Gastroparesis in type 2 diabetes mellitus: Prevalence, etiology, diagnosis, and treatment

Current Gastroenterology Reports

Volumn 9, Issue 4, 2007, Pages 270-279

  Intagliata, Nicolas ^b   Koch, Kenneth L ^a  

^a WAKE FOREST BAPTIST HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; CISAPRIDE; DOMPERIDONE; ERYTHROMYCIN; GLIPIZIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INSULIN GLARGINE; LONG ACTING INSULIN; METOCLOPRAMIDE; MORPHINE; MOSAPRIDE CITRATE; OLIVE OIL; ORAL ANTIDIABETIC AGENT; PLACEBO; PRAMLINTIDE; PROKINETIC AGENT; PROTEINASE INHIBITOR; SHORT ACTING DRUG;

AUTONOMIC NEUROPATHY; CLINICAL TRIAL; COMORBIDITY; DIABETIC KETOACIDOSIS; DIET THERAPY; DISEASE ASSOCIATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG POTENTIATION; ELECTROGASTROGRAPHY; ELECTROSTIMULATION; GASTRIC DYSMOTILITY; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL RADIOGRAPHY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PREVALENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; STOMACH EMPTYING; STOMACH PARESIS; STOMACH SCINTISCANNING;

ANTIEMETICS; DIABETES MELLITUS, TYPE 2; DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM; DIET; ELECTRIC STIMULATION THERAPY; GASTRIC EMPTYING; GASTROPARESIS; HUMANS; PREVALENCE; WORLD HEALTH;

EID: 34848840091     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-007-0030-3     Document Type: Review

References (72)

