Erythromycin improves glycaemic control in patients with Type II diabetes mellitus

Diabetologia

Volumn 43, Issue 4, 2000, Pages 411-415

  Ueno, N ^a   Inui, A ^a   Asakawa, A ^a   Takao, F ^b   Tani, S ^b   Komatsu, Y ^b   Itoh, Z ^c   Kasuga, M ^a  

^a KOBE UNIVERSITY   (Japan)

^b Komatsu Hospital   (Japan)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

Erythromycin; Insulin; Motilide; Motilin; Type II diabetes mellitus

Indexed keywords

ERYTHROMYCIN LACTOBIONATE; ERYTHROMYCIN STEARATE; FRUCTOSAMINE; GLIBENCLAMIDE; GLICLAZIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; MOTILIN; RECEPTOR;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0034088918     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051323     Document Type: Article

References (17)

1. Itoh Z (1997) Motilin and clinical application. Peptides 18: 593-608
2. Peeters TL (1993) Erythromycin and other macrolides as prokinetic agents. Gastroenterology 105: 1886-1899
3. Coulie B, Tack J, Peeters, T Janssens J (1998) Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans. Gut 43: 395-400
4. Mochiki E, Inui A, Satoh M, Mizumoto A, Itoh Z (1997) Motilin is a biosignal controlling the cyclic release of pancreatic polypeptide via the vagus in fasted dogs. Am J Physiol 272: G224-G232
5. Suzuki H, Mochiki E, Haga N, Satoh M, Mizumoto A, Itoh Z (1998) Motilin controls cyclic release of insulin through vagal cholinergic muscarinic pathways in fasted dogs. Am J Physiol 274: G87-G95
6. Asakawa A, Inui A, Momose K, Ueno N, Fujino MA, Kasuga M (1998) Motilin increases food intake in mice. Peptides 19: 987-990
7. Okano H, Inui A, Ueno N et al. (1996) EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion. Peptides 17: 985-900
8. Nishino T, Kodaira T, Shin S et al. (1981) Glucagon radio-immunoassay with use of antiserum to glucagon C-terminal fragment. Clin Chem 27: 1690-1697
9. Fujimoto S, Inui A, Kiyota N et al. (1997) Increased cholecystokinin and pancreatic polypeptide responses to a fatrich meal in patients with restrictive but not bulimic anorexia nervosa. Biol Psychiatry 41: 1068-1070
10. Shiba Y, Mizumoto A, Satoh M, Inui A, Itoh Z, Omura S (1996) Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs. Gastroenterology 110: 241-250
11. Porte D Jr (1991) β cells in type II diabetes mellitus. Diabetes 40: 166-180
12. Strubbe JH, Steffens AB (1993) Neural control of insulin secretion. Horm Metab Res 25: 507-512
13. Feighner SD, Tan CP, McKee KK et al. (1999) Receptor for motilin identified in the human gastrointestinal system. Science 284: 2184-2188
14. Tannis AA, Baggen MG, Wiggers RH, Ouwendijk RJ (1993) Side-effects of oral erythromycin for treatment of diabetic gastroparesis. Lancet 342: 1431
15. Janssens J, Peeters TL, Vantrappen G et al. (1990) Improvement of gastric emptying in diabetic gastroparesis by erythromycin. N Eng J Med 322: 1028-1031
16. Richards RD, Davenport K, McCallum RW (1993) The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. Am J Gastroenterol 88: 203-207
17. Choi MG, Camilleri M, Burton DD, Johnson S, Edmonds A (1998) Dose-related effects of N-Demethyl-N-Isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal on gastric emptying of solids in healthy human volunteers. J Pharmacol Exp Ther 285: 37-40