Which gender is better positioned in the process of liver surgery? Male or female?

Surgery Today

Volumn 37, Issue 10, 2007, Pages 823-830

  Yokoyama, Yukihiro ^a   Nagino, Masato ^a   Nimura, Yuji ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Estrogen; Hemorrhagic shock; Hepatic stress; Ischemia reperfusion; Sex hormone

Indexed keywords

ESTROGEN;

ESTROGEN ACTIVITY; ESTROGEN THERAPY; FEMALE; HORMONAL REGULATION; HUMAN; LIVER BLOOD FLOW; LIVER ISCHEMIA; LIVER REGENERATION; LIVER RESECTION; LIVER SURGERY; MALE; PARTIAL HEPATECTOMY; PREOPERATIVE EVALUATION; REVIEW; SEX DIFFERENCE; SURGICAL STRESS;

ESTROGENS; FEMALE; GONADAL STEROID HORMONES; HEPATECTOMY; HUMANS; ISCHEMIA; JAPAN; LIVER DISEASES; MALE; NITRIC OXIDE; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; REPERFUSION; SEX FACTORS; SHOCK, HEMORRHAGIC;

EID: 34648830825     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-007-3508-6     Document Type: Review

References (90)

1. X Yang EE Schadt S Wang H Wang AP Arnold L Ingram-Drake 2006 Tissue-specific expression and regulation of sexually dimorphic genes in mice Genome Res 16 8 995 1004
2. H Harada KP Pavlick IN Hines JM Hoffman S Bharwani L Gray 2001 Selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury J Appl Physiol 91 6 2816 22
3. DE Eckhoff G Bilbao L Frenette JA Thompson JL Contreras 2002 17-Beta-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha Surgery 132 2 302 9
4. D Jarrar P Wang WG Cioffi KI Bland IH Chaudry 2000 The female reproductive cycle is an important variable in the response to trauma-hemorrhage Am J Physiol Heart Circ Physiol 279 3 H1015 H1021
5. T Poynard P Mathurin CL Lai D Guyader R Poupon MH Tainturier 2003 A comparison of fibrosis progression in chronic liver diseases J Hepatol 38 3 257 65
6. A Colantoni R Idilman N De Maria N La Paglia J Belmonte F Wezeman 2003 Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines Alcohol Clin Exp Res 27 7 1184 9
7. A Francavilla PK Eagon A DiLeo L Polimeno C Panella AM Aquilino 1986 Sex hormone-related functions in regenerating male rat liver Gastroenterology 91 5 1263 70
8. A Francavilla A di Leo PK Eagon SQ Wu P Ove DH van Thiel 1984 Regenerating rat liver: correlations between estrogen receptor localization and deoxyribonucleic acid synthesis Gastroenterology 86 3 552 7
9. S Eden 1979 Age- and sex-related differences in episodic growth hormone secretion in the rat Endocrinology 105 2 555 60
10. T Kawai Y Yokoyama S Kawai S Yokoyama K Oda T Nagasaka 2006 Does estrogen contribute to the hepatic regeneration following portal branch ligation in rats? Am J Physiol Gastrointest Liver Physiol 292 G582 9
11. H Imamura R Shimada M Kubota Y Matsuyama A Nakayama S Miyagawa 1999 Preoperative portal vein embolization: an audit of 84 patients Hepatology 29 4 1099 105
12. N Yamanaka E Okamoto T Oriyama J Fujimoto K Furukawa E Kawamura 1994 A prediction scoring system to select the surgical treatment of liver cancer. Further refinement based on 10 years of use Ann Surg 219 4 342 6
13. H Jaeschke 1991 Reactive oxygen and ischemia/reperfusion injury of the liver Chem Biol Interact 79 2 115 36
14. H Jaeschke AP Bautista Z Spolarics JJ Spitzer 1991 Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia Free Radic Res Commun 15 5 277 84
15. H Jaeschke A Farhood CW Smith 1990 Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo FASEB J 4 3355 9
16. AB Lentsch A Kato H Yoshidome KM McMasters MJ Edwards 2000 Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury Hepatology 32 2 169 73
17. JC Garcia-Pagan JX ZhAng N SonIn K NakAnishi MG Clemens 1999 Ischemia/reperfusion induces an increase in the hepatic portal vasoconstrictive response to endothelin-1 Shock 11 5 325 9
18. JF Arnal S Clamens C Pechet A Negre-Salvayre C Allera JP Girolami 1996 Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production Proc Natl Acad Sci USA 93 9 4108 13