1. WHO Diabetes Fact Sheet http://www.who.int/mediacentre/factsheets/ fs12/en/index.html Accessed February 6, 2007.
2. CDC: National Diabetes Fact Sheet http://www.cdc.gov/diabetes/ pubs/estimates05.htm#top Accessed February 6, 2007.
3. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006, 29(Suppl 1):S43-S8.
4. Rundles R: Diabetic neuropathy: general review with report of 125 cases. Medicine 1945, 24:111-160.
5. Kassander P: Asymptomatic gastric retention in diabetics (gastroparesis diabeticorum). Ann Intern Med 1958, 48:797-812.
6. Wooten RL, Meriwether TW III: Diabetic gastric atony: a clinical study. JAMA 1961, 176:1082-1087.
7. Feldman M, Schiller LR: Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 1983, 98:378-384.
8. Schvarcz E, Palmer M, Ingberg CM et al.: Increased prevalence of upper gastrointestinal symptoms in long-term type 1 diabetes mellitus. Diabet Med 1996, 13:478-481.
9. Maleki D, Locke GR III, Camilleri M, et al.: Gastrointestinal tract symptoms among persons with diabetes mellitus in the community. Arch Intern Med 2000, 160:2808-2816.
10. Janatuinen E, Pikkarainen P, Laakso M, Pyorala K: Gastrointestinal symptoms in middle-aged diabetic patients. Scand J Gastroenterol. 1993, 28:427-432.
11. Bytzer P, Talley NJ, Leemon M, et al.: Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 2001, 161:1989-1996.
12. Enck P, Rathmann W, Spiekermann M, et al.: Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. Z Gastroenterol 1994, 32:637-641.
13. Ko GT, Chan WB, Chan JC, et al.: Gastrointestinal symptoms in Chinese patients with Type 2 diabetes mellitus. Diabet Med 1999, 16:670-674.
14. Spangeus A, EI-Salhy M, Suhr O, et al.: Prevalence of gastrointestinal symptoms in young and middle-aged diabetic patients. Scand J Gastroenterol 1999, 34:1196-1202.
15. Ricci JA, Siddique R, Stewart WF, et al.: Upper gastrointestinal symptoms in a U.S. national sample of adults with diabetes. Scand J Gastroenterol 2000, 35:152-159.
16. Leatherdale BA, Green DJ, Harding LK, et al.: Guar and gastric emptying in non-insulin dependent diabetes. Acta Diabetol Lat 1982, 19:339-343.
17. Sasaki H, Nagulesparan M, Dubois A, et al.: Hypergastrinemia in obese noninsulin-dependent diabetes: a possible reflection of high prevalence of vagal dysfunction. J Clin Endocrinol Metab 1983, 56:744-750.
18. Horowitz M, Harding PE, Maddox AF, et al.: Gastric and oesophageal. emptying in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1989, 32:151-159.
19. Chang CS, Kao CH, Wang YS, et al.: Discrepant pattern of solid and liquid gastric emptying in Chinese patients with type II diabetes metlitus. Nucl Med Commun 1996, 17:60-65.
20. Tung CF, Chang CS, Chen GH, et al.: Comprehensive gastric emptying study for type-II diabetes mellitus dyspeptic patients. Scand J Gastroenterol 1997, 32:884-887.
21. Annese V, Bassorti G, Caruso N, et al.: Gastrointestinal motor dysfunction, symptoms, and neuropathy in noninsulin-dependent (type 2) diabetes mellitus. J Clin Gastroenterol 1999, 29(2):171-177.
22. Moldovan C, Dumitrascu DL, Demian L, et al.: Gastroparesis in diabetes mellitus: an ultrasonographic study. Rom J Gastroenterol 2005, 14:19-22.
23. Aylett P: Gastric emptying and change of blood glucose level, as affected by glucagon and insulin. Clin Sci 1962, 22:171-178.
24. MacGregor IL, Gueller R, Watts HD, Meyer JH: The effect of acute hyperglycemia on gastric emptying in man. Gastroenterology 1976, 70:190-196.
25. Fraser RJ, Horowitz M, Maddox AF, et al.: Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1990, 33:675-680.
26. Schvarcz E, Palmer M, Aman J, et al.: Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 1997, 113:60-66.
27. Velchik MG, Reynolds JC, Alavi A: The effect of meal energy content on gastric emptying. J Nucl Med 1989, 30:1106-1110.
28. Jones KL, Horowitz M, Carney BI, et al.: Gastric emptying in early noninsulin-dependent diabetes mellitus. J Nucl Med 1996, 37:1643-1648.
29. Iber FL, Parveen S, Vandrunen M, et al.: Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Dig Dis Sci 1993, 38:45-50.
30. Chang CS, Lien HC, Yeh HZ, et al.: Effect of cisapride on gastric dysrhythmia and emptying of indigestible solids in type-II diabetic patients. Scand J Gastroenterol 1998, 33:600-604.
31. Koch KL, Stern RM, Stewart WR, Vasey MW: Gastric emptying and gastric myoelectrical activity in patients with diabetic gastroparesis: effect of long-term domperidone treatment. Am J Gastroenterol 1989, 84:1069-1075.
32. Horowitz M, O'Donovan D, Jones KL, et al.: Gastric emptying in diabetes: clinical significance and treatment. Diabet Med 2002, 19:177-194.
33. Zhao J, Frokjaer JB, Drewes AM, et al.: Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. World J Gastroenterol 2006, 12:2846-2857.
34. Bytzer P, Talley NJ, Hammer J, et al.: GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications. Am J Gastroenterol 2002, 97:604-611.
35. Rathmann W, Enck P, Frieling T, Gries FA: Visceral afferent neuropathy in diabetic gastroparesis. Diabetes Care 1991, 14:1086-1089.
36. Buysschaert M, Moulart M, Urbain JL, et al.: Impaired gastric emptying in diabetic patients with cardiac autonomic neuropathy. Diabetes Care 1987, 10:448-452.
37. Migdalis L, Thomaides T, Chairopoulos C, et al.: Changes of gastric emptying rate and gastrin levels are early indicators of autonomic neuropathy in type II diabetic patients. Clin Auton Res 2001, 11:259-263.
38. Yoshida MM, Schuffler MD, Sumi SM: There are no morphologic abnormalities of the gastric wall or abdominal vagus in patients with diabetic gastroparesis. Gastroenterology 1988, 94:907-914.
