Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes

BMC Cell Biology

Volumn 3, Issue , 2002, Pages

  Chen, Chii Shiarng ^a,b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b MOLECULAR PROBES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; FLUORESCENT DYE; INDICATOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; TUMOR PROMOTER;

ALKALINITY; ANIMAL CELL; ARTICLE; CELL PH; CELL SUBPOPULATION; CONTROLLED STUDY; COVALENT BOND; ENDOSOME; FLUORESCENCE MICROSCOPY; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; OXIDATION; REGULATORY MECHANISM;

BOVINAE;

EID: 2342664099     PISSN: 14712121     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2121-3-21     Document Type: Article

References (15)

1. Storrie B, Desjardins M: The biogenesis of lysosomes: is it a kiss and run, continuous fusion and fission process? BioEssays 1996, 18:895-903
2. Brabowski GA, Gatt S, Horowitz M: Acid β-glucosidase: enzymology and molecular biology of Gaucher disease. Crit Rev Biochem Mol Biol 1990, 25:385-414
3. Bach G, Chen CS, Pagano RE: Elevated lysosomal pH in Mucolipidosis type IV cells. Clin Chim Acta 1999, 280:173-179
4. Brunk UT, Cadenas E: The potential intermediate role of lysosomes in oxygen free radical pathology. APMIS 1988, 96:3-13
5. Zdolsek JM, Svensson I: Effect of reactive oxygen species on lysosomal membrane integrity. A study on a lysosomal fraction. Virchows Arch B Cell Pathol Incl ol Pathol 1993, 64:401-406
6. Aviram M, Rosenblat M, Etzioni A, Levy R: Activation of NADPH oxidase is required for macrophage-mediated oxidation of low-density lipoprotein. Metabolism 1996, 45:1069-1079
7. Robinson JP: Oxygen and nitrogen reactive metabolites and phagocytic cells. In: Phagocyte Function: A Guide for Research and Clinical Evaluation. (Edited by: J. P. Robinson, G. F. Babcock) Wiley-Liss, Inc. New York. 1998, 217-252
8. Chen CS, Bach G, Pagano RE: Abnormal transport along the lysosomal pathway in Mucolipidosis, type IV disease. Proc Natl Acad Sci USA 1998, 95:6373-6378
9. Wubbolts R, Fernandez-Borja M, Oomen L, Verwoerd D, Janssen H, Calafat J, Tulp A, Dusseljee S, Neefjes J: Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface. J Cell Biol 1996, 135:611-22
10. + antiporter. J Leukoc Biol 1989, 45:239-248
11. Ryan TC, Weil GJ, Newburger PE, Haugland R, Simons ER: Measurement of superoxide release in the phagovacuoles of immune complex-stimulated human neutrophils. J Immunol Methods 1990, 130:223-233
12. Styrt B, Klempner MS: Inhibition of neutrophil oxidative metabolism by lysosomotropic weak bases. Blood 1986, 67:334-342
13. Kindzelskii AL, Zhou MJ, Haugland RP, Boxer LA, Petty HR: Oscillatory pericellular proteolysis and oxidant deposition during neutrophil locomotion. Biophys J 1998, 74:90-97
14. Voetman AA, Weening RS, Hamers MN, Meerhof LJ, Bot AA, Roos D: Phagocytosing human neutrophils inactivate their own granular enzymes. J Clin Invest 1981, 67:1541-1549
15. Nilsson E, Ghassemifar R, Brunk UT: Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress. Histochem J 1997, 29:857-865