Homeostasis of exercise hyperpnea and optimal sensorimotor integration: The internal model paradigm

Respiratory Physiology and Neurobiology

Volumn 159, Issue 1, 2007, Pages 1-13

  Poon, Chi Sang ^a   Tin, Chung ^a,b   Yu, Yunguo ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Chemoreflex; Control of breathing; Exercise hyperpnea; Homeostasis; Internal model paradigm; Learning and memory; Optimality principle; Sensorimotor integration; Ventilatory load compensation

Indexed keywords

BREATHING PATTERN; CHEMORECEPTOR REFLEX; ENERGY; EXERCISE; FEEDBACK SYSTEM; GAS EXCHANGE; HOMEOSTASIS; HUMAN; HYPERPNEA; INSTRUMENTAL CONDITIONING; LUNG VENTILATION; MENTAL PERFORMANCE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; RESPIRATION CONTROL; RESPIRATORY FUNCTION; REVIEW; SENSORIMOTOR INTEGRATION; STATE DEPENDENT LEARNING;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CARBON DIOXIDE; CHEMORECEPTORS; EXERCISE; HOMEOSTASIS; HUMANS; OXYGEN; RESPIRATORY PHYSIOLOGY;

EID: 34548860085     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.02.020     Document Type: Review

References (181)

1. Abbrecht P.H., Rajagopal K.R., and Kyle R.R. Expiratory muscle recruitment during inspiratory flow-resistive loading and exercise. Am. Rev. Respir. Dis. 144 (1991) 113-120
2. Ahn A., Tewari M., Poon C., and Phillips R. The clinical applications of a systems approach. PLoS Med. 3 (2006) e209
3. Ahn A., Tewari M., Poon C., and Phillips R. The limits of reductionism in medicine: could systems biology offer an alternative?. PLoS Med. 3 (2006) e208
4. Åström K.J., and Wittenman B. Adaptive Control (1995), Addison Wesley
5. 2. Respir. Physiol. 109 (1997) 15-28
6. 2 increases ventilation but does not decrease the work of breathing during exercise. Am. J. Respir. Crit. Care Med. 163 (2001) 1128-1134
7. Bell H.J. Respiratory control at exercise onset: an integrated systems perspective. Respir. Physiol. Neurobiol. 152 (2006) 1-15
8. Bell H.J., and Duffin J. Respiratory response to passive limb movement is suppressed by a cognitive task. J. Appl. Physiol. 97 (2004) 2112-2120
9. Bell H.J., and Duffin J. Rapid increases in ventilation accompany the transition from passive to active movement. Respir. Physiol. Neurobiol. 152 (2006) 128-142
10. Bell H.J., Feenstra W., and Duffin J. The initial phase of exercise hyperpnoea in humans is depressed during a cognitive task. Exp. Physiol. 90 (2005) 357-365
11. Benchetrit G. Breathing pattern in humans: diversity and individuality. Respir. Physiol. 122 (2000) 123-129
12. 2 in control of breathing of awake exercising dogs. J. Appl. Physiol. 56 (1984) 1335-1339
13. Bernard C. Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux (1978-1979), Baillière et fils, Paris
14. Boulant J.A. Neuronal basis of Hammel's model for set-point thermoregulation. J. Appl. Physiol. 100 (2006) 1347-1354
15. Campbell E.J.M., Agostoni E., and Newsom Davis J. The Respiratory Muscles: Mechanics and Neural Control (1970), Saunders, Philadelphia, PA
16. Cannon W.B. Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches into the Function of Emotional Excitement (1915), Appleton, New York
17. Cannon W.B. The Wisdom of the Body (1932), Norton, New York
18. Casaburi R., Whipp B.J., Wasserman K., Beaver W.L., and Koyal S.N. Ventilatory and gas exchange dynamics in response to sinusoidal work. J. Appl. Physiol. 42 (1977) 300-301
19. Cathcart A.J., Herrold N., Turner A.P., Wilson J., and Ward S.A. Absence of long-term modulation of ventilation by dead-space loading during moderate exercise in humans. Eur. J. Appl. Physiol. 93 (2005) 411-420
