Interleukin-7 immunotherapy

Advances in Experimental Medicine and Biology

Volumn 601, Issue , 2007, Pages 321-333

  Sportès, Claude ^a   Gress, Ronald E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; CYTOKINE; INTERLEUKIN 7;

ANIMAL; BIOLOGICAL MODEL; CLINICAL TRIAL; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOTHERAPY; KINETICS; METABOLISM; METHODOLOGY; NEOPLASM; PHYSIOLOGY; REVIEW;

ANIMALS; BIOLOGICAL RESPONSE MODIFIERS; CLINICAL TRIALS; CYTOKINES; HUMANS; IMMUNE SYSTEM; IMMUNOLOGIC MEMORY; IMMUNOTHERAPY; INTERLEUKIN-7; KINETICS; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 34848875495     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-72005-0_35     Document Type: Conference Paper

References (56)

1. Akashi, K., Kondo, M., Freeden-Jeffry, U., Murray, R. and Weissman, I.L. (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89, 1033-1041.
2. Alderson, M.R., Tough, T.W., Ziegler, S.F. and Grabstein, K.H. (1991) Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J. Exp. Med. 173, 923-930.
3. Appasamy, P.M. (1999) Biological and clinical implications of interleukin-7 and lymphopoiesis. Cytokines Cell Mol. Ther. 5, 25-39.
4. Bohm, M., Moller, P., Kalbfleisch, U., Worm, M., Czarnetzki, B.M. and Schadendorf, D. (1994) Lysis of allogeneic and autologous melanoma cells by IL-7-induced lymphokineactivated killer cells. Br. J. Cancer 70, 54-59.
5. Bolotin, E., Annett, G., Parkman, R. and Weinberg, K. (1999) Serum levels of IL-7 in bone marrow transplant recipients: Relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 23, 783-788.
6. Dittel, B.N. and LeBien, T.W. (1995) The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J. Immunol. 154, 58-67.
7. Douek, D.C., Vescio, R.A., Betts, M.R., Brenchley, J.M., Hill, B.J., Zhang, L., Berenson, J.R., Collins, R.H. and Koup, R.A. (2000) Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T cell reconstitution. Lancet 355, 1875-1881.
8. El Kassar, N., Lucas, P.J., Klug, D.B., Zamisch, M., Merchant, M., Bare, C.V., Choudhury, B., Sharrow, S.O., Richie, E., Mackall, C.L. and Gress, R.E. (2004) A dose effect of IL-7 on thymocyte development. Blood 104, 1419-1427.
9. Fisher, A.G., Burdet, C., Bunce, C., Merkenschlager, M. and Ceredig, R. (1995) Lymphoproliferative disorders in IL-7 transgenic mice: Expansion of immature B cells which retain macrophage potential. Int. Immunol. 7, 415-423.
10. Freeden-Jeffry, U., Vieira, P., Lucian, L.A., McNeil, T., Burdach, S.E. and Murray, R. (1995) Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181, 1519-1526.
11. Fry, T.J., Connick, E., Falloon, J., Lederman, M.M., Liewehr, D.J., Spritzler, J., Steinberg, S.M., Wood, L.V., Yarchoan, R., Zuckerman, J., Landay, A. and Mackall, C.L. (2001) A potential role for interleukin-7 in T cell homeostasis. Blood 97, 2983-2990.
12. Fry, T.J. and Mackall, C.L. (2002) Interleukin-7: From bench to clinic. Blood 99, 3892-3904.
13. Fry, T.J., Moniuszko, M., Creekmore, S., Donohue, S.J., Douek, D.C., Giardina, S., Hecht, T.T., Hill, B.J., Komschlies, K., Tomaszewski, J., Franchini, G. and Mackall, C.L. (2003) IL-7 therapy dramatically alters peripheral T cell homeostasis in normal and SIV-infected nonhuman primates. Blood 101, 2294-2299.
14. Goodwin, R.G., Lupton, S., Schmierer, A., Hjerrild, K.J., Jerzy, R., Clevenger, W., Gillis, S., Cosman, D. and Namen, A.E. (1989) Human interleukin 7: Molecular cloning and growth factor activity on human and murine B-lineage cells. Proc. Natl. Acad. Sci. USA 86, 302-306.
15. Hakim, F.T., Cepeda, R., Kaimei, S., Mackall, C.L., McAtee, N., Zujewski, J., Cowan, K. and Gress, R.E. (1997) Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 90, 3789-3798.
16. Hakim, F.T. and Gress, R.E. (2005) Reconstitution of the lymphocyte compartment after lymphocyte depletion: A key issue in clinical immunology. Eur. J. Immunol. 35, 3099-3102.
17. Hakim, F.T., Memon, S.A., Cepeda, R., Jones, E.C., Chow, C.K., Kasten-Sportes, C., Odom, J., Vance, B.A., Christensen, B.L., Mackall, C.L. and Gress, R.E. (2005) Age-dependent incidence, time course, and consequences of thymic renewal in adults. J. Clin. Invest 115, 930-939.
18. Hofmeister, R., Khaled, A.R., Benbernou, N., Rajnavolgyi, E., Muegge, K. and Durum, S.K. (1999) Interleukin-7: Physiological roles and mechanisms of action. Cytokine Growth Factor Rev. 10, 41-60.
