Telmisartan attenuates chronic ciclosporin A nephrotoxicity in a pig model

Nephrology Dialysis Transplantation

Volumn 22, Issue 2, 2007, Pages 369-375

  Cibulskyte, Donata ^a   Pedersen, Michael ^a   Hørlyck, Arne ^a   Marcussen, Niels ^a   Hansen, Hans Erik ^a   Frøkiær, Jørgen ^a,b   Madsen, Melvin ^a   Mortensen, Jens ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Angiotensin II receptor blocker; Ciclosporin A; Nephrotoxicity; Pig; Renal enlargement; Telmisartan

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; CREATININE; CYCLOSPORIN A; HEMOGLOBIN; TELMISARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE MODEL; FEMALE; FIBROSING ALVEOLITIS; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY BIOPSY; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY SIZE; KIDNEY STRUCTURE; LIVER FUNCTION TEST; LONG TERM CARE; MEAN ARTERIAL PRESSURE; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RENAL PROTECTION; SWINE; TREATMENT DURATION;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BENZIMIDAZOLES; BENZOATES; BIOPSY; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CYCLOSPORINE; DISEASE MODELS, ANIMAL; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY FAILURE, CHRONIC; MAGNETIC RESONANCE IMAGING; RENAL CIRCULATION; SWINE; TREATMENT OUTCOME;

EID: 33846667304     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl631     Document Type: Article

References (21)

1. Campistol JM, Sacks SH. Mechanisms of nephrotoxicity. Transplantation 2000; 69: SS5-SS10
2. Lee DBN. Cyclosporine and the renin-angiotensin axis. Kidney Int 1997; 52: 248-260
3. Li C, Sun BK, Lim SW et al. Combined effects of losartan and pravastatin on interstitial inflammation and fibrosis in chronic cyclosporine-induced nephropathy. Transplantation 2005; 79: 1522-1529
4. Pichler RH, Franceschini N, Young BA et al. Pathogenesis of cyclosporine nephropathy: Roles of angiotensin II and osteopontin. J Am Soc Nephrol 1995; 6: 1186-1196
5. Thomas SE, Andoh TF, Pichler RH et al. Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis. Kidney Int 1998; 53: 897-908
6. Campistol JM, Inigo P, Jimenez W et al. Losartan decreases plasma levels of TGF-B1 in transplant patients with chronic allograft nephropathy. Kidney Int 1999; 56: 714-719
7. Chander V, Singh D, Tirkey N, Chander H, Chopra K. Amelioration of cyclosporine nephrotoxicity by irbesartan, a selective AT1 receptor antagonist. Ren Fail 2004; 26: 467-477
8. Cibulskyte D, Kaalund H, Pedersen M et al. Chronic cyclosporine nephrotoxicity: A pig model. Transplant Proc 2005; 37: 3298-3301
9. Frey BM, Sieber M, Mettker D, Ganger H, Frey FJ. Marked interspecies differences between humans and pigs in cyclosporine and prednisolone disposition. Drug Metab Dispos 1988; 16: 285-289
10. Grøn MC, Kristensen DH, Cibulskyte D et al. Changes in renal dimensions evaluated by magnetic resonance imaging and ultrasonography during long-term ciclosporin-a treatment. Acta Radiol 2006; 47: 58-64
11. Cheung CM, Shurrab AE, Buckley DL et al. MR-derived renal morphology and renal function in patients with atherosclerotic renovascular disease. Kidney Int 2006; 69: 715-722
12. Jorgensen, B, Keller AK, Radvanska E et al. Reproducibility of contrast enhanced magnetic resonance renography in adolescents. J Urol 2006; 176: 1171-1176
13. Ringgaard S, Christiansen T, Bak M, Pedersen M, Stodkilde-Jorgensen H, Flyvbjerg A. Measurement of renal vein blood flow in rats by high-field magnetic resonance. Kidney Int 1997; 52: 1359-1363
14. Cibulskyte D, Engberg A, Pedersen M et al. Kidney volume increases during log-term ciclosporin A treatment. Transplant Proc 2006; In Press
15. Vaden SL, Riviere JE. Pharmacokinetics, inhibition of lymphoblast transformation, and toxicity of cyclosporine in clinically normal pigs. Am J Vet Res 1990; 51: 399-403
16. Saad SY, Najjar TA. Effects of STZ-induced diabetes and its treatment with vanadyl sulphate on cyclosporine A-induced nephrotoxicity in rats. Arch Toxicol 2005; 79: 493-499
17. Dieperink H, Leyssac PP, Starklint H, Kemp E. Long-term cyclosporine nephrotoxicity in the rat: Effects on renal function and morphology. Nephrol Dial Transplant 1988; 3: 317-326
18. Robbins MEC. Single injection techniques in determining age-related changes in porcine renal function. Int J Appl Radiat Isot 1984; 35: 85-91
19. Terris JM. Swine as a model in renal physiology and nephrology: An overview. In: Tumbleson ME, ed. Swine in Biomedical Research. Plenum Press, New York: 1986; 1673-1689
20. Kopp JB, Klotman PE. Cellular and molecular mechanisms of cyclosporine nephrotoxicity. J Am Soc Nephrol 1990; 1: 162-179
21. Ruiz P, Kolbeck PC, Scroggs MW, Sanfilippo F. Associations between cyclosporine therapy and interstitial fibrosis in renal allograft biopsies. Transplantation 1988; 45: 91-95