Experimentally valid predictions of muscle force and EMG in models of motor-unit function are most sensitive to neural properties

Journal of Neurophysiology

Volumn 98, Issue 3, 2007, Pages 1581-1590

  Keenan, Kevin G ^a,b   Valero Cuevas, Francisco J ^a,b,c  

^a Cornell University   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ELECTROMYOGRAM; MATHEMATICAL MODEL; MONTE CARLO METHOD; MOTONEURON; MOTOR UNIT POTENTIAL; MUSCLE FORCE; NERVE POTENTIAL; PREDICTION; PRIORITY JOURNAL;

ALGORITHMS; ANIMALS; ELECTROMYOGRAPHY; MODELS, NEUROLOGICAL; MONTE CARLO METHOD; MOTOR NEURONS; MUSCLE, SKELETAL; REPRODUCIBILITY OF RESULTS;

EID: 34548850346     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00577.2007     Document Type: Article

References (70)

1. Andreassen S, Arendt-Nielsen L. Muscle fibre conduction velocity in motor units of the human anterior tibial muscle: a new size principle parameter. J Physiol 391: 561-571, 1987.
2. Armstrong JB, Rose PK, Vanner S, Bakker GJ, Richmond FJ. Compartmentalization of motor units in the cat neck muscle, biventer cervicis. J Neurophysiol 60: 30-45, 1988.
3. Baker SN, Lemon RN. Computer simulation of post-spike facilitation in spike-triggered averages of rectified EMG. J Neurophysiol 80: 1391-1406, 1998.
4. Basmajian JV, De Luca CJ. Muscles Alive: Their Functions Revealed by Electromyography. Baltimore, MD: Williams and Wilkins, 1985.
5. Bellemare F, Woods JJ, Johansson R, Bigland-Ritchie B. Motor-unit discharge rates in maximal voluntary contractions of three human muscles. J Neurophysiol 50: 1380-1392, 1983.
6. Bigland B, Lippold OCJ. The relation between force, velocity and integrated electrical activity in human muscles. J Physiol 123: 214-224, 1954.
7. Bigland-Ritchie B. EMG/force relations and fatigue of human voluntary contractions. Exerc Sport Sci Rev 9: 75-117, 1981.
8. Bigland-Ritchie B, Fuglevand AJ, Thomas CK. Contractile properties of human motor units: is man a cat? Neuroscientist 4: 240-249, 1998.
9. Bodine SC, Garfinkel A, Roy RR, Edgerton VR. Spatial distribution of motor unit fibers in the cat soleus and tibialis anterior muscles: local interactions. J Neurosci 8: 2142-2152, 1988.
10. Bodine SC, Roy RR, Eldred E, Edgerton VR. Maximal force as a function of anatomical features of motor units in the cat tibialis anterior. J Neurophysiol 57: 1730-1745, 1987.
11. Buchthal F, Erminio F, Rosenfalck P. Motor unit territory in different human muscles. Acta Physiol Scand 45: 72-87, 1959.
12. Connelly DM, Rice CL, Roos MR, Vandervoort AA. Motor unit firing rates and contractile properties in tibialis anterior of young and old men. J Appl Physiol 87: 843-852, 1999.
13. Day SJ, Hulliger M. Experimental simulation of cat electromyogram: evidence for algebraic summation of motor-unit action-potential trains. J Neurophysiol 86: 2144-2158, 2001.
14. De Luca CJ, LeFever RS, McCue MP, Xenakis AP. Behaviour of human motor units in different muscles during linearly varying contractions. J Physiol 329: 113-128, 1982.
15. Edgerton VR, Smith JL, Simpson DR. Muscle fiber type populations of human leg muscles. Histochem J 7: 259-266, 1975.
16. Enoka RM, Burnett RA, Graves AE, Kornatz KW, Laidlaw DH. Task- and age-dependent variations in steadiness. Prog Brain Res 123: 389-395, 1999.
17. Enoka RM, Christou EA, Hunter SK, Kornatz KW, Semmler JG, Taylor AM, Tracy BL. Mechanisms that contribute to differences in motor performance between young and old adults. J Electromyogr Kinesiol 13: 1-12, 2003.
18. Enoka RM, Fuglevand AJ. Motor unit physiology: some unresolved issues. Muscle Nerve 24: 4-17, 2001.
19. Erim Z, De Luca CJ, Mineo K, Aoki T. Rank-ordered regulation of motor units. Muscle Nerve 19: 563-573, 1996.
20. Farina D, Fortunato E, Merletti R. Noninvasive estimation of motor unit conduction velocity distribution using linear electrode arrays. IEEE Trans Biomed Eng 47: 380-388, 2000.
