Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]- radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR

Xenobiotica

Volumn 36, Issue 1, 2006, Pages 59-77

  Duckett, C J ^a,d   Lindon, J C ^a   Walker, H ^b,e   Abou Shakra, F ^b,f   Wilson, I D ^c   Nicholson, J K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b GV Instruments   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d KEELE UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f PERKINELMER INC   (United States)

Author keywords

3 Chloro 4 fluoroaniline; 14C radiolabelling; 19F NMR; Aniline metabolism; HPLC ICPMS; HPLC MS

Indexed keywords

ANILINE DERIVATIVE; CARBON 14; CHLORINE; GLUCURONIDE; SULFATE; SULFUR;

ACETYLATION; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; METABOLISM; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE ANALYSIS; RADIOASSAY; RAT; SULFATION; URINALYSIS;

ANILINE COMPOUNDS; ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA;

EID: 33644619009     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250500489927     Document Type: Article

References (11)

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