Neosporosis in Beagle dogs: Clinical signs, diagnosis, treatment, isolation and genetic characterization of Neospora caninum

Veterinary Parasitology

Volumn 149, Issue 3-4, 2007, Pages 158-166

  Dubey, J P ^a   Vianna, M C B ^a   Kwok, O C H ^a   Hill, D E ^a   Miska, K B ^a   Tuo, W ^a   Velmurugan, G V ^a   Conors, M ^b   Jenkins, M C ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b Pamela Pictures LLC   (United States)

Author keywords

Bradyzoites; Cell culture; Clinical signs; Gerbils; Isolation; Mice; Neospora caninum; Neosporosis; Sequence analysis

Indexed keywords

CLINDAMYCIN; GAMMA INTERFERON; PARASITE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BIOASSAY; BRADYZOITE; CELL CULTURE; CLINICAL EXAMINATION; CLINICAL FEATURE; CONTROLLED STUDY; DOG; FEMALE; GENE SEQUENCE; GENETIC ANALYSIS; GERBIL; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIMB WEAKNESS; MALE; NEOSPORA CANINUM; NONHUMAN; PARASITE ISOLATION; PARASITE VIABILITY; PARASITOSIS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEROLOGY; TACHYZOITE; TREATMENT DURATION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIPROTOZOAL AGENTS; BASE SEQUENCE; CLINDAMYCIN; COCCIDIOSIS; DNA, INTERGENIC; DOG DISEASES; DOGS; MOLECULAR SEQUENCE DATA; NEOSPORA;

CANIS FAMILIARIS; GERBILLINAE; MUS; NEOSPORA CANINUM;

EID: 34848870593     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2007.08.013     Document Type: Article

References (31)

