Stimulation of imidazoline receptors inhibits proliferation of human coronary artery vascular smooth muscle cells

Hypertension

Volumn 30, Issue 2, 1997, Pages 295-300

  Regunathan, Soundararajan ^a   Reis, Donald J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Angioplasty; Imidazoline; Muscle; Proliferation; Receptors; Smooth

Indexed keywords

AGMATINE; IDAZOXAN; IMIDAZOLINE RECEPTOR; NORADRENALIN; PLATELET DERIVED GROWTH FACTOR;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; VASCULAR SMOOTH MUSCLE;

EID: 0030811542     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.30.2.295     Document Type: Article

References (28)

1. Regunathan S, Reis DJ. Imadazoline receptors and their endogenous ligands. Annu Rev Pharmacol Toxicol. 1996;36:511-544.
2. Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, Reis DJ. Agmatine is an endogenous clonidine-displacing substance in brain. Science. 1994;263:966-969.
3. Regunathan S, Youngson C, Raasch W, Wang H, Reis DJ. Imadazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation. J Pharmacol Exp Ther. 1996;276:1272-1282.
4. Michel MC, Ernsberger P. Keeping an eye on the I-site: imidazoline preferring receptors. Trends Pharmacol Sci. 1992;13:369-370.
5. Berdeu D, Gross R, Peuch R, Loubatieres-Mariani MM, Bertrand G. Evidence for two different imidazoline sites on pancreatic b cells and vascular bed in rat. Eur J Pharmacol. 1995;275:91-98.
6. Gonzalez C, Regunathan S, Reis DJ, Estrada C. Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery. Br J Pharmacol. 1996;119:677-684.
7. London SM, Mayberg MR. Kinetics of bromodeoxyuridine uptake by smooth muscle cells after arterial injury. J Vasc Res. 1994;31:247-255.
8. Sers C, Riethmuller G, Johnson JP. Muc18, a melanoma-progression associated molecule, and its potential role in tumor vascularization and hematogenous spread. Cancer Res. 1994;54: 5689-5694.
9. 4+ mononuclear cells induce cytokine expression, vascular smooth muscle cell proliferation, and arterial occlusion after endothelial injury. Am J Pathol. 1994;145:1008-1014.
10. Cornwell TL, Soff GA, Traynor AE, Lincoln TM. Regulation of the expression of cyclic GMP-dependent protein kinase by cell density in vascular smooth muscle cells. J Vasc Res. 1994;31:330-337.
11. Chamley-Campbell JH, Campbell GR, Ross R. The smooth muscle cell in culture. Physiol Rev. 1979;59:1-61.
12. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature. 1994;372:231-236.
13. Haller H, Lindschau C, Quass P, Distler A, Luft FC. Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-α. Circ Res. 1995;76:21-29.
14. Meyer-Lehnert H, Schrier RW. Potential mechanism of cyclosporin A-induced vascular smooth muscle contraction. Hypertension. 1989; 13:350-362.
15. Wang H, Regunathan S, Ruggiero DA, Reis DJ. Production and characterization of antibodies specific for the imidazoline receptor protein. Mol Pharmacol. 1993;43:509-515.
16. Wang H, Regunathan S, Meeley MP, Reis DJ. Isolation and characterization of imidazoline receptor protein from bovine adrenal chromaffin cells. Mol Pharmacol. 1992;42:792-801.
17. Ruggiero DA, Regunathan S, Wang H, Milner TA, Reis DJ. Distribution of imidazoline receptor binding protein in the central nervous system. Ann N Y Acad Sci. 1995;763:208-221.
18. Regunathan S, Feinstein DL, Reis DJ. Expression of non-adrenergic imidazoline sites in rat cerebral cortical astrocytes. J Neurosci Res. 1993;34:681-688.
19. Escriba PV, Sastre M, Wang H, Regunathan S, Reis DJ, Garcia-Sevilla JA. Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues. Neurosci Lett. 1994;178:81-84.
20. Jackson CL, Schwartz SM. Pharmacology of smooth muscle cell replication. Hypertension. 1992;20:713-736.
21. Pouyssegur J, Seuwen K. Transmembrane receptors and intracellular pathways that control cell proliferation. Annu Rev Physiol. 1992;54:195-210.
22. Sastre M, Regunathan S, Reis DJ. Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatine. J Neurochem. 1996;67:1761-1765.
23. van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ. Receptor-tyrosine-kinase- and Gβy-mediated MAP kinase activation by a common signaling pathway. Nature. 1995;376:781-784.
24. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J. 1996; 9:726-735.
25. cdc2protem kinase during mitosis. Cell. 1989;58:361-372.
26. Watson MH, Venance SL, Pang SC, Mak AS. Smooth muscle cell proliferation: expression and kinase activities of p34 cdc and mitogen-activated protein kinase homologue. Circ Res. 1993;73: 109-117.
27. Irani K, Herzlinger S, Finkel T. Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells. Biochem Biophys Res Commun. 1994;202:1252-1258.
28. Erlinge D, Yoo H, Edvinsson L, Reis DJ, Wahlestedt C. Mitogenic effects of ATP on vascular smooth muscle cells vs other growth factors and sympathetic cotransmitters. Am J Physiol. 1993;265: H1089-H1097.