C-terminal fragment of α1-antitrypsin activates human monocytes to a pro-inflammatory state through interactions with the CD36 scavenger receptor and LDL receptor

Atherosclerosis

Volumn 158, Issue 1, 2001, Pages 41-51

  Janciauskiene, Sabina ^a   Moraga, Fabian ^a   Lindgren, Stefan ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

1 antitrypsin; C terminal fragment of 1 antitrypsin; CD36 scavenger receptor; LDL receptor; Monocytes; Pro inflammatory molecules

Indexed keywords

ALPHA 1 ANTITRYPSIN; CD36 ANTIBODY; CD36 ANTIGEN; GELATINASE B; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; RECEPTOR ANTIBODY; SCAVENGER RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; INCUBATION TIME; INFLAMMATORY CELL; LEUKOCYTE ACTIVATION; LIPID TRANSPORT; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; RESPIRATORY BURST;

ALPHA 1-ANTITRYPSIN; ANTIGENS, CD36; ARTERIOSCLEROSIS; CELLS, CULTURED; CHEMOKINE CCL2; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPOPROTEINS, LDL; MATRIX METALLOPROTEINASE 9; MEMBRANE PROTEINS; MONOCYTES; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PEPTIDE FRAGMENTS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034898431     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00767-X     Document Type: Article

References (63)

1. Macrophage scavenger receptors and foam cell formation
2. Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36
3. Scavenger receptors and oxidised low density lipoproteins
4. Differential expression of CD14, CD36 and the LDL receptor on human monocyte-derived macrophages
5. CD36 is a receptor for oxidized low density lipoprotein
6. Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects
7. Isolation of the thrombospondin membrane receptor
8. Monoclonal antibody OKM5 inhibits the in vitro binding of Plasmodium falciparum-infected erythrocytes to monocytes, endothelial, and C32 melanoma cells
9. Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor
10. Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion
11. Oxidised LDL regulates macrophage gene expression through ligand activation of PPARγ
12. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma
13. Regulated expression of CD36 during monocyte-to-macrophage differentiation: Potential role of CD36 in foam cell formation
14. TGF-beta1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages
15. Recognition and plasma clearance of endotoxin by scavenger receptors
16. CD36 induction on human monocytes upon adhesion to tumor necrosis factor-activated endothelial cells
17. Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans
18. Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators
19. Atherogenic properties of human monocytes induced by the carboxyl terminal proteolytic fragment of alpha-1-antitrypsin
20. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
21. Atherosclerosis - An inflammatory disease
22. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
23. Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha 1- antitrypsin and alpha 2-macroglobulin
24. Molecular interactions in human atherosclerotic plaques
25. Serum glycoproteins and severity of coronary atherosclerosis
26. Alpha-1-antitrypsin in human macrophages
27. Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages
28. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties
29. Human plasma proteinase inhibitors
30. Human neutrophil collagenase cleaves alpha-1-antitrypsin
31. Proteolytic inactivation of human alpha-1-antitrypsin by human stromelysin
32. The inactivation of human plasma alpha-1-proteinase inhibitor by proteinases from Staphylococcus aureus
33. Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and large increase in conformational stability upon cleavage at their reactive sites
34. Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin
35. Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT
36. In vitro fibril formation from alpha-1-antitrypsin-derived C-terminal peptides
37. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
38. β-amyloid (25-35) peptide and IFN-γ synergistically induce the production of the chemotactic cytokine MSP-1/JE in monocytes and microglial cells
39. The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent
40. Characterization of the binding of human low-density lipoprotein to primary monolayer cultures of rat hepatocytes
41. In vitro oxidised HDL is recognised by the scavenger receptor of macrophages: Implications for its protective role in vitro
42. Structure and variation of human alpha 1-antitrypsin
43. The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant
44. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
45. Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin
46. Characterization of the inactive fragment resulting from limited proteolysis of human alpha1-proteinase inhibitor by Crotalus adamanteus proteinase II
47. Purification of human plasma alpha 1-proteinase inhibitor and its inactivation by Pseudomonas aeruginosa elastase
48. Inactivation of human plasma alpha 1-proteinase inhibitor by a metalloproteinase from Serratia marcescens
49. Comparative cleavage sites within the reactive-site loop of native and oxidised alpha-1-proteinase inhibitor by selected bacterial proteinases
50. Activation mechanisms of matrix metalloproteinases
51. Mast cell proteinases activate precursor of collagenase and stromelysin but not of gelatinases A and B
52. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
53. Changing concepts of atherogenesis
54. Secretion of metalloproteinases by stimulated capillary endothelial cells, II: Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors
55. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
56. Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery
57. TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages
58. Evidence for hydroxyl radical generation by human monocytes
59. The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages
60. Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production
61. Lovastatin decreases the receptor-mediated degradation of acetylated and oxidized LDLs in human blood monocytes during the early stage of differentiation into macrophages
62. Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease
63. Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity