Quantification in positron emission tomography for research in pharmacology and drug development

Nuclear Medicine Communications

Volumn 25, Issue 7, 2004, Pages 643-646

  Cunningham, V J ^a   Gunn, R N ^a   Matthews, J C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Blood flow; Metabolic rate for glucose; Neuroreceptor function; Positron emission tomography; Quantification

Indexed keywords

GLUCOSE; ROLIPRAM; TRACER;

BIOCHEMISTRY; BLOOD BRAIN BARRIER; BLOOD FLOW VELOCITY; CONFERENCE PAPER; DRUG DISTRIBUTION; DRUG MECHANISM; GLUCOSE METABOLISM; HUMAN; IMAGING SYSTEM; IN VIVO STUDY; KINETICS; MEDICAL PRACTICE; METABOLIC RATE; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; VALIDATION PROCESS;

ALGORITHMS; ANIMALS; BRAIN; BRAIN MAPPING; DRUG DESIGN; FLUORODEOXYGLUCOSE F18; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; PHARMACOLOGY; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, SENSORY; RESEARCH;

EID: 3142626456     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/01.mnm.0000134330.38536.bc     Document Type: Article

References (14)

1. Crone C. The permeability of capillaries in various organs as determined by the use of the ‘indicator diffusion’ method. Acta Physiol Scand 1963; 58:103-113.
2. Kety SS. The theory and application of the exchange of inert gases at the lungs and tissues. Pharmacol Rev 1951; 3:1-41.
3. Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfield PM, Nutt J, et al. Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metab 1990; 10:675-686.
4. Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 1979; 6:371-388.
5. 14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 1977; 28:897-916.
6. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983; 3:1-7.
7. 18F-fluoro-2-deoxyglucose, the Patlak method, and an image-derived input function. J Cereb Blood Flow Metab 1998; 18:716-723.
8. Takikawa S, Dhawan V, Spetsieris P, Robeson W, Chaly T, Dahl R, et al. Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve. Radiology 1993; 188:131-136.
9. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15:217-227.
10. Gunn RN, Yap JT, Wells P, Osman S, Jones T, Cunningham VJ. A General method to correct PET data for tissue metabolites using a dual-scan approach. J Nucl Med 2000; 41:706-711.
11. Gunn RN, Gunn SR, Cunningham VJ. Positron emission tomography compartmental models. J Cereb Blood Flow Metab 2001; 21:635-652.
12. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 1997; 6:279-287.
13. 11C] Rolipram in man. J Cereb Blood Flow Metab 2004; 23:678.
14. Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 1992; 49:538-544.