davies T, Allen BR, et al. Low systemic exposure in infants with atopic dermatitis in a 1-year pharmacokinetic study with pimecrolimus cream 1%. Exp Dermatol 2006; 15: 138-41
    • (2006) Dermatol , vol.15 , pp. 138-141
    • Lakhanpaul, M.1    Davies, T.2    Allen, B.R.3
  • 48
    • 0037634522 scopus 로고    scopus 로고
    • Occlusive treatment of chronic hand dermatitis with pimecrolimus cream 1% results in low systemic exposure, is well tolerated, safe, and effective: An open study
    • Thaçi D, Steinmeyer K, Ebelin M-E, et al. Occlusive treatment of chronic hand dermatitis with pimecrolimus cream 1% results in low systemic exposure, is well tolerated, safe, and effective: an open study. Dermatology 2003; 207: 37-42
    • (2003) Dermatology , vol.207 , pp. 37-42
    • Thaçi, D.1    Steinmeyer, K.2    Ebelin, M.-E.3
  • 49
    • 0036169163 scopus 로고    scopus 로고
    • Low systemic exposure after repeated topical application of pimecrolimus (Elidel® ), SDZ ASM 981 in patients with atopic dermatitis
    • Van Leent EJM, Ebelin M-E, Burtin P, et al. Low systemic exposure after repeated topical application of pimecrolimus (Elidel® ), SDZ ASM 981 in patients with atopic dermatitis. Dermatology 2002; 204: 63-8
    • (2002) Dermatology , vol.204 , pp. 63-68
    • Van Leent, E.J.M.1    Ebelin, M.-E.2    Burtin, P.3
  • 50
    • 0034978116 scopus 로고    scopus 로고
    • Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome
    • Allen A, Siegfried E, Silverman R, et al. Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome. Arch Dermatol 2001; 137: 747-50
    • (2001) Arch Dermatol , vol.137 , pp. 747-750
    • Allen, A.1    Siegfried, E.2    Silverman, R.3
  • 51
    • 27544501788 scopus 로고    scopus 로고
    • Topical pimecrolimus: A novel therapeutic option for Netherton syndrome
    • Oji V, Beljan G, Beier K, et al. Topical pimecrolimus: a novel therapeutic option for Netherton syndrome. Br J Dermatol 2005; 153: 1067-8
    • (2005) Br J Dermatol , vol.153 , pp. 1067-1068
    • Oji, V.1    Beljan, G.2    Beier, K.3
  • 52
    • 35048864941 scopus 로고    scopus 로고
    • Topical aids Netherton's syndrome
    • Aug;
    • Mahoney D. Topical aids Netherton's syndrome. Skin Allergy News 2006 Aug; 37: 2
    • (2006) Skin Allergy News
    • Mahoney, D.1
  • 53
    • 35048871874 scopus 로고    scopus 로고
    • A pilot study of the efficacy and safety of pimecrolimus 1% cream in the treatment of Netherton syndrome: Interim results [poster P2401]
    • Feb 2-6; Washington, DC
    • Yan AC, Shah KN, Kubrak C, et al. A pilot study of the efficacy and safety of pimecrolimus 1% cream in the treatment of Netherton syndrome: interim results [poster P2401]. American Academy of Dermatology 65th Annual Meeting; 2007 Feb 2-6; Washington, DC
    • (2007) American Academy of Dermatology 65th Annual Meeting
    • Yan, A.C.1    Shah, K.N.2    Kubrak, C.3
  • 54
    • 35048836243 scopus 로고    scopus 로고
    • Drug Regulatory Affairs: Elidel (pimecrolimus) cream 1%. NDA 21-302 briefing document. 2005 Jan 25 [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005- 4089b2_03_04_Elidel%20Novartis%20Briefing%20Bookredacted.pdf [Accessed 2007 Jul 9]
    • Drug Regulatory Affairs: Elidel (pimecrolimus) cream 1%. NDA 21-302 briefing document. 2005 Jan 25 [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005- 4089b2_03_04_Elidel%20Novartis%20Briefing%20Bookredacted.pdf [Accessed 2007 Jul 9]
  • 56
    • 23844476199 scopus 로고    scopus 로고
    • Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis
    • Hultsch T, Kapp A, Spergel J. Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis. Dermatology 2005; 211: 174-87
    • (2005) Dermatology , vol.211 , pp. 174-187
    • Hultsch, T.1    Kapp, A.2    Spergel, J.3
  • 57
    • 35048817070 scopus 로고    scopus 로고
    • and Drug Administration, online, Available from URL:, Accessed Apr 5
    • US Food and Drug Administration. Pharmacokinetics/toxicokinetics [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/o5/briefing/ 2005-4089b2_01_07_Tox%20Review%20Redacted.pdf [Accessed 2005 Apr 5]
    • (2005) Pharmacokinetics/toxicokinetics
    • Food, U.S.1
  • 58
    • 35048826808 scopus 로고    scopus 로고
    • US Food and Drug Administration, Pediatric Advisory Committee. Discussion topic: risk evaluation, labeling, risk communication, and dissemination of information on potential cancer risk among pediatric patients treated for atopic dermatitis with topical dermatological immunosuppressants. Fujisawa Healthcare, Inc. February 15, 2005. Background package [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005- 4089b2_02_02_Protopic%20Fujisawa%20briefing.pdf [Accessed 2007 Jul 9]
    • US Food and Drug Administration, Pediatric Advisory Committee. Discussion topic: risk evaluation, labeling, risk communication, and dissemination of information on potential cancer risk among pediatric patients treated for atopic dermatitis with topical dermatological immunosuppressants. Fujisawa Healthcare, Inc. February 15, 2005. Background package [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005- 4089b2_02_02_Protopic%20Fujisawa%20briefing.pdf [Accessed 2007 Jul 9]
  • 59
    • 0343014929 scopus 로고
    • Toxicology of FK506 in the cynomolgus monkey: A clinical, biochemical, and histopathological study
    • Wijnen RMH, Ericzon B-G, Tiebosch ATMG, et al. Toxicology of FK506 in the cynomolgus monkey: a clinical, biochemical, and histopathological study. Transpl Int 1992; 5 Suppl. 1: S454-8
    • (1992) Transpl Int , vol.5 , Issue.SUPPL. 1
    • Wijnen, R.M.H.1    Ericzon, B.-G.2    Tiebosch, A.T.M.G.3
  • 60
    • 35048847603 scopus 로고    scopus 로고
    • Safety profile of tacrolimus ointment: Data from five years of post-marketing experience [poster P14]
    • Mar 3-7; San Francisco CA
    • Jaracz E, Maher R, Simon D, et al. Safety profile of tacrolimus ointment: data from five years of post-marketing experience [poster P14]. American Academy of Dermatology 64th Annual Meeting; 2006 Mar 3-7; San Francisco (CA)
    • (2006) American Academy of Dermatology 64th Annual Meeting
    • Jaracz, E.1    Maher, R.2    Simon, D.3
  • 61
    • 0033960226 scopus 로고    scopus 로고
    • Late clonal diseases of treated aplastic anemia
    • Socié G, Rosenfeld S, Frickhofen N, et al. Late clonal diseases of treated aplastic anemia. Semin Hematol 2000; 37: 91-101
    • (2000) Semin Hematol , vol.37 , pp. 91-101
    • Socié, G.1    Rosenfeld, S.2    Frickhofen, N.3
  • 62
    • 0027360514 scopus 로고
    • Malignant tumors occurring after treatment of aplastic anemia
    • Socié G, Henry-Amar M, Bacigalupo A, et al. Malignant tumors occurring after treatment of aplastic anemia. N Engl J Med 1993; 329: 1152-7
    • (1993) N Engl J Med , vol.329 , pp. 1152-1157
    • Socié, G.1    Henry-Amar, M.2    Bacigalupo, A.3
  • 63
    • 35048865991 scopus 로고    scopus 로고
    • Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis [abstract]