19. E Vegeto S Belcredito S Etteri S Ghisletti A Brusadelli C Meda 2003 Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol Proc Natl Acad Sci USA 100 16 9614 9
20. E Vegeto C Bonincontro G Pollio A Sala S Viappiani F Nardi 2001 Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia J Neurosci 21 6 1809 18
21. Y Yokoyama B Toth WC Kitchens MG Schwacha LW Rue 3rd KI Bland 2004 Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhage J Surg Res 121 1 25 30
22. F Palma C Jimenez E Moreno C Loinaz I Garcia JC Palomo 1999 Recipient factors as determinants of mortality after adult liver transplantation World J Surg 23 12 1282 8
23. R Francavilla N Hadzic ND Heaton M Rela AJ Baker A Dhawan 1998 Gender matching and outcome after pediatric liver transplantation Transplantation 66 5 602 5
24. BK Brooks MF Levy LW Jennings O Abbasoglu M Vodapally RM Goldstein 1996 Influence of donor and recipient gender on the outcome of liver transplantation Transplantation 62 12 1784 7
25. M Nagino J Kamiya T Arai H Nishio T Ebata Y Nimura 2005 One hundred consecutive hepatobiliary resections for biliary hilar malignancy: preoperative blood donation, blood loss, transfusion, and outcome Surgery 137 2 148 55
26. Y Adachi T Matsumata H Kuwano K Okadome K Sugimachi 1994 A clinical analysis of multiple organ failure following elective surgery Surg Today 24 4 333 6
27. S Kondo D Wang T Mayumi AS Klein GB Bulkley 1996 Effect of hemorrhagic shock and resuscitation upon hepatic phagocytic clearance and killing of circulating microorganisms Shock 5 2 106 11
28. Y Yokoyama Y Nimura M Nagino KI Bland IH Chaudry 2005 Current understanding of gender dimorphism in hepatic pathophysiology J Surg Res 128 1 147 56
29. P Wang G Singh MW Rana ZF Ba IH Chaudry 1990 Preheparinization improves organ function after hemorrhage and resuscitation Am J Physiol 259 R645 50
30. P Wang JG Hauptman IH Chaudry 1990 Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation J Surg Res 48 464 70
31. D Jarrar P Wang GY Song MW Knoferl WG Cioffi KI Bland 2000 Metoclopramide: a novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhage Am J Physiol Endocrinol Metab 278 1 E90 5
32. Y Mizushima P Wang D Jarrar WG Cioffi KI Bland IH Chaudry 2000 Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals Ann Surg 232 5 673 9
33. JF Kuebler D Jarrar B Toth KI Bland L Rue 3rd P Wang 2002 Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis Arch Surg 137 1 74 9
34. MW Wichmann MK Angele A Ayala WG Cioffi IH Chaudry 1997 Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock Shock 8 4 242 8
35. M Goto Y Takei S Kawano K Nagano S Tsuji E Masuda 1994 Endothelin-1 is involved in the pathogenesis of ischemia/reperfusion liver injury by hepatic microcirculatory disturbances Hepatology 19 3 675 81
36. H Chang GJ Wu SM Wang CR Hung 1993 Plasma endothelin level changes during hemorrhagic shock J Trauma 35 6 825 33
37. H Rensing I Bauer JX Zhang M Paxian BH Pannen Y Yokoyama 2002 Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver Hepatology 36 6 1453 65
38. BH Pannen M Bauer GF Noldge-Schomburg JX Zhang JL Robotham MG Clemens 1997 Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins Am J Physiol 272 6 Pt 2 H2736 45
39. P Wang ZF Ba MH Morrison A Ayala IH Chaudry 1992 Mechanism of the beneficial effect of pentoxifylline on hepatocellular function following trauma-hemorrhage and resuscitation Surgery 112 451 8
40. PJ O'Neill A Ayala P Wang ZF Ba MH Morrison AE Schultze 1994 Role of Kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitation Shock 1 43 7
41. CV Fontanilla DE Faunce MS Gregory KA Messingham EA Durbin LA Duffner 2000 Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma Alcohol Clin Exp Res 24 9 1392 9
