-
1
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drews J. Drug discovery: a historical perspective. Science 2001; 287: 1960-1964.
-
(2001)
Science
, vol.287
, pp. 1960-1964
-
-
Drews, J.1
-
2
-
-
0037446894
-
The G-protein-coupled receptor repertoires of human and mouse
-
Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA. The G-protein-coupled receptor repertoires of human and mouse. Proc. Natl. Acad. Sci. U.S.A. 2003; 100: 4903-4908.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 4903-4908
-
-
Vassilatis, D.K.1
Hohmann, J.G.2
Zeng, H.3
Li, F.4
Ranchalis, J.E.5
Mortrud, M.T.6
Brown, A.7
Rodriguez, S.S.8
Weller, J.R.9
Wright, A.C.10
Bergmann, J.E.11
Gaitanaris, G.A.12
-
3
-
-
11144246968
-
GPCR deorphanizations: The novel, the known and the unexpected transmitters
-
Civelli O. GPCR deorphanizations: the novel, the known and the unexpected transmitters. Trends Pharmacol. Sci 2005; 26: 15-19.
-
(2005)
Trends Pharmacol. Sci
, vol.26
, pp. 15-19
-
-
Civelli, O.1
-
4
-
-
0023786564
-
The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor
-
Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 1988; 335: 358-360.
-
(1988)
Nature
, vol.335
, pp. 358-360
-
-
Fargin, A.1
Raymond, J.R.2
Lohse, M.J.3
Kobilka, B.K.4
Caron, M.G.5
Lefkowitz, R.J.6
-
5
-
-
0024205444
-
Cloning and expression of a rat D2 dopamine receptor cDNA
-
Bunzow JR, Van Tol HH, Grandy DK, Albert P, Salon J, Christie M, Machida CA, Neve KA, Civelli O. Cloning and expression of a rat D2 dopamine receptor cDNA. Nature 1988; 336: 783-787.
-
(1988)
Nature
, vol.336
, pp. 783-787
-
-
Bunzow, J.R.1
Van Tol, H.H.2
Grandy, D.K.3
Albert, P.4
Salon, J.5
Christie, M.6
Machida, C.A.7
Neve, K.A.8
Civelli, O.9
-
6
-
-
0035313899
-
Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors
-
Civelli O, Nothacker HP, Saito Y, Wang Z, Lin SH, Reinscheid RK. Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. Trends Neurosci. 2001; 24: 230-237.
-
(2001)
Trends Neurosci
, vol.24
, pp. 230-237
-
-
Civelli, O.1
Nothacker, H.P.2
Saito, Y.3
Wang, Z.4
Lin, S.H.5
Reinscheid, R.K.6
-
8
-
-
1342281272
-
The identification of ligands at orphan G-protein coupled receptors
-
Wise A, Jupe SC, Rees S. The identification of ligands at orphan G-protein coupled receptors. Annu. Rev. Pharmacol. Toxicol. 2004; 44: 43-66.
-
(2004)
Annu. Rev. Pharmacol. Toxicol
, vol.44
, pp. 43-66
-
-
Wise, A.1
Jupe, S.C.2
Rees, S.3
-
9
-
-
33646391222
-
Orphan GPCRs and their ligands
-
Civelli O, Saito Y, Wang Z, Nothacker HP, Reinscheid RK. Orphan GPCRs and their ligands. Pharmacol. Ther. 2006; 110: 525-532.
-
(2006)
Pharmacol. Ther
, vol.110
, pp. 525-532
-
-
Civelli, O.1
Saito, Y.2
Wang, Z.3
Nothacker, H.P.4
Reinscheid, R.K.5
-
10
-
-
0041344654
-
Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155
-
Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F Jr, Zhang FL. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J. Biol. Chem. 2003; 278: 27652-27657.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 27652-27657
-
-
Jiang, Y.1
Luo, L.2
Gustafson, E.L.3
Yadav, D.4
Laverty, M.5
Murgolo, N.6
Vassileva, G.7
Zeng, M.8
Laz, T.M.9
Behan, J.10
Qiu, P.11
Wang, L.12
Wang, S.13
Bayne, M.14
Greene, J.15
Monsma Jr, F.16
Zhang, F.L.17
-
11
-
-
17844400914
-
The repertoire of G-protein-coupled receptors in fully sequenced genomes
-
Fredriksson R, Schiöth HB. The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol. Pharmacol. 2005; 67: 1414-1425.
-
(2005)
Mol. Pharmacol
, vol.67
, pp. 1414-1425
-
-
Fredriksson, R.1
Schiöth, H.B.2
-
12
-
-
0015224130
-
Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes
-
Anastasi A, Erspamer V, Bucci M. Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 1971; 27: 166-167.
-
(1971)
Experientia
, vol.27
, pp. 166-167
-
-
Anastasi, A.1
Erspamer, V.2
Bucci, M.3
-
14
-
-
0018663357
-
Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue
-
McDonald TJ, Jornvall H, Nilsson G, Vagne M, Ghatei M, Bloom SR, Mutt V. Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys. Res. Commun. 1979; 90: 227-233.