    • Arrelano F, Wentworth CM, Arana A, et al. Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis [abstract]. J Invest Dermatol 2006; 126: 1682
    • (2006) J Invest Dermatol , vol.126 , pp. 1682
    • Arrelano, F.1    Wentworth, C.M.2    Arana, A.3
  • 64
    • 0033795921 scopus 로고    scopus 로고
    • Incidence of skin cancer in 5356 patients following organ transplantation
    • Lindelöf B, Sigurgeirsson B, Gäbel H, et al. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol 2000; 143: 513-9
    • (2000) Br J Dermatol , vol.143 , pp. 513-519
    • Lindelöf, B.1    Sigurgeirsson, B.2    Gäbel, H.3
  • 65
    • 1942443952 scopus 로고    scopus 로고
    • Human papillomaviruses in transplant-associated skin cancers
    • Stockfleth E, Nindl I, Sterry W, et al. Human papillomaviruses in transplant-associated skin cancers. Dermatol Surg 2004; 30: 604-9
    • (2004) Dermatol Surg , vol.30 , pp. 604-609
    • Stockfleth, E.1    Nindl, I.2    Sterry, W.3
  • 66
    • 32844468634 scopus 로고    scopus 로고
    • Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation
    • Yarosh DB, Pena AV, Nay SL, et al. Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol 2005; 125: 1020-5
    • (2005) J Invest Dermatol , vol.125 , pp. 1020-1025
    • Yarosh, D.B.1    Pena, A.V.2    Nay, S.L.3
  • 67
    • 33745245725 scopus 로고    scopus 로고
    • Production and clearance of cyclobutane dipyrimidine dimers in UV-irradiated skin pretreated with 1% pimecrolimus or 0.1% triamcinolone acetonide creams in normal and atopic patients
    • Doelker L, Tran C, Gkomouzas A, et al. Production and clearance of cyclobutane dipyrimidine dimers in UV-irradiated skin pretreated with 1% pimecrolimus or 0.1% triamcinolone acetonide creams in normal and atopic patients. Exp Dermatol 2006; 15: 342-6
    • (2006) Exp Dermatol , vol.15 , pp. 342-346
    • Doelker, L.1    Tran, C.2    Gkomouzas, A.3
  • 68
    • 27844433642 scopus 로고    scopus 로고
    • Topical calcineurin inhibitors decrease the production of UVB-induced thymine dimers from hairless mouse epidermis
    • Tran C, Lübbe J, Sorg O, et al. Topical calcineurin inhibitors decrease the production of UVB-induced thymine dimers from hairless mouse epidermis. Dermatology 2005; 211: 341-7
    • (2005) Dermatology , vol.211 , pp. 341-347
    • Tran, C.1    Lübbe, J.2    Sorg, O.3
  • 69
    • 35048833387 scopus 로고    scopus 로고
    • Is there an association between the use of topical calcineurin inhibitors and skin cancer [abstract]
    • Margolis D, Ole H, Bilker W. Is there an association between the use of topical calcineurin inhibitors and skin cancer [abstract]. J Invest Dermatol 2006; 126: 1-198
    • (2006) J Invest Dermatol , vol.126 , pp. 1-198
    • Margolis, D.1    Ole, H.2    Bilker, W.3
  • 70
    • 28644444775 scopus 로고    scopus 로고
    • Review of the potential photo-cocarcinogenicity of topical calcineurin inhibitors: Position statement of the European Dermatology Forum
    • Ring J, Barker J, Behrendt H, et al. Review of the potential photo-cocarcinogenicity of topical calcineurin inhibitors: position statement of the European Dermatology Forum. J Eur Acad Dermatol Venereol 2005; 19: 663-71
    • (2005) J Eur Acad Dermatol Venereol , vol.19 , pp. 663-671
    • Ring, J.1    Barker, J.2    Behrendt, H.3
  • 71
    • 20444449850 scopus 로고    scopus 로고
    • Pneumococcal seroconversion after vaccination for children with atopic dermatitis treated with tacrolimus ointment
    • Stiehm ER, Roberts RL, Kaplan MS, et al. Pneumococcal seroconversion after vaccination for children with atopic dermatitis treated with tacrolimus ointment. J Am Acad Dermatol 2005; 53: S206-13