39. Barnett JL, Owyang C: Serum glucose concentration as a modulator of interdigestive gastric motility. Gastroenterology 1988, 94:739-744.
40. Fraser R, Horowitz M, Dent J: Hyperglycaemia stimulates pyloric motility in normal subjects. Gut. 1991, 32(5): 475-8.
41. Jebbink RJ, Samsom M, Bruijs PP, et al.: Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type I diabetes mellitus. Gastroenterology 1994, 107:1390-1397.
42. Sogabe M, Okahisa T, Tsujigami K, et al.: Ultrasonographic assessment of gastric motility in diabetic gastroparesis before and after attaining glycemic control. J Gastroenterol 2005, 40:583-590.
43. Holzapfel A, Festa A, Stacher-Janotta G, et al.: Gastric emptying in type II (non-insulin-dependent) diabetes mellitus before and after therapy readjustment: no influence of actual blood glucose concentration. Diabetologia 1999, 42:1410-1412.
44. Smith U: Gastric emptying in type 2 diabetes: quick or slow? Diabet Med 1996, 13(Suppl 5):S31-S33.
45. Phillips WT, Schwartz JG, McMahan CA: Rapid gastric emptying of an oral glucose solution in type 2 diabetic patients. J Nucl Med 1992, 33:1496-1500.
46. Schwartz JG, Green GM, Guan D, et al.: Rapid gastric emptying of a solid pancake meal in type II diabetic patients. Diabetes Care 1996, 19:468-471.
47. Frank JW, Saslow SB, Camilleri M, et al.: Mechanism of accelerated gastric emptying of liquids and hyperglycemia in patients with type II diabetes mellitus. Gastroenterology 1995, 109:755-765.
48. Bertin E, Schneider N, Abdelli N, et al.: Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy. Diabetes Metab 2001, 27:357-364.
49. Weytjens C, Keymeulen B, Van Haleweyn C, et al.: Rapid gastric emptying of a liquid meal in long-term type 2 diabetes mellitus. Diabet Med 1998, 15:1022-1027.
50. Parkman HP, Hasler WL, Fisher RS: American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterology 2004, 127:1592-1622.
51. Tougas G, Eaker EY, Abell TL, et al.: Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol 2000, 95:1456-1462.
52. Kuo B MR, Koch K, Chey WD, et al.: SmartPill, a novel ambulatory diagnostic test for measuring gastric emptying in health and disease [abstract]. Presented at Digestive Disease Week; Los Angeles, CA; May 20-25, 2006.
53. Koch KL: Electrogastrography: physiological basis and clinical application in diabetic gastropathy. Diabetes Technol Ther 2001, 3:51-62.
54. Abell TL, Bernstein VK, Cutts T, et al.: Treatment of gastroparesis: a multidisciplinary clinical review. Neurogastroenterol Motil 2006, 18:263-283.
55. Kong MF, Horowitz M: Gastric emptying in diabetes mellitus: relationship to blood-glucose control. Clin Geriatr Med 1999, 15:321-338.
56. Groop LC, Luzi L, DeFronzo RA, Melander A: Hyperglycaemia and absorption of sulphonylurea drugs. Lancet 1989, 2:129-130.
57. Schwartz IG, Guan D, Green GM, Phillips WT: Treatment with an oral proteinase inhibitor slows gastric emptying and acutely reduces glucose and insulin levels after a liquid meal in type II diabetic patients. Diabetes Care 1994, 17:255-262.
58. Phillips WT, Schwartz JG, McMahan CA: Reduced postprandial blood glucose levels in recently diagnosed non-insulin-dependent diabetics secondary to pharmacologically induced delayed gastric emptying. Dig Dis Sci 1993, 38:51-58.
59. Gonlachanvit S, Hsu CW, Boden GH, et al.: Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients. Dig Dis Sci 2003, 48:488-497.
60. Thompson RG, Gottlieb A, Organ K, et al.: Pramlintide: a human amylin analogue reduced postprandial plasma glucose, insulin, and C-peptide concentrations in patients with type 2 diabetes. Diabet Med 1997, 14:547-555.
61. Willms B, Werner J, Holst JJ, et al.: Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 1996, 81:327-332.
62. Gentilcore D, Chaikomin R, Jones KL, et al.: Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes. J Clin Endocrinol Metab 2006, 91:2062-2067.
63. Monnier L, Lapinski H, Colette C: Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care 2003, 26:881-885.
64. Talley NJ: Diabetic gastropathy and prokinetics. Am J Gastroenterol 2003, 98:264-271.
65. Petrakis IE, Vrachassotakis N, Sciacca V, et al.: Hyperglycaemia attenuates erythromycin-induced acceleration of solid-phase gastric emptying in idiopathic and diabetic gastroparesis. Scand J Gastroenterol 1999, 34:396-403.
66. Ueno N, Inui A, Asakawa A, et al.: Erythromycin improves glycaemic control in patients with type II diabetes mellitus. Diabetologia 2000, 43:411-415.
67. Asakawa H, Hayashi I, Fukui T, Tokunaga K: Effect of mosapride on glycemic control and gastric emptying in type 2 diabetes mellitus patients with gastropathy. Diabetes Res Clin Pract 2003, 61:175-182.
68. Horowitz M, Jones KL, Harding PE, Wishart JM: Relationship between the effects of cisapride on gastric emptying and plasma glucose concentrations in diabetic gastroparesis. Digestion 2002, 65:41-46.
69. Lehmann R, Honegger RA, Feinle C, et al.: Glucose control is not improved by accelerating gastric emptying in patients with type 1 diabetes mellitus and gastroparesis. a pilot study with cisapride as a model drug. Exp Clin Endocrinol Diabetes 2003, 111:255-261.
70. Koch KL: Nausea and vomiting. In Therapy of Digestive Disorders. Edited by Wolfe MM. Philadelphia: WB Saunders Company; 2006: 1003-1016.
71. van der Voort IR, Becker JC, Died KH, et al.: Gastric electrical stimulation results in improved metabolic control in diabetic patients suffering from gastroparesis. Exp Clin Endocrinol Diabetes. 2005, 113:38-42.
72. Rees DA, Alcolado JC: Animal models of diabetes mellitus. Diabet Med 2005, 22, 359-370.