20. Cecchini A.B., Melbin J., and Noordergraaf A. Set-point: is it a distinct structural entity in biological control?. J. Theor. Biol. 93 (1981) 387-394
21. Cherniack N., Butera R., Champagnat J., Duffin J., Khoo M., Prabhakar N., Poon C., Robbins P., Smith J., and Strohl K. Workshop on modeling in the 21st century: an executive summary. VIII Oxford Conference Panel on Biomedical Modeling. Adv. Exp. Med. Biol. 499 (2001) 9-14
22. Cherniack N.S., and Altose M.D. Respiratory responses to ventilatory loading. In: Hornbein T.F. (Ed). Regulation of Breathing vol. II (1981), Marcel Dekker, New York, NY 905-964
23. Clark J.M., Sinclair R.D., and Lenox J.B. Chemical and nonchemical components of ventilation during hypercapnic exercise in man. J. Appl. Physiol. 48 (1980) 1065-1076
24. 2 and in arterial pH. In: Fishman A.P., Cherniack N.S., and Widdicombe J.G. (Eds). Handbook of Physiology, Sect. 3: The Respiratory System, vol. II. Control of Breathing, Part 2 (1986), American Physiological Society, Bethesda, MD 475-528
25. Daly W.J., and Overley T. Modification of ventilatory regulation by hypnosis. J. Lab. Clin. Med. 68 (1966) 279-285
26. Dampney R.A., Coleman M.J., Fontes M.A., Hirooka Y., Horiuchi J., Li Y.W., Polson J.W., Potts P.D., and Tagawa T. Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin. Exp. Pharmacol. Physiol. 29 (2002) 261-268
27. Davidson P.R., and Wolpert D.M. Widespread access to predictive models in the motor system: a short review. J. Neural Eng. 2 (2005) S313-S319
28. Dejours P. Control of respiration in muscular exercise. In: Fenn W.O., and Rahn H. (Eds). Handbook of Physiology, Sect. 3: Respiration, vol. 1 (1964), American Physiological Society, Washington, D.C 631-648
29. Dempsey J.A., and Fregosi R.F. Adaptability of the pulmonary system to changing metabolic requirements. Am. J. Cardiol. 55 (1985) 59D-67D
30. Dempsey J., Forster H., and Ainsworth D. Regulation of hyperpnea, hyperventilation, and respiratory muscle recruitment during exercise. In: Dempsey J., and Pack A. (Eds). Regulation of Breathing (1995), Marcel Dekker, New York 1034-1065
31. Dick T.E., and Coles S.K. Ventrolateral pons mediates short-term depression of respiratory frequency after brief hypoxia. Respir. Physiol. 121 (2000) 87-100
32. Duffin J., Miller R., Romet T.T., Chant R.W., Ackles K., and Goode R.C. Sudden cold water immersion. Respir. Physiol. 23 (1975) 301-310
33. Durand E., Dauger S., Vardon G., Gressens P., Gaultier C., De Schonen S., and Gallego J. Classical conditioning of breathing pattern after two acquisition trials in 2-day-old mice. J. Appl. Physiol. 94 (2003) 812-818
34. Dworkin B.R. Learning and Physiological Regulation (1993), University of Chicago Press, Chicago
35. Eldridge F.L., and Millhorn D.E. Oscillation, gating, and memory in the respiratory control system. In: Fishman A.P., Cherniack N.S., and Widdicombe J.G. (Eds). Handbook of Physiology, Section 3: The Respiratory System, Vol. II: Control of Breathing, part 1 (1986), American Physiological Society, Bethesda, MD 93-114
36. Eldridge F.L., Morin D., Romaniuk J.R., Yamashiro S., Potts J.T., Ichiyama R.M., Bell H., Phillipson E.A., Killian K.J., Jones N.L., and Nattie E. Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans. J. Appl. Physiol. 100 (2006) 1743-1747
37. Engel L.A., and Paiva M. Gas Mixing and Distribution in the Lung (1985), Marcel Dekker, New York