21. Farina D, Fosci M, Merletti R. Motor unit recruitment strategies investigated by surface EMG variables. J Appl Physiol 92: 235-247, 2002.
22. Farina D, Merletti R. A novel approach for precise simulation of the EMG signal detected by surface electrodes. IEEE Trans Biomed Eng 48: 637-646, 2001.
23. Farina D, Merletti R, Enoka RM. The extraction of neural strategies from the surface EMG. J Appl Physiol 96: 1486-1495, 2004a.
24. Farina D, Mesin L, Martina S, Merletti R. A surface EMG generation model with multilayer cylindrical description of the volume conductor. IEEE Trans Biomed Eng 51: 415-426, 2004b.
25. Feinstein B, Lindegard B, Nyman E, Wohlfart G. Morphologic studies of motor units in normal human muscles. Acta Anat 23: 127-142, 1955.
26. Fuglevand AJ, Winter DA, Patla AE. Models of recruitment and rate coding organization in motor-unit pools. J Neurophysiol 70: 2470-2488, 1993.
27. Gydikov A, Kosarov D. Some features of different motor units in human biceps brachii. Pfluegers 347: 75-88, 1974.
28. Hamilton AF, Jones KE, Wolpert DM. The scaling of motor noise with muscle strength and motor unit number in humans. Exp Brain Res 157: 417-430, 2004.
29. Harris CM, Wolpert DM. Signal-dependent noise determines motor planning. Nature 394: 780-784, 1998.
30. Heckman CJ, Enoka RM. Physiology of the motor neuron and the motor unit. In: Clinical Neurophysiology of Motor Neuron Diseases (1st ed.), edited by Eisen A. Amsterdam; Boston: Elsevier, 2004, p. 119-147.
31. Henneman E. Relation between size of neurons and their susceptibility to discharge. Science 126: 1345-1347, 1957.
32. Hultborn H, Denton ME, Wienecke J, Nielsen JB. Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current. J Physiol 552: 945-952, 2003.
33. Inman VT, Ralston HJ, Saunders JB, Feinstein B, Wright EW. Relation of human electromyogram to muscular tension. Electroencephalogr Clin Neurophysiol 4: 187-194, 1952.
34. Johns RK, Fuglevand AJ. Evidence for intrinsic mechanisms underlying firing rate saturation in human motor neurons. Soc Neurosci Abstr 188.182, 2004.
35. Johnson MA, Polgar J, Weightman D, Appleton D. Data on the distribution of fiber types in thirty-six human muscles. An autopsy study. J Neurol Sci 18: 111-129, 1973.
36. Jones KE, Hamilton A, Wolpert DM. The sources of signal dependent noise during isometric force production. J Neurophysiol 88: 1533-1544, 2002.
37. Kamen G, Sison SV, Du CC, Patten C. Motor unit discharge behavior in older adults during maximal-effort contractions. J Appl Physiol 79: 1908-1913, 1995.
38. Kanda K, Hashizume K. Factors causing difference in force output among motor units in the rat medial gastrocnemius muscle. J Physiol 448: 677-695, 1992.
39. Keenan KG, Farina D, Maluf KS, Merletti R, Enoka RM. Influence of amplitude cancellation on the simulated electromyogram. J Appl Physiol 98: 120-131, 2005.
40. Keenan KG, Farina D, Merletti R, Enoka RM. Amplitude cancellation reduces the size of motor unit potentials averaged from the surface EMG. J Appl Physiol 100: 1928-1937, 2006a.
41. Keenan KG, Farina D, Merletti R, Enoka RM. Influence of motor unit properties on the size of the simulated evoked surface EMG potential. Exp Brain Res 169: 37-49, 2006b.
42. Keenan KG, Valero-Cuevas FJ. EMG amplitude is most sensitive to the range in innervation numbers: a large-scale computational sensitivity analysis. 16th Annual Meeting of the Neural Control of Movement Meeting, D-05 Key Biscayne, FL, 2006.
43. Kernell D. Synaptic influence on the repetitive activity elicited in cat lumbosacral motoneurons by long-lasting injected currents. Acta Physiol Scand 63: 409-410, 1965.
44. Kernell D, Eerbeek O, Verhey BA. Motor unit categorization on basis of contractile properties: an experimental analysis of the composition of the cat's m. peroneus longus. Exp Brain Res 50: 211-219, 1983.
45. Lacquaniti F, Soechting JF. Coordination of arm and wrist motion during a reaching task. J Neurosci 2: 399-408, 1982.
