Nicotine enhances the cyclic AMP-dependent protein kinase-mediated phosphorylation of α4 subunits of neuronal nicotinic receptors

Journal of Neurochemistry

Volumn 69, Issue 6, 1997, Pages 2427-2431

  Hsu, Yea Nan ^a   Edwards, Samuel C ^a   Wecker, Lynn ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Cyclic AMP dependent protein kinase; Neuronal nicotinic receptor; Nicotine; Phosphorylation; Xenopus oocytes

Indexed keywords

CYCLIC AMP; NICOTINIC RECEPTOR; PROTEIN KINASE C;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CATALYSIS; ELECTROPHORESIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENTIAL ANALYSIS; TORPEDO; XENOPUS;

ANIMALIA;

EID: 0030722148     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69062427.x     Document Type: Article

References (23)

1. Anand R., Conroy W. G., Schoepfer R., Whiting P., and Lindstrom J. (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J. Biol. Chem. 266, 11192-11198.
2. Downing J. E. G. and Role L. W. (1987) Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons. Proc. Natl. Acad. Sci. USA 84, 7739-7743.
3. Ellena J. F., Blazing M. A., and McNamee M. G. (1983) Lipid-protein interactions in reconstituted membranes containing acetylcholine receptor. Biochemistry 22, 5523-5535.
4. Flores C. M., Rogers S. W., Pabreza L. A., Wolfe B. B., and Kellar K. J. (1992) A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol. 41, 31-37.
5. Forn J. and Greengard P. (1978) Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices. Proc. Natl. Acad. Sci. USA 75, 5195-5199.
6. Heinemann S., Boulter J., Connolly J., Deneris E., Duvoisin R., Hartley M., Hermans-Borgmeyer I., Hollmann M., O'Shea-Greenfield A., Papke R., Rogers S., and Patrick J. (1991) The nicotinic receptor genes. Clin. Neuropharmacol. 14 (Supp. 1), S45-S61.
7. Hoffman P. W., Ravindran A., and Huganir R. L. (1994) Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes. J. Neurosci. 14, 4185-4195.
8. Hsu Y.-N., Amin J., Weiss D. S., and Wecker L. (1996) Sustained nicotine exposure differentially affects α3β2 and α4β2 neuronal nicotinic receptors expressed in Xenopus oocytes. J. Neurochem. 66, 667-675.
9. Huganir R. L., Delcour A. H., Greengard P., and Hess G. P. (1986) Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature 321, 774-776.
10. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277, 680-685.
11. Levitan I. B. (1994) Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu. Rev. Physiol. 56, 193-212.
12. Luetje C. W. and Patrick J. (1991) Both α-and α-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J. Neurosci. 11, 837-845.
13. Marley P.D., Thomson K. A., and Bralow R. A. (1995) Protein kinase A and nicotinic activation of bovine adrenal tyrosine hydroxylase. Br. J. Pharmacol. 114, 1687-1693.
14. Moss S. J., McDonald B. J., Rudhard Y., and Schoepfer R. (1996) Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor α7 subunit by cAMP-dependent protein kinase. Neuropharmacology 35, 1023-1028.
15. Nakayama H., Nakashima T., and Kurogochi Y. (1991) α-4 is a major acetylcholine binding subunit of cholinergic ligand affinity-purified nicotinic acetylcholine receptor from rat brains. Neurosci. Lett. 121, 122-124.
16. Nakayama H., Okuda H., and Nakayama T. (1993) Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro. Mol. Brain Res. 20, 171-177.
17. Ochoa E. L. M. and O'Shea S. M. (1994) Concomitant protein phosphorylation and endogenous acetylcholine release induced by nicotine: dependency on neuronal nicotinic receptors and desensitization. Cell. Mol. Neurobiol. 14, 315-340.
18. Schulz D.W. and Zigmond R. E. (1989) Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum. Neurosci. Lett. 98, 310-316.
19. Swope S. L., Qu Z., and Huganir R. L. (1995) Phosphorylation of the nicotinic acetylcholine receptor by protein tyrosine kinases. Ann. NY Acad. Sci. 757, 197-214.
20. Vijayaraghavan S., Schmid H. A., Halvorsen S. W., and Berg D. K. (1990) Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor a-type subunit. J. Neurosci. 10, 3255-3262.
21. Wada E., Wada K., Boulter J., Deneris E., Heinemann S., Patrick J., and Swanson L. W. (1989) Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in rat. J. Comp. Neurol. 284, 314-335.
22. Wilkie G. I., Hutson P. H., Stephens M. W., Whiting P., and Wonnacott S. (1993) Hippocampal nicotinic autoreceptors modulate acetylcholine release. Biochem. Soc. Trans. 21, 429-431.
23. Yu Z. J. and Wecker L. (1994) Chronic nicotinic administration differentially affects neurotransmitter release from rat striatal slices. J. Neurochem. 63, 186-194.