38. Entin P.L., Robertshaw D., and Rawson R.E. Thermal drive contributes to hyperventilation during exercise in sheep. J. Appl. Physiol. 85 (1998) 318-325
39. Favier R., Kepenekian G., Desplanches D., and Flandrois R. Effects of chronic lung denervation on breathing pattern and respiratory gas exchanges during hypoxia, hypercapnia and exercise. Respir. Physiol. 47 (1982) 107-119
40. Fink G.R., Adams L., Watson J.D., Innes J.A., Wuyam B., Kobayashi I., Corfield D.R., Murphy K., Jones T., Frackowiak R.S., et al. Hyperpnoea during and immediately after exercise in man: evidence of motor cortical involvement. J. Physiol. 489 Pt 3 (1995) 663-675
41. Flynn C., Forster H.V., Pan L.G., and Bisgard G.E. Role of hilar nerve afferents in hyperpnea of exercise. J. Appl. Physiol. 59 (1985) 798-806
42. Forster H.V. Exercise hyperpnea: where do we go from here?. Exerc. Sport Sci. Rev. 28 (2000) 133-137
43. Francis B.A., and Wonham W.M. The internal model principle for linear multivariable regulators. Appl. Math. Optimization 2 (1975) 170-194
44. Frazier D.T., Xu F., Lee L.Y., and Taylor R.F. Respiratory load compensation. III. Role of spinal cord afferents. J. Appl. Physiol. 75 (1993) 682-687
45. Gallagher C.G., and Younes M. Effect of pressure assist on ventilation and respiratory mechanics in heavy exercise. J. Appl. Physiol. 66 (1989) 1824-1837
46. Gallagher C.G., Sanii R., and Younes M. Response of normal subjects to inspiratory resistive unloading. J. Appl. Physiol. 66 (1989) 1113-1119
47. Gallego J., Nsegbe E., and Durand E. Learning in respiratory control. Behav. Modif. 25 (2001) 495-512
48. Gautier H. Interactions among metabolic rate, hypoxia, and control of breathing. J. Appl. Physiol. 81 (1996) 521-527
49. 2. Am. J. Respir. Crit. Care Med. 155 (1997) 2000-2009
50. Goldstein I., Goldstein S., Urbanetti J.A., and Anthonisen N.R. Effects of expiratory threshold loading during steady-state exercise. J. Appl. Physiol. 39 (1975) 697-701
51. Gozal D., Marcus C.L., Ward S.L., and Keens T.G. Ventilatory responses to passive leg motion in children with congenital central hypoventilation syndrome. Am. J. Respir. Crit. Care Med. 153 (1996) 761-768
52. Gray J.S. The multiple factor theory of the control of respiratory ventilation. Science 103 (1946) 739-744
53. Green A.M., Shaikh A.G., and Angelaki D.E. Sensory vestibular contributions to constructing internal models of self-motion. J. Neural Eng. 2 (2005) S164-S179
54. Greenberg H.E., Rapoport D.M., Gloeggler P.J., and Goldring R.M. Background ventilatory stimulus as a determinant of load compensation. J. Appl. Physiol. 66 (1989) 1352-1358
55. Grodins F.S. Analysis of factors concerned in regulation of breathing in exercise. Physiol. Rev. 30 (1950) 220-239
56. 2 inhalation; a theoretical study of a nonlinear biological regulator. J. Appl. Physiol. 7 (1954) 283-308
57. Grodins F.S., and Yamashiro S.M. Optimization of the mammalian respiratory gas transport system. Annu. Rev. Biophys. Bioeng. 2 (1973) 115-130
58. Grodins F.S., and Yamashiro S.M. What is the pattern of breathing regulated for?. In: von Euler C., and Langercrantz H. (Eds). Central Nervous Control Mechanisms in Breathing (1979), Pergaermon, New York 169-183
59. Haouzi P. Theories on the nature of the coupling between ventilation and gas exchange during exercise. Respir. Physiol. Neurobiol. 151 (2006) 267-279
60. 2 by somatic afferents in sheep. J. Physiol. 569 (2005) 975-987