1. Barber J.S., Holmdahl O.J.M., Owen M.R., Guy F., Uggla A., and Trees A.J. Characterization of the first European isolate of Neospora caninum (Dubey, Carpenter, Speer, Topper and Uggla). Parasitology 111 (1995) 563-568
2. Barber J.S., and Trees A.J. Clinical aspects of 27 cases of neosporosis in dogs. Vet. Rec. 139 (1996) 439-443
3. Basso W., Venturini L., Venturini M.C., Hill D.E., Kwok O.C.H., Shen S.K., and Dubey J.P. First isolation of Neospora caninum from the feces of a naturally infected dog. J. Parasitol. 87 (2001) 612-618
4. Bjerkås I., Mohn S.F., and Presthus J. Unidentified cyst-forming sporozoon causing encephalomyelitis and myositis in dogs. Z. Parasitenk. 70 (1984) 271-274
5. Buxton D., Maley S.W., Wright S., Thomson K.M., Rae A.G., and Innes E.A. The pathogenesis of experimental neosporosis in pregnant sheep. J. Comp. Path. 118 (1998) 267-279
6. Cuddon P., Lin D.S., Bowman D.D., Lindsay D.S., Miller T.K., Duncan I.D., DeLahunta A., Cummings J., Suter M., Cooper B., King J.M., and Dubey J.P. Neospora caninum infection in English springer spaniel littermates: diagnostic evaluation and organism isolation. J. Vet. Intern. Med. 6 (1992) 325-332
7. Dubey J.P. Review of Neospora caninum and neosporosis in animals. Korean J. Parasitol. 41 (2003) 1-16
8. Dubey J.P., Carpenter J.L., Speer C.A., Topper M.J., and Uggla A. Newly recognized fatal protozoan disease of dogs. J. Am. Vet. Med. Assoc. 192 (1988) 1269-1285
9. Dubey J.P., and Desmonts G. Serological responses of equids fed Toxoplasma gondii oocysts. Equine Vet. J. 19 (1987) 337-339
10. Dubey J.P., Dorough K.R., Jenkins M.C., Liddell S., Speer C.A., Kwok O.C.H., and Shen S.K. Canine neosporosis: clinical signs, diagnosis, treatment and isolation of Neospora caninum in mice and cell culture. Int. J. Parasitol. 28 (1998) 1293-1304
11. Dubey J.P., Garner M.M., Stetter M.D., Marsh A.E., and Barr B.C. Acute Sarcocystis falcatula-like infection in a carmine bee-eater (Merops nubicus) and immunohistochemical cross reactivity between Sarcocystis falcatula and Sarcocystis neurona. J. Parasitol. 87 (2001) 824-831
12. Dubey J.P., Hattel A.L., Lindsay D.S., and Topper M.J. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. J. Am. Vet. Med. Assoc. 193 (1988) 1259-1263
13. Dubey J.P., Knickman E., and Greene C.E. Neonatal Neospora caninum infections in dogs. Acta Parasitol. 50 (2005) 176-179
14. Dubey J.P., and Lindsay D.S. A review of Neospora caninum and neosporosis. Vet. Parasitol. 67 (1996) 1-59
15. Dubey J.P., Metzger, Hattel A.L., Lindsay D.S., and Fritz D.L. Canine cutaneous neosporosis: clinical improvement with clindamycin. Vet. Dermatol. 6 (1995) 37-43
16. Dubey J.P., and Schares G. Diagnosis of bovine neosporosis. Vet. Parasitol. 140 (2006) 1-34
17. Dubey J.P., and Sreekumar C. Redescription of Hammondia hammondi and its differentiation from Toxoplasma gondii. Int. J. Parasitol. 33 (2003) 1437-1453
18. Dubey J.P., Sreekumar C., Knickman E., Miska K.B., Vianna M.C.B., Kwok O.C.H., Hill D.E., Jenkins M.C., Lindsay D.S., and Greene C.E. Biologic, morphologic, and molecular characterisation of Neospora caninum isolates from littermate dogs. Int. J. Parasitol. 34 (2004) 1157-1167
19. Dubey J.P., Schares G., and Ortega L.M. Epidemiology of neosporosis and Neospora caninum. Clin. Microbiol. Rev. 20 (2007) 323-367
20. Gondim L.F.P., Pinheiro A.M., Santos P.O.M., Jesus E.E.V., Ribeiro M.B., Fernandes H.S., Almeida M.A.O., Freire S.M., Meyer R., and McAllister M.M. Isolation of Neospora caninum from the brain of a naturally infected dog, and production of encysted bradyzoites in gerbils. Vet. Parasitol. 101 (2001) 1-7
21. Hay W.H., Shell L.G., Lindsay D.S., and Dubey J.P. Diagnosis and treatment of Neospora caninum infection in a dog. J. Am. Vet. Med. Assoc. 197 (1990) 87-89
22. Jenkins M.C., Fetterer R., Schares G., Björkman C., Wapenaar W., McAllister M., and Dubey J.P. HPLC purification of recombinant NcGRA6 antigen improves enzyme-linked immunosorbent assay for serodiagnosis of bovine neosporosis. Vet. Parasitol. 131 (2005) 227-234
23. Lindsay D.S., and Dubey J.P. Immunohistochemical diagnosis of Neospora caninum in tissue sections. Am. J. Vet. Res. 50 (1989) 1981-1983
24. Lindsay D.S., and Dubey J.P. Canine neosporosis. J. Vet. Parasitol. 14 (2000) 1-11
25. Lindsay D.S., Rippey N.S., Cole R.A., Parsons L.C., Dubey J.P., Tidwell R.R., and Blagburn B.L. Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells. Am. J. Vet. Res. 55 (1994) 976-981
26. Marsh A.E., Barr B.C., Packham A.E., and Conrad P.A. Description of a new Neospora species (Protozoa: Apicomplexa: Sarcocystidae). J. Parasitol. 84 (1998) 983-991
27. McAllister M.M., Parmley S.F., Weiss L.M., Welch V.J., and McGuire A.M. An immunohistochemical method for detecting bradyzoite antigen (BAG5) in Toxoplasma gondii-infected tissues cross-reacts with a Neospora caninum bradyzoite antigen. J. Parasitol. 82 (1996) 354-355
28. McInnes L.M., Irwin P., Palmer D.G., and Ryan U.M. In vitro isolation and charcterisation of the first canine Neospora caninum isolate in Australia. Vet. Parasitol. 137 (2006) 355-363
29. Peters M., Wagner F., and Schares G. Canine neosporosis: clinical and pathological findings and first isolation of Neospora caninum in Germany. Parasitol. Res. 86 (2000) 1-7
30. Romand S., Thulliez P., and Dubey J.P. Direct agglutination test for serologic diagnosis of Neospora caninum infection. Parasitol. Res. 84 (1998) 50-53
31. Schares G., pantchev N., Barutzki D., Heydorn A.O., Bauer C., and Conraths F.J. Oocysts of Neospora caninum, Hammondia heydorni, Toxoplasma gondii and Hammondida hammondi in faeces collected from dogs in Germany. Int. J. Parasitol. 35 (2005) 1525-1537