A new amphiphilic derivative, N-{[4-(Lactobionamido)methyl] benzylidene}-1,2-dimethyl-2-(octylsulfanyl) ethylamine N-oxide, has a protective effect against copper-induced fulminant hepatitis in long-Evans cinnamon rats at an extremely low concentration compared with its original form α-phenyl-N-(tert-butyl) nitrone

Chemistry and Biodiversity

Volumn 4, Issue 9, 2007, Pages 2253-2267

  Asanuma, Taketoshi ^a   Yasui, Hironobu ^a   Inanami, Osamu ^a   Waki, Kenji ^a   Takahashi, Momoko ^a   Iizuka, Daisuke ^a   Uemura, Taketo ^a   Durand, Grégory ^b   Polidori, Ange ^b   Kon, Yasuhiro ^a   Pucci, Bernard ^b   Kuwabara, Mikinori ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF AVIGNON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ALPHA PHENYL N (TERT BUTYL)NITRONE; ASPARTATE AMINOTRANSFERASE; COPPER; GASTROINTESTINAL AGENT; N [[4 (LACTOBIONAMIDO)METHYL]BENZYLIDENE] 1,1 DIMETHYL 2 (OCTYLSULFANYL)ETHYLAMINE N OXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG SYNTHESIS; HEPATITIS; IMMUNOHISTOCHEMISTRY; JAUNDICE; LIVER PROTECTION; LONG EVANS CINNAMON RAT; MALE; MORTALITY; NONHUMAN; RAT; WEIGHT REDUCTION;

ANIMALS; ANTIOXIDANTS; COPPER; CYCLIC N-OXIDES; DEOXYGUANOSINE; DISACCHARIDES; HEPATITIS, TOXIC; IMINES; IMMUNOHISTOCHEMISTRY; LIVER; LIVER FAILURE, ACUTE; MALE; RATS; RATS, INBRED LEC; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

CINNAMOMUM VERUM; RATTUS;

EID: 34948834790     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200790184     Document Type: Article

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