Art, alpha-1-antitrypsin polymorphisms and intense creative energy: Blessing or curse?

NeuroToxicology

Volumn 28, Issue 5 SPEC. ISS., 2007, Pages 899-914

  Schmechel, Donald Everett ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alpha 1 antitrypsin or AAT; Anxiety and bipolar disorders; Art; Copper homeostasis; Neurodegeneration; Toxic exposures

Indexed keywords

ALPHA 1 ANTITRYPSIN; COPPER; IRON; LIPID; THIAMINE;

ADOLESCENT; ADULT; AGE; AGED; ANXIETY DISORDER; ART; ARTICLE; BEHAVIOR; BIPOLAR DISORDER; BRONCHUS REACTIVITY; CHI SQUARE TEST; CHRONIC OBSTRUCTIVE LUNG DISEASE; COPPER METABOLISM; CREATIVITY; DEGENERATIVE DISEASE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FATTY LIVER; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HETEROZYGOTE; HUMAN; HYPOGLYCEMIA; INFLAMMATION; IRON METABOLISM; LIPID METABOLISM; LIVER DISEASE; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MOOD; MOOD DISORDER; NERVE DEGENERATION; NUTRITION; OCCUPATION; ONSET AGE; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; THIAMINE DEFICIENCY; UNITED STATES; WHITE MATTER;

EID: 34948889907     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.05.011     Document Type: Article

References (60)

1. Ahn K.H., Lyoo I.K., Lee H.K., Song I.C., Oh J.S., Hwang J., et al. White matter hyperintensities in subjects with bipolar disorder. Psychiatry Clin Neurosci 58 5 (2004) 516-521
2. Aldonyte R., Jansson L., Ljungberg O., Larsson S., and Janciauskiene S. Polymerized alpha-antitrypsin is present on lung vascular endothelium. New insights into the biological significance of alpha-antitrypsin polymerisation. Histopathology 45 6 (2004) 587-592
3. Barnham K.J., McKinstry W.J., Multhaup G., Galatis D., Morton C.J., Curtain C.C., et al. Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem 278 19 (2003) 17401-17407
4. Barton J.C., McDonnell S.M., Adams P.C., Brissot P., Powell L.W., Edwards C.Q., et al. Management of hemochromatosis. Hemochromatosis Management Working Group. Ann Intern Med 129 11 (1998) 932-939
5. Berns G.S., Martin M., and Proper S.M. Limbic hyperreactivity in bipolar II disorder. Am J Psychiatry 159 2 (2002) 304-306
6. Beyer J.L., Kuchibhatla M., Payne M., Moo-Young M., Cassidy F., MacFall J., et al. Caudate volume measurement in older adults with bipolar disorder. Int J Geriatr Psychiatry 19 2 (2004) 109-114
7. Beyer J., Kuchibhatla M., Gersing K., and Krishnan K.R. Medical comorbidity in a bipolar outpatient clinical population. Neuropsychopharmacology 30 2 (2005) 401-404
8. Billingsley G.D., Walter M.A., Hammond G.L., and Cox D.W. Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1. Am J Hum Genet 2 (1993) 343-353
9. Blanco I., Bustillo E.F., and Rodriguez M.C. Distribution of alpha1-antitrypsin PI S and PI Z frequencies in countries outside Europe: a meta-analysis. Clin Genet 60 6 (2001) 431-441
10. Brambilla P., Glahn D.C., Balestrieri M., and Soares J.C. Magnetic resonance findings in bipolar disorder. Psychiatric Clin N Am 28 2 (2005) 443-467
11. Byth B.C., Billingsley G.D., and Cox D.W. Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha-1-antitrypsin deficiency. Am J Hum Genet 55 1 (1994) 126-133
12. Dahl M., Tybjaerg-Hansen A., Sillesen H., Jensen G., Steffensen R., and Nordestgaard B.G. Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study. Circulation 107 5 (2003) 747-752
13. de Serres F.J. Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys. Chest 122 5 (2002) 1818-1829
14. de Serres F.J. Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed. Environ Health Perspect 111 16 (2003) 1851-1854
15. de Serres F.J., Blanco I., and Fernandez-Bustillo E. Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World. Genet Med 7 3 (2005) 175-184
16. Eden E., Strange C., Holladay B., and Xie L. Asthma and allergy in alpha-1 antitrypsin deficiency. Respir Med 100 8 (2006) 1384-1391
17. Goodwin R.D., Jacobi F., and Thefeld W. Mental disorders and asthma in the community. Arch Gen Psychiatry 60 11 (2003) 1125-1130
18. Graziadei I., Kaserbacher R., Braunsteiner H., and Vogel W. The hepatic acute-phase proteins alpha 1-antitrypsin and alpha 2-macroglobulin inhibit binding of transferrin to its receptor. Biochem J 290 Pt 1 (1993) 109-113
19. Graziadei I., Gaggl S., Kaserbacher R., Braunsteiner H., and Vogel W. The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake. Blood 83 1 (1994) 260-268
20. Graziadei I., Weiss G., Egger C., Niederwieser D., Patsch J.R., and Vogel W. Modulation of iron metabolism in monocytic THP-1 cells and cultured human monocytes by the acute-phase protein alpha1-antitrypsin. Exp Hematol 26 11 (1998) 1053-1060
21. Graziadei I., Weiss G., Bohm A., Werner-Felmayer G., and Vogel W. Unidirectional upregulation of the synthesis of the major iron proteins, transferrin-receptor and ferritin, in HepG2 cells by the acute-phase protein alpha1-antitrypsin. J Hepatol 27 4 (1997) 716-725
22. Hayes V.M. Genetic diversity of the alpha-1-antitrypsin gene in Africans identified using a novel genotyping assay. Hum Mutat 22 1 (2003) 59-66
23. Haznedar M.M., Roversi F., Pallanti S., Baldini-Rossi N., Schnur D.B., Licalzi E.M., et al. Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry 57 7 (2005) 733-742
24. Helmer C., Letenneur L., Rouch I., Richard-Harston S., Barberger-Gateau P., Fabrigoule C., et al. Occupation during life and risk of dementia in French elderly community residents. J Neurol Neurosurg Psychiatry 71 3 (2001) 303-309
25. Hersh C.P., Dahl M., Ly N.P., Berkey C.S., Nordestgaard B.G., and Silverman E.K. Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis. Thorax 59 10 (2004) 843-849
26. Ikebe N., Akaike T., Miyamoto Y., Hayashida K., Yoshitake J., Ogawa M., and Maeda H. Protective effect of S-nitrosylated alpha(1)-protease inhibitor on hepatic ischemia-reperfusion injury. J Pharmacol Exp Ther 295 3 (2000) 904-911
27. Jamison K.R. Touched with fire: manic-depressive illness and the artistic temperament (1993), Free Press, Ontario
28. Janciauskiene S., Moraga F., and Lindgren S. C-terminal fragment of alpha1-antitrypsin activates human monocytes to a pro-inflammatory state through interactions with the CD36 scavenger receptor and LDL receptor. Atherosclerosis 158 1 (2001) 41-51
29. Karlsson J.L. Inheritance of creative intelligence (1978), Nelson-Hall, Chicago
30. Kawashiri M., Kajinami K., Nohara A., Yagi K., Inazu A., Koizumi J., et al. Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia. Am J Cardiol 86 8 (2000) 840-845
31. Knopman D.S., et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Committee of the American Academy of Neurology. Neurology 56 (2001) 1143-1153
