Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity

CNS Drug Reviews

Volumn 13, Issue 3, 2007, Pages 296-307

  Ito, Yasushi ^a   Akao, Yukihiro ^b   Shimazawa, Masamitsu ^a   Seki, Norio ^c   Nozawa, Yoshinori ^b   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^c Gifu Prefectural Research Institute for Human Life Technology   (Japan)

Author keywords

Caspase; Endoplasmic reticulum; ER ER stress; Lig 8; Lignin; Mitochondria

Indexed keywords

AT LIGNOCRESOL; AT LIGNOPYROGALLOL; CASPASE 3; CASPASE 8; CASPASE 9; CM LIGNOCRESOL; HYDROGEN PEROXIDE; LIGNIN; LIGNIN 8; LIGNIN ALKALI; LIGNOCATECHOL; LIGNOPYROGALLOL; LIGNORESORCINOL; N METHYL DEXTRO ASPARTIC ACID; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PROTEASOME INHIBITOR; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TUNICAMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; BIOLOGICAL ACTIVITY; CELL PROTECTION; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; IN VITRO STUDY; IONIZING RADIATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; NERVE CELL LESION; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROTON NUCLEAR MAGNETIC RESONANCE; RETINA INJURY; REVIEW;

ANIMALS; APOPTOSIS; BAMBUSA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGNIN; NECROSIS; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS;

EID: 34748855512     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.2007.00017.x     Document Type: Review

References (25)

1. Akao Y, Seki N, Nakagawa Y, Yi H, Matsumoto K, Ito Y, Ito K, Funaoka M, Maruyama W, Naoi M, et al 2004) A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Bioorg Med Chem 12 : 4791 4801.
2. DeGracia DJ, Montie HL (2004) Cerebral ischemia and the unfolded protein response. J Neurochem 91 : 1 8.
3. Feelisch M, Ostrowski J, Noack E (1989) On the mechanism of NO release from sydnonimines. J Cardiovasc Pharmacol 14 : S13 S22.
4. Funaoka M, Abe I (1989) Rapid separation of wood into carbohydrate and lignin with concentrated acid-phenol system. Tappi J 72 : 145 149.
5. Funaoka M, Fukatsu S (1996) Characteristics of lignin structural conversion in a phase-separative reaction system composed of cresol and sulfuric acid. Holzforschung 50 : 245 252.
6. Funaoka M, Matsubara M, Seki N, Fukatsu S (1995) Conversion of native lignin to highly phenolic functional polymer and its separation from lignocellulosics. Biotechnol Bioeng 46 : 545 552.
7. Hillion JA, Takahashi K, Maric D, Ruetzler C, Barker JL, Hallenbeck JM (2005) Development of an ischemic tolerance model in a PC12 cell line. J Cereb Blood Flow Metab 25 : 154 162.
8. Hong M, Li M, Mao C, Lee AS (2004) Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6. J Cell Biochem 92 : 723 732.
9. Imaizumi K, Tohyama M (2004) The regulation of unfolded protein response by OASIS, a transmembrane bZIP transcription factor, in astrocytes. Folia Pharmacol Jpn (Nippon Yakurigaku Zasshi) 124 : 383 390.
10. Ito Y, Shimazawa M, Akao Y, Nakajima Y, Seki N, Nozawa Y, Hara H (2006) Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo. J Pharmacol Sci 102 : 196 204.
11. Kawahara T, Yanagi H, Yura T, Mori K (1997) Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell 8 : 1845 1862.
12. Martin KR, Levkovitch-Verbin H, Valenta D, Baumrind L, Pease ME, Quigley HA (2002) Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat. Invest Ophthalmol Vis Sci 43 : 2236 2243.
13. Martinez AT, Speranza M, Ruiz-Duenas FJ, Ferreira P, Camarero S, Guillen F, Martinez MJ, Gutierrez A, del Rio JC (2005) Biodegradation of lignocellulosics: Microbial, chemical, and enzymatic aspects of the fungal attack of lignin. Int Microbiol 8 : 195 204.
14. Oh-hashi K, Maruyama W, Yi H, Takahashi T, Naoi M, Isobe K (1999) Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells. Biochem Biophys Res Commun 263 : 504 509.
15. Osborne NN, Ugarte M, Chao M (1999) Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Surv Ophthalmol 43 : 102 128.
16. Oyadomari S, Mori M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11 : 381 389.
17. Sucher NJ, Lipton SA, Dreyer EB (1997) Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res 37 : 3483 3493.
18. Suzuki H, Tochikura TS, Iiyama K, Yamazaki S, Yamamoto N, Toda S (1989) Lignosulfonate, a water-solubilized lignin from the waste liquor of pulping process, inhibits the infectivity and cytopathic effect of human immunodeficiency virus in vitro. Agric Biol Chem 53 : 3369 3372.
19. Tsujimoto Y, Shimizu S (2000) Bcl-2 family: Life-or-death switch. FEBS Lett 466 : 6 10.
20. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA (2006) S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441 : 513 517.
21. Vorwerk CK, Gorla MS, Dreyer EB (1999) An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy. Surv Ophthalmol 43 : 142 150.
22. Yoneda S, Tanihara H, Kido N, Honda Y, Goto W, Hara H, Miyawaki N (2001) Interleukin-1β mediates ischemic injury in the rat retina. Exp Eye Res 73 : 661 667.
23. Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M (2001) Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem 276 : 13935 13940.
24. Yücel YH, Gupta N, Zhang Q, Mizisin AP, Kalichman MW, Weinreb RN (2006) Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. Arch Ophthalmol 124 : 217 225.
25. Zoratti M, Szabo I (1995) The mitochondrial permeability transition. Biochem Biophys Acta 1241 : 139 176.