-
(1979)
Biochem Biophys. Res. Commun
, vol.90
, pp. 227-233
-
-
McDonald, T.J.1
Jornvall, H.2
Nilsson, G.3
Vagne, M.4
Ghatei, M.5
Bloom, S.R.6
Mutt, V.7
-
15
-
-
0020558866
-
Neuromedin B: A novel bombesin-like peptide identified in porcine spinal cord
-
Minamino N, Kangawa K, Matsuo H. Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 1983; 114: 541-548.
-
(1983)
Biochem. Biophys. Res. Commun
, vol.114
, pp. 541-548
-
-
Minamino, N.1
Kangawa, K.2
Matsuo, H.3
-
16
-
-
0021144604
-
Cloning and characterization of cDNAs encoding human gastrin-releasing peptide
-
Spindel ER, Chin WW, Price J, Rees LH, Besser GM, Habener JF. Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc. Natl. Acad. Sci. U.S.A. 1984; 81: 5699-5703.
-
(1984)
Proc. Natl. Acad. Sci. U.S.A
, vol.81
, pp. 5699-5703
-
-
Spindel, E.R.1
Chin, W.W.2
Price, J.3
Rees, L.H.4
Besser, G.M.5
Habener, J.F.6
-
17
-
-
0023681303
-
Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin
-
Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. J. Biol. Chem. 1988; 263: 13317-13323.
-
(1988)
J. Biol. Chem
, vol.263
, pp. 13317-13323
-
-
Krane, I.M.1
Naylor, S.L.2
Helin-Davis, D.3
Chin, W.W.4
Spindel, E.R.5
-
18
-
-
4944226721
-
Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist
-
Arlander SJ, Dong M, Ding XQ, Pinon DI, Miller LJ. Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist. Mol. Pharmacol. 2004; 66: 545-552.
-
(2004)
Mol. Pharmacol
, vol.66
, pp. 545-552
-
-
Arlander, S.J.1
Dong, M.2
Ding, X.Q.3
Pinon, D.I.4
Miller, L.J.5
-
20
-
-
2142823653
-
Recent advances in the investigation of the bioactive conformation of peptides active at the micro-opioid receptor. Conformational analysis of endomorphins
-
Gentilucci L, Tolomelli A. Recent advances in the investigation of the bioactive conformation of peptides active at the micro-opioid receptor. Conformational analysis of endomorphins. Curr. Top. Med. Chem. 2004; 4: 105-121.
-
(2004)
Curr. Top. Med. Chem
, vol.4
, pp. 105-121
-
-
Gentilucci, L.1
Tolomelli, A.2
-
21
-
-
0035181504
-
Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid in DMSO solution, by 1H NMR spectroscopy and molecular modeling calculation
-
In Y, Minoura K, Ohishi H, Minakata H, Kamigauchi M, Sugiura M, Ishida T. Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid in DMSO solution, by 1H NMR spectroscopy and molecular modeling calculation. J. Pept. Res. 2001; 58: 399-412,
-
(2001)
J. Pept. Res
, vol.58
, pp. 399-412
-
-
In, Y.1
Minoura, K.2
Ohishi, H.3
Minakata, H.4
Kamigauchi, M.5
Sugiura, M.6
Ishida, T.7
-
22
-
-
0002912489
-
-
Walsh JH, Dockray GJ eds, Raven Press: New York
-
Walsh JH. Gastrin. In Gut peptides, Walsh JH, Dockray GJ (eds.). Raven Press: New York, 1994; 75-121.
-
(1994)
Gut peptides
, pp. 75-121
-
-
Gastrin, W.J.H.1
-
23
-
-
0036117240
-
Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo
-
Ouafik L, Sauze S, Boudouresque F, Chinot O, Delfino C, Fina F, Vuaroqueaux V, Dussert C, Palmari J, Dufour H, Grisoli F, Casellas P, Brunner N, Martin PM. Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo. Am. J. Pathol. 2002; 160: 1279-1292.
-
(2002)
Am. J. Pathol
, vol.160
, pp. 1279-1292
-
-
Ouafik, L.1
Sauze, S.2
Boudouresque, F.3
Chinot, O.4
Delfino, C.5
Fina, F.6
Vuaroqueaux, V.7
Dussert, C.8
Palmari, J.9
Dufour, H.10
Grisoli, F.11
Casellas, P.12
Brunner, N.13
Martin, P.M.14
-
27
-
-
0027249595
-
-
Boguski MS, Lowe TM, Tolstoshev CM. dbEST-database for expressed sequence tags. Nat. Genet. 1993; 4: 332-333.
-
Boguski MS, Lowe TM, Tolstoshev CM. dbEST-database for "expressed sequence tags". Nat. Genet. 1993; 4: 332-333.
-
-
-
-
28
-
-
33644873213
-
-
Wu CH, Apweiler R, Bairoch A, Natale DA, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Mazumder R, O'Donovan C, Redaschi N, Suzek B. The universal protein resource (UniProt): an expanding universe of protein information. Nucleic Acids Res. 2006; 34: (Database issue): D187-D191.