61. Haouzi P., Chenuel B., Chalon B., Braun M., Bedez Y., Tousseul B., Claudon M., and Gille J.P. Isolation of the arterial supply to the carotid and central chemoreceptors in the sheep. Exp. Physiol. 88 (2003) 581-594
62. Harris R.B. Role of set-point theory in regulation of body weight. FASEB J. 4 (1990) 3310-3318
63. Hayashi F., Coles S.K., Bach K.B., Mitchell G.S., and McCrimmon D.R. Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats. Am. J. Physiol. 265 (1993) R811-R819
64. Helbling D., Boutellier U., and Spengler C.M. Modulation of the ventilatory increase at the onset of exercise in humans. Respir. Physiol. 109 (1997) 219-229
65. Henke K.G., Badr M.S., Skatrud J.B., and Dempsey J.A. Load compensation and respiratory muscle function during sleep. J. Appl. Physiol. 72 (1992) 1221-1234
66. Henry J.P., and Whitehorn W.V. Effect of cooling of orbital cortex on exercise hyperpnea in the dog. J. Appl. Physiol. 14 (1959) 241-244
67. Houk J.C. Control strategies in physiological systems. FASEB J. 2 (1988) 97-107
68. Hwang E.J., and Shadmehr R. Internal models of limb dynamics and the encoding of limb state. J. Neural Eng. 2 (2005) S266-S278
69. Imamizu H., Miyauchi S., Tamada T., Sasaki Y., Takino R., Putz B., Yoshioka T., and Kawato M. Human cerebellar activity reflecting an acquired internal model of a new tool. Nature 403 (2000) 192-195
70. Ioannou P.A., and Sun J. Robust Adaptive Control (1996), Prentice Hall PTR, Upper Saddle River, NJ
71. Ito M. Bases and implications of learning in the cerebellum - adaptive control and internal model mechanism. Prog. Brain Res. 148 (2005) 95-109
72. Jack S., Rossiter H.B., Pearson M.G., Ward S.A., Warburton C.J., and Whipp B.J. Ventilatory responses to inhaled carbon dioxide, hypoxia, and exercise in idiopathic hyperventilation. Am. J. Respir. Crit. Care Med. 170 (2004) 118-125
73. Johnson Jr. R.L. Gas exchange efficiency in congestive heart failure II. Circulation 103 (2001) 916-918
74. Juratsch C.E., Whipp B.J., Huntsman D.J., Laks M.M., and Wasserman K. Ventilatory control during experimental maldistribution of VA/Q in the dog. J. Appl. Physiol. 52 (1982) 245-253
75. Kao F. An experimental study of the pathways involved in exercise hyperpnoea employing cross-circulation techniques. In: Cunningham D., and Lloyd B.B. (Eds). The Regulation of Human Respiration (1963), Blackwell Science, Oxford 461-502
76. Karniel A. Three creatures named 'forward model'. Neural Netw. 15 (2002) 305-307
77. Kaufman M.P., and Forster H.V. Reflexes controlling Circulatory, Ventilatory and Airway Responses to Exercise (1996), American Physiological Society, Bethesda, MD
78. Keesey R.E., and Hirvonen M.D. Body weight set-points: determination and adjustment. J. Nutr. 127 (1997) 1875S-1883S
79. Keslacy S., Matecki S., Carra J., Borrani F., Candau R., Prefaut C., and Ramonatxo M. Effect of inspiratory threshold loading on ventilatory kinetics during constant-load exercise. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 (2005) R1618-R1624
80. Khoo M.C. Determinants of ventilatory instability and variability. Respir. Physiol. 122 (2000) 167-182
81. Krogh A., and Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J. Physiol. 47 (1913) 112-136
82. Kuo A.D. An optimal state estimation model of sensory integration in human postural balance. J. Neural Eng. 2 (2005) S235-S249
83. Lahiri S., Mei S.S., and Kao F.F. Vagal modulation of respiratory control during exercise. Respir. Physiol. 23 (1975) 133-146
84. Lopata M., Onal E., and Cromydas G. Respiratory load compensation in chronic airway obstruction. J. Appl. Physiol. 59 (1985) 1947-1954