    • (2005) J Am Acad Dermatol , vol.53
    • Stiehm, E.R.1    Roberts, R.L.2    Kaplan, M.S.3
  • 72
    • 0033769908 scopus 로고    scopus 로고
    • The sero-epidemiology of diphtheria in Western Europe
    • Edmunds WJ, Pebody RG, Aggerback H, et al. The sero-epidemiology of diphtheria in Western Europe. Epidemiol Infect 2000; 125: 113-25
    • (2000) Epidemiol Infect , vol.125 , pp. 113-125
    • Edmunds, W.J.1    Pebody, R.G.2    Aggerback, H.3
  • 73
    • 0035005750 scopus 로고    scopus 로고
    • The seroepidemiology of measles in Western Europe
    • de Melker H, Pebody RG, Edmunds WJ, et al. The seroepidemiology of measles in Western Europe. Epidemiol Infect 2001; 126: 249-59
    • (2001) Epidemiol Infect , vol.126 , pp. 249-259
    • de Melker, H.1    Pebody, R.G.2    Edmunds, W.J.3
  • 74
    • 0015912565 scopus 로고
    • Immune status of children one to four years of age as determined by history and antibody measurement
    • Gold E, Fevrier A, Hatch MH, et al. Immune status of children one to four years of age as determined by history and antibody measurement. N Engl J Med 1973; 289: 231-5
    • (1973) N Engl J Med , vol.289 , pp. 231-235
    • Gold, E.1    Fevrier, A.2    Hatch, M.H.3
  • 76
    • 35048875381 scopus 로고    scopus 로고
    • online, Available from URL:, Accessed Jul 9
    • Jyonouchi H. Delayed-type hypersensitivity [online]. Available from URL: http://www.emedicine.com/ped/topic558.htm [Accessed 2007 Jul 9]
    • (2007) Delayed-type hypersensitivity
    • Jyonouchi, H.1
  • 77
    • 0043204994 scopus 로고    scopus 로고
    • Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A
    • Meingassner JG, Fahrngruber H, Bavandi A. Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A. J Invest Dermatol 2003; 121: 77-80
    • (2003) J Invest Dermatol , vol.121 , pp. 77-80
    • Meingassner, J.G.1    Fahrngruber, H.2    Bavandi, A.3
  • 78
    • 10344221537 scopus 로고    scopus 로고
    • Pimecrolimus: An anti-inflammatory drug targeting the skin
    • Grassberger M, Steinhoff M, Schneider D, et al. Pimecrolimus: an anti-inflammatory drug targeting the skin. Exp Dermatol 2004; 13: 721-30
    • (2004) Exp Dermatol , vol.13 , pp. 721-730
    • Grassberger, M.1    Steinhoff, M.2    Schneider, D.3
  • 79
    • 0348012920 scopus 로고    scopus 로고
    • Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin
    • Niwa Y, Terashima T, Sumi H. Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin. Br J Dermatol 2003; 149: 960-7
    • (2003) Br J Dermatol , vol.149 , pp. 960-967
    • Niwa, Y.1    Terashima, T.2    Sumi, H.3
  • 80
    • 1842817485 scopus 로고    scopus 로고
    • Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation
    • Roman D, Ulrich P, Paul G, et al. Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation. Toxicol Lett 2004; 149: 133-40
    • (2004) Toxicol Lett , vol.149 , pp. 133-140
    • Roman, D.1    Ulrich, P.2    Paul, G.3
  • 81
    • 33646154439 scopus 로고    scopus 로고
    • The carcinogenic potential of tacrolimus ointment beyond immune suppression: A hypothesis creating case report
    • Becker JC, Houben R, Vetter CS, et al. The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report. BMC Cancer 2006; 6: 7
    • (2006) BMC Cancer , vol.6 , pp. 7
    • Becker, J.C.1    Houben, R.2    Vetter, C.S.3
  • 82
    • 18844382616 scopus 로고    scopus 로고
    • Are we starting to induce skin cancer in order to avoid topical steroids?