-
Wu CH, Apweiler R, Bairoch A, Natale DA, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Mazumder R, O'Donovan C, Redaschi N, Suzek B. The universal protein resource (UniProt): an expanding universe of protein information. Nucleic Acids Res. 2006; 34: (Database issue): D187-D191.
-
-
-
-
29
-
-
33846040633
-
-
Database issue, D21-D25
-
Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Wheeler DL. GenBank. Nucleic Acids Res. 2007; 35: (Database issue): D21-D25.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Benson, D.A.1
Karsch-Mizrachi, I.2
Lipman, D.J.3
Ostell, J.4
GenBank, W.D.L.5
-
31
-
-
0033452452
-
Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
-
Seidah NG, Chretien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 1999; 848: 45-62.
-
(1999)
Brain Res
, vol.848
, pp. 45-62
-
-
Seidah, N.G.1
Chretien, M.2
-
32
-
-
0030911517
-
Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2
-
Duncan EA, Brown MS, Goldstein JL, Sakai J. Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2, J. Biol. Chem. 1997; 272: 12778-12785.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 12778-12785
-
-
Duncan, E.A.1
Brown, M.S.2
Goldstein, J.L.3
Sakai, J.4
-
33
-
-
13044279492
-
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
-
Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Toure BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chretien M, Marcinkiewicz M. Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proc. Natl. Acad. Sci. U.S.A. 1999; 96: 1321-1326.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 1321-1326
-
-
Seidah, N.G.1
Mowla, S.J.2
Hamelin, J.3
Mamarbachi, A.M.4
Benjannet, S.5
Toure, B.B.6
Basak, A.7
Munzer, J.S.8
Marcinkiewicz, J.9
Zhong, M.10
Barale, J.C.11
Lazure, C.12
Murphy, R.A.13
Chretien, M.14
Marcinkiewicz, M.15
-
34
-
-
0037417807
-
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
-
Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc. Natl. Acad. Sci. U.S.A. 2003; 100: 928-933.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 928-933
-
-
Seidah, N.G.1
Benjannet, S.2
Wickham, L.3
Marcinkiewicz, J.4
Jasmin, S.B.5
Stifani, S.6
Basak, A.7
Prat, A.8
Chretien, M.9
-
35
-
-
0038013935
-
Characterization of Endothelin-converting enzyme-2, implication for a role in the nonclassical processing of regulatory peptides
-
Mzhavia N, Pan H, Fricker LD, Devi LA. Characterization of Endothelin-converting enzyme-2, implication for a role in the nonclassical processing of regulatory peptides. J. Biol. Chem, 2003; 278: 14704-14711.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14704-14711
-
-
Mzhavia, N.1
Pan, H.2
Fricker, L.D.3
Devi, L.A.4
-
36
-
-
3242749962
-
Cathepsin L and Arg/Lys aminopeptidase: A distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones
-
Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol. Chem. 2004; 385: 473-480.
-
(2004)
Biol. Chem
, vol.385
, pp. 473-480
-
-
Hook, V.1
Yasothornsrikul, S.2
Greenbaum, D.3
Medzihradszky, K.F.4
Troutner, K.5
Toneff, T.6
Bundey, R.7
Logrinova, A.8
Reinheckel, T.9
Peters, C.10
Bogyo, M.11
-
37
-
-
0034201441
-
EMBOSS: The European molecular biology open software suite
-
Rice P, Longden I, Bleasby A. EMBOSS: the European molecular biology open software suite. Trends Genet. 2000; 16: 276-277.
-
(2000)
Trends Genet
, vol.16
, pp. 276-277
-
-
Rice, P.1
Longden, I.2
Bleasby, A.3
-
41
-
-
2642549707
-
-
Shi L, Zhang Q, Rui W, Lu M, Jing X, Shang T, Tang J. Bio PD: a web-based information center for bioactive peptides. Regul, Pept. 2004; 120: 1-3.
-
Shi L, Zhang Q, Rui W, Lu M, Jing X, Shang T, Tang J. Bio PD: a web-based information center for bioactive peptides. Regul, Pept. 2004; 120: 1-3.
-
-
-
-
42
-
-
24944474686
-
Efficiency and limits of the serial analysis of gene expression (SAGE) method: Discussions based on first results in bovine trypanotolerance
-
Maillard JC, Berthier D, Thevenon S, Piquemal D, Chantal I, Marti J. Efficiency and limits of the serial analysis of gene expression (SAGE) method: discussions based on first results in bovine trypanotolerance. Vet. Immunol. Immunopathol. 2005; 108: 59-69.
-
(2005)
Vet. Immunol. Immunopathol
, vol.108
, pp. 59-69
-
-
Maillard, J.C.1
Berthier, D.2
Thevenon, S.3
Piquemal, D.4
Chantal, I.5
Marti, J.6
-
43
-
-
32944469603
-
The KISS1 metastasis suppressor: Mechanistic insights and clinical utility
-
Nash KT, Welch DR. The KISS1 metastasis suppressor: mechanistic insights and clinical utility. Front. Biosci. 2006; 11: 647-659.
-
(2006)
Front. Biosci
, vol.11
, pp. 647-659
-
-
Nash, K.T.1
Welch, D.R.2
|