A cross-strand Trp-Trp pair stabilizes the hPin1 WW domain at the expense of function

Protein Science

Volumn 16, Issue 10, 2007, Pages 2306-2313

  Jäger, Marcus ^a   Dendle, Maria ^a   Fuller, Amelia A ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

sheet; Protein engineering; Secondary structure propensity; Trp zipper; WW domain

Indexed keywords

HYDROGEN; INDOLE; LIGAND; MUTANT PROTEIN; PEPTIDYLPROLYL ISOMERASE PIN1; TRYPTOPHAN;

ARTICLE; BETA SHEET; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; HUMAN; HYDROGEN BOND; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN VARIANT; THERMODYNAMICS;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDYLPROLYL ISOMERASE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; TRYPTOPHAN;

EID: 34748874234     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.072904107     Document Type: Article

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