Zinc mediated normalization of histoarchitecture and antioxidant status offers protection against initiation of experimental carcinogenesis

Molecular and Cellular Biochemistry

Volumn 304, Issue 1-2, 2007, Pages 101-108

  Chadha, Vijayta Dani ^a   Vaiphei, K ^b   Dhawan, D K ^a  

^a PANJAB UNIVERSITY   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Antioxidant status; Experimental carcinogenesis; Zinc

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CATALASE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID; SUPEROXIDE DISMUTASE; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOGENESIS; COLON CANCER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG TISSUE LEVEL; HISTOPATHOLOGY; INHIBITION KINETICS; LIPID PEROXIDATION; MALE; NONHUMAN; RAT; TISSUE STRUCTURE; TREATMENT DURATION; TREATMENT OUTCOME; X RAY FLUORESCENCE;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTIOXIDANTS; CARCINOGENS; COLONIC NEOPLASMS; DRUG EVALUATION, PRECLINICAL; MALE; NEOPLASMS, EXPERIMENTAL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; ZINC;

RATTUS;

EID: 34648825471     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9490-x     Document Type: Article

References (37)

1. Shike M, Winawer SJ, Greenwald PH, Bloch A, Hill MJ, Swaroop SV (1990) Primary prevention of colorectal cancer: the WHO collaborating centre for prevention of colorectal cancer. Bull World Health Org 68:377-385
2. Pitot HC (1986) Fundamentals of oncology. Marcel Dekker, Inc., New York
3. Bartsch H, Nair J (2002) Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: Studies on exocyclic base adducts as stable oxidative stress markers. Cancer Detect Preven 22:308-312
4. Rogers AE, Nauss KM (1985) Rodent models for carcinoma of the colon. Dig Dis Sci 30:87S-102S
5. Manju V, Nalini N (2005) Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer. Clin Chim Acta 58:60-67
6. Potter JD, McMichael AJ (1986) Diet and cancer of the colon and rectum: a case-control study. J Natl Cancer Inst 76:557-569
7. Mukhtar H, Athar M (1988) Dietary anticarcinogens and cancer prevention. Clevel Clin J Med 55:507-508
8. Carter JW, Lancaster H, Hardman WE, Cameron IL (1997) Zinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in mice. Nutr Cancer 27(3):217-221
9. Singh KP, Zaidi SIA, Raisuddin S, Saxena AK, Murthy RC, Ray PK (1992) Effect of zinc on immune functions and host resistance against infection and tumor challenge. Immunopharmacol Immunotoxicol 14:813-840
10. Satoh M, Kondo Y, Mita M, Nakagawa I, Naganuma A, Imura N (1993) Prevention of carcinogenecity of anticancer drugs by metallothionein induction. Cancer Res 53:4767-4768
11. Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM, Mullin JM (1999) Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 20:1425-1431
12. Goel A, Dani V, Dhawan DK (2005) Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chem Biol Interact 156:131-140
13. Wills ED (1966) Mechanism of lipid peroxide formation in animal tissues. Biochem J 99:667-676
14. Ellman GL (1959) Tissue sulphydryl groups. Arch Biochem Biophys 82:70-77
15. Luck H (1971) In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 885-893 pp 885-893
16. Kono Y (1978) Generation of superoxide radical during auto oxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186:189-195
17. Carlberg I, Mannervik B (1985) Glutathione reductase. Methods Enzymol 113:484-490
18. Habig WH, Pabst MJ, Jacoby WB (1974) Glutathione-S-Transferase: The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
19. Lowry OH, Rorebrough NJ, Farr AL, Randall J (1951) Protein measurement with the folin phenol reagent. J Biol Chem 93:265-275
20. Dudeja PK, Brasitus TA (1990) 1,2-Dimethylhydrazine-induced alterations in lipid peroxidation in preneoplastic and neoplastic colonic tissues. Biochim Biophys Acta 1046:267-270
21. Hendrickse CW, Kelly R, Radley S, Donovan IA, Keighley MR, Neoptolemod JP (1994) Lipid peroxidation and prostaglandins in colorectal cancer. Br J Surg 81:1219-1223
22. Skrzydlewska E, Stanklewicz A, Michalak K, Sulkowaska M, Zalewski B, Piotrowski Z (2001) Antioxidant status and proteolytic-antiproteolytic balance in colorectal cancer. Folia Histochem Cytobiol 39:98-99
23. Seven A, Civelek S, Inci E, Korkut N, Burçak G (1999) Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma. Clin Biochem 32:369-373
24. Chvapil M, Ryan JN, Zukoski CF (1972) Effect of zinc on lipid peroxidation in liver microsomes and mitochondria. Proc Soc Exp Biol Med 140:642-646
25. Cabre M, Ferre N, Folch J, Paternain JL, Hernandez M, Castillo D, Joven G, Camps J (1995) Inhibition of hepatic cell nuclear DNA fragmentation by zinc in carbon tetrachloride-treated rats. J Hepatol 31:228-234
26. Bettger WJ, O'Dell BL (1981) A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 28:1425-1438
27. Pardeep S, Garg ML, Dhawan DK (2004) Protective role of zinc in nickel induced hepatotoxicity in rats. Chem Biol Interact 15:199-209
28. Younes M, Siegers CP (1981) Mechanistic aspects of enhanced lipid peroxidation following glutathione dependent depletion in vivo. Chem Biol Interact 34:257-266
29. Jakoby WB (1978) The glutathione tranferase in detoxification. In: Sies H, Wendel S (Eds) Functions of glutathione in liver and kidney. Springer, Berlin, pp 157-163
30. Al-Turk WA, Stohs SJ, El-Rashidy FH, Othman S, Shaheen O (1987) Changes in the glutathione, glutathione reductase and glutathione-s-transferase as a function of cell concentration and age. Pharmacology 34:1-8
31. Ludwig JC, Misiorowski RL, Chvapil M, Seymour MD (1980) Interaction of zinc ions with electron carrying coenzymes NADPH and NADH. Chem Biol Interact 30:25-34
32. Kyle ME, Miccadie S, Nakae D, Farber JL (1987) Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun 149:889-896
33. Mates JM, Sanchez-Jimenez F (1999) Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci 4:334-345
34. Burton GW, Cheesman KN, Ingold KV, Seater TF (1983) Lipid antioxidants and products of lipid peroxidation as potential tumor protective agents. Biochem Soc Trans 11:261-262
35. Reddy SB, John Charles M, Naga Raju GJ, Seetharami Reddy B, Seshi Reddy T, Rama Lakshmi PVB, Vijayan V (2004) Trace elemental analysis of cancer-afflicted intestine by PIXE technique. Biological Trace Element Res 102:265-281
36. Franklin RB, Feng P, Milon B, Desouki MM, Singh KK, Kajdaksy-Balla A, Bagasra O, Costello LC (2005) hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol Cancer 4:32
37. Szmigielski S, Litwin J (1964) The histochemical demonstration of zinc in blood granulocytes-the new test in diagnosis of neoplastic diseases. Cancer 17:1381-1384