19. Komschlies, K.L., Back, T.T., Gregorio, T.A., Gruys, M.E., Damia, G., Wiltrout, R.H. and Faltynek, C.R. (1994a) Effects of rhIL-7 on leukocyte subsets in mice: Implications for antitumor activity. Immunol. Ser. 61, 95-104.
20. Komschlies, K.L., Gregorio, T.A., Gruys, M.E., Back, T.C., Faltynek, C.R. and Wiltrout, R.H. (1994b) Administration of recombinant human IL-7 to mice alters the composition of Blineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases. J. Immunol. 152, 5776-5784.
21. Komschlies, K.L., Grzegorzewski, K.J. and Wiltrout, R.H. (1995) Diverse immunological and hematological effects of interleukin 7: Implications for clinical application. J. Leukoc. Biol. 58, 623-633.
22. Liu, W., Putnam, A.L., Xu-Yu, Z., Szot, G.L., Lee, M.R., Zhu, S., Gottlieb, P.A., Kapranov, P., Gingeras, T.R., Fazekas De Groth, B., Clayberger, C., Soper, D.M., Ziegler, S.F. and Bluestone, J.A. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203, 1701-1711.
23. Macchi, P., Villa, A., Giliani, S., Sacco, M.G., Frattini, A., Porta, F., Ugazio, A.G., Johnston, J.A., Candotti, F. and O'Shea, J.J. (1995) Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377, 65-68.
24. Mackall, C.L. (2000) T cell immunodeficiency following cytotoxic antineoplastic therapy: A review. Stem Cells 18, 10-18.
25. Mackall, C.L., Bare, C.V., Granger, L.A., Sharrow, S.O., Titus, J.A. and Gress, R.E. (1996) Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J. Immunol. 156, 4609-4616.
26. Mackall, C.L., Fleisher, T.A., Brown, M.R., Andrich, M.P., Chen, C.C., Feuerstein, I.M., Horowitz, M.E., Magrath, I.T., Shad, A.T., Steinberg, S.M., Wexler, L.H. and Gress, R.E. (1995) Age, thymopoiesis, and CD4+ T lymphocyte regeneration after intensive chemotherapy [see comments]. N. Engl. J. Med. 332, 143-149.
27. Mackall, C.L., Fleisher, T.A., Brown, M.R., Andrich, M.P., Chen, C.C., Feuerstein, I.M., Magrath, I.T., Wexler, L.H., Dimitrov, D.S. and Gress, R.E. (1997) Distinctions between CD8+ and CD4+ T cell regenerative pathways result in prolonged T cell subset imbalance after intensive chemotherapy. Blood 89, 3700-3707.
28. Mackall, C.L., Fleisher, T.A., Brown, M.R., Magrath, I.T., Shad, A.T., Horowitz, M.E., Wexler, L.H., Adde, M.A., McClure, L.L. and Gress, R.E. (1994) Lymphocyte depletion during treatment with intensive chemotherapy for cancer. Blood 84, 2221-2228.
29. Mackall, C.L., Granger, L., Sheard, M.A., Cepeda, R. and Gress, R.E. (1993) T cell regeneration after bone marrow transplantation-differential CD45 isoform expression on thymicderived versus thymic-independent progeny. blood 82, 2585-2594.
30. Mackall, C.L. and Gress, R.E. (1997) Pathways of T cell regeneration in mice and humans: Implications for bone marrow transplantation and immunotherapy. Immunol. Rev. 157, 61-72.
31. Maraskovsky, E., O'Reilly, L.A., Teepe, M., Corcoran, L.M., Peschon, J.J. and Strasser, A. (1997) Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor- deficient mice but not in mutant rag-1-/- mice. Cell 89, 1011-1019.
32. Melchionda, F., Fry, T.J., Milliron, M.J., McKirdy, M.A., Tagaya, Y. and Mackall, C.L. (2005) Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool. J. Clin. Invest. 115, 1177-1187.
33. Morrissey, P.J., Conlon, P., Charrier, K., Braddy, S., Alpert, A., Williams, D., Namen, A.E. and Mochizuki, D. (1991) Administration of IL-7 to normal mice stimulates Blymphopoiesis and peripheral lymphadenopathy. J. Immunol. 147, 561-568.
34. Muegge, K., Vila, M.P. and Durum, S.K. (1993) Interleukin-7: A cofactor for V(DJ) rrearrangement of the T cell receptor β gene. Science 261, 93-95.
35. Murphy, W.J. and Longo, D.L. (1997) The potential role of NK cells in the separation of graftversus- tumor effects from graft-versus-host disease after allogeneic bone marrow transplantation. Immunol. Rev. 157, 167-176.
36. Murray, R., Suda, T., Wrighton, N., Lee, F. and Zlotnik, A. (1989) IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int. Immunol. 1, 526-531.
37. Napolitano, L.A., Grant, R.M., Deeks, S.G., Schmidt, D., De Rosa, S.C., Herzenberg, L.A., Herndier, B.G., Andersson, J. and McCune, J.M. (2001) Increased production of IL-7 accompanies HIV-1-mediated T cell depletion: Implications for T cell homeostasis. Nat. Med. 7, 73-79.