85. Masaoka Y., and Homma I. The effect of anticipatory anxiety on breathing and metabolism in humans. Respir. Physiol. 128 (2001) 171-177
86. 2 ventilations in man. Bull Eur. Physiopathol Respir. 20 (1984) 501-506
87. Mateika J.H., and Duffin J. A review of the control of breathing during exercise. Eur. J. Appl. Physiol. Occup. Physiol. 71 (1995) 1-27
88. McKinley M., and Johnson A. The physiological regulation of thirst and fluid intake. News Physiol. Sci. 19 (2004) 1-6
89. Mitchell G.S., and Babb T.G. Layers of exercise hyperpnea: modulation and plasticity. Respir. Physiol. Neurobiol. 151 (2006) 251-266
90. Mitchell G.S., Douse M.A., and Foley K.T. Receptor interactions in modulating ventilatory activity. Am. J. Physiol. 259 (1990) R911-R920
91. Moosavi S.H., Guz A., and Adams L. Repeated exercise paired with "imperceptible" dead space loading does not alter VE of subsequent exercise in humans. J. Appl. Physiol. 92 (2002) 1159-1168
92. Morgan W.P. Psychogenic factors and exercise metabolism: a review. Med. Sci. Sports Exerc. 17 (1985) 309-316
93. Mortola J.P., and Frappell P.B. Ventilatory responses to changes in temperature in mammals and other vertebrates. Annu Rev. Physiol. 62 (2000) 847-874
94. 2 production and ventilation in the hypoxic kitten. J. Appl. Physiol. 74 (1993) 905-910
95. Mukhtar M.R., and Patrick J.M. Ventilatory drive during face immersion in man. J. Physiol. 370 (1986) 13-24
96. Newstead C.G. The relationship between ventilation and oxygen consumption in man is the same during both moderate exercise and shivering. J. Physiol. 383 (1987) 455-459
97. 2 set point on ventilatory response to exercise. J. Appl. Physiol. 51 (1981) 185-189
98. Osborn J.W., Jacob F., and Guzman P. A neural set point for the long-term control of arterial pressure: beyond the arterial baroreceptor reflex. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 (2005) R846-R855
99. 2 inhalation, and thermal stresses. J. Appl. Physiol. 61 (1986) 1577-1581
100. Paton J.Y., Swaminathan S., Sargent C.W., Hawksworth A., and Keens T.G. Ventilatory response to exercise in children with congenital central hypoventilation syndrome. Am. Rev. Respir. Dis. 147 (1993) 1185-1191
101. 2 load. J. Appl. Physiol. 51 (1981) 1398-1403
102. 2 production in ventilatory response to steady-state exercise. J. Clin. Invest. 68 (1981) 768-774
103. 2 load. J. Appl. Physiol. 50 (1981) 45-54
104. Phillipson E.A., Hickey R.F., Bainton C.R., and Nadel J.A. Effect of vagal blockade on regulation of breathing in conscious dogs. J. Appl. Physiol. 29 (1970) 475-479
105. Phillipson E.A., McClean P.A., Sullivan C.E., and Zamel N. Interaction of metabolic and behavioral respiratory control during hypercapnia and speech. Am. Rev. Respir. Dis. 117 (1978) 903-909
106. Poon C.S. Introduction: optimization hypothesis in the control of breathing. In: Honda Y., Miyamoto Y., Konno K., and Widdicombe J.G. (Eds). Control of Breathing and its Modeling Perspective (1992), Plenum, New York, NY 371-384
107. 2 and dead space loading. J. Appl. Physiol. 73 (1992) 591-595
108. Poon C.S. Organization of central pathways mediating the Hering-Breuer reflex and carotid chemoreflex. Adv. Exp. Med. Biol. 551 (2004) 95-100
109. Poon C.S. Optimal control of ventilation in hypoxia, hypercapnia and exercise. In: Whipp B.J., and Wiberg D.W. (Eds). Modelling and Control of Breathing (1983), Elsevier, New York 189-196
