Time-course of recovery of 5-HT1A receptors and changes in 5-HT1A receptor mRNA after irreversible inactivation with EEDQ

Molecular Brain Research

Volumn 38, Issue 2, 1996, Pages 233-242

  Raghupathi, Revathi K ^a   Brousseau, David A ^a   McGonigle, Paul ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 HT1A mRNA; 5HT1A receptors; Autoradiography; EEDQ; Hybridization, in situ; p MPPI; Receptor regulation

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; ALKYLATING AGENT; BRAIN RECEPTOR; IODINE 125; MESSENGER RNA; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; GENE EXPRESSION REGULATION; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR GENE;

ANIMALS; IN SITU HYBRIDIZATION; KINETICS; MALE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RNA PROBES; RNA, MESSENGER; SEROTONIN ANTAGONISTS; TRANSCRIPTION, GENETIC;

ANIMALIA; TRITIUM;

EID: 0029890291     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(95)00311-F     Document Type: Article

References (46)

1. 2 receptor stimulation. Mol. Pharmacol., 43 (1993) 349-355.
2. 2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat. Mol. Brain. Res., 11 (1991) 161-166.
3. 125I autoradiography. J. Neurosci. Methods, 32 (1990) 185-192.
4. 1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and (-)-1-(4-bromo-2,5-dimethexyphenyl)-2-aminopropane. Mol. Pharmacol., 44 (1993) 725-730.
5. 2 receptor recovery in mature and senescent rat brain after irreversible receptor modification: effect of chronic reserpine treatment. J. Pharmacol. Exp. Ther., 243 (1987) 69-75.
6. 1 dopamine receptor-mediated stimulation of rat striatal adenylate cyclase activity following irreversible receptor modification by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ): evidence for spare receptors. Neurosci. Lett., 69 (1986) 290-295.
7. Belleau, B., V. DiTullio and D. Godin. The mechanism of irreversible adrenergic blockade by N-carbethoxydihydroquinolines. Model studies with typical serine hydrolases. Biochem. Pharmacol., 18 (1969) 1039-1044.
8. 2 receptor mRNA in response to haloperidol treatment: a quantitative in situ hybridization study. Neuroscience, 45 (1991) 117-126.
9. Blier, P., C. de Montigny and Y. Chaput. A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. J. Clin. Psychiatry, 51 (Suppl. 4) (1990) 14-20.
10. 1A receptors after irreversible blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Proc. West. Pharmacol. Soc., 34 (1991) 387-393.
11. 1A receptor mRNA in rat brain. Soc. Neurosci. Abstr., 16 (1990) 290.6.
12. 2 receptor mRNA in rat frontal cortex. J. Neurochem., 61 (1993) 1270-1276.
13. 1A receptor mRNA expression. J. Neurosci., 13 (1993) 914-923.
14. Chang, K.J., J.F. Moran and Triggle, D.J. Mechanism of cholinergic antagonism by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Pharmacol. Res. Commun. 2 (1970) 63-66.
15. 1A receptor binding sites in some areas of the rat CNS during postnatal development. Int. J. Dev. Neurosci., 5 (1987) 171-180.
16. Dourish, C.T., P.H. Hutson, G.H. Kennet and G. Curzon. 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite, 1 (Suppl.) (1986) 127-140.
17. Eison, M.S. Serotonin: a common neurobiological substrate in anxiety and depression. J. Clin. Psychopharmacol., 10 (Suppl. 3) (1990) 26s-30s.
18. Frankfurt, M., C.R. McKittrick, S.D. Mendelson and B.S. McEwen. Effect of 5,7-dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding in rat brain. Neuroendocrinology, 59 (1994) 245-250.
19. Frankfurt, M., S.D. Mendelson, C.R. McKittrick and B.S. McEwen. Alterations of serotonin receptor binding in the hypothalamus following acute denervation. Brain Res., 601 (1993) 349-352.
20. 1A-mediated responses: Effects of treatments that modify serotonergic neurotransmission. Ann. NY Acad. Sci., 600 (1990) 460-474.
21. Glennon, R.A. Serotonin receptors: clinical implications. Neurosci. Biobehav. Rev., 14 (1990) 35-47.
22. Gozlan, H., A.-M. Laporte, S. Thibault, L.E. Schecter, F. Bolanos and M. Hamon. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology, 33 (1994) 423-431.
23. Hadcock, J.R., H.-Y. Wang and C.C. Malbon. Agonist-induced destabilization of β-adrenergic receptor mRNA. J. Biol. Chem., 264 (1989) 19928-19933.
24. 1A receptor regulation. Effects of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology, 4 (1991) 131-144.
25. 2 receptor mRNA expression in rat brain. Neuroscience, 47 (1992) 771-779.
26. 1A antagonist: p-MPPI. Life Sci., 55 (1994) 1459-1462.
27. Levy, A.D. and Van de Kar, L.D. Endocrine and receptor pharmacology of serotonergic anxiolytics, antipsychotics and antidepressants. Life Sci., 51 (1992) 83-94.
28. 1A receptor mRNA in the dentate gyrus of long-term adrenalectomized rats and rapid reversal by dexamethasone. Mol. Brain Res., 19 (1993) 328-332.
29. 2 dopamine receptor mRNA synthesis in a 6-hydroxydopamine parkinsonian rat model. Brain Res. Bull., 28 (1992) 697-701.
30. Lopez, J.F., D.T. Chalmers, D.M. Vasquez, H. Akil and S.J. Watson. Corticosteroid regulation of serotonin1A receptor mRNA and binding in the hippocampus. Neuropsychoparmacology, 9 (1993) 845 (abstract no. 178).
31. 3 receptors determined with EEDQ. Soc. Neurosci. Abstr., 20 (1994) 224.16.
32. 2 dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vivo: selective protection by neuroleptics. J. Pharmacol. Exp. Ther., 233 (1985) 656-662.
33. 1A agonists. Mol. Pharmacol., 37 (1990) 231-237.
34. Murphy, D.L. Neuropsychiatrie disorders and the multiple human brain serotonin receptor subtypes and subsystems. Neuropsychopharmacology, 3 (1990) 457-471.
35. Pazos, A. and J.M. Palacios. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. serotonin-1 receptors. Brain Res., 346 (1985) 205-230.
36. Pinto, W. and G. Battaglia. In vivo EEDQ dose-dependently inactivates rat brain 5-HT receptors but not 5-HT uptake sites. NeuroReport, 5 (1993) 61-64.
37. 2 receptor mRNA in rat striatum by chronic neuroleptic treatment. Eur. J. Pharmacol., 207 (1991) 165-168.
38. 2 receptor mRNA levels. Eur. J. Pharmacol., 207 (1991) 169-172.
39. 1A receptors and 5-HT uptake sites in rat brain: an autoradiographic analysis. Neuroendocrinology, 57 (1993) 1011-1018.
40. 1A receptor-related anxiolytics. Trends Pharmacol. Sci., 8 (1987) 432-437.
41. 1 receptor and of catecholaminergic systems in the behavioral response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur. J. Pharmacol., 106 (1985) 271-282.
42. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci., 6 (1986) 3474-3482.
43. 2 dopamine receptor mRNA during ontogenesis, lesion and chronic antagonist treatment. Life Sci., 50 (1991) 383-396.
44. 2 dopamine receptors in brain. J. Pharmacol. Exp. Ther., 257 (1991) 608-615.
45. 1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes. Mol. Pharmacol., 41 (1992) 1066-1072.
46. 1A ligand. J. Med. Chem., 37 (1994) 1406-1407.