38. Noguchi, M., Nakamura, Y., Russell, S.M., Ziegler, S.F., Tsang, M., Cao, X. and Leonard, W.J. (1993a) Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor [see comments]. Science 262, 1877-1880.
39. Noguchi, M., Yi, H., Rosenblatt, H.M., Filipovich, A.H., Adelstein, S., Modi, W.S., McBride, O.W. and Leonard, W.J. (1993b) Interleukin-2 receptor gamma chain mutation results in Xlinked severe combined immunodeficiency in humans. Cell 73, 147-157.
40. Park, J.H., Yu, Q., Erman, B., Appelbaum, J.S., Montoya-Durango, D., Grimes, H.L. and Singer, A. (2004) Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: A novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21, 289-302.
41. Peschon, J.J., Morrissey, P.J., Grabstein, K.H., Ramsdell, F.J., Maraskovsky, E., Gliniak, B.C., Park, L.S., Ziegler, S.F., Williams, D.E. and Ware, C.B. (1994) Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960.
42. Plum, J., De Smedt, M., Leclercq, G., Verhasselt, B. and Vandekerckhove, B. (1996) Interleukin- 7 is a critical growth factor in early human T cell development. Blood 88, 4239-4245.
43. Prieyl, J.A. and LeBien, T.W. (1996) Interleukin 7 independent development of human B cells. Proc. Natl. Acad. Sci. USA 93, 10348-10353.
44. Puel, A., Ziegler, S.F., Buckley, R.H. and Leonard, W.J. (1998) Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat. Genet. 20, 394-397.
45. Rodewald, H.R. and Fehling, H.J. (1998) Molecular and cellular events in early thymocyte development. Adv. Immunol. 69, 1-112.
46. Russell, S.M., Tayebi, N., Nakajima, H., Riedy, M.C., Roberts, J.L., Aman, M.J., Migone, T.S., Noguchi, M., Markert, M.L. and Buckley, R.H. (1995) Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development. Science 270, 797-800.
47. Sakata, T., Iwagami, S., Tsuruta, Y., Teraoka, H., Tatsumi, Y., Kita, Y., Nishikawa, S., Takai, Y. and Fujiwara, H. (1990) Constitutive expression of interleukin-7 mRNA and production of IL-7 by a cloned murine thymic stromal cell line. J. Leukoc. Biol. 48, 205-212.
48. Samaridis, J., Casorati, G., Traunecker, A., Iglesias, A., Gutierrez, J.C., Muller, U. and Palacios, R. (1991) Development of lymphocytes in interleukin 7-transgenic mice. Eur. J. Immunol. 21, 453-460.
49. Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S.I., Nanan, R., Kelleher, A. and Fazekas De Groth, B. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203, 1693-1700.
50. Sportes, C., McCarthy, N.J., Hakim, F., Steinberg, S.M., Liewehr, D.J., Weng, D., Kummar, S., Gea-Banacloche, J., Chow, C.K., Dean, R.M., Castro, K.M., Marchigiani, D., Bishop, M.R., Fowler, D.H. and Gress, R.E. (2005) Establishing a platform for immunotherapy: Clinical outcome and study of immune reconstitution after high-dose chemotherapy with progenitor cell support in breast cancer patients. Biol. Blood Marrow Transplant. 11, 472-483.
51. Sudo, T., Ito, M., Ogawa, Y., Iizuka, M., Kodama, H., Kunisada, T., Hayashi, S., Ogawa, M., Sakai, K. and Nishikawa, S. (1989) Interleukin 7 production and function in stromal celldependent B cell development. J. Exp. Med. 170, 333-338.
52. Sudo, T., Nishikawa, S., Ohno, N., Akiyama, N., Tamakoshi, M., Yoshida, H. and Nishikawa, S. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA 90, 9125-9129.
53. Talmadge, J.E., Jackson, J.D., Kelsey, L., Borgeson, C.D., Faltynek, C. and Perry, G.A. (1993) T cell reconstitution by molecular, phenotypic, and functional analysis in the thymus, bone marrow, spleen, and blood following split-dose polychemotherapy and therapeutic activity for metastatic breast cancer in mice. J. Immunother. 14, 258-268.
54. Tan, J.T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K.I. and Surh, C.D. (2001) IL-7 is critical for homeostatic proliferation and survival of na ve T cells. Proc. Natl. Acad. Sci. USA 98, 8732-8737.
55. Wiryana, P., Bui, T., Faltynek, C.R. and Ho, R.J. (1997) Augmentation of cell-mediated immunotherapy against herpes simplex virus by interleukins: Comparison of in vivo effects of IL-2 and IL-7 on adoptively transferred T cells. Vaccine 15, 561-563.
56. Yeoman, H., Clark, D.R. and DeLuca, D. (1996) Development of CD4 and CD8 single positive T cells in human thymus organ culture: IL-7 promotes human T cell production by supporting immature T cells. Dev. Comp. Immunol. 20, 241-263.