Challenges in the Diagnosis of the Right Patient for Testosterone Replacement Therapy{A figure is presented}

European Urology, Supplements

Volumn 6, Issue 17, 2007, Pages 862-867

  Wang, Christina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Androgen deficiency; Diagnosis; Hypogonadism; Serum testosterone; Testosterone deficiency syndrome; Testosterone replacement therapy

Indexed keywords

ALBUMIN; ANDROGEN; TESTOSTERONE;

ANDROGEN DEFICIENCY; BIOAVAILABILITY; BODY COMPOSITION; CLINICAL PRACTICE; HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HYPOGONADISM; LABORATORY TEST; LETHARGY; MALE; MOOD CHANGE; PRIORITY JOURNAL; QUESTIONNAIRE; REVIEW; SENSITIVITY AND SPECIFICITY; SEXUAL DYSFUNCTION; SYMPTOMATOLOGY; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE DEFICIENCY;

EID: 34548757197     PISSN: 15699056     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eursup.2007.08.002     Document Type: Review

References (32)

1. Nieschlag E. Testosterone treatment comes of age: new options for hypogonadal men. Clin Endocrinol 65 (2006) 275-281
2. Wang C., and Swerdloff R.S. Androgen replacement therapy in hypogonadal men. In: Winters S.J. (Ed). Male hypogonadism: basic, clinical and therapeutic principles (2003), Humana Press, Totowa, NJ 353-370
3. Morales A., Spevack M., Emerson L., et al. Adding to the controversy: pitfalls in the diagnosis of testosterone deficiency syndromes with questionnaires and biochemistry. Aging Male 10 (2007) 57-65
4. Liverman C.T., and Blazer D.G. Testosterone and aging: clinical research directions (2004), National Academies Press, Washington, DC
5. Nieschlag E., and Behre H.M. Testosterone: action, deficiency, substitution (2004), Cambridge University Press, Cambridge, United Kingdom
6. Traish A.M., Goldstein I., and Kim N.N. Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Eur Urol 52 (2007) 54-70
7. Benito M., Gomberg B., Wehrli F.W., et al. Deterioration of trabecular architecture in hypogonadal men. J Clin Endocrinol Metab 88 (2003) 1497-1502
8. Barrett-Connor E., Von Mühlen D.G., and Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo study. J Clin Endocrinol Metab 84 (1999) 573-577
9. Shores M.M., Sloan K.L., Matsumoto A.M., Moceri V.M., Felker B., and Kivlahan D.R. Increased incidence of diagnosed depressive illness in hypogonadal older men. Arch Gen Psychiatry 61 (2004) 162-167
10. Carnahan R.M., and Perry P.J. Depression in aging men: the role of testosterone. Drugs Aging 21 (2004) 361-376
11. Pope H.G., Cohane G.H., Kanayama G., Siegel A.J., and Hudson J.I. Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. Am J Psychiatry 160 (2003) 105-111
12. Steidle C., Schwartz S., Jacoby K., Sebree T., Smith T., and Bachand R. AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. J Clin Endocrinol Metab 88 (2003) 2673-2681
13. Wang C., Cunningham G., Dobs A., et al. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 89 (2004) 2085-2098
14. Wang C., Swedloff R.S., Iranmanesh A., et al. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Testosterone Gel Study Group. J Clin Endocrinol Metab 85 (2000) 2839-2853
15. Handelsman D.J. Testicular dysfunction in systemic disease. Endocrinol Metab Clin North Am 23 (1994) 839-856
16. Kapoor P., Luttrell B.M., and Williams D. The free androgen index is not valid for adult males. J Steroid Biochem Mol Biol 45 (1993) 325-326
17. Taieb J., Mathian B., Millot F., et al. Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children. Clin Chem 49 (2003) 1381-1395
18. Boyanov M.A., Boneva Z., and Christov V.G. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 6 (2003) 1-7
19. Sikaris K., McLachlan R.I., Kazlauskas R., de Kretser D., Holden C.A., and Handelsman D.J. Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays. J Clin Endocrinol Metab 90 (2005) 5928-5936
20. Betancourt-Albrecht M., and Cunningham G.R. Hypogonadism and diabetes. Int J Impot Res 15 Suppl 4 (2003) S14-S20
21. Heinemann L.A.J., Zimmermann T., Vermeulen A., Thiel C., and Hummel W. A new "aging males" symptoms rating scale. Aging Male 2 (1999) 105-114
22. Morley J.E., Charlton E., Patrick P., et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 49 (2000) 1239-1242
23. Smith K.W., Feldman H.A., and McKinlay J.B. Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men. Clin Endocrinol 53 (2000) 703-711
24. Morley J.E., Perry III H.M., Kevorkian R.T., and Patrick P. Comparison of screening questionnaires for the diagnosis of hypogonadism. Maturitas 53 (2006) 424-429
25. Corona G., Mannucci E., Petrone L., et al. ANDROTEST: a structured interview for the screening of hypogonadism in patients with sexual dysfunction. J Sex Med 3 (2006) 706-715
26. Wang C., Catlin D.H., Demers L.M., Starcevic B., and Swerdloff R.S. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem spectrometry. J Clin Endocrinol Metab 89 (2004) 534-543
27. Rosner W., Auchus R.J., Azziz R., Sluss P.M., and Raff H. Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society Position Statement. J Clin Endocrinol Metab 92 (2007) 405-413
28. Araujo A.B., O'Donnell A.B., Brambilla D.J., et al. Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 89 (2004) 5920-5926
29. Nieschlag E., Swerdloff R., Behre H.M., et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. Eur Urol 48 (2005) 1-4
30. http://www.issam.ch/freetesto.htm. Accessed 24/04/07.
31. The Endocrine Society. Testosterone therapy in adult men with androgen deficiency syndromes: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 91 (2006) 1995-2010
32. Qoubaitary A., Swerdloff R.S., and Wang C. Advances in male hormone substitution therapy. Expert Opin Pharmacother 6 (2005) 1493-1506