Silicon microdevice for emulsion production using three-dimensional flow focusing

Journal of Microelectromechanical Systems

Volumn 16, Issue 5, 2007, Pages 1201-1208

  Luque, Antonio ^a   Perdigones, Francisco A ^a   Esteve, Jaume ^b   Montserrat, Josep ^b   Gañán Calvo, Alfonso M ^a   Quero, José M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Microelectromechanical devices

Indexed keywords

COMPUTER SIMULATION; EMULSIONS; FLOW RATE; FLUIDICS; JETS; MICROFABRICATION; MICROMETERS; SILICON;

BIDIMENSIONAL ARRAY; FLOW FOCUSING;

MICROELECTROMECHANICAL DEVICES;

EID: 34948878622     PISSN: 10577157     EISSN: None     Source Type: Journal    
DOI: 10.1109/JMEMS.2007.901644     Document Type: Article

References (22)

1. C. Priest, S. Herminghaus, and R. Seemann, "Generation of monodisperse gel emulsions in a microfluidic device," Appl. Phys. Lett., vol. 88, no. 2, p. 024 106, Jan. 2006.
2. W. Deng, J. F. Klemic, X. Li, M. A. Reed, and A. Gomez, "Increase of electrospray throughput using multiplexed microfabricated sources for the scalable generation of monodisperse droplets," J. Aerosol Sci. vol. 37, no. 6, pp. 696-714, 2006.
3. G.-B. Lee, C.-I. Hung, B.-J. Ke, G.-R. Huang, B.-H. Hwei, and H.-F. Lai, "Hydrodynamic focusing for a micromachined flow cytometer," Trans. ASME, J. Fluids Eng., vol. 123, no. 3, pp. 672-679, Sep. 2001.
4. H.-J. Oh, S.-H. Kim, J.-Y. Baek, G.-H. Seong, and S.-H. Lee, "Hydrodynamic micro-encapsulation of aqueous fluids and cells via "on the fly" photopolymerization," J. Micromech. Microeng., vol. 16, no. 2, pp. 285-291, Feb. 2006.
5. J. H. Nieuwenhuis, J. Bastemeijer, P. M. Sarroc, and M. J. Vellekoopa, "Integrated flow-cells for novel adjustable sheath flows," Lab Chip vol. 3, no. 2, pp. 56-61, May 2003.
6. R. Yang, D. L. Feeback, and W. Wang, "Microfabrication and test of a three-dimensional polymer hydro-focusing unit for flow cytometry applications," Sens. Actuators A, Phys., vol. 118, no. 2, pp. 259-267, Feb. 2005.
7. A. M. Gañán-Calvo, "Generation of steady liquid microthreads and micron-sized monodisperse sprays in gas streams," Phys. Rev. Lett. vol. 80, no. 2, pp. 285-288, Jan. 1998.
8. A. M. Gañán-Calvo and J. M. Gordillo, "Perfectly monodisperse microbubbling by capillary flow focusing," Phys. Rev. Lett., vol. 87, no. 27, p. 274 501, Dec. 2001.
9. S. L. Anna, N. Bontoux, and H. A. Stone, "Formation of dispersions using flow-focusing in microchannels," Appl. Phys. Lett., vol. 82, no. 3, pp. 364-366, Jan. 2003.
10. J. B. Knight, A. Vishwanath, J. P. Brody, and R. H. Austin, "Hydrodynamic focusing in a silicon chip: Mixing nanoliters in microseconds," Phys. Rev. Lett., vol. 80, no. 17, pp. 3863-3866, Apr. 1998.
11. C. Simonnet and A. Groisman, "Two-dimensional hydrodynamic focusing in a simple microfluidic device," Appl. Phys. Lett., vol. 87, no. 11, p. 114 104, Sep. 2005.
12. L. Yobas, S. Martens, W. Ong, and N. Ranganathan, "High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets," Lab Chip, vol. 6, no. 8, pp. 1073-1079, 2006.
13. N. Sundararajan, M. S. Pio, L. P. Lee, and A. A. Berlinv, "Three-dimensional hydrodynamic focusing in polydimethylsiloxane (PDMS) microchannels," J. Microelectromech. Syst., vol. 13, no. 4, pp. 559-567, Aug. 2004.
14. G.-B. Lee, C.-C. Chang, S.-B. Huang, and R.-J. Yang, "The hydrodynamic focusing effect inside rectangular microchannels," J. Micromech. Microeng., vol. 16, no. 5, pp. 1024-1032, 2004.
15. S. Takeuchi, P. Garstecki, D. B. Weibel, and G. M. Whitesides, "An axisymmetric flow-focusing microfluidic device," Adv. Mater., vol. 17, no. 8, pp. 1067-1072, 2005.
16. O. Hofmann, P. Niedermann, and A.Manz, "Modular approach to fabrication of three-dimensional microchannel systems in PDMS-Application to sheath flow microchips," Lab Chip, vol. 1, no. 2, pp. 108-114, Dec. 2001.
17. L. Martín-Banderas, A. Rodríguez-Gil, A. Cebolla, S. Chávez, T. Berdún-Alvarez, J. M. F. Garcia, M. Flores-Mosquera, and A. M. Gañán-Calvo, "Towards high-throughput production of uniformly encoded microparticles," Adv. Mater., vol. 18, no. 5, pp. 559-564, 2006.
18. A. M. Gañán-Calvo, "Enhanced liquid atomization: From flow focusing to flow blurring," Appl. Phys. Lett., vol. 86, p. 214 101, 2004.
19. S.-H. Huang, W.-H. Tan, F.-G. Tseng, and S. Takeuchi, "A monolithically three-dimensional flow-focusing device for formation of single/double emulsions in closed/open microfluidic systems," J. Micromech. Microeng., vol. 16, no. 11, pp. 2336-2344, Nov. 2006.
20. Coventor Ware - Architect and Analyzer: Users & Reference Guide, Coventor, Inc., Cary, NC, 2004.
21. M. M. Dupin, I. Halliday, and C. M. Care, "Simulation of a microfluidic flow-focusing device," Phys. Rev. E-Statistical, Nonlinear, Soft Matter Physics, vol. 73, no. 5, p. 055 701, 2006.
22. B. Yang and Q. Lin, "A planar compliance-based self-adaptive microfluid variable resistor," J. Microelectromech. Syst., vol. 16, no. 2, pp. 411-419, Apr. 2007.