Ecstasy-induced reduction of the availability of the brain serotonin transporter as revealed by [11C](+)McN5652-PET and the multi-linear reference tissue model: Loss of transporters or artifact of tracer kinetic modelling?

Journal of Psychopharmacology

Volumn 21, Issue 6, 2007, Pages 628-634

  Buchert, Ralph ^a   Thiele, Frank ^b   Thomasius, Rainer ^a   Wilke, Florian ^a   Petersen, Kay ^a   Brenner, Winfried ^a   Mester, Janos ^a   Spies, Lothar ^b   Clausen, Malte ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b PHILIPS RESEARCH LABORATORIES   (Germany)

Author keywords

(+)McN5652; Ecstasy; Multi linear reference tissue method; PET; Serotonin transporter; Simplified reference tissue method

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; CARBON 11; ECSTASY; PSYCHEDELIC AGENT; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ARTIFACT REDUCTION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG USE; FEMALE; HUMAN; KINETICS; MAJOR CLINICAL STUDY; MALE; MULTI LINEAR REFERENCE TISSUE METHOD; NOISE REDUCTION; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REFERENCE VALUE; STATISTICAL ANALYSIS; THALAMUS;

ADULT; ARTIFACTS; BRAIN; CARBON RADIOISOTOPES; DATA INTERPRETATION, STATISTICAL; DOWN-REGULATION; FEMALE; HALLUCINOGENS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; ISOQUINOLINES; MALE; MODELS, BIOLOGICAL; MODELS, STATISTICAL; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE DISTRIBUTION;

EID: 34748864091     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881106071975     Document Type: Article

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