The pharmacokinetics and acute renal effects of oral microemulsion ciclosporin A in normal pigs

International Immunopharmacology

Volumn 6, Issue 4, 2006, Pages 627-634

  Cibulskyte, Donata ^a,b   Pedersen, Michael ^a,c   Hjelm Poulsen, Jørgen ^c   Hansen, Hans Erik ^a,b   Madsen, Melvin ^a,b   Mortensen, Jens ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Department of Renal Medicine ^*  (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Acute kidney failure; Ciclosporin A; Drug toxicity; Pharmacokinetics; Pig; Renal circulation

Indexed keywords

CREATININE; CYCLOSPORIN A;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN VERSUS ANIMAL COMPARISON; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; MICROEMULSION; NEPHROTOXICITY; NONHUMAN; NONLINEAR SYSTEM; PRIORITY JOURNAL; SWINE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CREATININE; CYCLOSPORINE; EMULSIONS; FEMALE; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY FUNCTION TESTS; RENAL CIRCULATION; SWINE;

EID: 33644549128     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2005.09.013     Document Type: Article

References (21)

1. W.M. Bennett, A. de Mattos, M.M. Meyer, T. Andoh, and J.M. Barry Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy Kidney Int 50 1996 1089 1100
2. A. Busauschina, P. Schnuelle, and F.J. van der Woude Cyclosporine nephrotoxicity Transplant Proc 36 Suppl 2S 2004 229S 233S
3. H. Zachariae, K. Kragballe, H.E. Hansen, N. Marcussen, and S. Olsen Renal biopsy findings in long-term cyclosporin treatment of psoriasis Br J Dermatol 136 1997 531 535
4. D.J. Goldstein, N. Zuech, V. Sehgal, A.D. Weinberg, R. Drusin, and D. Cohen Cyclosporine-associated end-stage nephropathy after cardiac transplantation: incidence and progression Transplantation 63 1997 664 668
5. A.O. Ojo, P.J. Held, F.K. Port, R.A. Wolfe, A.B. Leichtman, and E.W. Young Chronic renal failure after transplantation of a nonrenal organ N Engl J Med 349 2003 931 940
6. S.C. Cremers, E.M. Scholten, R.C. Schoemaker, E.G. Lentjes, P. Vermeij, and L.C. Paul A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas-kidney transplant recipients Nephrol Dial Transplant 18 2003 1201 1208
7. J. Grevel Absorption of cyclosporine A after oral dosing Transplant Proc 18 6 Suppl 5 1986 9 15
8. A.N. Warrens, J.B. Waters, A.D. Salama, and R.I. Lechler Improving the therapeutic monitoring of cyclosporin A Clin Transplant 13 1999 193 200
9. J.P. Reymond, J.L. Steimer, and W. Niederberger On the dose dependency of cyclosporin A absorption and disposition in healthy volunteers J Pharmacokinet Biopharm 16 1988 331 353
10. J.M. Terris Swine as a model in renal physiology and nephrology: an overview M.E. Tumbleson Swine in biomedical research vol. 3 1986 Plenum Press New York 1673 1689
11. S.L. Vaden, and J.E. Riviere Pharmacokinetics, inhibition of lymphoblast transformation, and toxicity of cyclosporine in clinically normal pigs Am J Vet Res 51 1990 399 403
12. B.M. Frey, M. Sieber, D. Mettler, H. Ganger, and F.J. Frey Marked interspecies differences between humans and pigs in cyclosporine and prednisolone disposition Drug Metab Dispos 16 1988 285 289
13. Cibulskyte D, Kaalund H, Pedersen M, Hørlyck A, Marcussen N, Hansen HE, et al. Chronic cyclosporine nephrotoxicity: a pig model. Transplant Proc (in press).
14. S.K. Dean, H. Scott, G.W. Keogh, S. Roberts, and B. Tuch Effect of immunosuppressive doses of cyclosporine on pancreatic beta cell function in pigs Am J Vet Res 63 2002 1501 1506
15. M.H. Beresini, D. Davalian, S. Alexander, R. Toton-Quinn, B. Barnett, and M.J. Cerelli Evaluation of EMIT cyclosporine assay for use with whole blood Clin Chem. 39 1993 2235 2241
16. C.H. Coulam, J.H. Lee, K.L. Wedding, D.M. Spielman, N.J. Pelc, and S.T. Kee Noninvasive measurement of extraction fraction and single-kidney glomerular filtration rate with MR imaging in swine with surgically created renal arterial stenoses Radiology 223 2002 76 82
17. M.E. Robbins Single injection techniques in determining age-related changes in porcine renal function Int J Appl Radiat Isot 35 1984 85 91
18. D. Calvert, and T. Terris Evaluation of the mechanism of cyclosporine A nephrotoxicity Adv Swine Biomed Res 1996 67 77
19. K.A. Andreoni, C.P. O'Donnell, J.F. Burdick, and J.L. Robotham Hepatic and renal blood flow responses to a clinical dose of intravenous cyclosporine in the pig Immunopharmacology 28 1994 87 94
20. P. Langers, S.C. Cremers, J. den Hartigh, E.M. Rijnbeek, J. Ringers, and C.B. Lamers Easy-to-use, accurate and flexible individualized Bayesian limited sampling method without fixed time points for ciclosporin monitoring after liver transplantation Aliment Pharmacol Ther 21 2005 549 557
21. H. Agerso, M. Wilken, J. Drustrup, P.M. Haahr, and K.D. Jorgensen Plasma concentration of hGH and anti-hGH antibodies after subcutaneous administration of hGH for 3 weeks to immunosuppressed pigs J Pharmacol Toxicol Methods 41 1999 1 8