110. Poon C.S. Ventilatory control in hypercapnia and exercise: optimization hypothesis. J. Appl. Physiol. 62 (1987) 2447-2459
111. Poon C.S. Analysis of linear and mildly nonlinear relationships using pooled subject data. J. Appl. Physiol. 64 (1988) 854-859
112. Poon C.S. Optimal regulation of ventilation during exercise. In: Khoo M.C. (Ed). Modeling and Parameter Estimation in Respiratoy Control (1989), Plenum, New York 25-37
113. Poon C.S. Effects of inspiratory elastic load on respiratory control in hypercapnia and exercise. J. Appl. Physiol. 66 (1989) 2400-2406
114. Poon C.S. Effects of inspiratory resistive load on respiratory control in hypercapnia and exercise. J. Appl. Physiol. 66 (1989) 2391-2399
115. Poon C.S. Optimization behavior of brainstem respiratory neurons. A cerebral neural network model. Biol. Cybern. 66 (1991) 9-17
116. Poon C.S. Adaptive neural network that subserves optimal homeostasis control of breathing. Ann. Biomed. Eng. 21 (1993) 501-508
117. Poon C.S. Synaptic plasticity and respiratory control. In: Khoo M.C.K. (Ed). Bioengineering Approaches to Pulmonary Physiology and Medicine (1996), Plenum, Los Angles 93-113
118. Poon C.S. Self-tuning optimal regulation of respiratory motor output by Hebbian covariance learning. Neural Netw. 9 (1996) 1367-1383
119. Poon C.S. Possible mechanism of augmented exercise hyperpnea in congestive heart failure. Circulation 104 (2001) E131
120. Poon C.S., and Greene J.G. Control of exercise hyperpnea during hypercapnia in humans. J. Appl. Physiol. 59 (1985) 792-797
121. Poon C.S., and Merfeld D. Internal models: the state of the art (Editorial for special issue: Sensory integration, state estimation, and motor control in the brain: role of internal models). J. Neural Eng. (2005) 2 10.1088/1741-2552/2/3/E01
122. Poon C.S., and Siniaia M.S. Plasticity of cardiorespiratory neural processing: classification and computational functions. Respir. Physiol. 122 (2000) 83-109
123. Poon C.S., and Young D.L. Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways. Behav. Brain Funct. 2 (2006) 29
124. Poon C.S., Lin S.L., and Knudson O.B. Optimization character of inspiratory neural drive. J. Appl. Physiol. 72 (1992) 2005-2017
125. Poon C.S., Siniaia M.S., Young D.L., and Eldridge F.L. Short-term potentiation of carotid chemoreflex: an NMDAR-dependent neural integrator. NeuroReport 10 (1999) 2261-2265
126. Poon C.S., Ward S.A., and Whipp B.J. Influence of inspiratory assistance on ventilatory control during moderate exercise. J. Appl. Physiol. 62 (1987) 551-560
127. Poon C.S., Younes M., and Gallagher C.G. Effects of expiratory resistive load on respiratory motor output in conscious humans. J. Appl. Physiol. 63 (1987) 1837-1845
128. Poon C.S., Young D.L., and Siniaia M.S. High-pass filtering of carotid-vagal influences on expiration in rat: role of N-methyl-D-aspartate receptors. Neurosci. Lett. 284 (2000) 5-8
129. Priban I.P., and Fincham W.F. Self-adaptive control and respiratory system. Nature 208 (1965) 339-343
130. Proctor D.F. Modifications of breathing for phonation. In: Fishman A.P. (Ed). Handbook of Physiology. Section 3: The Respiratory System. Vol. III, Mechanics of Breathing, Part 2 (1986) 597-604
131. Purves M.J. What do we breathe for?. In: von Euler C., and Lagercrantz H. (Eds). Central Nervous Control Mechanisms in Breathing (Wenner-Gren Center Int. Symp. Ser.) vol. 32 (1979), Pergamon, Oxford, UK 7-12
132. Remmers J.E. A century of control of breathing. Am. J. Respir. Crit. Care Med. 172 (2005) 6-11
