The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells

Molecular and Cellular Biochemistry

Volumn 304, Issue 1-2, 2007, Pages 219-226

  Yang, Di ^a   Qi, Yitao ^a   Chen, Qian ^a   Wang, Zhiqin ^a   Jin, Xi ^a   Gao, Jie ^a   Fu, Juanling ^b   Xiao, Xilong ^a   Zhou, Zongcan ^b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cdk4; Cell cycle regulation; Cell size; Cyclin A1; p53 mutation

Indexed keywords

CYCLIN A1; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; MESSENGER RNA; MUTANT PROTEIN; PLASMID DNA; PROTEIN P21; PROTEIN P27; PROTEIN P53;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MUTATIONAL ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; WILD TYPE;

CELL PROLIFERATION; CELLS, CULTURED; CYCLIN A; CYCLIN-DEPENDENT KINASE 4; FIBROBLASTS; GENES, P53; HUMANS; LUNG; POINT MUTATION; TRANSFECTION; UP-REGULATION;

EID: 34648840298     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9503-9     Document Type: Article

References (42)

1. Vousden KH (2000) p53: Death star. Cell 103:691-694
2. Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C (1992) Wild-type p53 activates transcription in vitro. Nature 358:83-86
3. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B (1992) Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256:827-830
4. Funk WD, Pak DT, Karas RH, Wright WE, Shay JW (1992) A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol 12:2866-2871
5. Miner Z, Kulesz-Martin M (1997) DNA binding specificity of proteins derived from alternatively spliced mouse p53 mRNAs. Nucleic Acids Res 25:1319-1326
6. Klein C, Planker E, Diercks T, Kessler H, Kunkele KP, Lang K, Hansen S, Schwaiger M (2001) NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA. J Biol Chem 276:49020-490207
7. el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B (1992) Definition of a consensus binding site for p53. Nat Genet 1:45-49
8. Osborne RJ, Merlo GR, Mitsudomi T, Venesio T, Liscia DS, Cappa AP, Chiba I, Takahashi T, Nau MM, Callahan R (1991) Mutations in the p53 gene in primary human breast cancers. Cancer Res 51:6194-6198
9. Bargonetti J, Friedman PN, Kern SE, Vogelstein B, Prives C (1991) Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65:1083-1091
10. Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B (1991) Identification of p53 as a sequence-specific DNA-binding protein. Science 252:1708-1711
11. Kern SE, Kinzler KW, Baker SJ, Nigro JM, Rotter V, Levine AJ, Friedman P, Prives C, Vogelstein B (1991) Mutant p53 proteins bind DNA abnormally in vitro. Oncogene 6:131-136
12. Vogelstein B, Kinzler KW (1992) p53 function and dysfunction. Cell 70:523-526
13. Mukhopadhyay T, Roth JA (1993) A codon 248 p53 mutation retains tumor suppressor function as shown by enhancement of tumor growth by antisense p53. Cancer Res 53:4362-4366
14. Levine AJ, Momand J, Finlay CA (1991) The p53 tumour suppressor gene. Nature 351:453-456
15. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49-53
16. Mizuarai S, Yamanaka K, Kotani H (2006) Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells. Cancer Res 66:6319-6326
17. Ko JL, Chiao MC, Chang SL, Lin P, Lin JC, Sheu GT, Lee H (2002) A novel p53 mutant retained functional activity in lung carcinomas. DNA Repair (Amst) 1:755-762
18. Fabian Z, Vecsernyes M, Pap M, Szeberenyi J (2006) The effects of a mutant p53 protein on the proliferation and differentiation of PC12 rat phaeochromocytoma cells. J Cell Biochem 99(5):1431-1441
19. Gloushankova N, Ossovskaya V, Vasiliev J, Chumakov P, Kopnin B (1997) Changes in p53 expression can modify cell shape of ras-transformed fibroblasts and epitheliocytes. Oncogene 15:2985-2989
20. Hsu CH, Lee SC, Yang YC, Lian ST, Shin SJ, Lin SR (2001) The p53 codon 249 mutant-derived from human functional adrenal tumors-can modify the cell shape of normal adrenocortical transfected cells. Cancer Lett 170:63-71
21. Chesnokov I, Chu WM, Botchan MR, Schmid CW (1996) p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner. Mol Cell Biol 16:7084-7088
22. Cairns CA, White RJ (1998) p53 is a general repressor of RNA polymerase III transcription. EMBO J 17:3112-3123
23. Fontoura BM, Sorokina EA, David E, Carroll RB (1992) p53 is covalently linked to 5.8S rRNA. Mol Cell Biol 12:5145-5151
24. Fontoura BM, Atienza CA, Sorokina EA, Morimoto T, Carroll RB (1997) Cytoplasmic p53 polypeptide is associated with ribosomes. Mol Cell Biol 17:3146-3154
25. Hunter T, Pines J (1994) Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79:573-582
26. Geng Y, Eaton EN, Picon M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA (1996) Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12:1173-1180
27. Knoblich JA, Lehner CF (1993) Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J 12:65-74
28. Cho NH, Choi YP, Moon DS, Kim H, Kang s, Ding O, Rha SY, Yang YJ, Cho SH (2006) Induction of cell apoptosis non-small cell lung cancer cells by cyclin Ai small interfering RNA. Cancer Sci 97(10):1082-1092
29. Ji P, Agrawal S, Diederichs S, Baumer N, Becker A, Cauvet T, Kowski S, Beger C, Welte K, Berdel WE, Serve H, Muller-Tidow C. (2005) Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. 24(16):2739-2744
30. Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307-310
31. Scian MJ, Stagliano KE, Ellis MA, Hassan S, Bowman M, Miles MF, Deb SP, Deb S (2004) Modulation of gene expression by tumor-derived p53 mutants. Cancer Res 64:7447-7454
32. Chen Q, Zhou H, Guo W, Samaranayake LP, Zhou M, Li B (2001) Correlation between the expression of cyclin A protein and p53 activity in oral squamous cell carcinomas. Cytobios 106:87-99
33. Rivera A, Mavila A, Bayless KJ, Davis GE, Maxwell SA (2006) Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells. Cell Mol Life Sci 63(12):1425-1439
34. Peart MJ, Prives C: Mutant p53 gain of function (2006) the NF-Y connection. Cancer Cell 10:173-174
35. Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, Blandino G, Piaggio G (2006) Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 10:191-202
36. Hui L, Zheng Y, Yan Y, Bargonetti J, Foster DA (2006) Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D. Oncogene 25(55):7305-7310
37. Gulati AP, Yang YM, Harter D, Mukhopadhyay A, Aggarwal BB, Benzil DL, Whysner J, Albino AP, Murali R, Jhanwar-Uniyal M (2006) Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1. Mol Carcinog 45:26-37
38. Soussi T, Lozano G (2005) p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun 331:834-842
39. Chin KV, Ueda K, Pastan I, Gottesman MM (1992) Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 255:459-462
40. Deb S, Jackson CT, Subler MA, Martin DW (1992) Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells. J Virol 66:6164-6170
41. Deb SP, Munoz RM, Brown DR, Subler MA, Deb S (1994) Wild-type human p53 activates the human epidermal growth factor receptor promoter. Oncogene 9:1341-1349
42. Cadwell C, Zambetti GP (2001) The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth. Gene 277:15-30