Rehydration of high-density sickle erythrocytes in vitro

Blood

Volumn 100, Issue 8, 2002, Pages 3017-3025

  David Holtzclaw, J ^a,b,c,d   Jiang, Maorong ^a,b,c,d   Yasin, Zahida ^a,b,c,d   Joiner, Clinton H ^a,b,c,d   Franco, Robert S ^a,b,c,d,e  

^a University of Cincinnati   (United States)

^b Cincinnati Comprehensive Sickle Cell Center   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; BUMETANIDE; CALCIUM ION; CHARYBDOTOXIN; HEMOGLOBIN; PHOSPHATIDYLSERINE; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM ION; STILBENE DERIVATIVE; VALINOMYCIN;

ARTICLE; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEHYDRATION; ERYTHROCYTE; HUMAN; INCUBATION TIME; OXYGENATION; PRIORITY JOURNAL; REHYDRATION; SICKLE CELL; SICKLE CELL ANEMIA; SICKLE CELL TRAIT;

EID: 0037108443     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-02-0631     Document Type: Article

References (29)

1. Hebbel R. Beyond hemoglobin polymerization: the red blood cell membrane and sickle cell disease pathophysiology, Blood. 1991;77:214-237.
2. Kaul D, Fabry M, Nagel R. Erythrocytic and vascular factors influencing the microcirculatory behavior of blood in sickle cell anemia. Ann N Y Acad Sci. 1989;565:316-326.
3. Joiner C. Cation transport and volume regulation in sickle red blood cells. Am J Physiol. 1993;264: C251-C270.
4. Hofrichter J, Ross P, Eaton W. Kinetics and mechanism of deoxyhemoglobin S gelation: a new approach to understanding sickle cell disease. Proc Natl Acad Sci U S A. 1974;71:4864-4868.
5. Brugnara C. Cation Homeostasis. In: Embury S, Hebbel R, Mohandas N, Steinber M, eds. Sickle Cell Disease: Basic Principles and Clinical Practice. New York, NY: Raven Press; 1994:173-194.
6. Bookchin R, Lew V. Pathophysiology of sickle cell anemia. Hematol Oncol Clin North Am. 1996;10: 1241-1253.
7. Bookchin R, Ortiz O, Lew V. Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia. J Clin Invest. 1991;87:113-124.
8. Joiner C, Jiang M, Franco R. Deoxygenation-induced cation fluxes in sickle cells, IV: modulation by external calcium. Am J Physiol. 1995;269: C403-C409.
9. Joiner C, Platt O, Lux S. Cation depletion by the sodium pump in red cells with pathological cation leaks: sickle cells and xerocytes. J Clin Invest. 1986;78:1487-1496.
10. Rhoda M,Apova M, Beuzard Y, Giraud F. Ca++ permeability in deoxygenated sickle cells. Blood. 1990;75:2453-2458.
11. Joiner C, Morris C, Cooper E. Deoxygenation-induced cation fluxes in sickle cells, III: cation selectivity and response to pH and membrane potential. Am J Physiol. 1993;264:C734-C744.
12. Joiner C. Deoxygenation-induced cation fluxes in sickle cells, II: inhibition by stilbene disulfonates. Blood. 1990;76:212-220.
13. Joiner C, Jiang M. Inhibition of deoxygenation-induced calcium influx in sickle red blood cells by dipyridamole and other transport inhibitors [abstract]. Blood. 1995;86:299a.
14. Joiner C, Jiang M, Claussen W, Roszell N, Yasin Z, Franco R. Dipyridamole inhibits sickling-induced cation fluxes in sickle red blood cells. Blood. 2001;97:3976-3983.
15. Tiffert T, Spivak J, Lew V. Magnitude of calcium influx required to induce dehydration of normal human red cells. Biochim Biophys Acta. 1988; 943:157-165.
16. De Franceschi L, Saadane N, Trudel M, Alper S, Brugnara C, Beuzard Y. Treatment with oral clotrimazole blocks Ca2+-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice: a model for therapy of sickle cell disease. J Clin Invest. 1994;93:1670-1676.
17. Brugnara C, Gee B, Armsby C, et al. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996;97:1227-1234.
18. + efflux is highly expressed in young human red cells containing normal hemoglobin or HbS. J Membr Biol. 1987;97:97-105.
19. Etzion Z, Lew V, Bookchin R. K(86Rb) transport heterogeneity in the low-density fraction of sickle cell anemia red blood cells. Am J Physiol. 1996; 271:C1111-C1121.
20. Bookchin R, Etzion Z, Sorette M, Mohandas N, Skepper J, Lew V. Identification and characterization of a newly recognized population of high-Na+, low-K+, low-density sickle and normal red cells. Proc Natl Acad Sci U S A. 2000;97:8045-8050.
21. Franco R, Lohmann J, Siberstein E, et al. Time-dependent changes in the density and hemoglobin F content of biotin-labeled sickle cells. J Clin Invest. 1998;101:2730-2740.
22. Franco R, Yasin Z, Lohmann J, et al. The survival characteristics of dense sickle cells. Blood. 2000; 96:3610-3617.
23. Horiuchi K, Asakura T. Formation of light irreversible sickled cells during deoxygenation-oxygenation cycles. J Lab Clin Med. 1987;110:653-660.
24. Holtzclaw J, Harris T, Jiang M, McGoron A, Joiner C, Franco R. Generation of light sickle erythrocytes from dense sickle erythrocytes during fast oxy/deoxy cycling [abstract]. Blood. 2000;96:601a.
25. McGoron A, Joiner C, Palascak M, Claussen W, Franco R. Dehydration of mature and immature sickle red blood cells during fast oxygenation/deoxygenation cycles; role of KCI cotransport and extracellular calcium. Blood. 2000;95:2164-2168.
26. Ney P, Christopher M, Hebbel R. Synergistic effects of oxidation and deformation on erythrocyte monovalent cation leak. Blood. 1990;75:1192-1198.
27. Platt OS. Exercise-induced hemolysis in sickle cell anemia: shear sensitivity and erythrocyte dehydration. Blood. 1982;59:1055-1060.
28. de Jong K, van Rossum L, Lubin B, Styles S, Kuypers F. Phosphatidyserine externalization in subpopulations of sickle cells [abstract]. Blood. 1997;90:125a.
29. Kaul D, Fabry M, Nagel R. Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proc Natl Acad Sci U S A. 1989;86:3356-3360.