133. Rohrer F. Physiologie der Atembewegung. In: Bethe A.T.J., von Bergmann G., Embden G., and Ellinger A. (Eds). Handbuch der Normalen und Pathologischen Physiologie vol. 2 (1925), Springer, Berlin
134. Romanovsky A.A. Do fever and anapyrexia exist? Analysis of set point-based definitions. Am. J. Physiol. Regul Integr. Comp. Physiol. 287 (2004) R992-R995
135. Schmidt-Nielsen K. How are control systems controlled?. Am. Scientist 82 (1994) 38-44
136. Secher N., Poon C.S., Ward S., Whipp B., and Duffin J. Supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise in humans. J. Appl. Physiol. 100 (2006) 1417-1418
137. Selye H. Homeostasis and heterostasis. Perspect. Biol. Med. 16 (1973) 441-445
138. Shea S.A., Andres L.P., Shannon D.C., and Banzett R.B. Ventilatory responses to exercise in humans lacking ventilatory chemosensitivity. J. Physiol. 468 (1993) 623-640
139. 2 breathing under inspiratory resistive load. J. Appl. Physiol. 78 (1995) 555-561
140. Sietsema K.E., Cooper D.M., Perloff J.K., Child J.S., Rosove M.H., Wasserman K., and Whipp B.J. Control of ventilation during exercise in patients with central venous-to-systemic arterial shunts. J. Appl. Physiol. 64 (1988) 234-242
141. Siniaia M.S., Young D.L., and Poon C.S. Habituation and desensitization of the Hering-Breuer reflex in rat. J. Physiol. 523 Pt 2 (2000) 479-491
142. Skott O. Body sodium and volume homeostasis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003) R14-R18
143. Somjen G. The missing error signal - regulation beyond negative feedback. News Physiol. Sci. 7 (1992) 184-185
144. Stevens S.S. To honor Fechner and repeal his law. Science 133 (1961) 80-86
145. Strange K. The end of "naive reductionism": rise of systems biology or renaissance of physiology?. Am. J. Physiol. Cell Physiol. 288 (2005) C968-C974
146. 2 loading in the awake dog. J. Appl. Physiol. 44 (1978) 311-316
147. Sutton R.S., and Barton A.G. Reinforcement Learning - An Introduction (1998), The MIT Press, Cambridge, MA
148. Thornton J.M., Guz A., Murphy K., Griffith A.R., Pedersen D.L., Kardos A., Leff A., Adams L., Casadei B., and Paterson D.J. Identification of higher brain centres that may encode the cardiorespiratory response to exercise in humans. J. Physiol. 533 (2001) 823-836
149. Tin C., and Poon C.S. Internal models in sensorimotor integration: perspectives from adaptive control theory. J. Neural Eng. 2 (2005) S147-S163
150. Tobin M.J., Mador M.J., Guenther S.M., Lodato R.F., and Sackner M.A. Variability of resting respiratory drive and timing in healthy subjects. J. Appl. Physiol. 65 (1988) 309-317
151. Tobin M.J., Perez W., Guenther S.M., D'Alonzo G., and Dantzker D.R. Breathing pattern and metabolic behavior during anticipation of exercise. J. Appl. Physiol. 60 (1986) 1306-1312
152. Turner D., and Stewart J.D. Associative conditioning with leg cycling and inspiratory resistance enhances the early exercise ventilatory response in humans. Eur. J. Appl. Physiol. 93 (2004) 333-339
153. Turner D.L., and Sumners D.P. Associative conditioning of the exercise ventilatory response in humans. Respir. Physiol. Neurobiol. 132 (2002) 159-168
154. Wagner J.A., Horvath S.M., and Dahms T.E. Cardiovascular, respiratory, and metabolic adjustments to exercise in dogs. J. Appl. Physiol. 42 (1977) 403-407
155. Waldrop, T.G., Eldridge, F.L., A. Iwamoto, G., Mitchell, J.H., 1996. Central Neural Control of Locomotion, Respiration and Circulation During Exercise. American Physiological Society, Bethesda, MD.