46. Laidlaw DH, Bilodeau M, Enoka RM. Steadiness is reduced and motor unit discharge is more variable in old adults. Muscle Nerve 23: 600-612, 2000.
47. Lawrence JH, De Luca CJ. Myoelectric signal versus force relationship in different human muscles. J Appl Physiol 54: 1653-1659, 1983.
48. Lexell J, Henriksson-Larsen K, Winblad B, Sjostrom M. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve 6: 588-595, 1983.
49. Lowery MM, Erim Z. A simulation study to examine the effect of common motoneuron inputs on correlated patterns of motor unit discharge. J Comput Neurosci 19: 107-124, 2005.
50. Lowery MM, Stoykov NS, Kuiken TA. A simulation study to examine the use of cross-correlation as an estimate of surface EMG cross talk. J Appl Physiol 94: 1324-1334, 2003.
51. McGill KC. Surface electromyogram signal modelling. Med Biol Eng Comput 42: 446-454, 2004.
52. Milner-Brown HS, Stein RB. The relation between the surface electromyogram and muscular force. J Physiol 246: 549-569, 1975.
53. Milner-Brown HS, Stein RB, Yemm R. Changes in firing rate of human motor units during linearly changing voluntary contractions. J Physiol 230: 371-390, 1973a.
54. Milner-Brown HS, Stein RB, Yemm R. The orderly recruitment of human motor units during voluntary isometric contractions. J Physiol 230: 359-370, 1973b.
55. Moritz CT, Barry BK, Pascoe MA, Enoka RM. Discharge rate variability influences the variation in force fluctuations across the working range of a hand muscle. J Neurophysiol 93: 2449-2459, 2005.
56. Perreault EJ, Day SJ, Hulliger M, Heckman CJ, Sandercock TG. Summation of forces from multiple motor units in the cat soleus muscle. J Neurophysiol 89: 738-744, 2003.
57. Rack PM, Westbury DR. The effects of length and stimulus rate on tension in the isometric cat soleus muscle. J Physiol 204: 443-460, 1969.
58. Rosenfalck P. Intra- and extracellular potential fields of active nerve and muscle fibers. Acta Physiol Scand Suppl 47: 239-246, 1969.
59. Santos VJ, Valero-Cuevas FJ. Reported anatomical variability naturally leads to multimodal distributions of Denavit-Hartenberg parameters for the human thumb. IEEE Trans Biomed Eng 53: 155-163, 2006.
60. Schieber MH. Muscular production of individuated finger movements: the roles of extrinsic finger muscles. J Neurosci 15: 284-297, 1995.
61. Schwindt PC, Calvin WH. Membrane-potential trajectories between spikes underlying motoneuron firing rates. J Neurophysiol 35: 311-325, 1972.
62. Slifkin AB, Newell KM. Variability and noise in continuous force production. J Mot Behav 32: 141-150, 2000.
63. Stålberg E, Antoni L. Electrophysiological cross section of the motor unit. J Neurol Neurosurg Psychiatry 43: 469-474, 1980.
64. Stegeman DF, Blok JH, Hermens HJ, Roeleveld K. Surface EMG models: properties and applications. J Electromyogr Kinesiol 10: 313-326, 2000.
65. Thoroughman KA, Shadmehr R. Electromyographic correlates of learning an internal model of reaching movements. J Neurosci 19: 8573-8588, 1999.
66. Valero-Cuevas FJ. An integrative approach to the biomechanical function and neuromuscular control of the fingers. J Biomech 38: 673-684, 2005.
67. Valero-Cuevas FJ, Johanson ME, Towles JD. Towards a realistic biomechanical model of the thumb: the choice of kinematic description may be more critical than the solution method or the variability/uncertainty of musculoskeletal parameters. J Biomech 36: 1019-1030, 2003.
68. Valero-Cuevas FJ, Zajac FE, Burgar CG. Large index-fingertip forces are produced by subject-independent patterns of muscle excitation. J Biomech 31: 693-703, 1998.
69. Yao W, Fuglevand AJ, Enoka RM. Motor-unit synchronization increases EMG amplitude and decreases force steadiness of simulated contractions. J Neurophysiol 83: 441-452, 2000.
70. Zhou P, Rymer WZ. Factors governing the form of the relation between muscle force and the electromyogram (EMG): a simulation study. J Neurophysiol: 2878-2886, 2004.