Depression in aging men: The role of testosterone

Drugs and Aging

Volumn 21, Issue 6, 2004, Pages 361-376

  Carnahan, Ryan M ^a   Perry, Paul J ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIDEPRESSANT AGENT; ANTIRETROVIRUS AGENT; FOLLITROPIN; HYDROCORTISONE; LUTEINIZING HORMONE; SEROTONIN UPTAKE INHIBITOR; TESTOSTERONE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE;

ACNE; AGING; ALCOHOL CONSUMPTION; DEPRESSION; DIET; DISEASE EXACERBATION; DRUG EFFICACY; DRUG FORMULATION; DRUG MONITORING; DRUG POTENTIATION; DRUG TOLERABILITY; EDEMA; ELECTROCONVULSIVE THERAPY; GENETIC POLYMORPHISM; GYNECOMASTIA; HEART ARRHYTHMIA; HORMONE METABOLISM; HORMONE SUBSTITUTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOGONADISM; IMPULSIVENESS; LIVER TOXICITY; MAINTENANCE THERAPY; MALE; MENTAL STRESS; NOCTURIA; OBESITY; PARKINSON DISEASE; PHYSICAL STRESS; POLYCYTHEMIA; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; REVIEW; SLEEP APNEA SYNDROME; SMOKING; SUICIDE ATTEMPT; TESTOSTERONE BLOOD LEVEL;

AGING; CHEMISTRY, PHARMACEUTICAL; CLINICAL TRIALS; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; HUMANS; MALE; TESTOSTERONE;

EID: 2342650753     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200421060-00002     Document Type: Review

References (59)

