Structural effect of a recombinant monoclonal antibody on hinge region peptide bond hydrolysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 858, Issue 1-2, 2007, Pages 254-262

  Xiang, Tao ^a   Lundell, Edwin ^a   Sun, Zuping ^a   Liu, Hongcheng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Hinge region; Hydrolysis; Mass spectrometry; Recombinant monoclonal antibody

Indexed keywords

HINGE REGION; RECOMBINANT MONOCLONAL ANTIBODY;

AMINO ACIDS; CHEMICAL BONDS; HYDROLYSIS; MASS SPECTROMETRY; PEPTIDES;

MONOCLONAL ANTIBODIES;

EDETIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; PROTEINASE INHIBITOR; RECOMBINANT ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTIBODIES, MONOCLONAL; EDETIC ACID; HUMANS; HYDROLYSIS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MODELS, BIOLOGICAL; PEPTIDES; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 34848897171     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.08.043     Document Type: Article

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