156. Waldrop T.G., Iwamoto G.A., and Haouzi P. Point:Counterpoint: supraspinal locomotor centers do/do not contribute significantly to the hyperpnea of dynamic exercise. J. Appl. Physiol. 100 (2006) 1077-1083
157. Wang L.Y., and Cerny F.J. Ventilatory response to exercise in simulated obesity by chest loading. Med. Sci. Sports Exerc. 36 (2004) 780-786
158. Ward S.A. Control of the exercise hyperpnoea in humans: a modeling perspective. Respir. Physiol. 122 (2000) 149-166
159. Ward S.A., and Poon C.S. Beyond chemoreflex: plasticity, redundancy and self-organization in respiratory control: a workshop summary. Adv. Exp. Med. Biol. 499 (2001) 267-272
160. Ward S.A., and Whipp B.J. Ventilatory control during exercise with increased external dead space. J. Appl. Physiol. 48 (1980) 225-231
161. Ward S.A., Whipp B.J., and Poon C.S. Density-dependent airflow and ventilatory control during exercise. Respir. Physiol. 49 (1982) 267-277
162. Wasserman K., Whipp B.J., and Casaburi R. Respiratory control during exercise. In: Fishman A.P., Cherniack N.S., and Widdicombe J.G. (Eds). Handbook of Physiology, Sect. 3: The Respiratory System, vol. II. Control of Breathing, Part 2 (1986), American Physiological Society, Bethesda, MD 595-619
163. 2 flow to the lungs and ventilatory control. In: Dempsey J.A., and Reed C.E. (Eds). Muscular Exercise and the Lung (1977), University of Wisconsin Press, Madison 103-135
164. Wasserman K., Zhang Y.Y., Gitt A., Belardinelli R., Koike A., Lubarsky L., and Agostoni P.G. Lung function and exercise gas exchange in chronic heart failure. Circulation 96 (1997) 2221-2227
165. Weibel E.R., Taylor C.R., and Hoppeler H. The concept of symmorphosis: a testable hypothesis of structure-function relationship. Proc. Natl. Acad. Sci. USA 88 (1991) 10357-10361
166. White M.D. Components and mechanisms of thermal hyperpnea. J. Appl. Physiol. 101 (2006) 655-663
167. Wiener N. Cybernetics: or Control and Communication in the Animal and the Machine (1948), M.I.T. Press, Cambridge, MA
168. Wood H.E., Fatemian M., and Robbins P.A. A learned component of the ventilatory response to exercise in man. J. Physiol. 553 (2003) 967-974
169. Wysocki M., Fiamma M.N., Straus C., Poon C.S., and Similowski T. Chaotic dynamics of resting ventilatory flow in humans assessed through noise titration. Respir. Physiol. Neurobiol. 153 (2006) 54-65
170. 2. J. Appl. Physiol. 15 (1960) 215-219
171. 2 signals. Am. J. Physiol. 238 (1980) R28-R35
172. Yamashiro, S.M., Poon, C.S., DiStefano, J.J., III, 1991. Modeling pioneer: Fred S. Grodins (1915-1989). J. Appl. Physiol. 70, 2763.
173. Young D.L., and Poon C.S. Hebbian Covariance Learning: A Nexus for Respiratory Variability, Memory, and Optimization? (1998), Plenum Press, New York
174. Young D.L., and Poon C.S. Soul searching and heart throbbing for biological modeling. Behav. Brain Sci. 24 (2001) 1080-1081
175. Young D.L., and Poon C.S. A Hebbian feedback covariance learning paradigm for self-tuning optimal control. IEEE Transact. Syst. Man Cybernet. - Part B 31 (2001) 173-186
176. Young D.L., Eldridge F.L., and Poon C.S. Integration-differentiation and gating of carotid afferent traffic that shapes the respiratory pattern. J. Appl. Physiol. 94 (2003) 1213-1229
177. 2 by somatic afferents'. J. Physiol. 572 (2006) 897-898
178. Zago M., and Lacquaniti F. Visual perception and interception of falling objects: a review of evidence for an internal model of gravity. J. Neural Eng. 2 (2005) S198-S208
179. Zuntz N., and Geppert J. Üeber die Natur der normalen Atemreize und den Ort ihrer Wirkung. Pflügers Arch Gesamte Physiol Menschen Tiere 38 (1886) 337-338
180. Zupan L.H., and Merfeld D.M. An internal model of head kinematics predicts the influence of head orientation on reflexive eye movements. J. Neural Eng. 2 (2005) S180-S197
181. Zuperku E.J., and McCrimmon D.R. Gain modulation of respiratory neurons. Respir. Physiol. Neurobiol. 131 (2002) 121-133