The sinoatrial node: Cell size does matter

Circulation Research

Volumn 101, Issue 7, 2007, Pages

  Boyett, M R ^a   Honjo, H ^b   Kodama, I ^b   Lancaster, M K ^c   Lei, M ^a   Musa, H ^a   Zhang, H ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NAGOYA UNIVERSITY   (Japan)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CONNEXIN 43; GAP JUNCTION PROTEIN; SODIUM CHANNEL; TETRODOTOXIN;

CELL SIZE; ELECTROPHYSIOLOGY; ENDOCARDIUM; LETTER; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SINUS NODE; SINUS NODE MEMBRANE POTENTIAL; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; CELL SIZE; HUMANS; SINOATRIAL NODE;

EID: 34848846327     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.161190     Document Type: Letter

References (15)

1. Lyashkov AE, Juhaszova M, Dobrzynski H, Vinogradova TM, Maltsev VA, Juhasz O, Spurgeon HA, Sollott SJ, Lakatta EG. Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size. Circ Res. 2007;100:1723-1731.
2. Honjo H, Boyett MR, Kodama I, Toyama J. Correlation between electrical activity and the size of rabbit sinoatrial node cells. J Physiol. 1996;496:795-808.
3. Honjo H, Lei M, Boyett MR, Kodama I. Heterogeneity of 4-aminopyridine sensitive current in rabbit sinoatrial node cells. Am J Physiol. 1999;276:H1295-H1304.
4. + current in rabbit sinoatrial node cells. Cardiovasc Res. 2000;46:433-441.
5. Zhang H, Holden AV, Kodama I, Honjo H, Lei M, Varghese T, Boyett MR. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am J Physiol. 2000;279:H397-H421.
6. K,s, in rabbit sinoatrial node cells. J Physiol. 2001;535:703-714.
7. Honjo H, Boyett MR, Coppen SR, Takagishi Y, Opthof T, Severs NJ, Kodama I. Heterogeneous expression of connexins in rabbit sinoatrial node cells: correlation between connexin isotype and cell size. Cardiovasc Res. 2002;53:89-96.
8. 2+ handling proteins in sinoatrial node. J Histochem Cytochem. 2002;50:311-324.
9. 2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control. J Physiol. 2004;556:481-494.
10. Kodama I, Boyett MR. Regional differences in the electrical activity of the rabbit sinus node. Pflügers Arch. 1985;404:214-226.
11. + currents in pacemaker activity in the sinoatrial node. Am J Physiol. 1997;272:H2793-H2806.
12. Tellez JO, Dobrzynski H, Greener ID, Graham GM, Laing E, Honjo H, Hubbard SJ, Boyett MR, Billeter R. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res. 2006;99:1384-1393.
13. Dobrzynski H, Lei M, Jones SA, Lancaster MK, Boyett MR. The gradient model of the rabbit sinoatrial node. Korean J Physiol Pharmacol. 2002;6:173-181.
14. Coppen SR, Kodama I, Boyett MR, Dobrzynski H, Takagishi Y, Honjo H, Yeh H-I, Severs NJ. Connexin45, a major connexin of the rabbit sinoatrial node, is co-expressed with connexin43 in a restricted zone at the nodal-crista terminalis border. J Histochem Cytochem. 1999;47:907-918.
15. Ren FX, Niu XL, Ou Y, Han ZH, Ling FD, Zhou SS, Li YJ. Morphological and electrophysiological properties of single myocardial cells from Koch triangle of rabbit heart. Chin Med J (Engl). 2006;119:2075-2084.