Studies of metabolism and disposition of potent human immunodeficiency virus (HIV) integrase inhibitors using 19F-NMR spectroscopy

Xenobiotica

Volumn 37, Issue 9, 2007, Pages 1000-1012

  Monteagudo, E ^a   Pesci, S ^a   Taliani, M ^a   Fiore, F ^a   Petrocchi, A ^a   Nizi, E ^a   Rowley, M ^a   Laufer, R ^a   Summa, V ^a  

^a IRBM   (Italy)

Author keywords

19F nuclear magnetic resonance (NMR) spectroscopy; Glucuronidation; Human immunodeficiency virus (HIV) integrase inhibitors; N methylpyrimidone metabolism

Indexed keywords

5 O GLUCURONIDE; DRUG METABOLITE; INTEGRASE INHIBITOR; MK 0518; N (4 FLUOROBENZYL) 5 HYDROXY 1 METHYL 2 (1 METHYL 1 [[(5 METHYL 1,3,4 OXADIAZOL 2 YL)CARBONYL]AMINO]ETHYL) 6 OXO 1,6 DIHYDROPYRIMIDINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 1 METHYL 2 (4 METHYLMORPHOLIN 3 YL) 6 OXO 1,6 DIHYDROPYRIMIDINE 4 CARBOXAMIDE; PYRIMIDINE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DATA ANALYSIS; DRUG DISPOSITION; DRUG ELIMINATION; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENCY; GLUCURONIDATION; HUMAN IMMUNODEFICIENCY VIRUS; HYDROLYSIS; MALE; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE ANALYSIS; RADIOCHEMISTRY; RAT; SOLID PHASE EXTRACTION; URINALYSIS;

ANIMALS; BIOTRANSFORMATION; DOGS; DRUG DESIGN; FLUORINE; GLUCURONIDES; HIV INFECTIONS; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; ORGANIC CHEMICALS; RATS; RATS, SPRAGUE-DAWLEY; SOLID PHASE EXTRACTION;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS; RATTUS;

EID: 34748823500     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250701652323     Document Type: Article

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