42. SW Chensue PD Terebuh DG Remick WE Scales SL Kunkel 1991 In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia Am J Pathol 138 395 402
43. Y Yokoyama JF Kuebler T Matsutani MG Schwacha KI Bland IH Chaudry 2003 Mechanism of the salutary effects of 17beta-estradiol following trauma-hemorrhage: direct downregulation of Kupffer cell proinflammatory cytokine production Cytokine 21 2 91 7
44. A Francavilla L Polimeno A DiLeo M Barone P Ove M Coetzee 1989 The effect of estrogen and tamoxifen on hepatocyte proliferation in vivo and in vitro Hepatology 9 4 614 20
45. D Alvaro G Alpini P Onori L Perego G Svegliata Baroni A Franchitto 2000 Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats Gastroenterology 119 6 1681 91
46. PK Eagon LE Porter A Francavilla A DiLeo DH Van Thiel 1985 Estrogen and androgen receptors in liver: their role in liver disease and regeneration Semin Liver Dis 5 1 59 69
47. B Fisher N Gunduz EA Saffer S Zheng 1984 Relation of estrogen and its receptor to rat liver growth and regeneration Cancer Res 44 6 2410 5
48. C Liddle GC Farrell 1993 Role of the oestrogen receptor in liver regeneration in the male rat J Gastroenterol Hepatol 8 6 524 9
49. M Makuuchi K Takayasu T Takuma S Yamazaki H Hasegawa S Nishiura 1984 Preoperative transcatheter embolization of the portal venous branch for patients receiving extended lobectomy due to the bile duct carcinoma J Jpn Soc Clin Surg 45 14 20
50. M Makuuchi BL Thai K Takayasu T Takayama T Kosuge P Gunven 1990 Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report Surgery 107 5 521 7
51. H Kinoshita K Sakai K Hirohashi S Igawa O Yamasaki S Kubo 1986 Preoperative portal vein embolization for hepatocellular carcinoma World J Surg 10 5 803 8
52. S Mochida I Ogata K Hirata Y Ohta S Yamada K Fujiwara 1990 Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats Gastroenterology 99 3 771 7
53. S Suzuki S Nakamura A Serizawa T Sakaguchi H Konno H Muro 1996 Role of Kupffer cells and the spleen in modulation of endotoxin-induced liver injury after partial hepatectomy Hepatology 24 1 219 25
54. M Shiomi Y Wakabayashi T Sano Y Shinoda Y Nimura Y Ishimura 1998 Nitric oxide suppression reversibly attenuates mitochondrial dysfunction and cholestasis in endotoxemic rat liver Hepatology 27 1 108 15
55. PJ Offner EE Moore WL Biffl 1999 Male gender is a risk factor for major infections after surgery Arch Surg 134 9 935 8
56. J Schroder V Kahlke KH Staubach P Zabel F Stuber 1998 Gender differences in human sepsis Arch Surg 133 1200 5
57. MW Wichmann D Inthorn HJ Andress FW Schildberg 2000 Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome Intensive Care Med 26 2 167 72
58. R Zellweger A Ayala S Stein CM DeMaso IH Chaudry 1997 Females in proestrus state tolerate sepsis better than males Crit Care Med 25 106 10
59. E Faist AE Baue H Dittmer 1983 Multiple organ failure in polytrauma patients J Trauma 23 775 87
60. K Inaba S Suzuki H Ihara T Sakaguchi S Baba T Urano 2005 Sexual dimorphism in endotoxin susceptibility after partial hepatectomy in rats J Hepatol 42 5 719 27
61. DJ Koo IH Chaudry P Wang 1999 Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis J Surg Res 83 2 151 7
62. T Suzuki T Shimizu HP Yu YC Hsieh MA Choudhry MG Schwacha 2007 Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage J Appl Physiol 102 1 163 8
63. T Suzuki T Shimizu HP Yu YC Hsieh MA Choudhry KI Bland 2006 17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha Surgery 140 2 141 8
64. HP Yu T Shimizu YC Hsieh T Suzuki MA Choudhry MG Schwacha 2006 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage J Leukoc Biol 79 5 963 70
65. K Kauser GM Rubanyi 1997 Potential cellular signaling mechanisms mediating upregulation of endothelial nitric oxide production by estrogen J Vasc Res 34 3 229 36
66. JP Buyon HM Korchak LE Rutherford M Ganguly G Weissmann 1984 Female hormones reduce neutrophil responsiveness in vitro Arthritis Rheum 27 6 623 30