    • May;
    • Niwa Y, Nasr I. Are we starting to induce skin cancer in order to avoid topical steroids? J Eur Acad Dermatol Venereol 2005 May; 19 (3): 387-9
    • (2005) J Eur Acad Dermatol Venereol , vol.19 , Issue.3 , pp. 387-389
    • Niwa, Y.1    Nasr, I.2
  • 83
    • 0036787041 scopus 로고    scopus 로고
    • Tacrolimus ointment for the treatment of atopic dermatitis is not associated with an increase in cutaneous infections
    • Fleischer Jr AB, Ling M, Eichenfield L, et al. Tacrolimus ointment for the treatment of atopic dermatitis is not associated with an increase in cutaneous infections. J Am Acad Dermatol 2002; 47: 562-70
    • (2002) J Am Acad Dermatol , vol.47 , pp. 562-570
    • Fleischer Jr, A.B.1    Ling, M.2    Eichenfield, L.3
  • 84
    • 0141924545 scopus 로고    scopus 로고
    • Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis
    • Torok HM, Maas-Irslinger R, Slayton RM. Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. Cutis 2003; 72: 161-6
    • (2003) Cutis , vol.72 , pp. 161-166
    • Torok, H.M.1    Maas-Irslinger, R.2    Slayton, R.M.3
  • 85
    • 3843142598 scopus 로고    scopus 로고
    • Intermittent topical corticosteroid/tacrolimus sequential therapy improves lichenification and chronic papules more efficiently than intermittent topical corticosteroid/ emollient sequential therapy in patients with atopic dermatitis
    • Nakahara T, Koga T, Fukagawa S, et al. Intermittent topical corticosteroid/tacrolimus sequential therapy improves lichenification and chronic papules more efficiently than intermittent topical corticosteroid/ emollient sequential therapy in patients with atopic dermatitis. J Dermatol 2004; 31: 524-8
    • (2004) J Dermatol , vol.31 , pp. 524-528
    • Nakahara, T.1    Koga, T.2    Fukagawa, S.3
  • 86
    • 0029051985 scopus 로고
    • Combined inhibition effects of tacrolimus and methylprednisolone on in vitro human lymphocyte proliferation
    • Lee MJ, Pyszczynski N, Jusko WJ. Combined inhibition effects of tacrolimus and methylprednisolone on in vitro human lymphocyte proliferation. Immunopharmacol Immunotoxicol 1995; 17: 335-45
    • (1995) Immunopharmacol Immunotoxicol , vol.17 , pp. 335-345
    • Lee, M.J.1    Pyszczynski, N.2    Jusko, W.J.3
  • 87
    • 33746609359 scopus 로고    scopus 로고
    • Safety and efficacy of early intervention with pimecrolimus cream 1% combined with corticosteroids for major flares in infants and children with atopic dermatitis
    • Siegfried E, Korman N, Molina C, et al. Safety and efficacy of early intervention with pimecrolimus cream 1% combined with corticosteroids for major flares in infants and children with atopic dermatitis. J Dermatolog Treat 2006; 17: 143-50
    • (2006) J Dermatolog Treat , vol.17 , pp. 143-150
    • Siegfried, E.1    Korman, N.2    Molina, C.3
  • 88
    • 3442882870 scopus 로고    scopus 로고
    • Consensus guidelines in diagnosis and treatment of atopic dermatitis
    • Eichenfield LF. Consensus guidelines in diagnosis and treatment of atopic dermatitis. Allergy 2004; 59 Suppl. 78: 86-92
    • (2004) Allergy , vol.59 , Issue.SUPPL. 78 , pp. 86-92
    • Eichenfield, L.F.1
  • 90
    • 0344430190 scopus 로고    scopus 로고
    • Eichenfield LF, Hanifin JM, Luger TA, et al. Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol 2003; 49: 1088-95
