Biogenesis of the secretory granule: Chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation

Biochemistry

Volumn 46, Issue 38, 2007, Pages 10999-11012

  Mosley, Coleman A ^a   Taupenot, Laurent ^b   Biswas, Nilima ^b   Taulane, Joseph P ^a   Olson, Norman H ^a   Vaingankar, Sucheta M ^b   Wen, Gen ^b   Schork, Nicholas J ^a   Ziegler, Michael G ^b   Mahata, Sushil K ^a,b,c   O'Connor, Daniel T ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER CONCENTRATION; CONFORMATIONS; DICHROISM; ELECTRON MICROSCOPY; HORMONES; MASS SPECTROMETRY; MOLECULAR MASS; MOLECULAR WEIGHT; X RAY SCATTERING;

BIOGENESIS; DENATURING GEL FILTRATION; TRANSMITTER STORAGE; TROPOMYOSIN;

BIOCHEMISTRY;

CHROMOGRANIN A; TROPOMYOSIN;

ALPHA HELIX; ANIMAL CELL; ARTICLE; BIOGENESIS; CIRCULAR DICHROISM; CONTROLLED STUDY; GEL FILTRATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SECRETORY GRANULE; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; ANIMALS; CATECHOLAMINES; CHROMAFFIN GRANULES; CHROMOGRANIN A; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; EXOCYTOSIS; HUMANS; MICE; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; SECRETORY VESICLES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34648836732     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700704r     Document Type: Article

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