67. JH Ashburn R Baveja N Kresge K Korneszczuk S Keller A Karaa 2004 Remote trauma sensitizes hepatic microcirculation to endothelin via caveolin inhibition of eNOS activity Shock 22 2 120 30
68. K Hisamoto M Ohmichi H Kurachi J Hayakawa Y Kanda Y Nishio 2001 Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells J Biol Chem 276 5 3459 67
69. B Darblade C Pendaries A Krust S Dupont MJ Fouque J Rami 2002 Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor Circ Res 90 4 413 9
70. H Harada S Bharwani KP Pavlick KS Korach MB Grisham 2004 Estrogen receptor-alpha, sexual dimorphism and reduced-size liver ischemia and reperfusion injury in mice Pediatr Res 55 3 450 6
71. H Harada KP Pavlick IN Hines DJ Lefer JM Hoffman S Bharwani 2003 Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: role of endothelial cell nitric oxide synthase Proc Natl Acad Sci USA 100 2 739 44
72. Y Takamatsu K Shimada K Yamaguchi S Kuroki K Chijiiwa M Tanaka 2006 Inhibition of inducible nitric oxide synthase prevents hepatic, but not pulmonary, injury following ischemia-reperfusion of rat liver Dig Dis Sci 51 3 571 9
73. C Hierholzer B Harbrecht JM Menezes J Kane J MacMicking CF Nathan 1998 Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock J Exp Med 187 6 917 28
74. TA Vos AS Gouw PA Klok R Havinga H van Goor S Huitema 1997 Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats Gastroenterology 113 4 1323 33
75. M Akishita K Kozaki M Eto M Yoshizumi M Ishikawa K Toba 1998 Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor Biochem Biophys Res Commun 251 1 17 21
76. AS Bilsel H Moini E Tetik F Aksungar B Kaynak A Ozer 2000 17Beta-estradiol modulates endothelin-1 expression and release in human endothelial cells Cardiovasc Res 46 3 579 84
77. RK Dubey EK Jackson PJ Keller B Imthurn M Rosselli 2001 Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism Hypertension 37 2 Part 2 640 4
78. J Vina J Sastre FV Pallardo J Gambini C Borras 2006 Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens Free Radic Res 40 12 1359 65
79. MR Reyes A Sifuentes-Alvarez B Lazalde 2006 Estrogens are potentially the only steroids with an antioxidant role in pregnancy: in vitro evidence Acta Obstet Gynecol Scand 85 9 1090 3
80. G Sener S Arbak P Kurtaran N Gedik BC Yegen 2005 Estrogen protects the liver and intestines against sepsis-induced injury in rats J Surg Res 128 1 70 8
81. V Payraudeau JP Sarsat J Sobczak C Brechot V Albaladejo 1998 Cyclin A2 and c-myc mRNA expression in ethinyl estradiol induced liver proliferation Mol Cell Endocrinol 143 1-2 107 16
82. Y Goto M Nagino Y Nimura 1998 Doppler estimation of portal blood flow after percutaneous transhepatic portal vein embolization Ann Surg 228 2 209 13
83. M Kawai K Naruse S Komatsu S Kobayashi M Nagino Y Nimura 2002 Mechanical stress-dependent secretion of interleukin 6 by endothelial cells after portal vein embolization: clinical and experimental studies J Hepatol 37 2 240 6
84. P Ouyang ED Michos RH Karas 2006 Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questions J Am Coll Cardiol 47 9 1741 53
85. GL Anderson M Limacher AR Assaf T Bassford SA Beresford H Black 2004 Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial JAMA 291 14 1701 12
86. RT Chlebowski SL Hendrix RD Langer ML Stefanick M Gass D Lane 2003 Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial JAMA 289 24 3243 53
87. ED Staren S Omer 2004 Hormone replacement therapy in postmenopausal women Am J Surg 188 2 136 49
88. FX Bosch J Ribes R Cleries M Diaz 2005 Epidemiology of hepatocellular carcinoma Clin Liver Dis 9 2 191 211 v
89. ZR Khan AI Neugut H Ahsan JA Chabot 1999 Risk factors for biliary tract cancers Am J Gastroenterol 94 1 149 52
90. SA Khan HC Thomas BR Davidson SD Taylor-Robinson 2005 Cholangiocarcinoma Lancet 366 9493 1303 14