    • Eichenfield LF, Hanifin JM, Luger TA, et al. Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol 2003; 49: 1088-95
  • 91
    • 4644275575 scopus 로고    scopus 로고
    • Disease management of atopic dermatitis: An updated practice parameter
    • Leung DYM, Nicklas RA, Li JT, et al. Disease management of atopic dermatitis: an updated practice parameter. Ann Allergy Asthma Immunol 2004; 93: S1-21
    • (2004) Ann Allergy Asthma Immunol , vol.93
    • Leung, D.Y.M.1    Nicklas, R.A.2    Li, J.T.3
  • 92
    • 0037343078 scopus 로고    scopus 로고
    • Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis
    • Sator P-G, Schmidt JB, Hönigsmann H. Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 2003; 48: 352-8
    • (2003) J Am Acad Dermatol , vol.48 , pp. 352-358
    • Sator, P.-G.1    Schmidt, J.B.2    Hönigsmann, H.3
  • 93
    • 0347324950 scopus 로고    scopus 로고
    • Current management of atopic dermatitis and interruption of the atopic march
    • Boguniewicz M, Eichenfield LF, Hultsch T. Current management of atopic dermatitis and interruption of the atopic march. J Allergy Clin Immunol 2003; 112: S140-50
    • (2003) J Allergy Clin Immunol , vol.112
    • Boguniewicz, M.1    Eichenfield, L.F.2    Hultsch, T.3
  • 94
    • 35048848596 scopus 로고    scopus 로고
    • GlaxoSmithKline. Cutivate cream 0.05% [prescribing information]. Pittsburgh (PA): GlaxoSmithKline, 2002
    • GlaxoSmithKline. Cutivate cream 0.05% [prescribing information]. Pittsburgh (PA): GlaxoSmithKline, 2002
  • 95
    • 0033863755 scopus 로고    scopus 로고
    • Adrenocortical function in patients with severe atopic dermatitis
    • Matsuda K, Katsunuma T, Iikura Y, et al. Adrenocortical function in patients with severe atopic dermatitis. Ann Allergy Asthma Immunol 2000; 85: 35-9
    • (2000) Ann Allergy Asthma Immunol , vol.85 , pp. 35-39
    • Matsuda, K.1    Katsunuma, T.2    Iikura, Y.3
  • 96
    • 0036125392 scopus 로고    scopus 로고
    • Safety of fluticasone propionate cream 0.05% for the treatment of severe and extensive atopic dermatitis in children as young as 3 months
    • Friedlander SF, Hebert AA, Allen DB, et al. Safety of fluticasone propionate cream 0.05% for the treatment of severe and extensive atopic dermatitis in children as young as 3 months. J Am Acad Dermatol 2002; 46: 387-93
    • (2002) J Am Acad Dermatol , vol.46 , pp. 387-393
    • Friedlander, S.F.1    Hebert, A.A.2    Allen, D.B.3
  • 97
    • 0034861903 scopus 로고    scopus 로고
    • The penetration of 0.005% fluticasone propionate ointment in eyelid skin
    • Tan M-H, Lebwohl M, Esser AC, et al. The penetration of 0.005% fluticasone propionate ointment in eyelid skin. J Am Acad Dermatol 2001; 45: 392-6
    • (2001) J Am Acad Dermatol , vol.45 , pp. 392-396
    • Tan, M.-H.1    Lebwohl, M.2    Esser, A.C.3
  • 98
    • 0036595910 scopus 로고    scopus 로고
    • Perceptions of physicians and pediatric patients about atopic dermatitis, its impact, and its treatment
    • Paller AS, McAlister RO, Doyle JJ, et al. Perceptions of physicians and pediatric patients about atopic dermatitis, its impact, and its treatment. Clin Pediatr (Phila) 2002; 41: 323-32
    • (2002) Clin Pediatr (Phila) , vol.41 , pp. 323-332
    • Paller, A.S.1    McAlister, R.O.2    Doyle, J.J.3


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