1. Lebowitz BD, Pearson PJ, Schneider LS, et al. Diagnosis and treatment of depression in late life. JAMA 1997; 278 (14): 1186-90
2. Meehan PJ, Saltzman LE, Sattin RW. Suicides among older United States residents: epidemiologic characteristics and trends. Am J Public Health 1991; 81: 1198-2000
3. Pearson JL, Conwell Y. Suicide in late life: challenges and opportunities for research. Int Psychogeriatr 1995; 7 (2): 131-5
4. Sternbach H. Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry 1998; 155: 1310-8
5. Wheeler MJ. The determination of bioavailable testosterone. Ann Clin Biochem 1995; 32: 345-57
6. Lund BC, Bever-Stille K, Perry PJ. Testosterone and andropause: the feasibility of androgen replacement therapy in elderly men. Pharmacotherapy 1999; 19 (8): 951-6
7. Gray A, Feldman HA, McKinlay JB, et al. Age, disease, and changing sex hormone levels in middle-aged men: results from the Massachusetts male aging study. J Clin Endocrinol Metab 1991; 73: 1016-25
8. Cohen PG. Aromatase, adiposity, aging, and disease: the hypogonadal-metabolic-atherogenic-disease and aging connection. Medical Hypotheses 2001; 56 (6): 702-8
9. Vermeulen A, Kaufman JM. Diagnosis of hypogonadism in the aging male. The Aging Male 2002; 5: 170-6
10. Bremner WJ, Vitiello V, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983; 56: 1278-81
11. Krithivas K, Yurgalevitch SM, Mohr BA, et al. Evidence that the CAG repeat in the androgen receptor gene is associated with age-related decline in serum androgen levels in men. J Endocrinology 1999; 162: 137-42
12. Vermeulen A, Kaufman JM. Ageing of the hypothalamic-pituitary-testicular axis in men. Horm Res 1995; 43: 25-8
13. Tenover JS. Androgen administration to aging men. Endocrinol Metab Clinics North Am 1994; 23 (4): 877-92
14. Deslypere P, Vermeulen A. Leydig cell function in normal men: effect of age, lifestyle, residence, diet, and activity. J Clin Endocrinol Metab 1984; 59 (5): 955-62
15. Webb CM, Adamson DL, de Zeigler D, et al. Effect of acute testosterone administration on myocardial ischemia in men with coronary artery disease. American Journal of Cardiology 1999; 83: 437-9
16. Rosano GMC, Leonardo F, Pagnotta P, et al. Acute anti-ischemic effect of testosterone on men with coronary artery disease. Circulation 1999; 99: 1666-70
17. Allen NE, Appleby PN, Davey GK, et al. Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men. Cancer Causes and Control 2002; 13: 353-63
18. Glass AR, Swerdoff RS, Bray GA, et al. Low serum testosterone and sex-hormone-binding-globulin in massively obese men. J Endocrinol Metab 1977; 45: 1211-9
19. Barrett-Connor E, Khaw K. Cigarette smoking and increased endogenous estrogen levels in men. Am J Epidemiol 1987; 126: 187-92
20. English KM, Pugh PJ, Parry H, et al. Effect of smoking on levels of bioavailable testosterone in healthy men. Clinical Science 2001; 100: 661-5
21. Persky H, O'Brien CP, Fine E, et al. The effect of alcohol and smoking on testosterone function and aggression in chronic alcoholics. Am J Psychiatry 1977; 134: 621-5
22. Allen NE, Appleby PN, Davey GK, et al. Hormones and diet low insulin-like growth factor-I but normal bioavailable androgens in vegan men. Br J Cancer 2000; 83: 95-7
23. Zitzmann M, Nieschlag E. Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs. Eur J Endocrinol 2001; 144: 183-97
24. Fournier P-E, Stalder J, Mermillod B, et al. Effects of a 110 kilometers ultra-marathon race on plasma hormone levels. Int J Sports Med 1997; 18: 252-6
25. Francis KT. The relationship of high and low trait psychological stress, serum testosterone, and serum cortisol. Experientia 1981; 37: 1296-7
26. Sachar EJ, Halpern F, Rosenfeld RS, et al. Plasma and urinary testosterone levels in depressed men. Arch Gen Psychiatry 1973; 28: 15-8
27. Shaw DM, Francis AF, Groom GV, et al. A pilot endocrine study in depression. Postgrad Med J 1977; 53 Suppl. 4: 172-4
28. Steiger A, von Bardeleben U, Wiedeman K, et al. Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission. J Psychiatr Res 1991; 25: 169-77
29. Vogel W, Klaiber EL, Broverman DM. Roles of the gonadal steroid hormones in psychiatric depression in men and women. Prog Neuropsychopharmacol 1978; 2: 487-503
30. Yesavage JA, Davidson J, Widrow L, et al. Plasma testosterone levels, depression, sexuality, and age. Biol Psychiatry 1985; 20: 222-5
31. Swinden DC, Deighton CM, Nott K, et al. Free testosterone and depression in male rheumatoid arthritis. Br J Rheumatol 1990; 29 (5): 401-2
32. Schweiger U, Deuschle M, Weber B, et al. Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom Med 1999; 61: 292-6
33. Kaneda Y, Fujii A. No relationship between testosterone levels and depressive symptoms in aging men. Eur Psychiatry 2002; 17: 411-3
34. Seidman SN, Araujo AB, Roose SP, et al. Low testosterone levels in elderly men with dysthymic disorder. Am J Psychiatry 2002; 159: 456-9
35. Barrett-Connor E, Von Mühlen DG, Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo study. J Clin Endocrinol Metab 1999; 84: 573-7
36. Booth A, Johnson DR, Granger DA. Testosterone and men's depression: the role of social behavior. J Health Soc Behav 1999; 40: 130-40
37. Perry PJ, Lund BC, Arndt S, et al. Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males: implications for testosterone replacement therapy. Ann Clin Psychiatry 2001; 13 (2): 75-80
38. Seidman SN, Araujo AB, Roose SP, et al. Testosterone level, androgen receptor polymorphism, and depressive symptoms in middle-aged men. Biol Psychiatry 2001; 50: 371-6
39. Shores MM, Sloan KL, Matsumoto AM, et al. Increased incidence of diagnosed depressive illness in hypgonadal older men. Arch Gen Psychiatry 2004; 61 (2): 162-7
40. Virkkunen M, Rawlings R, Tokola R, et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51 (1): 20-7
41. Rubinow DR, Schmidt PJ. Androgens, brain, and behavior. Am J Psychiatry 1996; 153 (8): 974-84
42. Gustavsson G, Träskman-Bendz L, Higley JD, et al. CSF testosterone in 43 male suicide attempters. Eur Neuropsychopharmacol 2003; 13: 105-9
43. Burris AS, Banks SM, Carter CS, et al. A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J Androl 1992; 13 (4): 297-304
44. Ehrenreich H, Halaris A, Ruether E, et al. Psychoendocrine sequelae of chronic testosterone deficiency. J Psychiatr Res 1999; 33: 379-87
45. Wang C, Alexander G, Berman N, et al. Testosterone replacement therapy improves mood in hypogonadal men: a clinical research center study. J Clin Endocrinol Metab 1996; 81: 3578-83
46. Seidman SN, Rabkin JG. Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression. J Affect Disord 1998; 48: 157-61
47. Seidman SN, Spatz E, Rizzo C, et al. Testosterone replacement therapy for hypogonadal men with major depressive disorder: a randomized, placebo-controlled trial. J Clin Psychiatry 2001; 62: 406-12
48. Pope HG, Cohane GH, Kanayama G, et al. Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. Am J Psychiatry 2003; 160 (1): 105-11
49. Perry PJ, Yates WR, Williams RD, et al. Testosterone therapy in late-life major depression in males. J Clin Psychiatry 2002; 63: 1096-101
50. Okun MS, McDonald WM, DeLong MR. Refractory nonmotor symptoms in male patients with Parkinson disease due to testosterone deficiency. Arch Neurol 2002; 39: 807-11
51. Okun MS, Walter BL, McDonald WM, et al. Beneficial effects of testosterone replacement therapy for the nonmotor symptoms of Parkinson disease. Arch Neurol 2002; 39: 1730-3
52. Mylonakis E, Koutkia P, Grinspoon S. Diagnosis and treatment of androgen deficiency in human immunodeficiency virus-infected men and women. Clin Infect Dis 2001; 33: 837-64
53. Basaria S, Dobs AS. Risks versus benefits of testosterone therapy in elderly men. Drugs Aging 1999; 13 (2): 131-42
54. Morales A, Lunenfeld B. Investigation, treatment, and monitoring of late-onset hypogonadism in males: official recommendations of the ISSAM. Aging Male 2002; 5: 74-86
55. Matsumoto AM, Sandblom RE, Schoene RB, et al. Testosterone replacement in hypogonadal men: effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin Endocrinol 1983; 22 (6): 713-21
56. Luboshitsky R, Aviv A, Hefetz A. Decreased pituitary-gonadal secretion in men with obstructive sleep apnea. J Clin Endocrinol Metab 2002; 87: 3394-8
57. English KM, Steeds RP, Jones TH, et al. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina. Circulation 2000; 102: 1906-11
58. Morgantaler A, Bruning CO, DeWolf WC. Occult prostate cancer in men with low serum testosterone levels. JAMA 1996; 276: 1904-6
59. Krishnan KR, Delong M, Kraemer H, et al. Comorbidity of depression with other medical diseases in the elderly. Biol Psychiatry 2002; 52 (6): 559-88