32. Lehrer P., Feldman J., Giardino N., Song H.S., and Schmaling K. Psychological aspects of asthma. J Consult Clin Psychol 70 3 (2002) 691-711
33. Lolin Y.I., and Ward A.M. Alpha-1-antitrypsin phenotypes and associated disease patterns in neurological patients. Acta Neurol Scand 91 5 (1995) 394-398
34. Malhi G.S., Lagopoulos J., Sachdev P., Mitchell P.B., Ivanovski B., and Parker G.B. Cognitive generation of affect in hypomania: an fMRI study. Bipolar Disorders 6 4 (2004) 271-285
35. Markusen A. The artistic dividend revisited (2004), Hubert Institute of Public Affairs, Minneapolis
36. Mashiba S., Wada Y., Takeya M., Sugiyama A., Hamakubo T., Nakamura A., et al. In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL. Arteriosc Thromb Vasc Biol 21 11 (2001) 1801-1808
37. Miller B.L., Boone K., Cummings J.L., Read S.L., and Mishkin F. Functional correlates of musical and visual ability in frontotemporal dementia. Br J Psychiatry 176 (2000) 458-463
38. Miller B.L., Ponton M., Benson D.F., Cummings J.L., and Mena I. Enhanced artistic creativity with temporal lobe degeneration. Lancet 348 9043 (1996) 1744-1745
39. Moraga F., and Janciauskiene S. Activation of primary human monocytes by the oxidized form of alpha1-antitrypsin. J Biol Chem 275 11 (2000) 7693-7700
40. Moraga F., Lindgren S., and Janciaskiene S. Effects of noninhibitory alpha-1-antitrypsin on primary human monocyte activation in vitro. Arch Biochem Biophys 386 2 (2001) 221-226
41. Mulgrew A.T., Taggart C., Lawless M.W., Green C.M., Brantly M.L., O'Neill S.J., and McElvaney N.G. Z alpha-1-antitrypsin polymerizes in the lung and serves as a neutrophil chemoattractant. Chest 125 5 (2004) 1607-1609
42. Parfrey H., Mahadeva R., and Lomas D.A. Alpha(1)-antitrypsin deficiency, liver disease and emphysema. Int J Biochem Cell Biol 35 7 (2003) 1009-1014
43. Perlmutter D.H. Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury. J Clin Investig 110 11 (2002) 1579-1583
44. Perlmutter D.H. Alpha1-antitrypsin deficiency: liver disease associated with retention of a mutant secretory glycoprotein in the endoplasmic reticulum. Methods Mol Biol 232 (2003) 39-56
45. Perlmutter D.H. Pathogenesis of chronic liver injury and hepatocellular carcinoma in alpha-1-antitrypsin deficiency. Pediatr Res 2 (2006) 233-238
46. Petersen R.C., et al. Practice parameter: early detection of mild dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Committee of the American Academy of Neurology. Neurology 56 (2001) 1133-1142
47. Schmechel D.E. Relationship between apolipoprotein E and susceptibility of neuro-degenerative disease. In: Briley M., and Sulser F. (Eds). Molecular genetics of mental disorders (2001), Martin Dunitz, London
48. Schmechel D.E., Burkhart D.S., Ange R., and Izard M.K. Cholinergic axonal dystrophy and mitochondrial pathology in prosimian primates. Exp Neurol 142 1 (1996) 11-127
49. Schmechel D.E., Tiller M.O., Han S.-H., Fail P., Ange R., Burkhart D.S., et al. Pattern of apolipoprotein-E immunoreactivity during brain aging. In: Roses A.D., Weisgraber K., and Christen Y. (Eds). Apolipo-protein E and Alzheimer's disease (1996), Springer-Verlag, Berlinn Heidelberg 27-48
50. Schmechel D.E., Browndyke J., and Ghio A. Strategies for the dissection of genetic-environmental interactions in neurodegenerative disorders. Neurotoxicology 27 (2006) 637-657
51. Schroeder W.T., Miller M.F., Woo S.L., and Saunders G.F. Chromosomal localization of the human alpha 1-antitrypsin gene (PI) to 14q31-32. Am J Hum Genet 37 5 (1985) 868-872
52. Scott B.B., and Egner W. Does alpha1-antitrypsin phenotype PiMZ increase the risk of fibrosis in liver disease due to hepatitis C virus infection?. Eur J Gastroenterol Hepatol 18 5 (2006) 521-523
53. Seixas S., Garcia O., Trovoada M.J., Santos M.T., Amorim A., and Rocha J. Patterns of haplotype diversity within the serpin gene cluster at 14q32.1: insights into the natural history of the alpha1-antitrypsin polymorphism. Hum Genet 108 1 (2001) 20-30
54. Strange C., Stoller J.K., Sandhaus R.A., Dickson R., and Turino G. Results of a survey of patients with alpha-1 antitrypsin deficiency. Respiration 73 2 (2006) 185-190
55. Talmud P.J., Martin S., Steiner G., Flavell D.M., Whitehouse D.B., Nagl S., et al. Diabetes Atherosclerosis Intervention Study Investigators. Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene. Arteriosc Thromb Vasc Biol 23 4 (2003) 644-649
56. Teckman J.H., and Perlmutter D.H. Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response. Am J Physiol Gastrointest Liver Physiol 279 5 (2000) G961-G974
57. Teckman J.H., An J.K., Loethen S., and Perlmutter D.H. Fasting in alpha1-antitrypsin deficient liver: constitutive activation of autophagy. Am J Physiol Gastrointest Liver Physiol 283 5 (2002) G1156-G1165
58. Teckman J.H., An J.K., Blomenkamp K., Schmidt B., and Perlmutter D. Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency. Am J Physiol Gastrointest Liver Physiol 286 5 (2004) G851-G862
59. Weiss G., Graziadel I., Urbanek M., Grunewald K., and Vogel W. Divergent effects of alpha 1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic (K562) and myelomonocytic (THP-1) cells. Biochem J 319 Pt 3 (1996) 897-902
60. Zandi P.P., Willour V.L., Huo Y., Chellis J., Potash J.B., MacKinnon D.F., et al. Genome screen of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2,11,13,14, and X. Am J Hum Genet 119B 1 (2003) 69-76